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The Role of Vitamin D in Wound Healing: Mechanistic Insights and Recent Advances
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Donglan ZHANG1, Shuyao ZHANG2, Haiyan LI2, *
Pharmacy Today | 2026, 36(6) : 474 - 480
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Pharmacy Today | 2026, 36(6): 474-480
The Role of Vitamin D in Wound Healing: Mechanistic Insights and Recent Advances
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Donglan ZHANG1, Shuyao ZHANG2, Haiyan LI2, *
Affiliations
  • 1.School of Nursing, Guangdong Medical University, Dongguan, Guangdong 523808, China
  • 2.Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, China
Published: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.012
Outline
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OBJECTIVE

To systematically elucidate the multidimensional mechanisms of vitamin D in wound healing, thereby providing scientific evidence for clinical treatment and offering new directions for wound repair research.

METHODS

The regulatory effects of vitamin D were analyzed on pathways including VDR, calcium signalling, anti-inflammation, TGF-β/Smad, Hippo, skin barrier-related signaling pathways, PI3K/AKT/HIF-1α, and Notch during different stages of wound healing.

RESULTS

Vitamin D exerted its effects on key aspects of wound healing-including cell proliferation, migration, differentiation, extracellular matrix synthesis and remodelling, inflammatory response, immune regulation, and angiogenesis-by regulating the aforementioned pathways. These pathways intertwined to form a regulatory network that promoted wound healing.

CONCLUSION

Vitamin D demonstrates significant potential in research into wound healing mechanisms, with its multi-pathway regulatory mechanisms providing multidimensional support for wound repair. Future research should further explore interactions between pathways, carry out clinical trials in humans, and investigate other relevant pathways to advance clinical applications.

vitamin D  /  wound healing  /  mechanism of action  /  signaling pathways
张冬兰, 张述耀, 李海燕. 维生素D在创面愈合中的作用机制研究进展. 今日药学, 2026 , 36 (6) : 474 -480 . DOI: 10.12048/j.issn.1674-229X.2026.06.012
Donglan ZHANG, Shuyao ZHANG, Haiyan LI. The Role of Vitamin D in Wound Healing: Mechanistic Insights and Recent Advances[J]. Pharmacy Today, 2026 , 36 (6) : 474 -480 . DOI: 10.12048/j.issn.1674-229X.2026.06.012
Appendix
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Year 2026 volume 36 Issue 6
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.06.012
  • Receive Date：2025-10-15
  • Online Date：2026-09-23
  • Published：2026-06-25
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History
  • Received：2025-10-15
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Affiliations
    1.School of Nursing, Guangdong Medical University, Dongguan, Guangdong 523808, China
    2.Guangzhou Red Cross Hospital, Jinan University, Guangzhou, Guangdong 510220, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.06.012
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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