Article(id=1211269159913132265, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269157790806494, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.04.02, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1611849600000, receivedDateStr=2021-01-29, revisedDate=1614960000000, revisedDateStr=2021-03-06, acceptedDate=null, acceptedDateStr=null, onlineDate=1766718672015, onlineDateStr=2025-12-26, pubDate=1619539200000, pubDateStr=2021-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766718672015, onlineIssueDateStr=2025-12-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766718672015, creator=13701087609, updateTime=1766718672015, updator=13701087609, issue=Issue{id=1211269157790806494, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='4', pageStart='319', pageEnd='424', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766718671510, creator=13701087609, updateTime=1766718756000, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1211269512217882745, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269157790806494, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1211269512217882746, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269157790806494, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=327, endPage=332, ext={EN=ArticleExt(id=1211269160206733553, articleId=1211269159913132265, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effect of cervical cancer-derived exosomal hsa_circ_0087432 on the proliferation and migration of HUVECs, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To analyze the expression of circRNA0087432 (hsa_circ_0087432) in serum exosomes of patients with cervical cancer, and explore its possible relationship with cervical cancer metastasis. Methods The cervical cancer tissue and serum of 30 patients, who were diagnosed as cervical squamous cell carcinoma from June 2019 to June 2020 in Guangzhou Panyu District Central Hospital and untreated with radiotherapy and chemotherapy before surgery, were collected as the experimental group.Normal cervical tissue and serum of 30 women without cervical cancer were used as control group. Real-time quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression level of hsa_circ_0087432 in cervical tissues and serum exosomes of patients with cervical cancer and healthy people; Siha cells were transfected with plasmid to overexpress hsa_circ_0087432. According to different treatments, Siha cells were divided into three groups: control group (untransfected plasmid), vector group (transfected with pLC5-ciR) and hsa_circ_0087432 group (transfected with hsa_circ_0087432-pLC5-ciR). The exosomes were collected and extracted, and the exosyndrome were characterized by transmission electron microscope (TEM), nanoparticle tracking analysis (NTA)and Western blotting; Endothelial cells were divided into three groups according to different treatments: control-Exs group (extracted exosomes from control group), vector-Exs group (extracted exosomes from vector group) and hsa_circ_0087432-Exs group (extracted exosomes from hsa_circ_0087432 group). CCK-8 kit was used to detect the effect of exosomes on proliferation of endothelial cells.The effect of exosomes on the migration of endothelial cells were detected by scratch test and Transwell. Results The results of TEM showed that most of the exosomes of Siha cells were elliptical or round. The particle size analysis showed that their diameters ranged of 30-150 nm. Western blotting showed that the expressions of CD9, CD81 and CD63 in the two groups of vesicles were positive. The qPCR results showed that the expression level of hsa_circ_0087432 in cervical tissue was significantly higher in experimental group than that in control group (4.03±1.51 vs. 1.00±0.26, P<0.01), and the expression level of hsa_circ_0087432 in serum exosomes was also obviously higher in experimental group than that in control group (1.97±0.04 vs. 1.02±0.23, P<0.01); CCK-8 results showed that, compared with the control-Exs group, the proliferation of human umbilical vein endothelial cells was significantly promoted in hsa_circ_0087432-Exs group (1.57±0.04 vs. 1.09±0.11, P<0.05). Scratch experiments showed that, 12 hours after treatment, the healing degree was better in hsa_circ_0087432-Exs group than that in control-Exs group (24.66%±2.92% vs. 15.01%±3.12%, P<0.05); and 24 hours after scratching, the healing degree was even better in hsa_circ_0087432-Exs group than that in control-Exs group (74.84%±13.22% vs. 38.70%±2.12%, P<0.01). Transwell also showed that the counted number of endothelial cells increased obviously in hsa_circ_0087432-Exs group than that in vector-Exs group and control-Exs group (1755.00±97.35 vs. 1218.00±103.53 vs. 1044.00±103.79) with significant difference (P<0.05). Conclusion The hsa_circRNA 0087432 is highly expressed in serum exosomes of patients with cervical cancer, and the exosomes derived from cervical cancer cells which over-pressing the hsa_circ_0087432 can promote the proliferation and migration of human umbilical vein endothelial cells.

