Full
Outline
To investigate a potential relationship between metabolic parameters and steady-state serum concentration of olanzapine (OLA) in patients treated with OLA combined with or without VAL in patients with mental disorders.
A retrospective analysis was performed on 225 inpatients with mental disorders who received OLA monotherapy or OLA-VAL combination therapy. The serum concentration of OLA was measured, and fasting blood samples were analyzed for insulin, glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and uric acid (UA). The effects of OLA serum concentration, with or without VAL, on the aforementioned parameters and the correlation with these parameters were investigated.
VAL co-administration decreased OLA concentration and C/D ratio by 19.57% (P < 0.01) and 32.76%(P < 0.001), respectively.Patients taking OLA combined with VAL had higher weight (4.83%, P <0.01), BMI (4.07%, P < 0.05) and UA level (8.96%, P < 0.05), but lower glucose level (13.83%, P < 0.05), than those taking OLA alone. VAL co-administration had no significant effect on the levels of TC, HDL-c, LDL-c, TG and INS.The serum OLA concentration was negatively correlated with body weight in the OLA-VAL combination group (r =-0.199, P < 0.05), and there exists no correlation with other metabolic parameters.
There is no correlation between the serum OLA concentration and glycolipid metabolic parameters in the OLA monotherapy group, however, a negative correlation is found between serum OLA concentration and body weight in the OLA-VAL combination group; meanwhile, significantly higher body weight, BMI and UA levels are observed in this group.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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