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Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database
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Fangyu SONG1, 2, Keqin FAN1, 2, Liangjing XIA3, Yuehui ZHANG2, Haizhu ZHANG1, Liangming ZHANG2, Tong CHEN4, Jiaqi SUN1, Zijun YAN2, 4, *
Pharmacy Today | 2026, 36(5) : 355 - 363
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Pharmacy Today | 2026, 36(5): 355-363
Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database
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Fangyu SONG1, 2, Keqin FAN1, 2, Liangjing XIA3, Yuehui ZHANG2, Haizhu ZHANG1, Liangming ZHANG2, Tong CHEN4, Jiaqi SUN1, Zijun YAN2, 4, *
Affiliations
  • 1.School of Pharmacy, Dali University, Dali, Yunnan 671000, China
  • 2.Department of Pharmacy, Panzhihua Central Hospital, Panzhihua, Sichuan 617067, China
  • 3.College of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
  • 4.School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for natural Products, Kunming Medical University, Kunming, Yunnan 650500, China
Published: 2026-05-25 doi: 10.12048/j.issn.1674-229X.2026.05.006
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OBJECTIVE

Based on the US FDA Adverse Event Reporting System (FAERS), this study comprehensively evaluated the adverse reaction characteristics of cephalosporins on the gastrointestinal system, and analyzed the risk heterogeneity among different drug varieties and the influence of patients' baseline characteristics.

METHODS

The data from the FAERS database from 1994 to 2024 were extracted, and disproportionality analysis combined with Bayesian method was used to mine the correlation signals between cephalosporins and gastrointestinal adverse events.

RESULTS

A total of 54.249 6 million adverse event reports were included, and 793 gastrointestinal system adverse events related to signal-positive cephalosporins were screened out.The signal intensity of cefdinir [ROR=2.69 (2.52-2.88)] was significantly higher than that of other drugs. The Bayesian method verified the association of high-risk events, such as the megacolon signal of cefixime [EBGM=75.21 (95%CI:23.54)]. The risk of signal-negative cephalosporin was low, and very few had a certain intensity of PT signal values.

CONCLUSION

This study analyzed the risk of gastrointestinal adverse reactions associated with the use of different types of cephalosporins. Among them, cefdinir had the highest risk of gastrointestinal-related adverse events (AEs), while non-oral signal-negative ceped drugs.

cephalosporins  /  FAERS  /  signal mining  /  gastrointestinal system  /  adverse reactions
宋方宇, 范科琴, 夏靓婧, 张月辉, 张海珠, 张良明, 陈彤, 孙佳琪, 晏子俊. 基于FAERS数据库的头孢菌素类药物胃肠系统不良事件信号挖掘与分析. 今日药学, 2026 , 36 (5) : 355 -363 . DOI: 10.12048/j.issn.1674-229X.2026.05.006
Fangyu SONG, Keqin FAN, Liangjing XIA, Yuehui ZHANG, Haizhu ZHANG, Liangming ZHANG, Tong CHEN, Jiaqi SUN, Zijun YAN. Investigation Into Gastrointestinal System Adverse Events Triggered by Cephalosporin Drugs: Insights From the FAERS Database[J]. Pharmacy Today, 2026 , 36 (5) : 355 -363 . DOI: 10.12048/j.issn.1674-229X.2026.05.006
Appendix
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Year 2026 volume 36 Issue 5
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.05.006
  • Receive Date：2025-09-15
  • Online Date：2026-09-23
  • Published：2026-05-25
Article Data
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History
  • Received：2025-09-15
Funding
Affiliations
    1.School of Pharmacy, Dali University, Dali, Yunnan 671000, China
    2.Department of Pharmacy, Panzhihua Central Hospital, Panzhihua, Sichuan 617067, China
    3.College of Chinese Medicine, Hong Kong Baptist University, Hong Kong 999077, China
    4.School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for natural Products, Kunming Medical University, Kunming, Yunnan 650500, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.05.006
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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