Article(id=1208518760273678561, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.12.02, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1616947200000, receivedDateStr=2021-03-29, revisedDate=1628438400000, revisedDateStr=2021-08-09, acceptedDate=null, acceptedDateStr=null, onlineDate=1766062925642, onlineDateStr=2025-12-18, pubDate=1640620800000, pubDateStr=2021-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766062925642, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766062925642, creator=13701087609, updateTime=1766062925642, updator=13701087609, issue=Issue{id=1208518757253779608, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='12', pageStart='1167', pageEnd='1267', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766062924920, creator=13701087609, updateTime=1766062998332, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208519065233125464, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208519065233125465, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1174, endPage=1180, ext={EN=ArticleExt(id=1208518761552941296, articleId=1208518760273678561, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effect of SE-hBCG on the immunogenicity of recombinant cytomegalovirus glycoprotein B and freeze-dried rabies vaccine for human use, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the effect of SE-hBCG on the immunogenicity of recombinant cytomegalovirus glycoprotein B (CgB) and freeze-dried rabies human vaccine (Rab). Methods A total of 145 SPF female BALB/c mice aged 6-8 weeks were selected for the following experiments. In experiment one, five groups of mice (five mice per group) received intramuscular injections of 0.2 ml of SE, SE-hBCG, CgB, SE+CgB or SE-hBCG+CgB three times (at week 0, 2 and 4), respectively.Two weeks after the last immunization was the endpoint of this experiment. In experiment two, four groups of mice (30 mice per group) received two intraperitoneally injections at week 0 and 1 with 0.2 ml of PBS, Rab, SE+Rab or SE-hBCG+Rab, respectively.Samples were collected at 4, 8, 10, 12, 14, 35 days after the first immunization. Spleen lymphocytes of mice were isolated after homogenizing spleens. The enzyme-linked immunosorbent spot assay (ELISPOT) was used to detect the number of antigen-specific IFN-γ and IL-4-secreting spot forming cells (IFN-γ-SFC or IL-4-SFC). Sera were harvested from eyeball blood. Antigen-specific IgG was detected using ELISA. Results SE-hBCG induced mice to produce CgB-specific Th1 responses as mice immunized with SE-hBCG produced greater numbers of IFN-γ-SFC than mice immunized with SE (266.0±87.9 vs. 104.5±28.8, P<0.05). Mice immunized with SE-hBCG adjuvanted CgB vaccines produced higher levels of CgB-specific IgG antibodies (18 800.0±2396.0) and greater numbers of IFN-γ-SFC (440.5±38.4) than mice immunized with CgB (3333.0±737.9 for CgB-specific IgG antibody titer and 189.2±21.4 for IFN-γ-SFC, P<0.05). Four days after the first immunization, SE or SE-hBCG adjuvanted Rab vaccines induced low-level anti-Rab IgG antibodies (OD₄₅₀≤0.2). Anti-Rab IgG antibodies of mice immunized with Rab, SE or SE-hBCG adjuvanted Rab peaked 12 days after the first immunization. Mice immunized with SE-hBCG adjuvanted Rab vaccines produced higher levels of anti-Rab IgG antibodies 8, 10, 14, and 35 days (1700.0±200.0, 19 400.0±1661.3, 23 000±358.9, 23 600.0±6038.2, respectively)after the first immunization than mice immunized with Rab (310.0±97.9, 6730.0±1655.4, 6000.0±1655.6, 4400.0±1655.5,respectively, P<0.05) and greater numbers of IFN-γ-SFC 4, 8, 14 and 35 days (110.8±52.5, 213.0±29.7, 105.2±33.7,80.4±36.8, respectively) after the first immunization than mice immunized with PBS (6.4±3.5, 32.2±12.9, 11.4±5.1, 4.4±2.5,respectively, P<0.05). Conclusion SE-hBCG could enhance the immunogenicity of CgB and Rab, and it is likely to become an immunopotentiator.

