Full
Outline
To mine and analyze adverse drug event (ADE) signals associated with the use of three tetracycline antibiotics (doxycycline，minocycline，and tigecycline) in children，providing evidence for the safe use of tetracyclines in pediatric populations.
ADE reports of doxycycline，minocycline，and tigecycline in children from Q1 2004 to Q2 2025 were extracted from the FDA Adverse Event Reporting System (FAERS) database. Data mining and analysis were performed using the Reporting Odds Ratio (ROR) method and the Bayesian Confidence Propagation Neural Network (BCPNN).
A total of 1 653 pediatric ADE reports were identified，involving doxycycline (664 reports)，minocycline (926 reports)，and tigecycline (63 reports). Significant signals were detected across 19 important System Organ Classes (SOCs). In children under 2 years old，only doxycycline was found to be associated with adverse reactions，primarily affecting the Blood/Lymphatic System，Metabolism/Nutrition，and Injury/Poisoning categories. In the 2-7 years age group，doxycycline-related events concentrated in Nervous System and Eye disorders，while tigecycline-related events concentrated in Gastrointestinal System disorders. For children aged 8-17 years old，signals were detected for all three drugs: doxycycline was primarily associated with Psychiatric and Gastrointestinal disorders; minocycline was mainly associated with nervous system，eye，and skin and subcutaneous tissue disorders. Tigecycline was primarily associated with injury and poisoning.
Adverse drug reactions (ADRs) of the three tetracyclines are varied across different pediatric age groups. Doxycycline is associated is neurological damage，Horner syndrome，and psychiatric adverse reactions. Minocycline will induce long-term autoimmune disorders，increasing the risk of type 1 diabetes. Tigecycline is found to induce unlabeled hypertriglyceridemia not stated in the drug labeling，necessitating enhanced lipid monitoring during clinical use.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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