, correspAuthors=Gui-Fen Chu, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Hong Xia, Xiang Yang, Ye Chen, Hu Li, Gui-Fen Chu), CN=ArticleExt(id=1211269162387771677, articleId=1211269159913132265, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=宫颈癌细胞外泌体hsa_circ_0087432对人脐静脉内皮细胞增殖及迁移的影响, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 分析环状RNA 0087432(hsa_circ_0087432)在宫颈癌患者血清外泌体中的表达，探讨其与宫颈癌转移可能存在的关系。方法 收集广州市番禺区中心医院2019年6月—2020年6月诊断为宫颈鳞癌且术前未行放化疗的30例患者的宫颈癌组织及血清作为实验组，另将30例未患宫颈癌的女性正常宫颈组织及血清作为对照组。采用实时定量聚合酶链反应(qPCR)检测hsa_circ_0087432在宫颈癌患者与健康人宫颈组织和血清外泌体中的表达水平。通过质粒转染Siha细胞以过表达hsa_circ_0087432，将Siha细胞依不同处理分为3组：control组(未转染质粒)，vector组(转染pLC5-ciR)及hsa_circ_0087432组(转染hsa_circ_0087432-pLC5-ciR)，并提取各组外泌体；采用透射电镜(TEM)、纳米颗粒跟踪分析技术(NTA)及Western blotting检测外泌体表征。将人脐静脉内皮细胞按不同处理分为3组：control-Exs组(Siha细胞来源外泌体)、vector-Exs组(vector组Siha细胞来源外泌体)、hsa_circ_0087432-Exs组(hsa_circ_0087432组Siha细胞来源外泌体)，采用CCK-8试剂盒检测外泌体对人脐静脉内皮细胞增殖的影响，采用划痕实验及Transwell检测外泌体对人脐静脉内皮细胞迁移的影响。结果 电镜下观察结果显示，Siha细胞的外泌体大部分呈椭圆形或圆形，粒径分析显示其直径大小分布在30~150 nm；Western blotting检测结果显示，两组囊泡中的CD9、CD81及CD63表达均呈阳性；qPCR结果显示，实验组宫颈组织hsa_circ_0087432表达量明显高于对照组(4.03±1.51 vs. 1.00±0.26，P<0.01)，且血清外泌体中hsa_circ_0087432表达量也明显高于对照组(1.97±0.04 vs. 1.02±0.23，P<0.01)。CCK-8检测结果显示，hsa_circ_0087432-Exs可明显促进人脐静脉内皮细胞增殖(1.57±0.04 vs. 1.09±0.11，P<0.05)。划痕实验结果显示，干预12 h后，circ_0087432-Exs组的迁移面积占比高于control-Exs组(24.66%±2.92% vs. 15.01%±3.12%，P<0.05)，且24 h后hsa_circ_0087432-Exs组的迁移面积占比明显高于control-Exs组(74.84%±13.22% vs. 38.70%±2.12%，P<0.01)。Transwell检测结果也显示，与vector-Exs组及control-Exs组比较，hsa_circ_0087432-Exs组迁移细胞数量明显增多，差异有统计学意义[分别为(1218.00±103.53)个、(1044.00±103.79)个、(1755.00±97.35)个，P<0.05]。结论 hsa_circ_0087432在宫颈癌患者血清外泌体中呈高表达，且过表达hsa_circ_0087432的宫颈癌细胞来源的外泌体可促进人脐静脉内皮细胞增殖与迁移。

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夏红，医学博士，副主任医师，主要从事宫颈癌及癌前病变防治方面的研究

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夏红，医学博士，副主任医师，主要从事宫颈癌及癌前病变防治方面的研究

