Article(id=1208154042178580863, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208154038609228128, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2022.02.0203, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1618761600000, receivedDateStr=2021-04-19, revisedDate=null, revisedDateStr=null, acceptedDate=1620662400000, acceptedDateStr=2021-05-11, onlineDate=1765975970071, onlineDateStr=2025-12-17, pubDate=1645977600000, pubDateStr=2022-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1765975970071, onlineIssueDateStr=2025-12-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1765975970071, creator=13701087609, updateTime=1765975970071, updator=13701087609, issue=Issue{id=1208154038609228128, tenantId=1146029695717560320, journalId=1189873630562394117, year='2022', volume='47', issue='2', pageStart='107', pageEnd='212', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1765975969218, creator=13701087609, updateTime=1765976148463, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1208154790459192257, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208154038609228128, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1208154790459192258, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208154038609228128, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=203, endPage=212, ext={EN=ArticleExt(id=1208154042618982796, articleId=1208154042178580863, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress on SGLT2 inhibitor in heart failure with preserved ejection fraction, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

At present, there is a relatively complete guideline for heart failure with ejection fraction reduction (HFrEF), but there is still a lack of evidence-based medical evidence for heart failure with preserved ejection fraction (HFpEF) treatment criteria.In recent years, a large amount of evidence has emerged that a new oral hypoglycemic drug sodium-glucose cotransporter 2 inhibitor(SGLT2i) can significantly reduce the risk of cardiovascular death and the hospitalization rate of heart failure in patients with type 2 diabetes mellitus, and improve the prognosis of HFrEF. However, there is still a lack of overall understanding of the mechanism and research progress of SGLT2i in the treatment of HFpEF. This article reviews the pathological mechanism of HFpEF, the mechanism of action of SGLT2i and the related research on the treatment of HFpEF, in order to provide reference for the clinical drug treatment of HFpEF.

, correspAuthors=Yong-Ming Liu, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xiao-Yan Jia, Yong-Ming Liu), CN=ArticleExt(id=1208154043369763261, articleId=1208154042178580863, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=SGLT2i在射血分数保留心力衰竭中的作用研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

目前针对射血分数降低心力衰竭(HFrEF)已有相对完整的指南共识，但仍缺乏射血分数保留心力衰竭(HFpEF)治疗标准的循证医学证据。近年来，新型口服降糖药物钠-葡萄糖共转运蛋白2抑制剂(SGLT2i)在2型糖尿病患者心血管获益方面涌现出大量证据，多项临床试验显示其可明显降低2型糖尿病患者的心血管死亡风险和因心衰住院率，改善HFrEF预后，但对SGLT2i治疗HFpEF的作用机制及研究进展仍缺乏整体认识。本文从HFpEF的病理机制、SGLT2i的作用机制及HFpEF的相关治疗几个方面进行综述，以期为HFpEF的临床药物治疗提供参考。

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贾晓艳，硕士研究生，主要从事心力衰竭方面的研究

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贾晓艳，硕士研究生，主要从事心力衰竭方面的研究

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Diabetes Obes Metab, 2018, 20(8): 1977-1982., articleTitle=SGLT2 inhibitors and risk of stroke in patients with type 2 diabetes: a systematic review and meta-analysis, refAbstract=null)], funds=[Fund(id=1208154046272221821, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, awardId=GSWSKY-2019-08, language=EN, fundingSource=Health Industry Project of Gansu Province(GSWSKY-2019-08), fundOrder=null, country=null), Fund(id=1208154046372885123, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, awardId=GSWSKY-2019-08, language=CN, fundingSource=甘肃省卫生行业计划(GSWSKY-2019-08), fundOrder=null, country=null), Fund(id=1208154046473548422, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, awardId=20YF8FA079, language=EN, fundingSource=Special Project for Local Science and Technology Development under the Leadership of the Central Committee of Gansu Province(20YF8FA079), fundOrder=null, country=null), Fund(id=1208154046586794635, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, awardId=20YF8FA079, language=CN, fundingSource=甘肃省中央领导地方科技发展专项(20YF8FA079), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1208154043860496849, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, xref=1, ext=[AuthorCompanyExt(id=1208154043881468372, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, companyId=1208154043860496849, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China), AuthorCompanyExt(id=1208154043923411415, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, companyId=1208154043860496849, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹兰州大学第一临床医学院，兰州 730000)]), AuthorCompany(id=1208154044028269025, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, xref=2, ext=[AuthorCompanyExt(id=1208154044040851939, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, companyId=1208154044028269025, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Geriatric Cardiology, the First Hospital of Lanzhou University/Gansu Provincial Clinical Research Center for Geriatric Medicine, Lanzhou 730000, China), AuthorCompanyExt(id=1208154044057629156, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, companyId=1208154044028269025, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第一医院老年心血管科/甘肃省老年疾病临床医学研究中心，兰州 730000)])], figs=[ArticleFig(id=1208154045794071136, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, language=EN, label=Fig.1, caption=Pathophysiologic mechanism of heart failure with preserved ejection fraction (HFpEF)(Revised according to reference [35]), figureFileSmall=sgbwjONRH3b4UfMDmT4XFg==, figureFileBig=5EEdRa2GY+H4QQ19/ATo/w==, tableContent=null), ArticleFig(id=1208154045877957226, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, language=CN, label=图1, caption=射血分数保留心力衰竭(HFpEF)的病理生理机制(根据文献[35]修改)

LA. 左心房；LV. 左心室；PH. 肺动脉高压；PV. 肺血管；RV. 右心室

, figureFileSmall=sgbwjONRH3b4UfMDmT4XFg==, figureFileBig=5EEdRa2GY+H4QQ19/ATo/w==, tableContent=null), ArticleFig(id=1208154046079283827, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, language=EN, label=Fig.2, caption=The hypoglycemic and cardiovascular mechanism of SGLT2i (Revised according to reference [38]), figureFileSmall=t39Dv2dhOFj00o0a0Pdb2g==, figureFileBig=PRI/TKIaoManfsDluCM4vA==, tableContent=null), ArticleFig(id=1208154046150587000, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1208154042178580863, language=CN, label=图2, caption=SGLT2i的降糖及心血管作用机制(根据参考文献[38]修改)

SGLT2i. 钠-葡萄糖共转运蛋白2抑制剂

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