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Yiqi Chutan Formula Inhibits Lung Cancer Via Remodulating Gut and Tumor Microbiota
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Zhicong YANG1, Xinyi ZHOU1, Lexin CHEN1, Nianhong LAI1, 2, Tao ZHANG1, 2, Chutian MAI1, 2, Enxin ZHANG1, 2, Xiaojun ZHANG1, *
Pharmacy Today | 2026, 36(7) : 498 - 504
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Pharmacy Today | 2026, 36(7): 498-504
Yiqi Chutan Formula Inhibits Lung Cancer Via Remodulating Gut and Tumor Microbiota
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Zhicong YANG1, Xinyi ZHOU1, Lexin CHEN1, Nianhong LAI1, 2, Tao ZHANG1, 2, Chutian MAI1, 2, Enxin ZHANG1, 2, Xiaojun ZHANG1, *
Affiliations
  • 1.Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
  • 2.Shenzhen Baoan Authentic Traditional Chinese Medicine Therapy Hospital, Shenzhen, Guangdong 518101, China
Published: 2026-07-25 doi: 10.12048/j.issn.1674-229X.2026.07.003
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OBJECTIVE

This study aimed to investigate the anti-lung cancer effects of Yiqi Chutan formula (YQCTF) and explore its remodeling effects on the gut and tumor microecology.

METHODS

Mice were subcutaneously implanted with LLC cells to establish a xenograft model and were intragastrically administered different extracts of YQCTF. Tumor volume and weight were recorded and the peripheral blood cell analysis was performed. 16S rRNA sequencing was used to analyze the composition and abundance of the gut and tumor microbiota.

RESULTS

Different YQCTF extracts inhibited the tumor growth in LLC-bearing mice，reduced the spleen index，and reduced the proportion of peripheral blood mononuclear cells. Furthermore，YQCTF intervention modulated the microbial structure by suppressing the abundance of Prevotella, Oscillibacter，and Alistipes in the gut，while increasing the abundance of Prevotella in tumor tissue. It also inhibited the enrichment of Clostridium_XIVa in both intestinal contents and tumor tissues.

CONCLUSION

YQCTF attenuates lung cancer growth in mice by modulating the microbiota，including restoring short-chain fatty acid-producing bacterial communities，and suppressing pro-inflammatory bacteria.

Yiqi Chutan formula  /  lung cancer  /  16S rRNA  /  gut microbiota  /  tumor microecology
杨智聪, 周昕怡, 陈乐鑫, 赖年红, 张涛, 麦楚填, 张恩欣, 张晓君. 益气除痰方调控肠道及肿瘤微生态抗肺癌进展的作用. 今日药学, 2026 , 36 (7) : 498 -504 . DOI: 10.12048/j.issn.1674-229X.2026.07.003
Zhicong YANG, Xinyi ZHOU, Lexin CHEN, Nianhong LAI, Tao ZHANG, Chutian MAI, Enxin ZHANG, Xiaojun ZHANG. Yiqi Chutan Formula Inhibits Lung Cancer Via Remodulating Gut and Tumor Microbiota[J]. Pharmacy Today, 2026 , 36 (7) : 498 -504 . DOI: 10.12048/j.issn.1674-229X.2026.07.003
Appendix
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Year 2026 volume 36 Issue 7
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.07.003
  • Receive Date：2025-12-01
  • Online Date：2026-10-27
  • Published：2026-07-25
Article Data
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History
  • Received：2025-12-01
Funding
Affiliations
    1.Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
    2.Shenzhen Baoan Authentic Traditional Chinese Medicine Therapy Hospital, Shenzhen, Guangdong 518101, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.07.003
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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