Innovation-driven development needs to vigorously cultivate and carry forward the craftsmanship. Vigorously promoting the craftsmanship in all walks of life is conducive to building an innovative country, and it is also necessary to build a country with manufacturer of quality products and a country with a strong socialist culture. However, the path mechanism and boundary conditions of how craftsmanship affects employee’ innovation behavior are still unclear. Therefore, data from 454 paired survey questionnaires between employees and their supervisors collected at three time points was used to analyze this research question. Based on model of proactive motivation process and antecedents, the process and boundary conditions of craftsmanship in promoting employee innovation behavior through affecting psychological availability were discussed and analyzed. It reveals that craftsmanship positively affects employees’ innovation behavior. Psychological availability plays a mediating role between craftsmanship and employee innovation behavior. Promotive ethical leadership positively moderates the relationship between craftsmanship and psychological availability, when the level of promotive ethical leadership is higher, this moderating effect is more obvious, at the same time, promotive ethical leadership positively moderates the mediating effect of psychological availability between craftsmanship and employee innovation behavior. Prohibitive ethical leadership cannot play a significant boundary role in the relationship between craftsmanship and psychological availability. The conclusion reveals the important role of promoting craftsmanship in improving employees’ innovation ability, and shows that appropriate leadership style can further strengthen the positive impact of craftsmanship on employees’ work performance.