首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1207433496528789759, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1207433493215289544, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2022.08.0795, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1640620800000, receivedDateStr=2021-12-28, revisedDate=null, revisedDateStr=null, acceptedDate=1647446400000, acceptedDateStr=2022-03-17, onlineDate=1765804178602, onlineDateStr=2025-12-15, pubDate=1661616000000, pubDateStr=2022-08-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1765804178602, onlineIssueDateStr=2025-12-15, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1765804178602, creator=13701087609, updateTime=1765804178602, updator=13701087609, issue=Issue{id=1207433493215289544, tenantId=1146029695717560320, journalId=1189873630562394117, year='2022', volume='47', issue='8', pageStart='745', pageEnd='850', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1765804177811, creator=13701087609, updateTime=1765804292764, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1207433975413444883, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1207433493215289544, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1207433975413444884, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1207433493215289544, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=795, endPage=801, ext={EN=ArticleExt(id=1207433497636086038, articleId=1207433496528789759, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Analysis of the influencing factors for prognosis of patients with non-severe pulmonary acute respiratory distress syndrome, columnId=1190310109000602400, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Clinical Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the influencing factors for prognosis in non-severe (mild to moderate) pulmonary acute respiratory distress syndrome (ARDS) patients, and evaluate the efficacy of the risk factors to predict the prognosis. Methods The data of 123 patients with non-severe pulmonary ARDS, hospitalized in the Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital (West Campus) from January 2017 to June 2021, were retrospectively enrolled, and divided into two groups according to 30-day survival condition, i.e., non-survivor group (n=45) and survivor group (n=78). Baseline characteristics, complications, arterial blood gas, blood routine, and levels of fibrinogen, C-reactive protein (CRP), procalcitonin,albumin and brain natriuretic peptide (BNP) were compared between the two groups. Kaplan-Meier and Cox survival analysis were adopted to analyze the risk factors which could affect the survival situation of patients with non-severe pulmonary ARDS.ROC curves were used to assess the efficacy of the risk factors to predict prognosis. Results Compared with survivor group, the proportion of patients with renal insufficiency, deep venous thrombosis and shock, APACHE Ⅱ score, body temperature, respiratory rate, neutrophil to lymphocyte ratio (NLR), fibrinogen and CRP levels in non-survivor group increased, and arterial partial pressure of carbon dioxide (PaCO2), platelet count and albumin levels decreased (P<0.05). Kaplan-Meier survival analysis showed that kidney failure, deep venous thrombosis and shock were the risk factors of 30-day death in patients with non-severe pulmonary ARDS (P<0.05). Univariate Cox analysis demonstrated that heart rate, temperature, respiratory rate, PaCO2, NLR, WBC, platelet count, fibrinogen, CRP, albumin and APACHE Ⅱ score were the risk factors of 30-day death in patients with non-severe pulmonary ARDS (P<0.05). Multivariate Cox analysis showed that higher APACHE Ⅱ score (HR=1.094, 95%CI 1.009-1.120, P=0.031), higher NLR (HR=1.087, 95%CI 1.012-1.167, P=0.021) and the presence of shock presented during course (HR=3.135, 95%CI 1.315-6.964, P=0.010) were independent risk factors for 30-day death of patients with non-severe pulmonary ARDS. The cut-off value of APACHE Ⅱ score and NLR in predicting mortality were 16.5 and 8.13, and the area under the curve (AUC) were 0.803 (95%CI 0.727-0.879) and 0.772 (95%CI 0.688-0.856), respectively. Conclusions APACHE Ⅱ score >16.5, NLR >8.13 and presence of shock were the independent risk factors of mortality for patients with non-severe pulmonary ARDS, and these factors could effectively predict prognosis.

