Article(id=1208518758373658783, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2021.12.12, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1609084800000, receivedDateStr=2020-12-28, revisedDate=1620748800000, revisedDateStr=2021-05-12, acceptedDate=null, acceptedDateStr=null, onlineDate=1766062925189, onlineDateStr=2025-12-18, pubDate=1640620800000, pubDateStr=2021-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766062925189, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766062925189, creator=13701087609, updateTime=1766062925189, updator=13701087609, issue=Issue{id=1208518757253779608, tenantId=1146029695717560320, journalId=1189873630562394117, year='2021', volume='46', issue='12', pageStart='1167', pageEnd='1267', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766062924920, creator=13701087609, updateTime=1766062998332, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208519065233125464, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208519065233125465, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208518757253779608, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1245, endPage=1250, ext={EN=ArticleExt(id=1208518758671454373, articleId=1208518758373658783, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress of effect of exosomal microRNAs and long non-coding RNAs on breast cancer, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Exosomes are microcapsules with a diameter of 30-150 nm, which contain such active substances as proteins,lipids, metabolites, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), and promote tumorigenesis and development by mediating intercellular communication and regulating tumor microenvironment. miRNAs and lncRNAs are the important components of non-coding RNAs, which play an important role in the occurrence and development of breast cancer mediated by exosomes. The present paper mainly summarized the role of exosomal miRNAs and lncRNAs derived from breast cancer cells in breast cancer progression, microenvironment and drug resistance, the effects of exosomal miRNAs and lncRNAs derived from breast cancer microenvironment on the development of breast cancer, and the clinical potential of exosomal miRNAs and lncRNAs as biomarkers in breast cancer.
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外泌体是一种直径为30~150 nm的微囊泡,其内包含蛋白质、脂质、代谢产物、微小RNAs(miRNAs)及长链非编码RNAs(lncRNAs)等活性物质,可通过介导细胞间信息交流、调节肿瘤微环境促进肿瘤的发生发展。miRNAs及lncRNAs是非编码RNAs中重要的组成部分,通过外泌体介导在乳腺癌的发生发展中起重要作用。该文主要总结乳腺癌细胞来源外泌体miRNAs及lncRNAs在乳腺癌进展、微环境及耐药等方面的作用,乳腺癌微环境来源外泌体miRNAs及lncRNAs对乳腺癌发生发展的影响,以及外泌体miRNAs及lncRNAs作为乳腺癌生物标志物的潜力。
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