To explore the unique techniques of traditional Chinese medicine (TCM) processing in the Lingnan Yuebang, promote its processing culture, and expand research on regionally characteristic processing methods.

Using the 1984 edition of Guangdong TCM Processing Standards and the 2020 edition of Pharmacopoeia of the People's Republic of China as research subjects, 553 Chinese medicinal materials were systematically analyzed from three aspects: excipient usage, processing methods, and special processing techniques. Comparative analysis was conducted to summarize the distinctive features of Lingnan Yuebang TCM processing.

① Compared with the Pharmacopoeia of China, the processing of Lingnan Yuebang traditional Chinese medicine was more widely used in sand, rice, soil, talcum powder, wine, salt, honey and ginger. There were 8 kinds of special auxiliary materials, including rice swill, soil, flour, sesame oil, onion juice, coptis root, scutellaria root and phellodendron bark. ②There were 17 kinds of the same processing methods in Guangdong Paogui and China Pharmacopoeia, but the processing methods in Guangdong Paogui were more abundant in fresh medicine, clean preparation and cutting. ③ Most of the special processing techniques of Lingnan Yuebang were steaming, including steaming, wine steaming, salt steaming, vinegar steaming and so on. There were 82 kinds of traditional Chinese medicines using steaming.

The processing technology of traditional Chinese medicine of Lingnan Yuebang is unique, and its processing method and cultural connotation have distinct regional characteristics. As an important part of the processing of traditional Chinese medicine, the processing technology of Lingnan Yuebang deserves further study and attention to promote the inheritance and innovation of Lingnan traditional Chinese medicine.