, correspAuthors=Xiu-Yun He, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Ting-Hui Li, Bin-Yu Li, Xi-Hui Ma, Xiu-Yun He), CN=ArticleExt(id=1208518763016753468, articleId=1208518760273678561, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=SE-hBCG对重组巨细胞病毒糖蛋白B及冻干人用狂犬病疫苗免疫原性的影响, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨含角鲨烯的水包油纳米乳剂-热灭活卡介苗(SE-hBCG)对重组巨细胞病毒糖蛋白B(CgB)及冻干人用狂犬病疫苗(Rab)免疫原性的影响。方法 选取145只SPF级6~8周龄雌性BALB/c小鼠进行以下实验。实验1：取25只小鼠，分成SE组、SE-hBCG组、CgB组、SE+CgB组、SE-hBCG+CgB组等5组，每组5只；于实验开始第0、2、4周分别给每只小鼠肌内注射SE、SE-hBCG、CgB、SE+CgB、SE-hBCG+CgB各0.2 ml，末次免疫后2周解剖小鼠。实验2：取120只小鼠，分成PBS组、Rab组、SE+Rab组、SE-hBCG+Rab组等4组，每组30只；于实验开始第0周及第1周每只小鼠分别腹腔注射PBS、Rab、SE+Rab、SE-hBCG+Rab各0.2 ml，于初免后第4、8、10、12、14、35天各解剖5只小鼠。无菌摘取小鼠脾脏，制备脾淋巴细胞悬液，采用酶联免疫斑点实验(ELISPOT)检测抗原特异的IFN-γ或IL-4的斑点形成细胞数(IFN-γ-SFC或IL-4-SFC)；取小鼠眼球血，离心后收集血清，采用酶联免疫吸附试验(ELISA)检测抗原特异的IgG水平。结果 SE-hBCG组诱导小鼠产生CgB特异的IFN-γ-SFC(266.0±87.9)高于SE组(104.5±28.8，P<0.05)；SE-hBCG+CgB组诱导小鼠产生抗-CgB IgG抗体滴度(18 800.0±2396.0)及CgB特异的IFN-γ-SFC(440.5±38.4)高于CgB组(抗体滴度为3333.0±737.9，IFN-γ-SFC为189.2±21.4，P<0.05)。SE+Rab或SE-hBCG+Rab初免后第4天可诱导低水平抗-Rab IgG抗体(OD₄₅₀≤0.2)；Rab、SE+Rab及SE-hBCG+Rab组抗-Rab IgG抗体均于初免后第12天达到峰值；SE-hBCG+Rab组于初免后第8、10、14及35天检测的抗-Rab IgG抗体(分别为1700.0±200.0、19 400.0±1661.3、23 000±358.9、23 600.0±6038.2)均高于Rab组(分别为310.0±97.9、6730.0±1655.4、6000.0±1655.6、4400.0±1655.5，P<0.05)。SE-hBCG+Rab组初免后第4、8、14及35天检测的Rab特异IFN-γ-SFC(分别为110.8±52.5、213.0±29.7、105.2±33.7、80.4±36.8)均高于对照组(分别为6.4±3.5、32.2±12.9、11.4±5.1、4.4±2.5，P<0.05)。结论 SE-hBCG可增强CgB及Rab的免疫原性，是一种较好的免疫增强剂。

, correspAuthors=何秀云, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=WKcskjwTOo5MPwn2KbtSnA==, magXml=s/oSm6tXvu67xmHpo8blPQ==, pdfUrl=null, pdf=LvLKQmo0MGA0z8ieprBugA==, pdfFileSize=991481, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=MBrWbNGEKqyslaidXmpv0A==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=t+FsMm7bitvaIfCDx9ymog==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=李廷慧, 李彬钰, 马锡惠, 何秀云)}, authors=[Author(id=1208518763436183902, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208518763545235815, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518763436183902, language=EN, stringName=Ting-Hui Li, firstName=Ting-Hui, middleName=null, lastName=Li, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208518763633316204, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518763436183902, language=CN, stringName=李廷慧, firstName=廷慧, middleName=null, lastName=李, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹解放军总医院第八医学中心皮肤科，北京 100091, bio={"content":"

李廷慧，博士研究生，主要从事白癜风及感染性皮肤病方面的研究

"}, bioImg=null, bioContent=

李廷慧，博士研究生，主要从事白癜风及感染性皮肤病方面的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208518763251634505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=1, ext=[AuthorCompanyExt(id=1208518763268411723, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China), AuthorCompanyExt(id=1208518763272606028, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹解放军总医院第八医学中心皮肤科，北京 100091)])]), Author(id=1208518763767533939, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208518763893363068, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518763767533939, language=EN, stringName=Bin-Yu Li, firstName=Bin-Yu, middleName=null, lastName=Li, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208518763985637761, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518763767533939, language=CN, stringName=李彬钰, firstName=彬钰, middleName=null, lastName=李, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹解放军总医院第八医学中心皮肤科，北京 100091, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208518763251634505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=1, ext=[AuthorCompanyExt(id=1208518763268411723, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China), AuthorCompanyExt(id=1208518763272606028, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹解放军总医院第八医学中心皮肤科，北京 100091)])]), Author(id=1208518764111466886, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208518764224713106, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518764111466886, language=EN, stringName=Xi-Hui Ma, firstName=Xi-Hui, middleName=null, lastName=Ma, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208518764333765017, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518764111466886, language=CN, stringName=马锡惠, firstName=锡惠, middleName=null, lastName=马, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹解放军总医院第八医学中心皮肤科，北京 100091, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208518763251634505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=1, ext=[AuthorCompanyExt(id=1208518763268411723, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China), AuthorCompanyExt(id=1208518763272606028, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹解放军总医院第八医学中心皮肤科，北京 100091)])]), Author(id=1208518764417651102, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=hexiuyun_309@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1208518764535091624, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518764417651102, language=EN, stringName=Xiu-Yun He, firstName=Xiu-Yun, middleName=null, lastName=He, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
