Article(id=1208516103454715912, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208516099369464789, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2022.01.0046, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1613404800000, receivedDateStr=2021-02-16, revisedDate=null, revisedDateStr=null, acceptedDate=1626969600000, acceptedDateStr=2021-07-23, onlineDate=1766062292206, onlineDateStr=2025-12-18, pubDate=1643299200000, pubDateStr=2022-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1766062292206, onlineIssueDateStr=2025-12-18, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1766062292206, creator=13701087609, updateTime=1766062292206, updator=13701087609, issue=Issue{id=1208516099369464789, tenantId=1146029695717560320, journalId=1189873630562394117, year='2022', volume='47', issue='1', pageStart='1', pageEnd='101', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1766062291230, creator=13701087609, updateTime=1766062975431, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208518969208738485, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208516099369464789, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208518969208738486, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208516099369464789, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=46, endPage=52, ext={EN=ArticleExt(id=1208516104096444450, articleId=1208516103454715912, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effects of activating PPARγ on the expression of AP-1 and inflammatory response in lung tissues of mice infected with Mycobacterium tuberculosis, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the effect of activating peroxisome proliferator-activated receptor γ (PPARγ) on the expression of activator protein-1 (AP-1) and inflammatory response in lung tissues of mice infected with Mycobacterium tuberculosis(MTB). Methods A total of 50 healthy SPF C57BL/6 male mice aged 6 to 8 weeks were randomly divided into five groups (10 each group): control group, MTB group, MTB+Rosiglitazone group, MTB+GW9662 group, and MTB+ Rosiglitazone+GW9662 group. Lung tissue samples of mice were collected to detect the bacteria load. The protein and mRNA expression levels of PPARγ and AP-1 in lung tissues were detected by Western blotting and real-time fluorescent quantitative PCR (RT-qPCR). The contents of tumor necrosis factor (TNF)-α, interleukin (IL)-10 and IL-6 in lung tissues were determined by enzyme-linked immunosorbent assay (ELISA). The pathological changes in the lung tissue of mice were observed by HE staining. Results Compared with MTB infection alone, PPARγ agonist rosiglitazone significantly increased the bacteria load in lung tissue of MTB-infected mice (P<0.05).Compared with control group, the expression of PPARγ and the content of inflammatory cytokines in the lung tissues of MTB infected mice were significantly increased, while the expression of AP-1 was significantly decreased, and the differences were statistically significant (P<0.05). When giving PPARγ agonist rosiglitazone at the same time as MTB infection, the expression level of AP-1 in lung tissue of mice was significantly decreased compared with MTB group (P<0.05). In addition, in MTB+Rosiglitazone group, the contents of IL-6 and TNF-α were (160.71±20.36) pg/ml and (343.55±58.48) pg/ml, respectively, both of which were down-regulated compared with MTB group [(232.59±21.73) pg/ml and (511.99±69.83) pg/ml]. Interestingly, the content of IL-10 in MTB+Rosiglitazone group [(105.97±10.38) pg/ml], significantly higher than that in MTB group [(83.25±9.00) pg/ml,P<0.05]. GW9662, a PPARγ antagonist, could reverse the above effects of rosiglitazone. Conclusion Activation of PPARγ can down-regulate the expression of AP-1 in the lung tissues of MTB-infected mice, thereby inhibiting the lung tissues inflammatory and affecting the clearance of MTB.

, correspAuthors=Xiao-Qun Han, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Hai-Li Wang, Xiao-Qun Han, Nan-Yan Fu, Jing Yang, Zhi-Xing Zhou, Qin Deng, Xiao-Jie Zhao, Dong-Mei Liu), CN=ArticleExt(id=1208516106201985162, articleId=1208516103454715912, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=激活PPARγ对结核分枝杆菌感染小鼠肺组织AP-1表达及炎症反应的影响, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨激活过氧化物酶体增殖物激活受体γ(PPARγ)对结核分枝杆菌(MTB)感染小鼠肺组织激活蛋白-1(AP-1)表达及炎症反应的影响。方法 6~8周龄SPF级健康雄性C57BL/6小鼠50只，随机分为对照组、MTB组、MTB+罗格列酮组、MTB+GW9662组、MTB+罗格列酮+GW9662组，每组10只。收集小鼠肺组织标本，检测各组小鼠肺组织荷菌量；采用Western blotting及RT-qPCR检测肺组织PPARγ、AP-1蛋白及mRNA表达水平；ELISA法检测肺组织肿瘤坏死因子(TNF)-α、白细胞介素(IL)-10及IL-6含量；HE染色观察小鼠肺组织病理学变化。结果 与单纯MTB感染比较，PPARγ激动剂罗格列酮明显增加了MTB感染小鼠肺组织荷菌量(P<0.05)。与对照组比较，MTB感染后小鼠肺组织PPARγ表达及炎性细胞因子含量明显升高，AP-1表达明显降低，差异均有统计学意义(P<0.05)。在MTB感染的同时给予PPARγ激动剂罗格列酮，小鼠肺组织AP-1表达水平较MTB组明显降低，差异有统计学意义(P<0.05)；MTB+罗格列酮组IL-6、TNF-α含量分别为(160.71±20.36) pg/ml、(343.55±58.48) pg/ml，与MTB组[分别为(232.59±21.73) pg/ml、(511.99±69.83) pg/ml]比较明显降低，但IL-10含量为(105.97±10.38) pg/ml，与MTB组[(83.25±9.00) pg/ml]比较明显升高，差异均有统计学意义(P<0.05)。PPARγ拮抗剂GW9662则逆转了罗格列酮所致的上述作用。结论 激活PPARγ能下调MTB感染小鼠肺组织AP-1的表达，进而抑制肺组织炎症反应，影响机体对MTB的清除。

