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Research Progress on the Mechanism of Chaihu Shugan San in Treating Anxiety
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Fei WANG1, 2, 3, 4, 5, 6, Huibiao LI1, 2, 3, 4, 5, 6, Kunyu LIU1, 2, 3, 4, 5, 6, Muyuan CHEN1, 2, 3, 4, 5, *
Pharmacy Today | 2026, 36(2) : 154 - 160
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Pharmacy Today | 2026, 36(2): 154-160
Research Progress on the Mechanism of Chaihu Shugan San in Treating Anxiety
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Fei WANG1, 2, 3, 4, 5, 6, Huibiao LI1, 2, 3, 4, 5, 6, Kunyu LIU1, 2, 3, 4, 5, 6, Muyuan CHEN1, 2, 3, 4, 5, *
Affiliations
  • 1.The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
  • 2.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
  • 3.Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong 510405, China
  • 4.Guangdong Engineering Technology Research Center of Commercialization of Lingnan Special Medical Institution Preparations, Guangzhou, Guangdong 510405, China
  • 5.Guangdong Engineering Research Center of Commercialization of Medical Institution Preparations and Traditional Chinese Medicines, Guangzhou, Guangdong 510405, China
  • 6.Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
Published: 2026-02-25 doi: 10.12048/j.issn.1674-229X.2026.02.012
Outline
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Chaihu Shugan San, which recorded in the classic book Complete Works of Jingyue, is a classic formula of traditional Chinese medicine. It has the efficacies of soothing the liver, regulating qi, activating blood circulation, and relieving pain.Since the Ming Dynasty, it has been widely used in clinical practice.Anxiety is a common emotional mental disorder that severely affects the quality of life of patients. At present, Western medicine mainly relies on drugs for the treatment of anxiety, but such drugs have certain side effects. Traditional Chinese medicine has unique advantages in treating anxiety. This paper reviews the research progress on the treatment of anxiety disorder with Chaihu Shugan San in recent years.It analyzes and summarizes the relevant published literature, and explores the etiology, pathogenesis and TCM understanding of anxiety disorder. The aim is to investigate the mechanisms of Chaihu Shugan San in treating anxiety disorder, so as to provide a theoretical basis for future research on this topic and offer new ideas for clinical treatment.

Chaihu Shugan San  /  anxiety  /  research progress
王菲, 李辉标, 刘昆宇, 陈慕媛. 柴胡疏肝散治疗焦虑症研究进展. 今日药学, 2026 , 36 (2) : 154 -160 . DOI: 10.12048/j.issn.1674-229X.2026.02.012
Fei WANG, Huibiao LI, Kunyu LIU, Muyuan CHEN. Research Progress on the Mechanism of Chaihu Shugan San in Treating Anxiety[J]. Pharmacy Today, 2026 , 36 (2) : 154 -160 . DOI: 10.12048/j.issn.1674-229X.2026.02.012
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Year 2026 volume 36 Issue 2
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.02.012
  • Receive Date：2025-04-22
  • Online Date：2026-09-23
  • Published：2026-02-25
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  • Received：2025-04-22
Funding
Affiliations
    1.The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
    2.The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, China
    3.Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou, Guangdong 510405, China
    4.Guangdong Engineering Technology Research Center of Commercialization of Lingnan Special Medical Institution Preparations, Guangzhou, Guangdong 510405, China
    5.Guangdong Engineering Research Center of Commercialization of Medical Institution Preparations and Traditional Chinese Medicines, Guangzhou, Guangdong 510405, China
    6.Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.02.012
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