Based on the theory of traditional Chinese medicine，to develop a functional food with homology between medicine and food，composed of Hericium erinaceus，Astragalus radix，Paeonia radix alba，Citri reticulatae pericarpium，Amomi fructus，Magrarita pulveratum，etc.，and to evaluate its auxiliary protective function against gastric mucosal injury.

The anti-Helicobacter pylori activity was evaluated through in vitro experiments. The rat model of alcohol-induced gastric mucosal injury was adopted to evaluate its protective effect on gastric mucosa. The health care function of assisting in protecting gastric mucosa was evaluated through human clinical trials.

In vitro experiments indicated that this functional food had inhibitory and killing effects on the standard strain of Helicobacter pylori (ATCC 700392)，with a minimum inhibitory concentration (MIC) of 75 mg·mL^-1 and a minimum bactericidal concentration (MBC) of 150 mg·mL^-1. Animal experiments showed that the total lesion score of the gastric mucosa histopathological examination in the 4.50 g·kg^-1 BW dose group was significantly lower than that in the model control group (P<0.05). The gastric mucosal injury score indices in the 1.50 g·kg^-1 BW and 4.50 g·kg^-1 BW dose groups were also significantly lower than those in the model control group，indicating an auxiliary protective effect on mucosal injury. Human clinical trials revealed that，compared with their own baseline before the trial，the clinical symptom and sign scores related to gastric mucosal injury in the trial group were significantly reduced (P<0.05).

This study successfully develops a functional food with a clear auxiliary protective function against gastric mucosal injury. Its mechanism of action may be related to the inhibition of Helicobacter pylori and the enhancement of gastric mucosal defense，and it has a good application prospect.