As an important force driving the high-quality development of the manufacturing industry, "SRDI" (Specialized, Refinement, Differential and Innovation) small and medium-sized enterprises (SMEs) play an important role in improving the quality and safety of the manufacturing industry. "SRDI" SMEs can enhance the quality of the manufacturing industry by strengthening the innovation power of the manufacturing industry, improving the brand value, and promoting transformation and upgrading. By promoting the integrity of the manufacturing industry chain, enhancing industrial advantages and promoting the smooth flow of the industry chain, they will improve the industrial safety of the manufacturing industry. At the same time, a technology-led industrial safety guarantee mode, a market-driven industrial safety guarantee mode, a technology-led efficiency enhancement mode and a market-driven efficiency optimization mode have been formed. Based on such consideration, efforts should be made to develop "SRDI" SMEs in key niche areas, enhance their capacity, and promote their integration and development with large enterprises. For the government and relevant departments, they should strategically plan the development of "SRDI" SMEs, improve the precision of policy support, strengthen the supply of basic research technology, and improve the business environment.