Home Journals Articles Updates About
CN
image
收藏切换
Simultaneous Determination of Three Impurities in Trihexyphenidyl Hydrochloride Tablets by GC-MS
收藏切换
Kang SHI1, Xueyan CHEN2, Junliang DUAN3, Fengyun PAN3, Wenzhi WEI2, *
Pharmacy Today | 2026, 36(4) : 282 - 285
Less
收藏切换
Pharmacy Today | 2026, 36(4): 282-285
Simultaneous Determination of Three Impurities in Trihexyphenidyl Hydrochloride Tablets by GC-MS
Full
Kang SHI1, Xueyan CHEN2, Junliang DUAN3, Fengyun PAN3, Wenzhi WEI2, *
Affiliations
  • 1.School of Pharmacy, Qinghai Minzu University, Xining, Qinghai 810016, China
  • 2.Qinghai Provincial Drug Inspection and Testing Institute/NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Tibetan Medicine)/Qinghai Provincial Key Laboratory of Modernization of Traditional Chinese and Tibetan Medicine, Xining, Qinghai 810016, China
  • 3.Zhongke Puyan (Beijing) Technology, Beijing 100096, China
Published: 2026-04-25 doi: 10.12048/j.issn.1674-229X.2026.04.006
Outline
收藏切换
OBJECTIVE

To develop a gas chromatography-mass spectrometry (GC-MS) method for the determination of cyclohexane and potential genotoxic impurities (chlorocyclohexane and 1-cyclohexyl-1-phenylethanol) in trihexyphenidyl hydrochloride tablets.

METHODS

The VF-WAXms capillary column (30 m × 0.25 mm, 1.00 μm) was used. High-purity helium was used as the carrier gas at a flow rate of 2.0 mL·min-1, with a split ratio of 5∶1 and an injection volume of 2 μL. The mass spectrometer was equipped with an electron ionization (EI) source and operated in the selected ion monitoring (SIM) mode for detection.

RESULTS

The results showed that chlorocyclohexane, cyclohexanol, and 1-cyclohexyl-1-phenylethanol exhibited good linear relationships in the range of 25-250 ng·mL-1, with detection limits (LOD) of 10.2, 10.0 and 9.8 ng·mL-1, and quantification limits (LOQ) of 25.4, 25.0 and 24.5 ng·mL-1, respectively. The average recovery rates (n = 6) were 98.93%, 102.93% and 99.97%, respectively.

CONCLUSION

The established method has good specificity and high sensitivity, and can serve as a reference for the quality control of trihexyphenidyl hydrochloride tablets.

GC-MS  /  trihexyphenidyl hydrochloride  /  chlorocyclohexane  /  cyclohexanol  /  1-cyclohexyl-1-phenylethanol
史康, 陈学艳, 段军良, 潘峰云, 魏文芝. GC-MS法同时测定盐酸苯海索片中3种杂质. 今日药学, 2026 , 36 (4) : 282 -285 . DOI: 10.12048/j.issn.1674-229X.2026.04.006
Kang SHI, Xueyan CHEN, Junliang DUAN, Fengyun PAN, Wenzhi WEI. Simultaneous Determination of Three Impurities in Trihexyphenidyl Hydrochloride Tablets by GC-MS[J]. Pharmacy Today, 2026 , 36 (4) : 282 -285 . DOI: 10.12048/j.issn.1674-229X.2026.04.006
Appendix
Less
Year 2026 volume 36 Issue 4
118
27
Cite this Article
BibTeX
Article Info
doi: 10.12048/j.issn.1674-229X.2026.04.006
  • Receive Date：2026-01-08
  • Online Date：2026-09-23
  • Published：2026-04-25
Article Data
Affiliations
History
  • Received：2026-01-08
Funding
Affiliations
    1.School of Pharmacy, Qinghai Minzu University, Xining, Qinghai 810016, China
    2.Qinghai Provincial Drug Inspection and Testing Institute/NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Tibetan Medicine)/Qinghai Provincial Key Laboratory of Modernization of Traditional Chinese and Tibetan Medicine, Xining, Qinghai 810016, China
    3.Zhongke Puyan (Beijing) Technology, Beijing 100096, China
References
Share
https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.04.006
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House