Article(id=1209139837190403026, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1209139833285505965, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.07.10, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1610985600000, receivedDateStr=2021-01-19, revisedDate=1621785600000, revisedDateStr=2021-05-24, acceptedDate=null, acceptedDateStr=null, onlineDate=1766211001918, onlineDateStr=2025-12-20, pubDate=1627401600000, pubDateStr=2021-07-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766211001918, onlineIssueDateStr=2025-12-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766211001918, creator=13701087609, updateTime=1766211001918, updator=13701087609, issue=Issue{id=1209139833285505965, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='7', pageStart='637', pageEnd='742', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766211000986, creator=13701087609, updateTime=1766212174313, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1209144754630168707, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1209139833285505965, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1209144754630168708, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1209139833285505965, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=702, endPage=709, ext={EN=ArticleExt(id=1209139837584667616, articleId=1209139837190403026, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress on the mechanism of resistance in endocrine therapy for breast cancer, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Breast cancer is the most common malignant tumor in the world. Endocrine therapy is an important treatment for HR positive breast cancer, and its drugs are mainly divided into premenopausal estrogen receptor antagonists and postmenopausal aromatase inhibitors, but drug resistance has become a major challenge in endocrine therapy for breast cancer. This article reviews the drug resistance mechanism and the latest research results of endocrine therapy in premenopausal and postmenopausal breast cancer from the aspects of gene regulation, estrogen and coregulatory cofactor, growth factor signal pathway, cell cycle regulation,autophagy and apoptosis, non-coding RNA regulation, immune surveillance, etc., in order to provide a new basis for clinical solution of endocrine therapy resistance in breast cancer.

, correspAuthors=Ying Yuan, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Aisa Adilai, Jing Zhao, Ying Yuan), CN=ArticleExt(id=1209139838310281222, articleId=1209139837190403026, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=乳腺癌内分泌治疗耐药机制的研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

乳腺癌是目前全球范围内最常见的恶性肿瘤之一。内分泌治疗是激素受体(HR)阳性乳腺癌重要的治疗方式，治疗药物主要分为绝经前使用的雌激素受体拮抗剂和绝经后使用的芳香化酶抑制剂等，但耐药问题是目前乳腺癌内分泌治疗的重大挑战。该文从基因调控、雌激素与共调辅助因子、生长因子信号通路、细胞周期调控机制、自噬与凋亡机制、非编码RNA调控、免疫监视等方面对绝经前后乳腺癌内分泌治疗的耐药机制和最新的研究结果进行综述，以期为临床解决乳腺癌内分泌治疗耐药问题提供新的依据。

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阿迪莱·艾萨，硕士研究生，主要从事肿瘤诊断与治疗方面的研究

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阿迪莱·艾萨，硕士研究生，主要从事肿瘤诊断与治疗方面的研究

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ER. 雌激素受体；ESR1. 编码雌激素受体的基因；HER2. 人类表皮生长因子受体2；EGFR. 表皮生长因子受体；IGFR. 胰岛素样生长因子受体；MAPK. 丝裂原活化蛋白激酶；PI3K. 磷脂酰肌醇3-激酶；AKT. 丝氨酸苏氨酸激酶；mTOR. 哺乳动物雷帕霉素靶蛋白；JNK. c-Jun氨基末端激酶；CDK4/6. 细胞周期蛋白依赖性激酶4/6；CCND1. 细胞周期蛋白D1；MDM2. 双微体2基因；BCL-2. 一种主要抑制凋亡的基因；Survivin蛋白. 一种抑制肿瘤细胞凋亡的蛋白质；UPR. 未折叠蛋白反应；GRP78. 葡萄糖调节蛋白78；P450. 细胞色素P450；CYP2D6. 细胞色素P450家族中的重要成员之一；lncRNA. 长链非编码核糖核酸；miRNA. 微小核糖核酸；MTA1. 肿瘤转移相关基因1；LC-3. 微管相关蛋白1轻链3；Beclin-1. 哺乳动物ATG6同源蛋白；LAMP. 溶酶体相关膜蛋白；AIB1. 乳腺癌扩增基因1

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