²Department of Urology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208518764635754924, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, authorId=1208518764417651102, language=CN, stringName=何秀云, firstName=秀云, middleName=null, lastName=何, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹解放军总医院第八医学中心皮肤科，北京 100091
²解放军总医院第三医学中心泌尿外科医学部，北京 100039, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208518763251634505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=1, ext=[AuthorCompanyExt(id=1208518763268411723, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China), AuthorCompanyExt(id=1208518763272606028, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹解放军总医院第八医学中心皮肤科，北京 100091)]), AuthorCompany(id=1208518763343909204, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=2, ext=[AuthorCompanyExt(id=1208518763352297814, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763343909204, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Urology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China), AuthorCompanyExt(id=1208518763360686424, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763343909204, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²解放军总医院第三医学中心泌尿外科医学部，北京 100039)])])], keywords=[Keyword(id=1208518765852103091, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, orderNo=1, keyword=oil-in-water nanomoemulsion), Keyword(id=1208518765952766394, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, orderNo=2, keyword=Bacille Calmette-Guerin vaccine), Keyword(id=1208518766045041085, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, orderNo=3, keyword=cytomegalovirus glycoprotein B), Keyword(id=1208518766145704387, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, orderNo=4, keyword=rabies vaccine), Keyword(id=1208518766292505031, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, orderNo=1, keyword=水包油纳米乳剂), Keyword(id=1208518766372196810, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, orderNo=2, keyword=卡介苗), Keyword(id=1208518766464471502, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, orderNo=3, keyword=巨细胞病毒糖蛋白B), Keyword(id=1208518766531580370, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, orderNo=4, keyword=狂犬病疫苗)], refs=[Reference(id=1208518767861174805, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2014, volume=191, issue=3, pageStart=823, pageEnd=829, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Shah G, Zhang G, Chen F, journalName=J Urol, refType=null, unstructuredReference=Shah G, Zhang G, Chen F, et al. Loss of bacillus Calmette-Guérin viability adversely affects the direct response of urothelial carcinoma cells to bacillus Calmette- Guérin exposure[J]. J Urol, 2014, 191(3): 823-829., articleTitle=Loss of bacillus Calmette-Guérin viability adversely affects the direct response of urothelial carcinoma cells to bacillus Calmette- Guérin exposure, refAbstract=null), Reference(id=1208518767949255193, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2004, volume=22, issue=11-12, pageStart=1498, pageEnd=1508, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Haile M, Schröder U, Hamasur B, journalName=Vaccine, refType=null, unstructuredReference=Haile M, Schröder U, Hamasur B, et al. Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guerin (BCG) in Eurocine L3 adjuvant protects against tuberculosis[J]. Vaccine, 2004, 22(11-12): 1498-1508., articleTitle=Immunization with heat-killed Mycobacterium bovis bacille Calmette-Guerin (BCG) in Eurocine L3 adjuvant protects against tuberculosis, refAbstract=null), Reference(id=1208518768041529885, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2005, volume=85, issue=1-2, pageStart=107, pageEnd=114, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Haile M, Hamasur B, Jaxmar T, journalName=Tuberculosis (Edinb), refType=null, unstructuredReference=Haile M, Hamasur B, Jaxmar T, et al. Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice[J]. Tuberculosis (Edinb), 2005, 85(1-2): 107-114., articleTitle=Nasal boost with adjuvanted heat-killed BCG or arabinomannan-protein conjugate improves primary BCG-induced protection in C57BL/6 mice, refAbstract=null), Reference(id=1208518768121221669, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2014, volume=10, issue=10, pageStart=e1004485, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Buffen K, Oosting M, Quintin J, journalName=PLoS Pathog, refType=null, unstructuredReference=Buffen K, Oosting M, Quintin J, et al. Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer[J]. PLoS Pathog, 2014, 10(10): e1004485., articleTitle=Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer, refAbstract=null), Reference(id=1208518768242856487, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2020, volume=12, issue=12, pageStart=3679, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Whang YM, Yoon DH, Hwang GY, journalName=Cancers (Basel), refType=null, unstructuredReference=Whang YM, Yoon DH, Hwang GY, et al. Liposome-encapsulated bacillus calmette-guerin cell wall skeleton enhances antitumor efficiency for bladder cancer in vitro and in vivo via induction of AMP-activated protein kinase[J]. Cancers (Basel), 2020, 12(12): 3679., articleTitle=Liposome-encapsulated bacillus calmette-guerin cell wall skeleton enhances antitumor efficiency for bladder cancer in vitro and in vivo via induction of AMP-activated protein kinase, refAbstract=null), Reference(id=1208518768360297001, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=2531, pageEnd=null, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Pampena MB, Cartar HC, Cueto GR, journalName=Front Immunol, refType=null, unstructuredReference=Pampena MB, Cartar HC, Cueto GR, et al. Dissecting the immune stimulation promoted by CSF-470 vaccine plus adjuvants in cutaneous melanoma patients: long term antitumor immunity and short term release of acute inflammatory reactants[J]. Front Immunol, 2018, 9: 2531., articleTitle=Dissecting the immune stimulation promoted by CSF-470 vaccine plus adjuvants in cutaneous melanoma patients: long term antitumor immunity and short term release of acute inflammatory reactants, refAbstract=null), Reference(id=1208518768515486256, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2015, volume=48, issue=6, pageStart=597, pageEnd=603, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Lu JB, Chen BW, Wang GZ, journalName=J Microbiol Immunol Infect, refType=null, unstructuredReference=Lu JB, Chen BW, Wang GZ, et al. Recombinant tuberculosis vaccine AEC/BC02 induces antigen-specific cellular responses in mice and protects guinea pigs in a model of latent infection[J]. J Microbiol Immunol Infect, 2015, 48(6): 597-603., articleTitle=Recombinant tuberculosis vaccine AEC/BC02 induces antigen-specific cellular responses in mice and protects guinea pigs in a model of latent infection, refAbstract=null), Reference(id=1208518768637121075, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2012, volume=166, issue=5, pageStart=953, pageEnd=963, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Kakeda M, Yamanaka K, Kitagawa H, journalName=Br J Dermatol, refType=null, unstructuredReference=Kakeda M, Yamanaka K, Kitagawa H, et al. Heat-killed bacillus Calmette-Guérin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells[J]. Br J Dermatol, 2012, 166(5): 953-963., articleTitle=Heat-killed bacillus Calmette-Guérin and Mycobacterium kansasii antigen 85B combined vaccination ameliorates dermatitis in a mouse model of atopic dermatitis by inducing regulatory T cells, refAbstract=null), Reference(id=1208518768741978678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2003, volume=49, issue=3, pageStart=177, pageEnd=184, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Banzhoff A, Nacci P, Podda A, journalName=Gerontology, refType=null, unstructuredReference=Banzhoff A, Nacci P, Podda A. A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis[J]. Gerontology, 2003, 49(3): 177-184., articleTitle=A new MF59-adjuvanted influenza vaccine enhances the immune response in the elderly with chronic diseases: results from an immunogenicity meta-analysis, refAbstract=null), Reference(id=1208518768872002106, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2014, volume=36, issue=6, pageStart=440, pageEnd=446, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Huang XY, Zhang CQ, Li JL, journalName=Chin J Antitubercul, refType=null, unstructuredReference=Huang XY, Zhang CQ, Li JL, et al. MF59 adjuvant enhances immunogenicity of heat-killed BCG[J]. Chin J Antitubercul, 2014, 36(6): 440-446., articleTitle=MF59 adjuvant enhances immunogenicity of heat-killed BCG, refAbstract=null), Reference(id=1208518768989442621, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2014, volume=36, issue=6, pageStart=440, pageEnd=446, url=null, language=null, rfNumber=[10], rfOrder=10, authorNames=黄香玉, 张春青, 李军丽, journalName=中国防痨杂志, refType=null, unstructuredReference=[黄香玉, 张春青, 李军丽, 等. MF59佐剂增强热灭活卡介苗的免疫原性[J]. 