, correspAuthors=韩晓群, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=f7phkZDhRdyRKY5lcZd/WA==, magXml=4WjPhtSaXcft4wbIrnP1+w==, pdfUrl=null, pdf=0+adc9OTZP9uDtAKVyNAqQ==, pdfFileSize=4122146, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=Jv/KOTeFvkIGMcjfsMajLg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=xL5EuGxgWx/3LMlPG81W3Q==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=王海利, 韩晓群, 付南燕, 杨婧, 周智兴, 邓琴, 赵晓杰, 刘冬梅)}, authors=[Author(id=1208516106730467505, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516106843713721, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516106730467505, language=EN, stringName=Hai-Li Wang, firstName=Hai-Li, middleName=null, lastName=Wang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516106948571328, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516106730467505, language=CN, stringName=王海利, firstName=海利, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹宜春学院化学与生物工程学院，江西宜春 336000, bio={"content":"

王海利，硕士研究生，主要从事临床药学方面的研究

"}, bioImg=null, bioContent=

王海利，硕士研究生，主要从事临床药学方面的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106474614940, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=1, ext=[AuthorCompanyExt(id=1208516106483003550, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106495586463, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹宜春学院化学与生物工程学院，江西宜春 336000)])]), Author(id=1208516107061817542, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=763633126@qq.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1208516107162480846, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516107061817542, language=EN, stringName=Xiao-Qun Han, firstName=Xiao-Qun, middleName=null, lastName=Han, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{2, *}, address=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516108374634707, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516107061817542, language=CN, stringName=韩晓群, firstName=晓群, middleName=null, lastName=韩, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{2, *}, address=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])]), Author(id=1208516108483686616, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516108685013215, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516108483686616, language=EN, stringName=Nan-Yan Fu, firstName=Nan-Yan, middleName=null, lastName=Fu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516108806648038, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516108483686616, language=CN, stringName=付南燕, firstName=南燕, middleName=null, lastName=付, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])]), Author(id=1208516108987003120, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516109137998071, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516108987003120, language=EN, stringName=Jing Yang, firstName=Jing, middleName=null, lastName=Yang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516109314158848, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516108987003120, language=CN, stringName=杨婧, firstName=婧, middleName=null, lastName=杨, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])]), Author(id=1208516109427405062, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516109536456973, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516109427405062, language=EN, stringName=Zhi-Xing Zhou, firstName=Zhi-Xing, middleName=null, lastName=Zhou, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516109662286100, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516109427405062, language=CN, stringName=周智兴, firstName=智兴, middleName=null, lastName=周, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])]), Author(id=1208516109825863961, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=5, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516110002024736, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516109825863961, language=EN, stringName=Qin Deng, firstName=Qin, middleName=null, lastName=Deng, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516110098493733, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516109825863961, language=CN, stringName=邓琴, firstName=琴, middleName=null, lastName=邓, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=², address=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])]), Author(id=1208516110211739947, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516110308208947, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516110211739947, language=EN, stringName=Xiao-Jie Zhao, firstName=Xiao-Jie, middleName=null, lastName=Zhao, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516110446620985, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516110211739947, language=CN, stringName=赵晓杰, firstName=晓杰, middleName=null, lastName=赵, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹宜春学院化学与生物工程学院，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106474614940, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=1, ext=[AuthorCompanyExt(id=1208516106483003550, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106495586463, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹宜春学院化学与生物工程学院，江西宜春 