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Outline
To analyze the rationality and safety of clinical use of PD-1 inhibitors as novel antitumor drugs, providing guidance for their standardized and safe clinical application.
This study randomly selected inpatient medical records from April to June 2024 (before clinical pharmacist intervention) as the control group, and records from July 2024 to June 2025 (after intervention) as the intervention group. The rationality and safety of PD-1 inhibitor use were analyzed, with each 3-month period constituting a cycle. Results from each cycle were compared with those of the preceding cycle. Statistical analysis was performed to compare the rationality and safety of PD-1 inhibitor use between the first, second, third, and fourth intervention cycles and the pre-intervention cycle.
Post-intervention improvements were observed in prescription qualified rate, proportion of off-label use rate, and number of adverse drug reaction reports for PD-1 inhibitors. For prescription compliance and expanded clinical use indicators, the differences between the first, second, third, and fourth intervention cycles versus the pre-intervention cycle showed statistical significance (P<0.05).
Clinical pharmacist intervention enhances the rationality and standardization of PD-1 inhibitor use in clinical practice, facilitates timely identification of new or severe adverse reactions, and enables appropriate treatment measures, thereby reducing patient mortality, prolonging survival time, and reducing patients'medical costs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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