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Mol Cancer, 2019, 18(1): 76., articleTitle=Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors, refAbstract=null), Reference(id=1211269171111924402, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, doi=null, pmid=null, pmcid=null, year=2018, volume=25, issue=19, pageStart=1365, pageEnd=1370, url=null, language=null, rfNumber=[24], rfOrder=26, authorNames=Cui HJ, Zhang YN, Li HT, journalName=Chin J Cancer Prev Treat, refType=null, unstructuredReference=Cui HJ, Zhang YN, Li HT. Mechanism of exosome miRNG29 in cervical cancer metastasis[J]. Chin J Cancer Prev Treat, 2018, 25(19): 1365-1370., articleTitle=Mechanism of exosome miRNG29 in cervical cancer metastasis, refAbstract=null), Reference(id=1211269171267113659, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, doi=null, pmid=null, pmcid=null, year=2018, volume=25, issue=19, pageStart=1365, pageEnd=1370, url=null, language=null, rfNumber=[24], rfOrder=27, authorNames=崔虎军, 张亚男, 李慧亭, journalName=中华肿瘤防治杂志, refType=null, unstructuredReference=[崔虎军, 张亚男, 李慧亭. 外泌体miRNA29在宫颈癌转移中作用机制探讨[J]. 中华肿瘤防治杂志, 2018, 25(19): 1365-1370.], articleTitle=外泌体miRNA29在宫颈癌转移中作用机制探讨, refAbstract=null)], funds=[Fund(id=1211269167152501283, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, awardId=201904010363, language=EN, fundingSource=Guangzhou Science and Technology Plan Project(201904010363), fundOrder=null, country=null), Fund(id=1211269167244775977, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, awardId=201904010363, language=CN, fundingSource=广州市科技计划项目(201904010363), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1211269162626847015, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, xref=null, ext=[AuthorCompanyExt(id=1211269162639429929, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, companyId=1211269162626847015, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Gynecology, Guangzhou Panyu District Central Hospital, Guangzhou 511040, China), AuthorCompanyExt(id=1211269162647818538, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, companyId=1211269162626847015, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=广州市番禺区中心医院妇科，广州 511040)])], figs=[ArticleFig(id=1211269165290230266, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=EN, label=Fig.1, caption=The expression level of hsa_circ_0087432 in cervical tissue (A) and serum exosomes (B) in experimental group and control group, figureFileSmall=Lwelt7nz0xkZnU6YNiawTA==, figureFileBig=TrkQ3EYChebFaxrmNhWA7Q==, tableContent=null), ArticleFig(id=1211269165466391045, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=CN, label=图1, caption=实验组与对照组宫颈组织(A)及血清外泌体(B)中hsa_circ_0087432的表达水平

与对照组比较，(1)P<0.01。

, figureFileSmall=Lwelt7nz0xkZnU6YNiawTA==, figureFileBig=TrkQ3EYChebFaxrmNhWA7Q==, tableContent=null), ArticleFig(id=1211269166754042379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=EN, label=Fig.2, caption=Exosomes, particle size, identification of characteristic proteins and intracellular uptake, figureFileSmall=NFPoV6lzQFErAGvNstfFmw==, figureFileBig=RU4ZJtMkRK4TNOlrAAJXJA==, tableContent=null), ArticleFig(id=1211269166867288594, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=CN, label=图2, caption=外泌体电镜图、粒径分析、特征蛋白的鉴定及细胞内摄取

A. Siha细胞来源的外泌体电镜图；B. NTA分析Siha细胞的外泌体粒径；C. 外泌体表面蛋白CD9、CD81和CD63的表达；D. 人脐静脉内皮细胞摄取外泌体实验

, figureFileSmall=NFPoV6lzQFErAGvNstfFmw==, figureFileBig=RU4ZJtMkRK4TNOlrAAJXJA==, tableContent=null), ArticleFig(id=1211269166946980377, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=EN, label=Fig.3, caption=Exocrine derived from the cells which over-pressing the hsa_circ_0087432 can promote the proliferation and migration of human umbilical vein endothelial cells, figureFileSmall=INoIBtuxgFLqpBr5l3fhVQ==, figureFileBig=OJswq9dtO8/ZDRnCQI2Umw==, tableContent=null), ArticleFig(id=1211269167043449375, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269159913132265, language=CN, label=图3, caption=过表达hsa_circ_0087432后细胞分泌的外泌体对人脐静脉内皮细胞迁移的影响

A、C. 人脐静脉内皮细胞12、24 h划痕实验；B、D. 人脐静脉内皮细胞迁移实验；与control-Exs组比较，(1)P<0.05，(2)P<0.01；与vector-Exs组比较，(3)P<0.01。

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