336000)])]), Author(id=1208516110564061504, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, orderNo=7, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1208516110744416588, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516110564061504, language=EN, stringName=Dong-Mei Liu, firstName=Dong-Mei, middleName=null, lastName=Liu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1208516110861857104, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, authorId=1208516110564061504, language=CN, stringName=刘冬梅, firstName=冬梅, middleName=null, lastName=刘, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=¹, address=¹宜春学院化学与生物工程学院，江西宜春 336000, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1208516106474614940, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=1, ext=[AuthorCompanyExt(id=1208516106483003550, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106495586463, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹宜春学院化学与生物工程学院，江西宜春 336000)])])], keywords=[Keyword(id=1208516110966714710, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, orderNo=1, keyword=Mycobacterium tuberculosis), Keyword(id=1208516111243538778, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, orderNo=2, keyword=inflammatory response), Keyword(id=1208516111377756513, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, orderNo=3, keyword=peroxisome proliferator-activated receptor γ), Keyword(id=1208516111465836903, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, orderNo=4, keyword=activator protein-1), Keyword(id=1208516111558111595, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, orderNo=1, keyword=结核分枝杆菌), Keyword(id=1208516111629414768, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, orderNo=2, keyword=炎症反应), Keyword(id=1208516112866734456, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, orderNo=3, keyword=过氧化物酶体增殖物激活受体γ), Keyword(id=1208516112946426236, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, orderNo=4, keyword=激活蛋白-1)], refs=[Reference(id=1208516114687062464, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=150, issue=null, pageStart=525, pageEnd=545, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Campaniço A, Moreira R, Lopes F, journalName=Eur J Med Chem, refType=null, unstructuredReference=Campaniço A, Moreira R, Lopes F. Drug discovery in tuberculosis. New drug targets and antimycobacterial agents[J]. Eur J Med Chem, 2018, 150: 525-545., articleTitle=Drug discovery in tuberculosis. New drug targets and antimycobacterial agents, refAbstract=null), Reference(id=1208516114754171332, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2019, volume=20, issue=20, pageStart=E5055, pageEnd=null, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Cheng HS, Tan WR, Low ZS, journalName=Int J Mol Sci, refType=null, unstructuredReference=Cheng HS, Tan WR, Low ZS, et al. Exploration and development of PPAR modulators in health and disease: an update of clinical evidence[J]. Int J Mol Sci, 2019, 20(20): E5055., articleTitle=Exploration and development of PPAR modulators in health and disease: an update of clinical evidence, refAbstract=null), Reference(id=1208516114854834633, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=1778, pageEnd=null, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Hu SF, He WT, Du XL, journalName=Front Immunol, refType=null, unstructuredReference=Hu SF, He WT, Du XL, et al. Vitamin B₁ helps to limit Mycobacterium tuberculosis growth via regulating innate immunity in a peroxisome proliferator-activated receptor-γ-dependent manner[J]. Front Immunol, 2018, 9: 1778., articleTitle=Vitamin B₁ helps to limit Mycobacterium tuberculosis growth via regulating innate immunity in a peroxisome proliferator-activated receptor-γ-dependent manner, refAbstract=null), Reference(id=1208516114942915020, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=36, issue=9, pageStart=816, pageEnd=820, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=Han XQ, Pan BJ, Fu NY, journalName=Immunol J, refType=null, unstructuredReference=Han XQ, Pan BJ, Fu NY, et al. PPARγ expression in tuberculosis patients and its relationship with lipid metabolism and inflammatory response[J]. Immunol J, 2020, 36(9): 816-820., articleTitle=PPARγ expression in tuberculosis patients and its relationship with lipid metabolism and inflammatory response, refAbstract=null), Reference(id=1208516115035189710, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=9, pageStart=816, pageEnd=820, url=null, language=null, rfNumber=[4], rfOrder=4, authorNames=韩晓群, 潘炳校, 付南燕, journalName=免疫学杂志, refType=null, unstructuredReference=[韩晓群, 潘炳校, 付南燕, 等. 结核病患者PPARγ表达与机体脂代谢及炎症反应的关系[J]. 