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Preventive effects of Hericium coralloides crude polysaccharides on DSS-induced chronic colitis in mice
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Juan YANG1, 2, Hongyu WANG4, Jieting CHEN2, Lulu CHU2, Yuji JIANG2, 3, *
Mycosystema | 2026, 45(2) : 250151
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Mycosystema | 2026, 45(2): 250151
• Research paper •
Preventive effects of Hericium coralloides crude polysaccharides on DSS-induced chronic colitis in mice
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Juan YANG1, 2, Hongyu WANG4, Jieting CHEN2, Lulu CHU2, Yuji JIANG2, 3, *
Affiliations
  • 1 Anshun Vocational and Technical College, Anshun 561000, Guizhou, China
  • 2 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
  • 3 Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
  • 4 The Institute of Edible Fungi, Fujian Academy of Agricultural Sciences, Fuzhou 350012, Fujian, China

    • ORCID: YANG Juan (0000-0002-9010-9362)

Published: 2026-02-22 doi: 10.13346/j.mycosystema.250151
Outline
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The prevention effects of Hericium coralloides polysaccharides (HCP) on chronic colitis and the impact of HCP on gut microbial communities in mice were investigated. Sixty mices were randomly divided into six groups: blank control (CK), model control (MC), positive control (PC), low-dose HCP (L-HCP), medium-dose HCP (M-HCP), and high-dose HCP (H-HCP). Biochemical indicators of serum, colonic tissue and histopathological sections were compared among these groups, and 16S rRNA high-throughput sequencing was used to analyze the relative abundance and the diversity of the intestinal microflora at the phyla and class levels. Results showed that HCP significantly reduced the levels of serum interleukin-1β (IL-1β), serum interleukin-2 (IL-2), serum interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the serum, and decreased the levels of the Toll-like receptor 4 (TLR4), cysteine protease 1 (Casp-1), apoptosis-associated speck-like protein (ASC) and phosphorylated p65 protein (pp65) in colonic tissue. The 16S rRNA sequencing showed that HCP significantly increased the α-diversity indices Chao1, Shannon, and observed species, reduced the Simpson index, and regulated the abundance of Bacteroides and Firmicutes, thereby reducing colonic tissue damage. In conclusion, HCP can prevent DSS-induced chronic colitis and possesses potential utilization value in the field of functional food.

Hericium coralloides fruiting body polysaccharide  /  chronic enteritis  /  high-throughput sequencing  /  intestinal microbiota
Juan YANG, Hongyu WANG, Jieting CHEN, Lulu CHU, Yuji JIANG. Preventive effects of Hericium coralloides crude polysaccharides on DSS-induced chronic colitis in mice[J]. Mycosystema, 2026 , 45 (2) : 250151 - . DOI: 10.13346/j.mycosystema.250151
Funding
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  • Key Fund of Anshun Vocational College(N202304)
  • Science and Technology Plan of Anshun City(安市科农[2025]17号)
Appendix
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Year 2026 volume 45 Issue 2
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54
23
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Article Info
doi: 10.13346/j.mycosystema.250151
  • Receive Date：2025-05-18
  • Online Date：2026-04-29
  • Published：2026-02-22
Article Data
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History
  • Received：2025-05-18
  • Accepted：2025-07-09
Funding
Key Fund of Anshun Vocational College(N202304)
Science and Technology Plan of Anshun City(安市科农[2025]17号)
Affiliations
    1 Anshun Vocational and Technical College, Anshun 561000, Guizhou, China
    2 College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
    3 Mycological Research Center, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
    4 The Institute of Edible Fungi, Fujian Academy of Agricultural Sciences, Fuzhou 350012, Fujian, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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