Full
Outline
Patients with EGFR-mutated lung adenocarcinoma often develop acquired resistance to targeted drugs such as Osimertinib，leading to poor prognosis. Tumor stem cell properties are an important mechanism for drug resistance，and the role of the stemness gene SOX-2 in Osimertinib resistance remains unclear. This study aimed to investigate the function of SOX-2 in Osimertinib resistance in EGFR-mutated lung adenocarcinoma.
This study first analyzed the expression of SOX-2 in lung adenocarcinoma and its correlation with prognosis using the public databases GEPIA，TIMER，and HPA. Additionally，SOX-2 was overexpressed in lung adenocarcinoma cell lines H1975 and PC9，and cellular sensitivity to Osimertinib was assessed using the CCK-8 assay. Sphere-forming capacity was evaluated via 3D Matrigel culture assay.
Overexpression of SOX-2 significantly enhanced the resistance of H1975 and PC9 cells to Osimertinib and enhanced their clonogenic capacity and proliferative ability under three-dimensional culture conditions.
High SOX-2 expression promotes Osimertinib resistance in EGFR-mutated lung adenocarcinoma，and this study provides experimental evidence for the prognosis assessment of EGFR-mutated lung adenocarcinoma.
65
14
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
