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Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats
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Shaohua WU1, Lu LIU1, Wen DENG2, Xialing LEI1, Weixuan CHEN2, Qianliang ZHANG2, Jianmin GUO1, Wei YANG1, *
Pharmacy Today | 2026, 36(6) : 416 - 420
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Pharmacy Today | 2026, 36(6): 416-420
Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats
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Shaohua WU1, Lu LIU1, Wen DENG2, Xialing LEI1, Weixuan CHEN2, Qianliang ZHANG2, Jianmin GUO1, Wei YANG1, *
Affiliations
  • 1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China
  • 2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China
Published: 2026-06-25 doi: 10.12048/j.issn.1674-229X.2026.06.003
Outline
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OBJECTIVE

To explore the effects of Chuanxiong broken-wall decoction pieces (CXBDP) on acute and long-term toxicity in SD rats, and compare them with traditional Chuanxiong decoction pieces (CXDP), so as to provide more data support for clinical medication.

METHODS

Acute toxicity: SD rats were given a single oral dose of CXBDP 10.08 g·kg-1 and CXDP 10.08 g·kg-1, and then observed for 2 weeks.Long-term toxicity: SD rats were orally given CXBDP 0.54, 1.35, 3.78 g·kg-1, CXDP 0.54, 3.78 g·kg-1 for 4 weeks, and then allowed to recover for 4 weeks after drug withdrawal. The effects of CXBDP and CXDP on rats' clinical observation, body weight, food intake, hematology, blood biochemistry, organ weight, organ coefficient and histopathological indicators were investigated.

RESULTS

Acute toxicity: no obvious toxic reactions was observed after single oral administration of CXBDP 10.08 g·kg-1 (maximum dose) and CXDP 10.08 g·kg-1. Long-term toxicity: no obvious toxic reactions was observed in SD rats after continuous oral administration of CXBDP (0.54, 1.35, and 3.78 g·kg-1) and CXDP (0.54 and 3.78 g·kg-1) for 4 weeks, as well as during the 4-week recovery period after drug withdrawal.

CONCLUSION

There were no statistically significant difference in safety between CXBDP and traditional CXDP in SD rats.

Chuanxiong broken-wall decoction pieces  /  Chuanxiong decoction pieces  /  SD rats  /  acute toxicity  /  long-term toxicity
吴少华, 柳璐, 邓雯, 雷夏凌, 陈炜旋, 张前亮, 郭健敏, 杨威. 川芎破壁饮片对SD大鼠急性毒性和长期毒性试验研究. 今日药学, 2026 , 36 (6) : 416 -420 . DOI: 10.12048/j.issn.1674-229X.2026.06.003
Shaohua WU, Lu LIU, Wen DENG, Xialing LEI, Weixuan CHEN, Qianliang ZHANG, Jianmin GUO, Wei YANG. Study on Acute and Long-term Toxicity of Chuanxiong Broken-wall Decoction Pieces to SD Rats[J]. Pharmacy Today, 2026 , 36 (6) : 416 -420 . DOI: 10.12048/j.issn.1674-229X.2026.06.003
Appendix
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Year 2026 volume 36 Issue 6
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.06.003
  • Receive Date：2025-09-30
  • Online Date：2026-09-23
  • Published：2026-06-25
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History
  • Received：2025-09-30
Funding
Affiliations
    1.Guangzhou Bay Area Institute of Biomedicine, Guangdong Lewwin Pharmaceutical Research Institute Co., Ltd., Guangdong Provincial Key Laboratory of Drug Non-Clinical Evaluation and Research, TCM Non-clinic Evaluation Branch of National Engineering Research Center for Modernization of Traditional Chinese Medicine, Guangdong Engineering Research Center for Innovative Drug Evaluation and Research, Guangzhou, Guangdong 510990, China
    2.Zhongshan Zhongzhi Pharmaceutical Group Co., Ltd., National Enterprise Technology Center Chinese Medicine Broken-walled Pieces Joint Engineering Research Center, Zhongshan, Guangdong 528437, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.06.003
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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