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Case Analysis and Literature Review of Flagellate Dermatitis Caused by Bleomycin
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Jinlan LI1, Rui QIU2, Xinyi DONG3, Weiting LIANG4, *
Pharmacy Today | 2025, 35(8) : 629 - 633
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Pharmacy Today | 2025, 35(8): 629-633
Case Analysis and Literature Review of Flagellate Dermatitis Caused by Bleomycin
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Jinlan LI1, Rui QIU2, Xinyi DONG3, Weiting LIANG4, *
Affiliations
  • 1.Department of Pharmacy, Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410031, China
  • 2.Jianyang People's Hospital, Jianyang, Sichuan 641400, China
  • 3.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China
  • 4.Sun Yat-Sen University Cancer Center / State Key Laboratory of Oncology in South China / Guangdong Provincial Clinical Research Center for Cancer, Guanzhou, Guangdong 510060, China
Published: 2025-08-25 doi: 10.12048/j.issn.1674-229X.2025.08.013
Outline
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OBJECTIVE

Through the analysis of a case of flagellate dermatitis caused by the use of bleomycin, to summarize and analyze the related skin toxicity of bleomycin, so as to provide reference for clinical rational drug use.

METHODS

The treatment course of the patient was followed up, and the relevant literatures about flagellate dermatitis caused by bleomycin were searched and statistically analyzed by China National Knowledge Infrastructure, Wanfang, VIP, Google Scholar, Web of Science and PubMed.

RESULTS

The occurrence time of flagellate dermatitis caused by bleomycin in this case was 10 days after the first chemotherapy. Following admission, his condition showed gradual improvement following treatment with topical halomethasone ointment and freeze-dried human immunoglobulin for intravenous injection. A total of 52 articles on flagellate dermatitis caused by bleomycin were searched through the literature, including 25 males (47.2%) and 28 females (52.8%). The median time of occurrence was 25 days. The rash was mainly treated by local or systemic use of glucocorticoids. All patients' rashes improved.

CONCLUSION

Flagellate dermatitis is rare in clinic, but it is mostly mild to moderate. Doctors and clinical pharmacists should pay attention to the management of such adverse reactions and so as to improve the quality of life of patients.

bleomycin  /  flagellate dermatitis  /  case analysis  /  literature review
Jinlan LI, Rui QIU, Xinyi DONG, Weiting LIANG. Case Analysis and Literature Review of Flagellate Dermatitis Caused by Bleomycin[J]. Pharmacy Today, 2025 , 35 (8) : 629 -633 . DOI: 10.12048/j.issn.1674-229X.2025.08.013
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doi: 10.12048/j.issn.1674-229X.2025.08.013
  • Receive Date：2024-08-20
  • Online Date：2026-02-11
  • Published：2025-08-25
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History
  • Received：2024-08-20
Funding
Affiliations
    1.Department of Pharmacy, Hunan Cancer Hospital / The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410031, China
    2.Jianyang People's Hospital, Jianyang, Sichuan 641400, China
    3.School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China
    4.Sun Yat-Sen University Cancer Center / State Key Laboratory of Oncology in South China / Guangdong Provincial Clinical Research Center for Cancer, Guanzhou, Guangdong 510060, China
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https://castjournals.cast.org.cn/joweb/jryx/EN/10.12048/j.issn.1674-229X.2025.08.013
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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