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Regulation mechanism of Sparassis latifolia polysaccharide improving glucose metabolism disorder in skeletal muscle of mice based on transcriptomics analysis
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Zhen WANG1, Wen JIN2, Xin WEI2, Jinling CAO2, Shaojun YUN2, Feier CHENG2, Cuiping FENG2, *
Mycosystema | 2026, 45(3) : 250196
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Mycosystema | 2026, 45(3): 250196
• Research paper •
Regulation mechanism of Sparassis latifolia polysaccharide improving glucose metabolism disorder in skeletal muscle of mice based on transcriptomics analysis
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Zhen WANG1, Wen JIN2, Xin WEI2, Jinling CAO2, Shaojun YUN2, Feier CHENG2, Cuiping FENG2, *
Affiliations
  • 1 Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, Shanxi, China
  • 2 College of Food Science and Engineering, Shanxi Agricultural University, Jinzhong 030801, Shanxi, China

    • ORCID: Feng Cuiping (0000-0002-9133-6081)

Published: 2026-03-22 doi: 10.13346/j.mycosystema.250196
Outline
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The study was designed to investigate the improvement effect and molecular mechanism of Sparassis latifolia polysaccharide (SLPs) on glucose metabolism in skeletal muscle of mice with glucose metabolism disorder induced by high-fat diet combined with streptozotocin (STZ). The results showed that SLPs intervention could significantly reduce the impaired glucose tolerance and insulin resistance and increase skeletal muscle glycogen content and improve the morphological damage of skeletal muscle caused by glucose metabolism disorder. Transcriptome analysis identified a total of 965 differentially expressed genes (DEGs). GO annotation and enrichment analysis showed that these genes were mainly involved in tissue development, animal organ morphogenesis, small molecule metabolism, myofibril, glycogen binding, and organic acid binding. The enrichment analysis of KEGG further revealed that DEGs were mainly enriched in PI3k/Akt signal pathway, AGE-RAGE signal pathway related to diabetic complications, insulin resistance, AMPK signal pathway and other signal pathways. In addition, SLPs could regulate the expression of genes and proteins related to AMPK/SIRT1/PGC-1α signal pathway and the activities of key enzymes in skeletal muscle of mice to improve glucose metabolism disorder in skeletal muscle, protect skeletal muscle damage, and maintain the metabolic homeostasis of the body. This study provides a theoretical basis for the development of SLPs as functional food ingredients.

Sparassis latifolia polysaccharides  /  glucose metabolism  /  skeletal muscle  /  transcriptomics  /  AMPK/SIRT1/PGC-1α signaling pathway
Zhen WANG, Wen JIN, Xin WEI, Jinling CAO, Shaojun YUN, Feier CHENG, Cuiping FENG. Regulation mechanism of Sparassis latifolia polysaccharide improving glucose metabolism disorder in skeletal muscle of mice based on transcriptomics analysis[J]. Mycosystema, 2026 , 45 (3) : 250196 - . DOI: 10.13346/j.mycosystema.250196
Funding
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  • Science and Technology Achievement Transformation Guidance Special Project of Shanxi Province(202304021301055)
  • Earmarked Fund for Modern Agro-industry Technology Research System of Shanxi Province(2025CYJSTX09-02)
  • Major Special Science and Technology Projects of Shanxi Province(202301140601015)
  • Special Project for Patent Commercialization of Shanxi Province(202301009)
Appendix
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Year 2026 volume 45 Issue 3
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51
23
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Article Info
doi: 10.13346/j.mycosystema.250196
  • Receive Date：2025-06-30
  • Online Date：2026-04-30
  • Published：2026-03-22
Article Data
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History
  • Received：2025-06-30
  • Accepted：2025-08-12
Funding
Science and Technology Achievement Transformation Guidance Special Project of Shanxi Province(202304021301055)
Earmarked Fund for Modern Agro-industry Technology Research System of Shanxi Province(2025CYJSTX09-02)
Major Special Science and Technology Projects of Shanxi Province(202301140601015)
Special Project for Patent Commercialization of Shanxi Province(202301009)
Affiliations
    1 Shanxi Institute for Functional Food, Shanxi Agricultural University, Taiyuan 030031, Shanxi, China
    2 College of Food Science and Engineering, Shanxi Agricultural University, Jinzhong 030801, Shanxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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