, correspAuthors=Jing Wang, authorNote=null, correspAuthorsNote=
*E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Wei Sun, Jing Wang), CN=ArticleExt(id=1207433498508501326, articleId=1207433496528789759, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=非重型肺源性急性呼吸窘迫综合征患者的预后影响因素分析, columnId=1190310109164180259, journalTitle=解放军医学杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=

目的 分析非重型(轻、中型)肺源性急性呼吸窘迫综合征(ARDS)患者的预后影响因素及其对预后的预测效能。方法 收集2017年1月－2021年6月北京朝阳医院京西院区收治的非重型肺源性ARDS患者123例，根据30 d生存情况分为死亡组(n=45)与存活组(n=78)。比较两组基线资料、合并症、基础疾病、动脉血气、血常规、纤维蛋白原、C反应蛋白(CRP)、降钙素原、白蛋白及脑钠肽(BNP)水平。采用Kaplan-Meier和Cox生存分析探讨非重型肺源性ARDS患者生存状态的影响因素，采用受试者工作特征曲线(ROC)分析影响因素对预后的预测效能。结果 与存活组比较，死亡组患者出现肾功能不全、深静脉血栓及休克的比例增高，APACHE Ⅱ评分、体温、呼吸频率、中性粒细胞/淋巴细胞比值(NLR)以及纤维蛋白原、CRP水平增高，动脉血二氧化碳分压(PaCO2)、血小板计数和白蛋白水平降低(P<0.05)。Kaplan-Meier生存分析显示，肾功能不全、深静脉血栓及休克是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05)。单因素Cox生存分析显示，心率、体温、呼吸频率、PaCO2、NLR、白细胞计数、血小板计数、纤维蛋白原、CRP、白蛋白及APACHEⅡ评分是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05)。多因素Cox生存分析显示，高APACHE Ⅱ评分(HR=1.094，95%CI 1.009~1.120，P=0.031)、高NLR(HR=1.087，95%CI 1.012~1.167，P=0.021)及病程中出现休克(HR=3.135，95%CI 1.315~6.964，P=0.010)是非重型肺源性ARDS患者30 d死亡的独立危险因素。APACHE Ⅱ评分及NLR预测非重型肺源性ARDS患者30 d死亡的临界值分别为16.5分、8.13，曲线下面积(AUC)分别为0.803(95%CI 0.727~0.879)、0.772(95%CI 0.688~0.856)。结论 APACHEⅡ评分>16.5分、NLR>8.13及出现休克是非重型肺源性ARDS患者死亡的独立危险因素，这些因素对于该类患者的预后有较高的预测效能。

, correspAuthors=王晶, authorNote=null, correspAuthorsNote=
王晶，E-mail：
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=2Vg2vBKP6kROraN7SjL6kg==, magXml=IMPXS0d+f7RxrbsvNm8S2Q==, pdfUrl=null, pdf=xErP7ACJRnt+FJrG2teGzw==, pdfFileSize=909542, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=/apSHghil53jfBAS3ocCCw==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=ILrX1fdK444BWcyLCUY4HQ==, mapNumber=null, authorCompany=null, fund=null, authors=

孙伟，医学硕士，主治医师，主要从事急性呼吸窘迫综合征及慢性阻塞性肺疾病的临床研究

, authorsList=孙伟, 王晶)}, authors=[Author(id=1207700246520501202, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1207700246759576533, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, authorId=1207700246520501202, language=EN, stringName=Wei Sun, firstName=Wei, middleName=null, lastName=Sun, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1207700246864434135, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, authorId=1207700246520501202, language=CN, stringName=孙伟, firstName=伟, middleName=null, lastName=孙, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043, bio={"content":"

孙伟，医学硕士，主治医师，主要从事急性呼吸窘迫综合征及慢性阻塞性肺疾病的临床研究

"}, bioImg=null, bioContent=

孙伟，医学硕士，主治医师，主要从事急性呼吸窘迫综合征及慢性阻塞性肺疾病的临床研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1207700246012990412, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, xref=null, ext=[AuthorCompanyExt(id=1207700246017184718, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China), AuthorCompanyExt(id=1207700246025573326, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043)])]), Author(id=1207700247036400604, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=wangjingdoc@126.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1207700247552299999, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, authorId=1207700247036400604, language=EN, stringName=Jing Wang, firstName=Jing, middleName=null, lastName=Wang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1207700247636186081, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, authorId=1207700247036400604, language=CN, stringName=王晶, firstName=晶, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1207700246012990412, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, xref=null, ext=[AuthorCompanyExt(id=1207700246017184718, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China), AuthorCompanyExt(id=1207700246025573326, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043)])])], keywords=[Keyword(id=1207700247971730406, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, orderNo=1, keyword=acute respiratory distress syndrome), Keyword(id=1207700248118531048, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, orderNo=2, keyword=prognosis), Keyword(id=1207700248852534252, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, orderNo=3, keyword=mortality), Keyword(id=1207700250458952686, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, orderNo=4, keyword=neutrophil to lymphocyte