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PDCoV nsp14 interferes with the interferon pathway by degradin MAVS, MyD88, and TRAF3 proteins via the autophagy and proteasome pathways
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Journal of Integrative Agriculture | 2026, 25(9) : 3829 - 3841
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Journal of Integrative Agriculture | 2026, 25(9): 3829-3841
• Animal Science · Veterinary Medicine •
PDCoV nsp14 interferes with the interferon pathway by degradin MAVS, MyD88, and TRAF3 proteins via the autophagy and proteasome pathways
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Yiyi Song1,2*, Ning Kong1,2*, Lanlan Zheng3*, Yu Zhang4*, Xueying Zhai1, Wenzhen Qin1, Xinyu Yang1, Xiaoquan Wang1, Ao Gao3, Wu Tong1, Changlong Liu1, Hao Zheng1, Hai Yu1, Wen Zhang5, Guangzhi Tong1,2, Tongling Shan1,2#
Affiliations
    1Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 201100, China
    2Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225000, China
    3College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450000, China
    4Department of Preventive Dentistry, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 201100, China
    5School of Medicine, Jiangsu University, Zhenjiang 212000, China
About Author:
Yiyi Song, E-mail: 1814105954@qq.com; Ning Kong, E-mail: kongning@shvri.ac.cn; Lanlan Zheng, E-mail: lanlan@henau.edu.cn; Yu Zhang, E-mail: zy24ymjulia@163.com; #Correspondence Tongling Shan, E-mail: shantongling@shvri.ac.cn; * These authors contributed equally to this study.
doi: 10.1016/j.jia.2025.04.015
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Porcine deltacoronavirus (PDCoV) is a newly identified pathogen that can potentially undergo cross-species transmission to threaten the safety of swine and humans. The mechanism by which PDCoV nonstructural protein 14 (nsp14) inhibits the expression of IFN-β is unknown. In this study, we showed that PDCoV nsp14 degrades the MAVS, MyD88 and TRAF3 proteins in host cells by proteasomal and autophagy pathways. PDCoV nsp14 recruits the E3 ubiquitin ligase MARCH8 for catalyzing MAVS, MyD88 and TRAF3 protein ubiquitination. These proteins were recognized and transported to lysosomes by the cargo receptor NDP52 for degradation to inhibit the expression of IFN-β. Furthermore, MAVS, MyD88 and TRAF3 were also found to degrade PDCoV nsp14 by selective autophagy. These results reveal the dual function of selective autophagy in the PDCoV nsp14 and host proteins, which can promote the ubiquitination of viral particles and host antiviral proteins to degrade them both for regulating the relationship between virus infection and host innate immunity.
PDCoV  /  nsp14  /  interferon  /  autophagosome  /  proteasome
Yiyi Song, Ning Kong, Lanlan Zheng, Yu Zhang, Xueying Zhai, Wenzhen Qin, Xinyu Yang, Xiaoquan Wang, Ao Gao, Wu Tong, Changlong Liu, Hao Zheng, Hai Yu, Wen Zhang, Guangzhi Tong, Tongling Shan. PDCoV nsp14 interferes with the interferon pathway by degradin MAVS, MyD88, and TRAF3 proteins via the autophagy and proteasome pathways[J]. Journal of Integrative Agriculture, 2026 , 25 (9) : 3829 -3841 . DOI: 10.1016/j.jia.2025.04.015
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Year 2026 volume 25 Issue 9
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doi: 10.1016/j.jia.2025.04.015
  • Online Date：2026-08-28
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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