Article(id=1211268824494633164, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211268819788632695, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.01.14, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1591891200000, receivedDateStr=2020-06-12, revisedDate=1603296000000, revisedDateStr=2020-10-22, acceptedDate=null, acceptedDateStr=null, onlineDate=1766718592046, onlineDateStr=2025-12-26, pubDate=1611763200000, pubDateStr=2021-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766718592046, onlineIssueDateStr=2025-12-26, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766718592046, creator=13701087609, updateTime=1766718592046, updator=13701087609, issue=Issue{id=1211268819788632695, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='1', pageStart='1', pageEnd='100', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766718590924, creator=13701087609, updateTime=1766718828068, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1211269814484594852, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211268819788632695, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1211269814484594853, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1211268819788632695, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=84, endPage=88, ext={EN=ArticleExt(id=1211268824813400282, articleId=1211268824494633164, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress on the relationship between haptoglobin and diabetic kidney disease, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Haptoglobin (HP) is a kind of plasma glycoprotein with genetic polymorphism, secreted mainly in liver and has two alleles of HP1 and HP2, can form three potential genotypes: HP1-1, HP2-1 and HP2-2, which has the function of binding to free hemoglobin and antioxidation. At present, many studies have shown that HP may be a potential biomarker of diabetic kidney disease. Because of the special structure and function of HP, it has certain advantages in early diagnosis and prognosis prediction of diabetic nephropathy. The relationship has been mainly reviewed in present paper between the expression level of HP and its genotypes in the occurrence, development, diagnosis and prognosis prediction of diabetic nephropathy.

, correspAuthors=Xiang-Mei Chen, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yu-Jing Ke, Zhe-Yi Dong, Xiang-Mei Chen), CN=ArticleExt(id=1211268825266385143, articleId=1211268824494633164, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=触珠蛋白与糖尿病肾病的关系研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

触珠蛋白(HP)是一种具有遗传多态性的血浆糖蛋白，主要在肝脏分泌，有HP1和HP2两种等位基因，可形成3种潜在的基因型：HP1-1、HP2-1和HP2-2，具有结合游离血红蛋白及抗氧化等功能。HP由于特殊的结构及功能，在糖尿病肾病早期诊断及预后预测中均具有一定的优势，可能是糖尿病肾病的潜在生物标志物。该文主要综述HP表达水平及其基因型与糖尿病肾病发生、发展、诊断及预后之间的关系。

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²Department of Nephrology, General Hospital of Chinese PLA/Institute of Nephrology of PLA/State Key Laboratory of Kidney Diseases/National Chronic Nephropathy Clinical Research Center/Beijing Key Laboratory of Kidney Disease Research, Beijing 100853, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1211268827103490350, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1211268824494633164, authorId=1211268825790673181, language=CN, stringName=柯雨景, firstName=雨景, middleName=null, lastName=柯, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹广东药科大学临床医学院，广州 510006
²解放军总医院肾脏病科/解放军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心/肾脏疾病研究北京市重点实验室，北京 100853, bio={"content":"

柯雨景，硕士研究生，主要从事糖尿病合并肾脏疾病相关研究。E-mail：1247531115@qq.com

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柯雨景，硕士研究生，主要从事糖尿病合并肾脏疾病相关研究。E-mail：1247531115@qq.com

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