Full
Outline
To develop a dual-crosslinked hydrogel loaded with berberine hydrochloride and to evaluate its physicochemical properties and drug release behavior.
Soluble silk fibroin with high resolubility rate was prepared by autoclaving combined with freeze-drying. A stable silk fibroin-tannic acid hydrogel matrix was established by optimizing the concentration and ratio of silk fibroin to tannic acid. Glucono-δ-lactone (GDL) was then introduced to modulate the gelation process, thereby constructing a silk fibroin-tannic acid/sodium alginate-Ca2+ dual-crosslinked hydrogel dual-crosslinked hydrogel loaded with berberine hydrochloride. The in vitro drug release profiles were investigated in buffers at different pH values.
The optimal mass concentrations of silk fibroin and tannic acid were 4% and 0.25%, respectively, under which a stable hydrogel was formed. When 0.32 g of GDL was added, the dual-crosslinked hydrogel formed rapidly and maintained color stability at different temperatures. The hydrogel exhibited injectability, and the release rate of its loaded berberine hydrochloride was significantly faster at pH 7.4 than at pH 5.5.
The as-prepared berberine hydrochloride-loaded dual-crosslinked hydrogel possesses both injectability and pH responsiveness, the developed hydrogel can provide a scientific basis for the development of localized drug delivery systems and novel dressings for chronic wounds.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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