Full
Outline
To analyze the risk factors for early low tacrolimus blood concentration in lung transplant patients and to develop and evaluate a risk prediction model.
A retrospective analysis of medical records of hospitalized lung transplant patients who had their tacrolimus blood concentrations monitored within three months post-transplantation.Univariate and multivariate Logistic regression analysis were used to screen the risk factors for tacrolimus plasma concentration below the lower limit in the early postoperative period of lung transplantation patients. A nomogram model was developed using R software.
Logistic regression analysis identified age, sex, azole antifungal agents, and carbapenem antibiotics as independent risk factors for subtherapeutic tacrolimus blood concentrations (P <0.05). Based on these factors, a nomogram model was established.Model evaluation showed an area under the curve (AUC) of 0.919, and bootstrap validation demonstrated the good model fit with a mean absolute error of 0.022. The decision curve analysis (DCA) showed that when the threshold probability ranged from 0.1-0.91, the curve lay between the 'all events' and 'no events' curves, indicating the model achieved a high net benefit.
This study developed a risk prediction model for low tacrolimus blood concentrations in lung transplant recipients in the early stages, which can help guide individualized clinical dosing regimens.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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