免疫学杂志, 2020, 36(9): 816-820.], articleTitle=结核病患者PPARγ表达与机体脂代谢及炎症反应的关系, refAbstract=null), Reference(id=1208516115127464402, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2016, volume=12, issue=10, pageStart=e1005972, pageEnd=null, url=null, language=null, rfNumber=[5], rfOrder=5, authorNames=Cheekatla SS, Tripathi D, Venkatasubramanian S, journalName=PLoS Pathog, refType=null, unstructuredReference=Cheekatla SS, Tripathi D, Venkatasubramanian S, et al. NK-CD11c+ cell crosstalk in diabetes enhances IL-6-mediated inflammation during Mycobacterium tuberculosis infection[J]. PLoS Pathog, 2016, 12(10): e1005972., articleTitle=NK-CD11c+ cell crosstalk in diabetes enhances IL-6-mediated inflammation during Mycobacterium tuberculosis infection, refAbstract=null), Reference(id=1208516115257487828, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2017, volume=35, issue=1, pageStart=26, pageEnd=28, url=null, language=null, rfNumber=[6], rfOrder=6, authorNames=Xu Y, Wu LY, Chen YR, journalName=J Guangdong Med Univ, refType=null, unstructuredReference=Xu Y, Wu LY, Chen YR, et al. Establishment of low dose Bacillus Calmette-Guerin aerosol infected mouse model[J]. J Guangdong Med Univ, 2017, 35(1): 26-28., articleTitle=Establishment of low dose Bacillus Calmette-Guerin aerosol infected mouse model, refAbstract=null), Reference(id=1208516115332985302, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2017, volume=35, issue=1, pageStart=26, pageEnd=28, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=许怡, 吴丽瑜, 陈煜锐, journalName=广东医科大学学报, refType=null, unstructuredReference=[许怡, 吴丽瑜, 陈煜锐, 等. 低剂量卡介苗气溶胶感染小鼠模型的建立[J]. 广东医科大学学报, 2017, 35(1): 26-28.], articleTitle=低剂量卡介苗气溶胶感染小鼠模型的建立, refAbstract=null), Reference(id=1208516115421065689, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2019, volume=29, issue=5, pageStart=104, pageEnd=108, url=null, language=null, rfNumber=[7], rfOrder=8, authorNames=Liu ZH, Mu DY, Zhan LJ, journalName=Chin J Comp Med, refType=null, unstructuredReference=Liu ZH, Mu DY, Zhan LJ, et al. Comparison of the application of two methods of Mycobacterium tuberculosis culture in a mouse model of Mycobacterium tuberculosis infection[J]. Chin J Comp Med, 2019, 29(5): 104-108., articleTitle=Comparison of the application of two methods of Mycobacterium tuberculosis culture in a mouse model of Mycobacterium tuberculosis infection, refAbstract=null), Reference(id=1208516115492368860, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2019, volume=29, issue=5, pageStart=104, pageEnd=108, url=null, language=null, rfNumber=[7], rfOrder=9, authorNames=刘志昊, 穆大业, 占玲俊, journalName=中国比较医学杂志, refType=null, unstructuredReference=[刘志昊, 穆大业, 占玲俊, 等. 两种结核分枝杆菌培养法在结核小鼠感染模型实验中的应用对比[J]. 中国比较医学杂志, 2019, 29(5): 104-108.], articleTitle=两种结核分枝杆菌培养法在结核小鼠感染模型实验中的应用对比, refAbstract=null), Reference(id=1208516115559477727, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=215, issue=4, pageStart=1135, pageEnd=1152, url=null, language=null, rfNumber=[8], rfOrder=10, authorNames=Huang L, Nazarova EV, Tan SM, journalName=J Exp Med, refType=null, unstructuredReference=Huang L, Nazarova EV, Tan SM, et al. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny[J]. J Exp Med, 2018, 215(4): 1135-1152., articleTitle=Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny, refAbstract=null), Reference(id=1208516115634975201, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=111, issue=null, pageStart=170, pageEnd=177, url=null, language=null, rfNumber=[9], rfOrder=11, authorNames=Guirado E, Rajaram MV, Chawla A, journalName=Tuberculosis(Edinb), refType=null, unstructuredReference=Guirado E, Rajaram MV, Chawla A, et al. Deletion of PPARγ in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice[J]. Tuberculosis(Edinb), 2018, 111: 170-177., articleTitle=Deletion of PPARγ in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice, refAbstract=null), Reference(id=1208516115718861284, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=14, issue=7, pageStart=e1007151, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=12, authorNames=Díaz Acosta CC, Dias AA, Rosa TLSA, journalName=PLoS Pathog, refType=null, unstructuredReference=Díaz Acosta CC, Dias AA, Rosa TLSA, et al. PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves[J]. PLoS Pathog, 2018, 14(7): e1007151., articleTitle=PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves, refAbstract=null), Reference(id=1208516115794358757, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2019, volume=93, issue=9, pageStart=e00030, pageEnd=19, url=null, language=null, rfNumber=[11], rfOrder=13, authorNames=Huang S, Zhu BB, Cheon IS, journalName=J Virol, refType=null, unstructuredReference=Huang S, Zhu BB, Cheon IS, et al. PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection[J]. J Virol, 2019, 93(9): e00030-19., articleTitle=PPAR-γ in macrophages limits pulmonary inflammation and promotes host recovery following respiratory viral infection, refAbstract=null), Reference(id=1208516115874050535, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=104, issue=4, pageStart=737, pageEnd=741, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=Nobs