中国防痨杂志, 2014, 36(6): 440-446.], articleTitle=MF59佐剂增强热灭活卡介苗的免疫原性, refAbstract=null), Reference(id=1208518769111077441, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2015, volume=31, issue=8, pageStart=651, pageEnd=657, url=null, language=null, rfNumber=[11], rfOrder=11, authorNames=Song QD, Huang XY, Zhu CZ, journalName=Immunol J, refType=null, unstructuredReference=Song QD, Huang XY, Zhu CZ, et al. MF59/hBCG combination adjuvant enhances the recruitment and MCP-1 secretion of macrophages[J]. Immunol J, 2015, 31(8): 651-657., articleTitle=MF59/hBCG combination adjuvant enhances the recruitment and MCP-1 secretion of macrophages, refAbstract=null), Reference(id=1208518770289676871, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2015, volume=31, issue=8, pageStart=651, pageEnd=657, url=null, language=null, rfNumber=[11], rfOrder=12, authorNames=宋庆德, 黄香玉, 朱传智, journalName=免疫学杂志, refType=null, unstructuredReference=[宋庆德, 黄香玉, 朱传智, 等. MF59/hBCG复合佐剂促进巨噬细胞募集和分泌MCP-1[J]. 免疫学杂志, 2015, 31(8): 651-657.], articleTitle=MF59/hBCG复合佐剂促进巨噬细胞募集和分泌MCP-1, refAbstract=null), Reference(id=1208518770381951563, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=31, issue=3, pageStart=230, pageEnd=235, url=null, language=null, rfNumber=[12], rfOrder=13, authorNames=He XY, Zhu CZ, Li BY, journalName=Chin J Biol, refType=null, unstructuredReference=He XY, Zhu CZ, Li BY, et al. Effect of compound adjuvant consisting of oil-in-water microspheres and BCG on immunogenicity of Mycobacterium tuberculosis fusion protein PstS1-LEP[J]. Chin J Biol, 2018, 31(3): 230-235., articleTitle=Effect of compound adjuvant consisting of oil-in-water microspheres and BCG on immunogenicity of Mycobacterium tuberculosis fusion protein PstS1-LEP, refAbstract=null), Reference(id=1208518770461643343, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=31, issue=3, pageStart=230, pageEnd=235, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=何秀云, 朱传智, 李彬钰, journalName=中国生物制品学杂志, refType=null, unstructuredReference=[何秀云, 朱传智, 李彬钰, 等. 水油微球/BCG复合佐剂对结核杆菌融合蛋白PstS1-LEP免疫原性的影响[J]. 中国生物制品学杂志, 2018, 31(3): 230-235.], articleTitle=水油微球/BCG复合佐剂对结核杆菌融合蛋白PstS1-LEP免疫原性的影响, refAbstract=null), Reference(id=1208518770595861075, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=115, issue=24, pageStart=6267, pageEnd=6272, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=Nelson CS, Huffman T, Jenks JA, journalName=Proc Natl Acad Sci U S A, refType=null, unstructuredReference=Nelson CS, Huffman T, Jenks JA, et al. HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions[J]. Proc Natl Acad Sci U S A, 2018, 115(24): 6267-6272., articleTitle=HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions, refAbstract=null), Reference(id=1208518770704912980, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2016, volume=34, issue=3, pageStart=313, pageEnd=319, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=Bernstein DI, Munoz FM, Callahan ST, journalName=Vaccine, refType=null, unstructuredReference=Bernstein DI, Munoz FM, Callahan ST, et al. Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: a randomized clinical trial[J]. Vaccine, 2016, 34(3): 313-319., articleTitle=Safety and efficacy of a cytomegalovirus glycoprotein B (gB) vaccine in adolescent girls: a randomized clinical trial, refAbstract=null), Reference(id=1208518770813964889, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2009, volume=360, issue=12, pageStart=1191, pageEnd=1199, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=Pass RF, Zhang CP, Evans A, journalName=N Engl J Med, refType=null, unstructuredReference=Pass RF, Zhang CP, Evans A, et al. Vaccine prevention of maternal cytomegalovirus infection[J]. N Engl J Med, 2009, 360(12): 1191-1199., articleTitle=Vaccine prevention of maternal cytomegalovirus infection, refAbstract=null), Reference(id=1208518770910433884, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2002, volume=185, issue=5, pageStart=686, pageEnd=690, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=Bernstein DI, Schleiss MR, Berencsi K, journalName=J Infect Dis, refType=null, unstructuredReference=Bernstein DI, Schleiss MR, Berencsi K, et al. Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults[J]. J Infect Dis, 2002, 185(5): 686-690., articleTitle=Effect of previous or simultaneous immunization with canarypox expressing cytomegalovirus (CMV) glycoprotein B (gB) on response to subunit gB vaccine plus MF59 in healthy CMV-seronegative adults, refAbstract=null), Reference(id=1208518771019485793, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=null, pageStart=14, pageEnd=21, url=null, language=null, rfNumber=[17], rfOrder=19, authorNames=Del Giudice G, Rappuoli R, Didierlaurent AM, journalName=Semin Immunol, refType=null, unstructuredReference=Del Giudice G, Rappuoli R, Didierlaurent AM. Correlates of adjuvanticity: a review on adjuvants in licensed vaccines[J]. Semin Immunol, 2018, 39: 14-21., articleTitle=Correlates of adjuvanticity: a review on adjuvants in licensed vaccines, refAbstract=null), Reference(id=1208518771115954789, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=20, authorNames=Guo SN, journalName=null, refType=null, unstructuredReference=Guo SN. Quality evaluation study on BCG-CpG-DNA adjuvanted human rabies vaccine[D]. Beijing: National Institutes for Food and Drug Control, 2017., articleTitle=Quality evaluation study on BCG-CpG-DNA adjuvanted human rabies vaccine, refAbstract=null), Reference(id=1208518771187257961, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2017, volume=null, issue=null, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=21, authorNames=郭胜楠, journalName=null, refType=null, unstructuredReference=[郭胜楠. BCG-CpG-DNA佐剂人用狂犬病疫苗的质量评价研究[D]. 北京: 中国食品药品检定研究院, 2017.], articleTitle=BCG-CpG-DNA佐剂人用狂犬病疫苗的质量评价研究, refAbstract=null), Reference(id=1208518771287921259, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=null, pageStart=35, pageEnd=43, url=null, language=null, rfNumber=[19], rfOrder=22, authorNames=de Bree LCJ, Koeken VACM, Joosten LAB, journalName=Semin Immunol, refType=null, unstructuredReference=de Bree LCJ, Koeken VACM, Joosten LAB, et al. Non-specific effects of vaccines: Current evidence and potential implications[J]. Semin Immunol, 2018, 39: 35-43., articleTitle=Non-specific effects of vaccines: Current evidence and potential implications, refAbstract=null), Reference(id=1208518771376001645, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=13, issue=10, pageStart=1193, pageEnd=1208, url=null, language=null, rfNumber=[20], rfOrder=23, authorNames=Butkeviciute E, Jones CE, Smith SG, journalName=Future Microbiol, refType=null, unstructuredReference=Butkeviciute E, Jones CE, Smith SG. Heterologous effects of infant BCG vaccination: potential mechanisms of immunity[J]. Future Microbiol, 2018, 13(10): 1193-1208., articleTitle=Heterologous effects of infant BCG vaccination: potential mechanisms of immunity, refAbstract=null), Reference(id=1208518771451499121, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=2869, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=24, authorNames=Uthayakumar D, Paris S, Chapat L, journalName=Front Immunol, refType=null, unstructuredReference=Uthayakumar D, Paris S, Chapat L, et al. Non-specific effects of vaccines illustrated through the BCG example: from observations to demonstrations[J]. Front Immunol, 2018, 9: 2869., articleTitle=Non-specific effects of vaccines illustrated through the BCG example: from observations to demonstrations, refAbstract=null), Reference(id=1208518771598299764, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2014, volume=6, issue=2, pageStart=152, pageEnd=158, url=null, language=null, rfNumber=[22], rfOrder=25, authorNames=Kleinnijenhuis J, Quintin J, Preijers F, journalName=J Innate Immun, refType=null, unstructuredReference=Kleinnijenhuis J, Quintin J, Preijers F, et al. Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity[J]. J Innate Immun, 2014, 6(2): 152-158., articleTitle=Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity, refAbstract=null), Reference(id=1208518771686380149, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, doi=null, pmid=null, pmcid=null, year=2018, volume=172, issue=1-2, pageStart=176, pageEnd=190, url=null, language=null, rfNumber=[23], rfOrder=26, authorNames=Kaufmann E, Sanz J, Dunn JL, journalName=Cell, refType=null, unstructuredReference=Kaufmann E, Sanz J, Dunn JL, et al. BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis[J]. Cell, 2018, 172(1-2): 176-190., articleTitle=BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis, refAbstract=null)], funds=[Fund(id=1208518767659848203, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, awardId=7172212, language=EN, fundingSource=Natural Science Foundation of Beijing(7172212), fundOrder=null, country=null), Fund(id=1208518767768900111, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, awardId=7172212, language=CN, fundingSource=北京市自然科学基金(7172212), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1208518763251634505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=1, ext=[AuthorCompanyExt(id=1208518763268411723, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Department of Dermatology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing 