Article(id=1208795421661590166, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208795418612339683, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.10.01, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1603555200000, receivedDateStr=2020-10-25, revisedDate=1624118400000, revisedDateStr=2021-06-20, acceptedDate=null, acceptedDateStr=null, onlineDate=1766128886857, onlineDateStr=2025-12-19, pubDate=1635350400000, pubDateStr=2021-10-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766128886857, onlineIssueDateStr=2025-12-19, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766128886857, creator=13701087609, updateTime=1766128886857, updator=13701087609, issue=Issue{id=1208795418612339683, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='10', pageStart='955', pageEnd='1060', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766128886129, creator=13701087609, updateTime=1766128956061, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208795711982924071, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208795418612339683, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208795711982924072, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208795418612339683, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=955, endPage=960, ext={EN=ArticleExt(id=1208795421984551578, articleId=1208795421661590166, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=OPN/IGF1 promotes the corticospinal tract regeneration by increasing neuron IGFR expression, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objectives To study the role and associated potential molecular mechanism of osteopontin/insulin-like growth factor 1 (OPN/IGF1) in the corticospinal tract (CST) regeneration. Methods A total of 28 adult C57BL/6 mice (6-8 weeks old) were randomized into the experimental group (injection of AAV-OPN/IGF1, n=14) and control group (injection of AAV-PLAP, n=14) after training of single pellet retrieval. After received the unilateral pyramidotomy surgery, animals received AAV-OPN/IGF1 or AAV-PLAP at the injury site. Further, we employed the movement behaviour test to evaluate spinal motor recovery at 2-week intervals till 12-week after surgery. The protein kinase Cγ (PKCγ) staining in the dorsal funiculus of the cervical spinal cord indicated surgical efficiency. Lastly, we examined the axon sprouting and expression levels of ribosomal protein S6 kinase (pS6)and insulin-like growth factor receptor (IGFR) in neurons using immunohistochemical staining to study the potential mechanism of OPN/IGF1 to promote axon prouting. Results After evaluating PKCγ staining to indicate surgery effectiveness, a total of ten mice were in the experimental group and eight in the control group. In the mouse unilateral pyramidotomy model, OPN/IGF1 has not much effect on the recovery of motor function compared with the control group. After the overexpression of OPN/IGF1 on cortical neurons, sprouting of the spared CST was increased by the elevated expression of pS6 and IGFR, and the difference was statistically significant (P<0.05). Conclusions OPN/IGF1 promotes the sprouting of the CST by increasing the expression of neuronal IGFR and pS6.

, correspAuthors=Fang Cui, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Qian Zhang, Kun Zhang, Zeng-Qiang Zhang, Jian-Yong Li, Fang Cui), CN=ArticleExt(id=1208795422781469358, articleId=1208795421661590166, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=OPN/IGF1促进小鼠皮质脊髓束轴突再生的作用及机制研究, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 研究骨桥蛋白(OPN)/胰岛素样生长因子1(IGF1)在小鼠皮质脊髓束(CST)再生中的作用及相关分子机制。方法 6~8周龄C57BL/6小鼠28只，随机分为实验组与对照组，每组14只。建立小鼠单侧锥体束横断模型，实验组在损伤对侧皮质注射腺相关病毒(AAV)-OPN/IGF1，对照组在损伤对侧皮质注射AAV-胎盘碱性磷酸酶(PLAP)。术后每2周采用行为学方法评估小鼠运动功能的恢复情况。术后12周处死小鼠，采用脊髓蛋白激酶Cγ(PKCγ)免疫组化染色判断皮质脊髓束横断情况；采用红色荧光蛋白(RFP)免疫组化染色分析轴突发芽的情况；采用免疫荧光染色检测神经元OPN和IGF1相关信号通路中核糖体蛋白S6激酶(pS6)和胰岛素样生长因子受体(IGFR)表达情况，研究OPN/IGF1促进轴突发芽的分子机制。结果 通过采用PKCγ免疫组化染色判断皮质脊髓束残余情况，最终实验组入组小鼠10只，对照组入组小鼠8只。实验组与对照组相比，OPN/IGF1对小鼠运动功能恢复无明显作用；皮质神经元高表达OPN/IGF1以后，损伤对侧皮质脊髓束发芽增多，神经元pS6和IGFR表达均明显高于对照组，差异有统计学意义(P<0.05)。结论 OPN/IGF1可通过增加神经元IGFR和pS6表达而促进CST发芽。

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张倩，博士研究生，主要从事脑血管病、神经系统变性病、周围神经病的诊疗研究

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张倩，博士研究生，主要从事脑血管病、神经系统变性病、周围神经病的诊疗研究

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BL. 基线；AAV. 腺相关病毒；PLAP. 胎盘碱性磷酸酶；IGF1. 胰岛素样生长因子1；A. 不规则步行梯测试[实验组(n=9)，对照组(n=8)]；B. 糖丸抓取测试[实验组(n=6)，对照组(n=6)]；C. 握食意大利面测试[实验组(n=9)，对照组(n=7)]

, figureFileSmall=KUDqk3AFE/bOesus3prczw==, figureFileBig=AbA7lTQgGJ8IKULtUeNU3Q==, tableContent=null), ArticleFig(id=1208795432063464285, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208795421661590166, language=EN, label=Fig. 2, caption=Axon sprouted to the contralateral side in mice after unilateral pyramidotomy, figureFileSmall=nwJ9Zo5HKzcz56gcUMV7ng==, figureFileBig=BA9pQ1acU2AJuifV9xH7Ww==, tableContent=null), ArticleFig(id=1208795432176710500, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208795421661590166, language=CN, label=图2, caption=单侧锥体束横断术后小鼠未损伤侧轴突向对侧发芽情况

AAV. 腺相关病毒；PLAP. 胎盘碱性磷酸酶；IGF1. 胰岛素样生长因子1；A. 颈椎(C₆)RPF免疫组化染色(显示未损伤侧轴突向损伤侧发芽情况，bar=500 μm)；B. 轴突数量统计(通过中央导水管画一水平线，Mid、Z1、Z2是3条把灰质分为3等份的垂直线，统计通过三条垂直线的轴突数量)；C. 实验组(n=8)和对照组(n=5)分别通过Mid、Z1、Z2三条垂直线的轴突数量相对于各自锥体交叉前标记轴突数量的比值的统计学分析，与对照组比较，(1)P<0.05，(2)P<0.01。

, figureFileSmall=nwJ9Zo5HKzcz56gcUMV7ng==, figureFileBig=BA9pQ1acU2AJuifV9xH7Ww==, tableContent=null), ArticleFig(id=1208795432277373802, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208795421661590166, language=EN, label=Fig. 3, caption=Expressions of neuronal pS6 and IGFR in mice after unilateral pyramidotomy, figureFileSmall=SP6KNLrKN2nxxjyAawpQgQ==, figureFileBig=E3XZ6KktnAsNorFB9DLXZg==, tableContent=null), ArticleFig(id=1208795432399008626, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208795421661590166, language=CN, label=图3, caption=单侧锥体束横断术后小鼠神经元pS6(A)及IGFR(B)的表达(n=6，bar=20 μm)

pS6. 核糖体蛋白S6激酶；IGFR. 胰岛素样生长因子受体；AAV. 腺相关病毒；PLAP. 胎盘碱性磷酸酶；IGF1. 胰岛素样生长因子1；与对照组比较，(1)P<0.05。

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