SP, Kopf M, journalName=J Leukoc Biol, refType=null, unstructuredReference=Nobs SP, Kopf M. PPAR-γ in innate and adaptive lung immunity[J]. J Leukoc Biol, 2018, 104(4): 737-741., articleTitle=PPAR-γ in innate and adaptive lung immunity, refAbstract=null), Reference(id=1208516115957936617, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2021, volume=114, issue=null, pageStart=154338, pageEnd=null, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=Christofides A, Konstantinidou E, Jani C, journalName=Metabolism, refType=null, unstructuredReference=Christofides A, Konstantinidou E, Jani C, et al. The role of peroxisome proliferator-activated receptors (PPAR) in immune responses[J]. Metabolism, 2021, 114: 154338., articleTitle=The role of peroxisome proliferator-activated receptors (PPAR) in immune responses, refAbstract=null), Reference(id=1208516116033434091, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=11, issue=null, pageStart=1848, pageEnd=null, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=Petrilli JD, Müller I, Araújo LE, journalName=Front Immunol, refType=null, unstructuredReference=Petrilli JD, Müller I, Araújo LE, et al. Differential host pro-inflammatory response to mycobacterial cell wall lipids regulated by the Mce1 operon[J]. Front Immunol, 2020, 11: 1848., articleTitle=Differential host pro-inflammatory response to mycobacterial cell wall lipids regulated by the Mce1 operon, refAbstract=null), Reference(id=1208516116138291694, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=28, issue=5, pageStart=410, pageEnd=415, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=Yang H, Zhao LF, Zhang L, journalName=Chin J Hepatol, refType=null, unstructuredReference=Yang H, Zhao LF, Zhang L, et al. Rosiglitazone inhibits hepatic stellate cell proliferation by regulating peroxisome proliferator-activated receptor gamma/heme oxygenase-1 expression[J]. Chin J Hepatol, 2020, 28(5): 410-415., articleTitle=Rosiglitazone inhibits hepatic stellate cell proliferation by regulating peroxisome proliferator-activated receptor gamma/heme oxygenase-1 expression, refAbstract=null), Reference(id=1208516117308502512, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=5, pageStart=410, pageEnd=415, url=null, language=null, rfNumber=[15], rfOrder=18, authorNames=杨慧, 赵龙凤, 张丽, journalName=中华肝脏病杂志, refType=null, unstructuredReference=[杨慧, 赵龙凤, 张丽, 等.罗格列酮调控PPARγ/HO-1的表达抑制肝星状细胞增殖[J]. 中华肝脏病杂志, 2020, 28(5):410-415.], articleTitle=罗格列酮调控PPARγ/HO-1的表达抑制肝星状细胞增殖, refAbstract=null), Reference(id=1208516117400777203, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=175, issue=20, pageStart=3928, pageEnd=3946, url=null, language=null, rfNumber=[16], rfOrder=19, authorNames=Cho RL, Yang CC, Tseng HC, journalName=Br J Pharmacol, refType=null, unstructuredReference=Cho RL, Yang CC, Tseng HC, et al. Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation[J]. Br J Pharmacol, 2018, 175(20): 3928-3946., articleTitle=Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation, refAbstract=null), Reference(id=1208516117484663286, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=316, issue=null, pageStart=108928, pageEnd=null, url=null, language=null, rfNumber=[17], rfOrder=20, authorNames=Zhang Y, Wang C, Jia ZL, journalName=Chem Biol Interact, refType=null, unstructuredReference=Zhang Y, Wang C, Jia ZL, et al. Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway[J]. Chem Biol Interact, 2020, 316: 108928., articleTitle=Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway, refAbstract=null), Reference(id=1208516117593715193, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2020, volume=9, issue=11, pageStart=E2470, pageEnd=null, url=null, language=null, rfNumber=[18], rfOrder=21, authorNames=Papavassiliou AG, Musti AM, journalName=Cells, refType=null, unstructuredReference=Papavassiliou AG, Musti AM. The multifaceted output of c-Jun biological activity: focus at the junction of CD8 T cell activation and exhaustion[J]. Cells, 2020, 9(11): E2470., articleTitle=The multifaceted output of c-Jun biological activity: focus at the junction of CD8 T cell activation and exhaustion, refAbstract=null), Reference(id=1208516117698572797, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=101, issue=null, pageStart=585, pageEnd=596, url=null, language=null, rfNumber=[19], rfOrder=22, authorNames=Yan CG, Deng CM, Liu XF, journalName=Mol Immunol, refType=null, unstructuredReference=Yan CG, Deng CM, Liu XF, et al. TNF-α induction of IL-6 in alveolar type Ⅱ epithelial cells: Contributions of JNK/c-Jun/AP-1 element, C/EBPΔ/C/EBP binding site and IKK/NF-κB p65/κB site[J]. Mol Immunol, 2018, 101: 585-596., articleTitle=TNF-α induction of IL-6 in alveolar type Ⅱ epithelial cells: Contributions of JNK/c-Jun/AP-1 element, C/EBPΔ/C/EBP binding site and IKK/NF-κB p65/κB site, refAbstract=null), Reference(id=1208516117795041792, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2019, volume=97, issue=1, pageStart=72, pageEnd=84, url=null, language=null, rfNumber=[20], rfOrder=23, authorNames=Wu CM, Li A, Hu J, journalName=Immunol Cell Biol, refType=null, unstructuredReference=Wu CM, Li A, Hu J, et al. Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages[J]. Immunol Cell Biol, 2019, 97(1): 72-84., articleTitle=Histone deacetylase 2 is essential for LPS-induced inflammatory responses in macrophages, refAbstract=null), Reference(id=1208516117887316481, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=27, issue=147, pageStart=170077, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=24, authorNames=Ravimohan S, Kornfeld H, Weissman D, journalName=Eur Respir Rev, refType=null, unstructuredReference=Ravimohan S, Kornfeld H, Weissman D, et al. Tuberculosis and lung damage: from epidemiology to pathophysiology[J]. Eur Respir Rev, 2018, 27(147): 170077., articleTitle=Tuberculosis and lung damage: from epidemiology to pathophysiology, refAbstract=null), Reference(id=1208516117987979779, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2017, volume=7, issue=null, pageStart=43829, pageEnd=null, url=null, language=null, rfNumber=[22], rfOrder=25, authorNames=Yang ML, Wang CT, Yang SJ, journalName=Sci Rep, refType=null, unstructuredReference=Yang ML, Wang CT, Yang SJ, et al. IL-6 ameliorates acute lung injury in influenza virus infection[J]. Sci Rep, 2017, 7: 43829., articleTitle=IL-6 ameliorates acute lung injury in influenza virus infection, refAbstract=null), Reference(id=1208516118059282949, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=null, pageStart=438, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=26, authorNames=Woo M, Wood C, Kwon D, journalName=Front Immunol, refType=null, unstructuredReference=Woo M, Wood C, Kwon D, et al. Mycobacterium tuberculosis infection and innate responses in a new model of lung alveolar macrophages[J]. Front Immunol, 2018, 9: 438., articleTitle=Mycobacterium tuberculosis infection and innate responses in a new model of lung alveolar macrophages, refAbstract=null), Reference(id=1208516118147363335, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2016, volume=84, issue=5, pageStart=1301, pageEnd=1311, url=null, language=null, rfNumber=[24], rfOrder=27, authorNames=Phuah J, Wong EA, Gideon HP, journalName=Infect Immun, refType=null, unstructuredReference=Phuah J, Wong EA, Gideon HP, et al. Effects of B cell depletion on early Mycobacterium tuberculosis infection in cynomolgus macaques[J]. Infect Immun, 2016, 84(5): 1301-1311., articleTitle=Effects of B cell depletion on early Mycobacterium tuberculosis infection in cynomolgus macaques, refAbstract=null), Reference(id=1208516118239638025, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, doi=null, pmid=null, pmcid=null, year=2016, volume=38, issue=2, pageStart=153, pageEnd=166, url=null, language=null, rfNumber=[25], rfOrder=28, authorNames=Dorhoi A, Kaufmann SH, journalName=Semin Immunopathol, refType=null, unstructuredReference=Dorhoi A, Kaufmann SH. Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis[J]. Semin Immunopathol, 2016, 38(2): 153-166., articleTitle=Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis, refAbstract=null)], funds=[Fund(id=1208516114435404216, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, awardId=81760356, language=EN, fundingSource=National Natural Science Foundation of China(81760356), fundOrder=null, country=null), Fund(id=1208516114561233340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, awardId=81760356, language=CN, fundingSource=国家自然科学基金(81760356), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1208516106474614940, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=1, ext=[AuthorCompanyExt(id=1208516106483003550, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106495586463, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106474614940, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹宜春学院化学与生物工程学院，江西宜春 336000)]), AuthorCompany(id=1208516106608832678, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, xref=2, ext=[AuthorCompanyExt(id=1208516106617221288, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Immunology and Microbiology, Medical College of Yichun University, Yichun, Jiangxi 336000, China), AuthorCompanyExt(id=1208516106625609898, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, companyId=1208516106608832678, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²宜春学院医学院医学免疫与微生物学教研室，江西宜春 336000)])], figs=[ArticleFig(id=1208516113130975620, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Fig.1, caption=Comparison of MTB bacterial load in lung tissue of mice in each group, figureFileSmall=KDi0/NNXtHTRaeLi/rxbGw==, figureFileBig=Jv/KOTeFvkIGMcjfsMajLg==, tableContent=null), ArticleFig(id=1208516113244221833, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=图1, caption=各组小鼠肺组织结核分枝杆菌荷菌量比较