ratio), Keyword(id=1207700250853217265, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, orderNo=5, keyword=shock), Keyword(id=1207700250953880564, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, orderNo=1, keyword=急性呼吸窘迫综合征), Keyword(id=1207700251088098294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, orderNo=2, keyword=预后), Keyword(id=1207700251239093240, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, orderNo=3, keyword=病死率), Keyword(id=1207700251331367929, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, orderNo=4, keyword=中性粒细胞/淋巴细胞比值), Keyword(id=1207700251465585659, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, orderNo=5, keyword=休克)], refs=[Reference(id=1207700259350876185, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2017, volume=195, issue=7, pageStart=860, pageEnd=870, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Pham T, Rubenfeld GD, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=Pham T, Rubenfeld GD. Fifty years of research in ARDS. The epidemiology of acute respiratory distress syndrome. A 50th birthday review[J]. Am J Respir Crit Care Med, 2017, 195(7):860-870., articleTitle=Fifty years of research in ARDS. The epidemiology of acute respiratory distress syndrome. A 50th birthday review, refAbstract=null), Reference(id=1207700259497676827, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=45, issue=12, pageStart=1309, pageEnd=1314, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Zhang RH, Xia JG, Zhan QY, journalName=Med J Chin PLA, refType=null, unstructuredReference=Zhang RH, Xia JG, Zhan QY. Research progress on risk factors and predictive scores of sepsis patients developing into acute respiratory distress syndrome[J]. Med J Chin PLA, 2020, 45(12): 1309-1314., articleTitle=Research progress on risk factors and predictive scores of sepsis patients developing into acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700259829026844, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=12, pageStart=1309, pageEnd=1314, url=null, language=null, rfNumber=[2], rfOrder=2, authorNames=张芮豪, 夏金根, 詹庆元, journalName=解放军医学杂志, refType=null, unstructuredReference=[张芮豪, 夏金根, 詹庆元. 脓毒症并发急性呼吸窘迫综合征的危险因素及预测评分研究进展[J]. 解放军医学杂志, 2020, 45(12): 1309-1314.], articleTitle=脓毒症并发急性呼吸窘迫综合征的危险因素及预测评分研究进展, refAbstract=null), Reference(id=1207700259912912925, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=45, issue=4, pageStart=435, pageEnd=440, url=null, language=null, rfNumber=[3], rfOrder=3, authorNames=Zheng GL, Ding JC, Li XF, journalName=Med J Chin PLA, refType=null, unstructuredReference=Zheng GL, Ding JC, Li XF, et al. Application of mobile extracorporeal membrane oxygenation in inter-hospital transport of pediatric acute respiratory distress syndrome: retrospective studies for 7 case[J]. Med J Chin PLA, 2020, 45(4): 435-440., articleTitle=Application of mobile extracorporeal membrane oxygenation in inter-hospital transport of pediatric acute respiratory distress syndrome: retrospective studies for 7 case, refAbstract=null), Reference(id=1207700260026159135, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=null, issue=4, pageStart=435, pageEnd=440, url=null, language=null, rfNumber=[3], rfOrder=4, authorNames=郑贵浪, 丁家畅, 李旭锋, journalName=解放军医学杂志, refType=null, unstructuredReference=[郑贵浪, 丁家畅, 李旭锋, 等. 移动体外膜肺氧合在小儿急性呼吸窘迫综合征院际转运中的应用：7例回顾性病例研究[J]. 解放军医学杂志, 2020, 45(4): 435-440.], articleTitle=移动体外膜肺氧合在小儿急性呼吸窘迫综合征院际转运中的应用：7例回顾性病例研究, refAbstract=null), Reference(id=1207700260151988257, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2018, volume=319, issue=7, pageStart=698, pageEnd=710, url=null, language=null, rfNumber=[4], rfOrder=5, authorNames=Fan E, Brodie D, Slutsky AS, journalName=JAMA, refType=null, unstructuredReference=Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: Advances in diagnosis and treatment[J]. JAMA, 2018, 319(7): 698-710., articleTitle=Acute respiratory distress syndrome: Advances in diagnosis and treatment, refAbstract=null), Reference(id=1207700260307177507, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2017, volume=195, issue=6, pageStart=725, pageEnd=736, url=null, language=null, rfNumber=[5], rfOrder=6, authorNames=Yadav H, Thompson BT, Gajic O, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=Yadav H, Thompson BT, Gajic O. Fifty years of research in ARDS. Is acute respiratory distress syndrome a preventable disease?