100091, China), AuthorCompanyExt(id=1208518763272606028, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763251634505, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹解放军总医院第八医学中心皮肤科，北京 100091)]), AuthorCompany(id=1208518763343909204, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, xref=2, ext=[AuthorCompanyExt(id=1208518763352297814, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763343909204, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Urology, the Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China), AuthorCompanyExt(id=1208518763360686424, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, companyId=1208518763343909204, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²解放军总医院第三医学中心泌尿外科医学部，北京 100039)])], figs=[ArticleFig(id=1208518766682575323, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, label=Fig. 1, caption=Comparison of the anti-CgB IgG antibody levels in mice immunized with different immunogens, figureFileSmall=+71+tXphCYxa3uqM9OHF9A==, figureFileBig=MBrWbNGEKqyslaidXmpv0A==, tableContent=null), ArticleFig(id=1208518766753878497, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, label=图1, caption=小鼠不同免疫原诱导的抗-CgB IgG抗体滴度比较(以SE组血清为临界值)

SE. 含角鲨烯的水包油纳米乳剂；hBCG. 热灭活卡介苗；CgB. 巨细胞病毒糖蛋白B；与SE-hBCG组比较，(1)P<0.05；与CgB组比较，(2)P<0.05。

, figureFileSmall=+71+tXphCYxa3uqM9OHF9A==, figureFileBig=MBrWbNGEKqyslaidXmpv0A==, tableContent=null), ArticleFig(id=1208518766971982316, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, label=Fig. 2, caption=CgB-specific IFN-γ-SFC (A) and IL-4-SFC (B) induced by different immunogens of mice, figureFileSmall=D6k4fHOmSr9f544BqRhfIA==, figureFileBig=20rf8YkhH/FhXmF1BLrljw==, tableContent=null), ArticleFig(id=1208518767060062705, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, label=图2, caption=不同免疫原诱导小鼠CgB特异IFN-γ-SFC (A)及IL-4-SFC (B)的比较

SFC. 斑点形成细胞数；SE. 含角鲨烯的水包油纳米乳剂；hBCG. 热灭活卡介苗；CgB. 巨细胞病毒糖蛋白B；与SE组比较，(1)P<0.05；与SE-hBCG组比较，(2)P<0.05；与CgB组比较，(3)P<0.05；与SE+CgB组比较，(4)P<0.05。

, figureFileSmall=D6k4fHOmSr9f544BqRhfIA==, figureFileBig=20rf8YkhH/FhXmF1BLrljw==, tableContent=null), ArticleFig(id=1208518767160726005, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, label=Fig. 3, caption=Influence of SE-hBCG on the anti-Rab IgG antibodies, figureFileSmall=pL/gpikEGGm+BolRdlgLjw==, figureFileBig=MmuVb6mQm27n7JHMUirtRQ==, tableContent=null), ArticleFig(id=1208518767273972216, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, label=图3, caption=SE-hBCG对Rab诱导抗-Rab IgG抗体水平的影响

SE. 含角鲨烯的水包油纳米乳剂；hBCG. 热灭活卡介苗；Rab. 狂犬病疫苗；A. 初免后第4天各组抗体水平(OD₄₅₀)；B. 各组不同时间点抗体滴度比较(以PBS组血清为临界值)；与PBS组比较，(1)P<0.05；与Rab组比较，(2)P<0.05；与SE+Rab组比较，(3)P<0.05。

, figureFileSmall=pL/gpikEGGm+BolRdlgLjw==, figureFileBig=MmuVb6mQm27n7JHMUirtRQ==, tableContent=null), ArticleFig(id=1208518767399801340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=EN, label=Fig. 4, caption=Levels of Rab-specific IFN-γ-secreting spot forming cells of mice in each group after the first immunization, figureFileSmall=WARd0XNDNX3d2GGQb8dEHQ==, figureFileBig=W+3jG55nDOq8JH0EJHFtbQ==, tableContent=null), ArticleFig(id=1208518767483687428, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208518760273678561, language=CN, label=图4, caption=各组小鼠初免后不同时间点Rab特异的IFN-γ-SFC水平比较

SE. 含角鲨烯的水包油纳米乳剂；hBCG. 热灭活卡介苗；Rab. 狂犬病疫苗；与PBS组比较，(1)P<0.05；与Rab组比较，(2)P<0.05；与SE+Rab组比较，(3)P<0.05。

, figureFileSmall=WARd0XNDNX3d2GGQb8dEHQ==, figureFileBig=W+3jG55nDOq8JH0EJHFtbQ==, tableContent=null)], attaches=null, journal=Journal(id=1146441329971666965, delFlag=0, nameCn=解放军医学杂志, nameEn=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, issn=0577-7402, eissn=null, cn=11-1056/R, coden=null, periodic=0, language=CN, oaType=是, ccby=CC BY-NC-ND, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=6srot5PcoYX30Oa4xeTmeg==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1751262512917, updatedTime=1761735725513, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=6srot5PcoYX30Oa4xeTmeg==, picEn=ELwBh5xqrSTlIs7HmSNt2Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369167564968109, language=CN, name=解放军医学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725537, updatedTime=1761735725537, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369167615299758, language=EN, name=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725549, updatedTime=1761735725549, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189873630562394117, websiteList=[Website(id=1189873845923287108, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN, language=CN, createTime=1761617631655, createBy=18614031015, updateTime=1761622010471, updateBy=18614031015, name=解放军医学杂志-中文, tplId=1146099689490845704, title=