Article(id=1211269040002166842, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269034906088369, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.03.15, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1589731200000, receivedDateStr=2020-05-18, revisedDate=1612281600000, revisedDateStr=2021-02-03, acceptedDate=null, acceptedDateStr=null, onlineDate=1766718643427, onlineDateStr=2025-12-26, pubDate=1616860800000, pubDateStr=2021-03-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766718643427, onlineIssueDateStr=2025-12-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766718643427, creator=13701087609, updateTime=1766718643427, updator=13701087609, issue=Issue{id=1211269034906088369, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='3', pageStart='213', pageEnd='318', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766718642212, creator=13701087609, updateTime=1766718779849, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1211269612247838856, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269034906088369, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1211269612247838857, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211269034906088369, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=306, endPage=310, ext={EN=ArticleExt(id=1211269041226903622, articleId=1211269040002166842, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress of cancer-associated fibroblasts in gastric cancer, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Gastric cancer is the fifth leading incidence and the third leading cause of death in the world. Gastric cancer patients in China are often in advanced stages and have a poor prognosis. Cancer progression depends not only on the cancer cells themselves, but also on the physiological state and composition of the tumor microenvironment in which they are located. Cancer-associated fibroblasts as the major cell type in the tumor microenvironment played an important role in cancer progression. This paper mainly expounds the origin and classification of cancer-associated fibroblasts, and its research progress on gastric cancer invasion and metastasis, growth, angiogenesis, matrix remodeling, immunomodulation and cancer suppression, and summarizes the relevant anti-tumor strategies by targeting cancer-associated fibroblasts in gastric cancer, to provide more information for use of cancer-associated fibroblasts in targeted therapy of gastric cancer.

, correspAuthors=Yuan-Yi Xu, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Jia-Xin Guo, Yuan-Yi Xu), CN=ArticleExt(id=1211269041583419488, articleId=1211269040002166842, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=胃癌癌相关成纤维细胞研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

胃癌是全球发病率第五、病死率第三的癌症。在中国，胃癌患者就诊时多为晚期且预后较差。癌症进展不仅取决于癌细胞自身，还取决于其所处的环境即肿瘤微环境的生理状态与构成改变，其中癌相关成纤维细胞作为肿瘤微环境中重要的细胞类型，在癌症进展中发挥着重要作用。该文阐述癌相关成纤维细胞的来源和分型，以及对胃癌侵袭转移、生长、血管生成、基质重塑、免疫调节及抑癌等方面作用的研究进展，总结靶向胃癌中癌相关成纤维细胞的相关抗肿瘤策略，以期为癌相关成纤维细胞应用于胃癌的靶向治疗提供更多信息。

, correspAuthors=徐远义, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=o0L6mvOLEBXY8sTJ1LiG/Q==, magXml=i1jHxxjn2Do4rrDsDr31CQ==, pdfUrl=null, pdf=Idgmvx826VaTJXbUC4wRHA==, pdfFileSize=1258476, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=By7DPmnl8a6+2CsSGiU7EQ==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=郭嘉欣, 徐远义)}, authors=[Author(id=1211269041931546750, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269040002166842, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=1310857125@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1211269042040598665, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269040002166842, authorId=1211269041931546750, language=EN, stringName=Jia-Xin Guo, firstName=Jia-Xin, middleName=null, lastName=Guo, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Pathology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1211269042111901839, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211269040002166842, authorId=1211269041931546750, language=CN, stringName=郭嘉欣, firstName=嘉欣, middleName=null, lastName=郭, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=宁夏医科大学基础医学院病理系，银川 750004, bio={"content":"

郭嘉欣，硕士研究生，主要从事消化道肿瘤免疫方面的研究。E-mail：1310857125@qq.com

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郭嘉欣，硕士研究生，主要从事消化道肿瘤免疫方面的研究。E-mail：1310857125@qq.com

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