To explore the pharmacological effects of water extract of Ficus hirta on enhancing immunity and improving gastrointestinal function.

Sixty healthy male Kunming (KM) mice, weighing 18-22 g, were randomly divided into 6 groups: normal group, model group, positive (Thymus-intestinal peptide) group, low-, medium-, and high-dose groups of the test drug, with 10 mice in each group. Except for the normal group, the other groups were given intraperitoneal injection of cyclophosphamide combined with 5-fluorouracil to prepare mice models of immunosuppression and gastrointestinal dysfunction. The normal and model groups were given distilled water, and the positive group and the test drug groups were given the corresponding drugs for 7 consecutive days. The intestinal charcoal transit rate, blood cell count, serum inflammatory cytokines and immune protein levels of the mice were detected, and the pathological damage of intestinal and spleen tissues was observed, and pathological injury of intestinal and spleen tissues were observed.

Compared with the model group, the water extract of Ficus hirta significantly significantly increased the levels of IgA, IgE, IgM, IL-2, and IFN-γ in the plasma supernatant of mice and increased the spleen index, increased the intestinal charcoal transit rate and the number of red blood cells in the blood of mice, and alleviated the pathological injury degree of intestinal and spleen tissues of mice, and to some extent alleviated the immunosuppression induced by cyclophosphamide combined with 5-Fu in mice induced by cyclophosphamide combined with 5-Fu in mice.

This study confirmed that the water extract of Ficus hirta has a promoting effect on enhancing immunity and improving gastrointestinal peristalsis, and provides data reference for the development and utilization of Ficus hirta resources.