MTB. 结核分枝杆菌；CFU. 菌落形成单位；与MTB组比较，(1)P<0.05；与MTB+罗格列酮组比较，(2)P<0.05

, figureFileSmall=KDi0/NNXtHTRaeLi/rxbGw==, figureFileBig=Jv/KOTeFvkIGMcjfsMajLg==, tableContent=null), ArticleFig(id=1208516113479102871, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Fig.2, caption=Comparison of PPARγ expression levels in lung tissue of mice in each group, figureFileSmall=EWDv//QskL6UjTkAv6zLjg==, figureFileBig=uRjRfuDoEPiFUTSNGLy99Q==, tableContent=null), ArticleFig(id=1208516113567183258, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=图2, caption=各组小鼠肺组织PPARγ表达水平比较

MTB. 结核分枝杆菌；PPARγ. 过氧化物酶体增殖物激活受体γ；A. 各组小鼠肺组织PPARγ mRNA的表达；B. 各组小鼠肺组织PPARγ蛋白的表达；与对照组比较，(1)P<0.05；与MTB组比较，(2)P<0.05；与MTB+罗格列酮组比较，(3)P<0.05

, figureFileSmall=EWDv//QskL6UjTkAv6zLjg==, figureFileBig=uRjRfuDoEPiFUTSNGLy99Q==, tableContent=null), ArticleFig(id=1208516113680429471, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Fig.3, caption=Comparison of AP-1 expression levels in lung tissue of mice in each group, figureFileSmall=ue4LRyjoPUBZ7E7C8M8XlA==, figureFileBig=7cI0DbOODfhQWPgTPNo1dQ==, tableContent=null), ArticleFig(id=1208516113781092773, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=图3, caption=各组小鼠肺组织AP-1表达水平比较

MTB. 结核分枝杆菌；AP-1. 激活蛋白-1；A. 各组小鼠肺组织AP-1 mRNA的表达；B. 各组小鼠肺组织AP-1蛋白的表达；与对照组比较，(1)P<0.05；与MTB组比较，(2)P<0.05；与MTB+罗格列酮组比较，(3)P<0.05

, figureFileSmall=ue4LRyjoPUBZ7E7C8M8XlA==, figureFileBig=7cI0DbOODfhQWPgTPNo1dQ==, tableContent=null), ArticleFig(id=1208516113852395941, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Fig.4, caption=Comparison the content of inflammatory cytokines in lung tissue of mice in each group, figureFileSmall=em5cUaXvwS3a/mmERpnfyw==, figureFileBig=67mj0KFu74hjGQNuecpsnQ==, tableContent=null), ArticleFig(id=1208516113948864936, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=图4, caption=各组小鼠肺组织炎性细胞因子含量比较

MTB. 结核分枝杆菌；IL-6. 白细胞介素-6；IL-10. 白细胞介素-10；TNF-α. 肿瘤坏死因子-α；与对照组比较，(1)P<0.05；与MTB组比较，(2)P<0.05；与MTB+罗格列酮组比较，(3)P<0.05

, figureFileSmall=em5cUaXvwS3a/mmERpnfyw==, figureFileBig=67mj0KFu74hjGQNuecpsnQ==, tableContent=null), ArticleFig(id=1208516114028556714, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Fig.5, caption=Pathological changes of lung tissue of mice in each group, figureFileSmall=COt8L44OgKR2jVm4rqmDuw==, figureFileBig=9cC0HLH5Nlb9mGkzYjSsEg==, tableContent=null), ArticleFig(id=1208516114145997229, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=图5, caption=各组小鼠肺组织病理学变化

MTB. 结核分枝杆菌

, figureFileSmall=COt8L44OgKR2jVm4rqmDuw==, figureFileBig=9cC0HLH5Nlb9mGkzYjSsEg==, tableContent=null), ArticleFig(id=1208516114213106096, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=EN, label=Tab.1, caption=

