Article(id=1208862462825329432, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208862455166538583, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.08.14, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1609171200000, receivedDateStr=2020-12-29, revisedDate=1622044800000, revisedDateStr=2021-05-27, acceptedDate=null, acceptedDateStr=null, onlineDate=1766144870716, onlineDateStr=2025-12-19, pubDate=1630080000000, pubDateStr=2021-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766144870716, onlineIssueDateStr=2025-12-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766144870716, creator=13701087609, updateTime=1766144870716, updator=13701087609, issue=Issue{id=1208862455166538583, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='8', pageStart='743', pageEnd='848', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766144868890, creator=13701087609, updateTime=1766144939527, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208862751481524455, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208862455166538583, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208862751481524456, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208862455166538583, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=827, endPage=830, ext={EN=ArticleExt(id=1208862463320257320, articleId=1208862462825329432, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress of PET molecular imaging in rimmed vacuolar myopathy, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Rimmed vacuole myopathy is a group of disease with characteristic myopathological features, which including deposition of abnormal proteins, such as β-amyloid protein (Aβ) and phosphorylated tau proteins etc. In recent years, positron emission tomography (PET) has been widely used in the imaging diagnosis of Alzheimer's disease (AD) due to the development of molecular imaging technology. Recently, some studies have indicated that molecular imaging PET can also show the abnormal deposition proteins in muscles, which is helpful for the early diagnosis and differential diagnosis of rimmed vacuolar myopathy, and provides a new application for PET. The application directions of PET in rimmed vacuolar myopathy were reviewed in this article, in order to provide a reference base for the implementation of clinical work.

, correspAuthors=Qiang Shi, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Ke Li, Qiang Shi), CN=ArticleExt(id=1208862464490468199, articleId=1208862462825329432, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=正电子断层显像技术在镶边空泡肌病中的应用研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

镶边空泡肌病是具有特征性骨骼肌病理特点的一组疾病，其病理特点之一为β淀粉样蛋白(Aβ)及磷酸化tau蛋白在肌纤维中的异常沉积。近年来得益于分子影像技术的发展，正电子断层显像技术(PET)已被广泛应用于阿尔茨海默病的影像诊断，分子影像PET亦可以显示肌肉内沉积的异常蛋白，有助于镶边空泡肌病的早期诊断及鉴别诊断，为PET提供了新的应用方向。该文主要对PET在镶边空泡肌病中的应用进展进行综述，以期为临床工作的实施提供参考依据。

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李珂，博士研究生，主要从事神经肌肉疾病方面的研究

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李珂，博士研究生，主要从事神经肌肉疾病方面的研究

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J Neurol Neurosurg Psychiatry, 2011, 82(9): 1060-1062., articleTitle=Increased ¹¹C PIB-PET levels in inclusion body myositis are indicative of amyloid beta deposition, refAbstract=null), Reference(id=1208862470756757590, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, doi=null, pmid=null, pmcid=null, year=2020, volume=39, issue=5, pageStart=243, pageEnd=244, url=null, language=null, rfNumber=[18], rfOrder=19, authorNames=Li K, Dang H, Shi Q, journalName=Clin Neuropathol, refType=null, unstructuredReference=Li K, Dang H, Shi Q. ¹¹C-PIB PET of inclusion body myositis:Molecular imaging of amyloid beta expression improving imaging-pathology correlations[J]. 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Ann Rheum Dis, 2019, 78(5): 657-662., articleTitle=¹⁸F Florbetapir positron emission tomography: identification of muscle amyloid in inclusion body myositis and differentiation from polymyositis, refAbstract=null), Reference(id=1208862471146827872, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, doi=null, pmid=null, pmcid=null, year=2020, volume=99, issue=31, pageStart=e21524, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=23, authorNames=Zhang YT, Li K, Pu CQ, journalName=Medicine (Baltimore), refType=null, unstructuredReference=Zhang YT, Li K, Pu CQ, et al. A novel application of tau PET in the diagnosis of sporadic inclusion body myositis: a case report[J]. 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SUV. 标准化摄取值；箭头指示为AD组典型的低代谢(FDG)及典型的淀粉样沉积(PIB)

, figureFileSmall=2GCuf9kDV1RimFdFUumVIw==, figureFileBig=awpB6LY6NKHZp7xIb6A/aQ==, tableContent=null), ArticleFig(id=1208862466998662129, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, language=EN, label=Fig.2, caption=¹¹C-PIB PET/CT scans of sporadic inclusion body myositis patient and myalgia patient of unclear aetiology^[17], figureFileSmall=+VNZd7X6VAZjzwqYsX6nhg==, figureFileBig=7ibM1GhhcEIkhXTZoP+akw==, tableContent=null), ArticleFig(id=1208862467069965303, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, language=CN, label=图2, caption=散发性包涵体肌炎患者与不明原因肌痛患者的¹¹C-PIB PET/CT图像^[17]

A. 散发性包涵体肌炎患者(腓肠肌标准化摄取值SUV=0.73)；B. 不明原因肌痛患者(腓肠肌SUV=0.45)

, figureFileSmall=+VNZd7X6VAZjzwqYsX6nhg==, figureFileBig=7ibM1GhhcEIkhXTZoP+akw==, tableContent=null), ArticleFig(id=1208862467162239992, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, language=EN, label=Fig.3, caption=¹⁸F-florbetapir PET/CT images of patient with sporadic inclusion body myositis (A) and patient with polymyositis (B)^[21], figureFileSmall=DilCClThI23ft1DcEWx2/Q==, figureFileBig=GcXZJ6g5ln6T8S8u8M7YWw==, tableContent=null), ArticleFig(id=1208862468386976763, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208862462825329432, language=CN, label=图3, caption=散发性包涵体肌炎患者与多发性肌炎患者的¹⁸F-florbetapir PET/CT图像^[21]

与多发性肌炎患者比较，散发性包涵体肌炎患者SUV值明显增高；红色表明示踪剂摄取增加

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