解放军医学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924939378520839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=articleTextType, value=kx, createTime=1761629813284, updateTime=1761629813284, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939353355012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=banner, value=null, createTime=1761629813278, updateTime=1761629813278, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939399492362, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=grayFlag, value=0, createTime=1761629813289, updateTime=1761629813289, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939344966403, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629813276, updateTime=1761629813276, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939412075276, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=minRunFlag, value=0, createTime=1761629813292, updateTime=1761629813292, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939374326534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic, createTime=1761629813283, updateTime=1761629813283, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939407880971, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=silenceFlag, value=0, createTime=1761629813291, updateTime=1761629813291, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939361743621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761629813280, updateTime=1761629813280, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939386909448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeColor, value=null, createTime=1761629813286, updateTime=1761629813286, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939395298057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeStyle, value=null, createTime=1761629813288, updateTime=1761629813288, creator=18614031015, updator=18614031015)]), Website(id=1189873846057504839, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN, language=EN, createTime=1761617631687, createBy=18614031015, updateTime=1761622030030, updateBy=18614031015, name=解放军医学杂志-英文, tplId=1146101810881728533, title=Medical Journal of Chinese People’s Liberation Army, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924968168223505, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=articleTextType, value=kx, createTime=1761629820148, updateTime=1761629820148, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968147251982, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=banner, value=null, createTime=1761629820143, updateTime=1761629820143, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968185000724, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=grayFlag, value=0, createTime=1761629820152, updateTime=1761629820152, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968138863373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629820141, updateTime=1761629820141, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968197583638, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=minRunFlag, value=0, createTime=1761629820155, updateTime=1761629820155, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968159834896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic, createTime=1761629820146, updateTime=1761629820146, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968193389333, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=silenceFlag, value=0, createTime=1761629820154, updateTime=1761629820154, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968155640591, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761629820145, updateTime=1761629820145, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968172417810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeColor, value=null, createTime=1761629820149, updateTime=1761629820149, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968180806419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeStyle, value=null, createTime=1761629820151, updateTime=1761629820151, creator=18614031015, updator=18614031015)])], journalTitle=解放军医学杂志, weixinUrl=null, journalUrl=http://zh.jfjyxzz.org.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Medical Journal of Chinese People’s Liberation Army, journalPhotoCn=6srot5PcoYX30Oa4xeTmeg==, journalPhotoEn=ELwBh5xqrSTlIs7HmSNt2Q==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.2021.12.02, detailUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.2021.12.02, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/PDF/10.11855/j.issn.0577-7402.2021.12.02, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/PDF/10.11855/j.issn.0577-7402.2021.12.02, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)