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The Impact of Active Probiotics on Promoting Lead Excretion and Relieving Constipation
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Zhili YAN1, Xinyue ZHANG2, Wenqing CHEN1, Yiju WEI2, *
Pharmacy Today | 2026, 36(1) : 6 - 11
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Pharmacy Today | 2026, 36(1): 6-11
The Impact of Active Probiotics on Promoting Lead Excretion and Relieving Constipation
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Zhili YAN1, Xinyue ZHANG2, Wenqing CHEN1, Yiju WEI2, *
Affiliations
  • 1.College of Basic Medicine and Forensic Medicine, Baotou Medical College, Inner Mongolia University of Science and Technologic, Baotou, NeiMongol 014040, China
  • 2.School of Life Sciences, Shandong First Medical University, Taian, Shandong 271016, China
Published: 2026-01-25 doi: 10.12048/j.issn.1674-229X.2026.01.002
Outline
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OBJECTIVE

To investigate the effects of active liquid probiotics on the laxative efficacy and promotion of lead excretion in zebrafish.

METHODS

Zebrafish at 5 dpf (days post fertilization) were stained with Nile Red and then divided into 3 groups, treated at 28 °C for 1 day, and their intestinal fluorescence intensity was analyzed. Zebrafish at 6 hpf (hours post fertilization) were used to establish a lead poisoning model, treated at 28 ℃ for 4 days, and then the lead content in vivo was determined.

RESULTS

The maximum tested concentration (MTC) of active liquid probiotics for laxative effect in zebrafish was 15.6 µL·mL-1. At this concentration, the intestinal fluorescence intensity of the probiotic group was significantly reduced (compared with the normal control group, P < 0.001). Similarly, for its effect on promoting lead excretion in zebrafish, the MTC was 7.81 µL·mL-1, and the lead content in the probiotic group at this concentration decreased by approximately 50% compared with the model group (P < 0.001).

CONCLUSION

Active liquid probiotics can rapidly colonize the zebrafish intestine and promote the proliferation of beneficial flora, thereby achieving laxative effects and regulating intestinal vitality. Active liquid probiotics can utilize their unique ion-binding capacity to specifically adsorb heavy metal lead for excretion, enhancing lead excretion.

active probiotics  /  Lactobacillus  /  intestinal health  /  promotion of lead excretion  /  laxative effect
严致立, 张馨月, 陈文清, 魏义举. 活性益生菌对促进排铅及润肠通便功效的影响. 今日药学, 2026 , 36 (1) : 6 -11 . DOI: 10.12048/j.issn.1674-229X.2026.01.002
Zhili YAN, Xinyue ZHANG, Wenqing CHEN, Yiju WEI. The Impact of Active Probiotics on Promoting Lead Excretion and Relieving Constipation[J]. Pharmacy Today, 2026 , 36 (1) : 6 -11 . DOI: 10.12048/j.issn.1674-229X.2026.01.002
Appendix
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Year 2026 volume 36 Issue 1
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Article Info
doi: 10.12048/j.issn.1674-229X.2026.01.002
  • Receive Date：2025-08-12
  • Online Date：2026-09-23
  • Published：2026-01-25
Article Data
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History
  • Received：2025-08-12
Funding
Affiliations
    1.College of Basic Medicine and Forensic Medicine, Baotou Medical College, Inner Mongolia University of Science and Technologic, Baotou, NeiMongol 014040, China
    2.School of Life Sciences, Shandong First Medical University, Taian, Shandong 271016, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2026.01.002
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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