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Clinical Research Progress of Semaglutide
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Yikai CHEN1a, Zhiqi LUO1b, Wenjiao WU2, Siyu ZENG2, Zhongze LI2, Hongai WANG2, *
Pharmacy Today | 2026, 36(2) : 147 - 153
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Pharmacy Today | 2026, 36(2): 147-153
Clinical Research Progress of Semaglutide
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Yikai CHEN1a, Zhiqi LUO1b, Wenjiao WU2, Siyu ZENG2, Zhongze LI2, Hongai WANG2, *
Affiliations
  • 1a.School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China
  • 1b.College of International, Jinan University, Guangzhou, Guangdong 510632, China
  • 2.the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong 510317, China
Published: 2026-02-25 doi: 10.12048/j.issn.1674-229X.2026.02.011
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Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, is widely used to treat diabetes mellitus, obesity, and cardiovascular diseases. By activating the GLP-1 receptor, semaglutide enhances insulin secretion and inhibits glucagon release, effectively lowering blood glucose levels. Additionally, semaglutide has multiple beneficial effects, including weight loss and improvement of cardiovascular diseases, and has demonstrated potential in treating conditions such as non-alcoholic fatty liver disease and polycystic ovary syndrome. Semaglutide exhibits significant efficacy in patients with type 2 diabetes mellitus and high safety profile when used in combination with other medications in these patients, underscoring its broad clinical applicability. This article aims to review the mechanisms of action of semaglutide and its clinical research progress in the treatment of diabetes mellitus, cardiovascular diseases, and obesity, exploring its clinical application potential and future prospects.

Semaglutide  /  type 2 diabetes mellitus  /  cardiovascular diseases  /  obesity  /  adverse reactions
陈奕楷, 罗芷祺, 武文姣, 曾泗宇, 李忠泽, 王红爱. 司美格鲁肽的临床应用与研究现状. 今日药学, 2026 , 36 (2) : 147 -153 . DOI: 10.12048/j.issn.1674-229X.2026.02.011
Yikai CHEN, Zhiqi LUO, Wenjiao WU, Siyu ZENG, Zhongze LI, Hongai WANG. Clinical Research Progress of Semaglutide[J]. Pharmacy Today, 2026 , 36 (2) : 147 -153 . DOI: 10.12048/j.issn.1674-229X.2026.02.011
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Year 2026 volume 36 Issue 2
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.02.011
  • Receive Date：2025-04-07
  • Online Date：2026-09-23
  • Published：2026-02-25
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  • Received：2025-04-07
Affiliations
    1a.School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China
    1b.College of International, Jinan University, Guangzhou, Guangdong 510632, China
    2.the Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong 510317, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.02.011
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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