Full
Outline
To compare the efficacy and safety differences between edaravone dexborneol and edaravone in Acute ischemic stroke (AIS).
Randomized controlled trials (RCTs) of edaravone dexborneol versus edaravone in the treatment of AIS were identified by systematically searching PubMed, Embase, Cochrane Library, CNKI, VIP Database, Wanfang Data, and SinoMed. The risk of bias of included studies was assessed according to the Cochrane bias risk assessment tool, and meta-analysis was performed using R 4.4.1 and RevMan 5.3. The efficacy outcomes included changes from baseline in the National Institutes of Health Stroke Scale (NIHSS) scores, the Modified Rankin Scale (mRS) scores, the Barthel Index (BI), and clinical response rate at 14 days post-treatment. Adverse reactions occurring during treatment were considered as safety indicators.
A total of 19 studies involving 2 885 patients were ultimately included. After 14 days of treatment, compared with the edaravone group, the edaravone dexborneol group was more effective in improving the clinical response rate [RR =1.22, 95%CI =1.13-1.33, P < 0.000 1] and the BI [MD =10.60, 95%CI =8.12-13.07, P < 0.000 1], and in reducing the NIHSS [MD =-1.92, 95%CI = -2.61-1.23, P < 0.000 1] and mRS [MD = 1.69, 95%CI = -2.49--0.90, P < 0.000 1]. In terms of safety, edaravone dexborneol group had a lower incidence of adverse reactions during the treatment period than the edaravone group [RR =0.47, 95%CI =0.33-0.69, P < 0.000 1].
Edaravone dexborneol group exhibited superior efficacy and safety compared with edaravone group in the treatment of AIS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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