In the digital economy era, the liability of newness is mainly manifested as the inability of datasensitive entrepreneurial activities to enter the market due to data scarcity. Based on the dual attributes of public data as both a data factor and a public service, the effect of open public data on regional datasensitive entrepreneurship was examined over the sample period from 2010 to 2019. A quasinatural experiment based on the launch of open public data platforms by local governments was employed to identify the causal impact. The empirical results indicate that open public data significantly promotes regional datasensitive entrepreneurship and alleviates the liability of newness. Mechanism analysis reveals that open public data releases regional market demand potential, provides more highquality production factors, and improves the business environment. These effects stimulate the market entry of datasensitive entrepreneurs, forming marketenabling, factorenabling, and institutionalenabling effects. Further analysis shows that the positive effect is amplified with better data quality and higher regional information accessibility. Open public data also enhances overall regional entrepreneurial activity. The facilitating effect is stronger in cities with lower degrees of market segmentation. These findings may offer implications for overcoming the liability of newness in the digital economy and for creating a digital environment that supports entrepreneurial activities.