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A Comparative Study on the Antibacterial, Antiviral, and Anti-Inflammatory Activities of Sea Buckthorn Leaf Extracts from Different Origins
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Xiaolun ZHANG1, 2, Zhaojun DING2, 3, Changyu YAN2, 3, Xiaomin LI4, 5, Jian ZOU2, 3, Zhengchao TU3, Zhen WANG3, Kurihara HIROSHI2, 3, 4, 5, Rongrong HE2, 3, Lei LIANG1, 2, 3, *, Yifang LI2, 3, *
Pharmacy Today | 2025, 35(8) : 576 - 582
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Pharmacy Today | 2025, 35(8): 576-582
A Comparative Study on the Antibacterial, Antiviral, and Anti-Inflammatory Activities of Sea Buckthorn Leaf Extracts from Different Origins
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Xiaolun ZHANG1, 2, Zhaojun DING2, 3, Changyu YAN2, 3, Xiaomin LI4, 5, Jian ZOU2, 3, Zhengchao TU3, Zhen WANG3, Kurihara HIROSHI2, 3, 4, 5, Rongrong HE2, 3, Lei LIANG1, 2, 3, *, Yifang LI2, 3, *
Affiliations
  • 1.School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China
  • 2.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, Guangdong 510632, China
  • 3.School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China
  • 4.Perfect (Guangdong) Commodity Co., Ltd., Zhongshan, Guangdong 528400, China
  • 5.Perfect Life Sciences Research Institute Co., Ltd., Zhongshan, Guangdong 528400, China
Published: 2025-08-25 doi: 10.12048/j.issn.1674-229X.2025.08.003
Outline
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OBJECTIVE

To compare the antibacterial (against Escherichia coli/Salmonella), antiviral (against HSV-1/2), and NF-κB inhibitory activity of sea buckthorn leaf extracts (SBLE) from different origins.

METHODS

SBLEs were prepared using 65% ethanol for hot reflux extraction of sea buckthorn leaves from different origins. The differences in their fingerprint profiles were analyzed by liquid chromatography. The colorimetric method was used to detect the inhibitory activity of Escherichia coli and Salmonella. The CCK-8 assay was employed to evaluate the activity of Vero cells infected with HSV-1/2. The luciferase reporter assay was conducted to assess the activity of NF-κB in TNF-α-induced NF-κB reporter (Luc)-HEK 293 cells.

RESULTS

SBLE from Datong and Huzhu exhibited better inhibitory effects on Escherichia coli (with EC50 values of 184.3 and 211.6 μg·mL-1, respectively) and Salmonella (with EC50 values of 284.6 and 300.9 μg·mL-1, respectively). SBLE from Datong, Pingan, Huzhu, Youyu, Heshun, and Zhangbei showed similar inhibitory effects on HSV-1 and HSV-2, with EC50 values ranging from 27 to 36 μg·mL-1. SBLE from Heshun, Zhangbei, and Huzhu exhibited better inhibition of NF-κB, with EC50 values of 122.6, 137.1, and 154.1 μg·mL-1, respectively.

CONCLUSION

The activities of SBLE from different origins vary, with SBLE from Datong exhibiting the best anti-Escherichia coli/Salmonella activity, SBLE from Youyu showing the best anti-HSV-1/2 activity, and SBLE from Heshun having the best NF-κB inhibitory effect.

sea buckthorn leaves  /  activity comparison  /  Escherichia coli  /  Salmonella  /  HSV-1/2  /  NF-κB
Xiaolun ZHANG, Zhaojun DING, Changyu YAN, Xiaomin LI, Jian ZOU, Zhengchao TU, Zhen WANG, Kurihara HIROSHI, Rongrong HE, Lei LIANG, Yifang LI. A Comparative Study on the Antibacterial, Antiviral, and Anti-Inflammatory Activities of Sea Buckthorn Leaf Extracts from Different Origins[J]. Pharmacy Today, 2025 , 35 (8) : 576 -582 . DOI: 10.12048/j.issn.1674-229X.2025.08.003
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Article Info
doi: 10.12048/j.issn.1674-229X.2025.08.003
  • Receive Date：2024-08-07
  • Online Date：2026-02-11
  • Published：2025-08-25
Article Data
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History
  • Received：2024-08-07
Funding
Affiliations
    1.School of Traditional Chinese Medicine, Jinan University, Guangzhou, Guangdong 510632, China
    2.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, Guangdong 510632, China
    3.School of Pharmacy, Jinan University, Guangzhou, Guangdong 510632, China
    4.Perfect (Guangdong) Commodity Co., Ltd., Zhongshan, Guangdong 528400, China
    5.Perfect Life Sciences Research Institute Co., Ltd., Zhongshan, Guangdong 528400, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2025.08.003
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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