Primer sequences of real-time qPCR

, figureFileSmall=null, figureFileBig=null, tableContent=

引物	引物序列	产物大小
β-actin	正向5'-CACGATGGAGGGGCCGGACTCATC-3'	240 bp
	反向5'-TAAAGACCTCTATGCCAACACAGT-3'
PPARγ	正向5'-GTGGGGATGTCTCACAATGC-3'	203 bp
	反向5'-TTTCCTGTCAAGATCGCCCT-3'
AP-1	正向5'-GAGCGGACCTTATGGCTACA-3'	192 bp
	反向5'-CCGTTGCTGGACTGGATTAT-3'

), ArticleFig(id=1208516114322158003, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208516103454715912, language=CN, label=表1, caption=

RT-qPCR引物序列

, figureFileSmall=null, figureFileBig=null, tableContent=

引物	引物序列	产物大小
β-actin	正向5'-CACGATGGAGGGGCCGGACTCATC-3'	240 bp
	反向5'-TAAAGACCTCTATGCCAACACAGT-3'
PPARγ	正向5'-GTGGGGATGTCTCACAATGC-3'	203 bp
	反向5'-TTTCCTGTCAAGATCGCCCT-3'
AP-1	正向5'-GAGCGGACCTTATGGCTACA-3'	192 bp
	反向5'-CCGTTGCTGGACTGGATTAT-3'

)], attaches=null, journal=Journal(id=1146441329971666965, delFlag=0, nameCn=解放军医学杂志, nameEn=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, issn=0577-7402, eissn=null, cn=11-1056/R, coden=null, periodic=0, language=CN, oaType=是, ccby=CC BY-NC-ND, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=6srot5PcoYX30Oa4xeTmeg==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1751262512917, updatedTime=1761735725513, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=6srot5PcoYX30Oa4xeTmeg==, picEn=ELwBh5xqrSTlIs7HmSNt2Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369167564968109, language=CN, name=解放军医学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725537, updatedTime=1761735725537, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369167615299758, language=EN, name=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725549, updatedTime=1761735725549, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189873630562394117, websiteList=[Website(id=1189873845923287108, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN, language=CN, createTime=1761617631655, createBy=18614031015, updateTime=1761622010471, updateBy=18614031015, name=解放军医学杂志-中文, tplId=1146099689490845704, title=解放军医学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924939378520839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=articleTextType, value=kx, createTime=1761629813284, updateTime=1761629813284, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939353355012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=banner, value=null, createTime=1761629813278, updateTime=1761629813278, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939399492362, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=grayFlag, value=0, createTime=1761629813289, updateTime=1761629813289, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939344966403, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629813276, updateTime=1761629813276, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939412075276, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=minRunFlag, value=0, createTime=1761629813292, updateTime=1761629813292, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939374326534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic, createTime=1761629813283, updateTime=1761629813283, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939407880971, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=silenceFlag, value=0, createTime=1761629813291, updateTime=1761629813291, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939361743621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761629813280, updateTime=1761629813280, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939386909448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeColor, value=null, createTime=1761629813286, updateTime=1761629813286, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939395298057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeStyle, value=null, createTime=1761629813288, updateTime=1761629813288, creator=18614031015, updator=18614031015)]), Website(id=1189873846057504839, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN, language=EN, createTime=1761617631687, createBy=18614031015, updateTime=1761622030030, updateBy=18614031015, name=解放军医学杂志-英文, tplId=1146101810881728533, title=Medical Journal of Chinese People’s Liberation Army, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924968168223505, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=articleTextType, value=kx, createTime=1761629820148, updateTime=1761629820148, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968147251982, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=banner, value=null, createTime=1761629820143, updateTime=1761629820143, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968185000724, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=grayFlag, value=0, createTime=1761629820152, updateTime=1761629820152, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968138863373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629820141, updateTime=1761629820141, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968197583638, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=minRunFlag, value=0, createTime=1761629820155, updateTime=1761629820155, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968159834896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic, createTime=1761629820146, updateTime=1761629820146, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968193389333, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=silenceFlag, value=0, createTime=1761629820154, updateTime=1761629820154, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968155640591, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761629820145, updateTime=1761629820145, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968172417810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeColor, value=null, createTime=1761629820149, updateTime=1761629820149, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968180806419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeStyle, value=null, createTime=1761629820151, updateTime=1761629820151, creator=18614031015, updator=18614031015)])], journalTitle=解放军医学杂志, weixinUrl=null, journalUrl=http://zh.jfjyxzz.org.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Medical Journal of Chinese People’s Liberation Army, journalPhotoCn=6srot5PcoYX30Oa4xeTmeg==, journalPhotoEn=ELwBh5xqrSTlIs7HmSNt2Q==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.2022.01.0046, detailUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.2022.01.0046, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/PDF/10.11855/j.issn.0577-7402.2022.01.0046, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/PDF/10.11855/j.issn.0577-7402.2022.01.0046, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)