[J]. Am J Respir Crit Care Med, 2017, 195(6): 725-736., articleTitle=Fifty years of research in ARDS. Is acute respiratory distress syndrome a preventable disease?, refAbstract=null), Reference(id=1207700260479143971, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2016, volume=315, issue=8, pageStart=788, pageEnd=800, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=Bellani G, Laffey JG, Pham T, journalName=JAMA, refType=null, unstructuredReference=Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries[J]. JAMA, 2016, 315(8): 788-800., articleTitle=Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries, refAbstract=null), Reference(id=1207700260739190820, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=33, issue=1, pageStart=69, pageEnd=73, url=null, language=null, rfNumber=[7], rfOrder=8, authorNames=Gao Y, Li J, journalName=Chin Crit Care Med, refType=null, unstructuredReference=Gao Y, Li J. Significance of combined application of biomarkers in the diagnosis and prognosis assessment of patients with acute respiratory distress syndrome[J]. Chin Crit Care Med, 2021, 33(1): 69-73., articleTitle=Significance of combined application of biomarkers in the diagnosis and prognosis assessment of patients with acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700260848242725, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=1, pageStart=69, pageEnd=73, url=null, language=null, rfNumber=[7], rfOrder=9, authorNames=高杨, 李军, journalName=中华危重病急救医学, refType=null, unstructuredReference=[高杨, 李军. 生物标志物联合应用在急性呼吸窘迫综合征患者诊断及预后评估中的意义[J]. 中华危重病急救医学, 2021, 33(1): 69-73.], articleTitle=生物标志物联合应用在急性呼吸窘迫综合征患者诊断及预后评估中的意义, refAbstract=null), Reference(id=1207700261661937703, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2011, volume=56, issue=4, pageStart=420, pageEnd=428, url=null, language=null, rfNumber=[8], rfOrder=10, authorNames=Villar J, Pérez-Méndez L, Basaldúa S, journalName=Respir Care, refType=null, unstructuredReference=Villar J, Pérez-Méndez L, Basaldúa S, et al. A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and PaO2/FiO2 at ARDS onset can predict mortality[J]. Respir Care, 2011, 56(4): 420-428., articleTitle=A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and PaO2/FiO2 at ARDS onset can predict mortality, refAbstract=null), Reference(id=1207700262031036457, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=56, issue=null, pageStart=222, pageEnd=228, url=null, language=null, rfNumber=[9], rfOrder=11, authorNames=Kotok D, Yang L, Evankovich JW, journalName=J Crit Care, refType=null, unstructuredReference=Kotok D, Yang L, Evankovich JW, et al. The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients[J]. J Crit Care, 2020, 56: 222-228., articleTitle=The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients, refAbstract=null), Reference(id=1207700262551130155, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2018, volume=30, issue=10, pageStart=978, pageEnd=982, url=null, language=null, rfNumber=[10], rfOrder=12, authorNames=Li X, Yu J, Huang W, journalName=Chin Crit Care Med, refType=null, unstructuredReference=Li X, Yu J, Huang W, et al. Risk factors analysis of acute respiratory distress syndrome in intensive care unit traumatic patients[J]. Chin Crit Care Med, 2018, 30(10): 978-982., articleTitle=Risk factors analysis of acute respiratory distress syndrome in intensive care unit traumatic patients, refAbstract=null), Reference(id=1207700263750701101, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=99, issue=36, pageStart=2816, pageEnd=2819, url=null, language=null, rfNumber=[11], rfOrder=13, authorNames=Yang Q, Yan CS, Wang YF, journalName=Chin Med J, refType=null, unstructuredReference=Yang Q, Yan CS, Wang YF, et al. Serial changes in biomarkers in pulmonary and extrapulmonary acute respiratory distress syndrome[J]. Chin Med J, 2019, 99(36): 2816-2819., articleTitle=Serial changes in biomarkers in pulmonary and extrapulmonary acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700264023330863, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=1998, volume=158, issue=1, pageStart=3, pageEnd=11, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=Gattinoni L, Pelosi P, Suter PM, journalName=Am J Respir Crit Care Med, refType=null, unstructuredReference=Gattinoni L, Pelosi P, Suter PM, et al. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?[J]. Am J Respir Crit Care Med, 1998, 158(1): 3-11., articleTitle=Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?, refAbstract=null), Reference(id=1207700264136577073, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2017, volume=318, issue=14, pageStart=1335, pageEnd=1345, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=Cavalcanti AB, Suzumura ÉA, Laranjeira LN, journalName=JAMA, refType=null, unstructuredReference=Cavalcanti AB, Suzumura ÉA, Laranjeira LN, et al. Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP)vs low PEEP on mortality in patients with acute respiratory distress syndrome: A randomized clinical trial[J]. JAMA, 2017, 318(14): 1335-1345., articleTitle=Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP)vs low PEEP on mortality in patients with acute respiratory distress syndrome: A randomized clinical trial, refAbstract=null), Reference(id=1207700264274989107, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2020, volume=38, issue=3, pageStart=641, pageEnd=647, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=Huang Z, Fu Z, Huang W, journalName=Am J Emerg Med, refType=null, unstructuredReference=Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis[J]. Am J Emerg Med, 2020, 38(3): 641-647., articleTitle=Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis, refAbstract=null), Reference(id=1207700264388235317, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=52, issue=3, pageStart=859, pageEnd=867, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=Ferro D, Matias M, Neto J, journalName=Stroke, refType=null, unstructuredReference=Ferro D, Matias M, Neto J, et al. Neutrophil-to-lymphocyte ratio predicts cerebral edema and clinical worsening early after reperfusion therapy in stroke[J]. Stroke, 2021, 52(3): 859-867., articleTitle=Neutrophil-to-lymphocyte ratio predicts cerebral edema and clinical worsening early after reperfusion therapy in stroke, refAbstract=null), Reference(id=1207700264509870135, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=11, pageStart=1104, pageEnd=1111, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=Mao WJ, Yin C, Li B, journalName=Med J Chin PLA, refType=null, unstructuredReference=Mao WJ, Yin C, Li B, et al. Predictive value of preoperative inflammatory immune and nutritional indicators for the prognosis of patients with thymoma[J]. Med J Chin PLA, 2021, 46(11): 1104-1111., articleTitle=Predictive value of preoperative inflammatory immune and nutritional indicators for the prognosis of patients with thymoma, refAbstract=null), Reference(id=1207700264669253689, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=11, pageStart=1104, pageEnd=1111, url=null, language=null, rfNumber=[16], rfOrder=19, authorNames=毛文杰, 尹泚, 李斌, journalName=解放军医学杂志, refType=null, unstructuredReference=[毛文杰, 尹泚, 李斌, 等. 术前炎症免疫及营养指标对胸腺瘤患者预后的预测价值[J]. 解放军医学杂志, 2021, 46(11): 1104-1111.], articleTitle=术前炎症免疫及营养指标对胸腺瘤患者预后的预测价值, refAbstract=null), Reference(id=1207700265008992315, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2018, volume=10, issue=1, pageStart=273, pageEnd=282, url=null, language=null, rfNumber=[17], rfOrder=20, authorNames=Wang Y, Ju M, Chen C, journalName=J Thorac Dis, refType=null, unstructuredReference=Wang Y, Ju M, Chen C, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study[J]. J Thorac Dis, 2018, 10(1):273-282., articleTitle=Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study, refAbstract=null), Reference(id=1207700265386479677, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=51, issue=2, pageStart=161, pageEnd=167, url=null, language=null, rfNumber=[18], rfOrder=21, authorNames=Li W, Ai X, Ni Y, journalName=Shock, refType=null, unstructuredReference=Li W, Ai X, Ni Y, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in patients with acute respiratory distress syndrome: A retrospective cohort study[J]. Shock, 2019, 51(2): 161-167., articleTitle=The association between the neutrophil-to-lymphocyte ratio and mortality in patients with acute respiratory distress syndrome: A retrospective cohort study, refAbstract=null), Reference(id=1207700265759772735, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=40, issue=7, pageStart=565, pageEnd=583, url=null, language=null, rfNumber=[19], rfOrder=22, authorNames=Silvestre-Roig C, Fridlender ZG, Glogauer M, journalName=Trends Immunol, refType=null, unstructuredReference=Silvestre-Roig C, Fridlender ZG, Glogauer M, et al. Neutrophil diversity in health and disease[J]. Trends Immunol, 2019, 40(7):565-583., articleTitle=Neutrophil diversity in health and disease, refAbstract=null), Reference(id=1207700266346975297, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2022, volume=23, issue=1, pageStart=155, pageEnd=null, url=null, language=null, rfNumber=[20], rfOrder=23, authorNames=Song C, Li H, Mao Z, journalName=Respir Res, refType=null, unstructuredReference=Song C, Li H, Mao Z, et al. Delayed neutrophil apoptosis may enhance NET formation in ARDS[J]. Respir Res, 2022, 23(1):155., articleTitle=Delayed neutrophil apoptosis may enhance NET formation in ARDS, refAbstract=null), Reference(id=1207700266472804419, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=382, issue=2, pageStart=111486, pageEnd=null, url=null, language=null, rfNumber=[21], rfOrder=24, authorNames=Song C, Li H, Li Y, journalName=Exp Cell Res, refType=null, unstructuredReference=Song C, Li H, Li Y, et al. NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization[J]. Exp Cell Res, 2019, 382(2): 111486., articleTitle=NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization, refAbstract=null), Reference(id=1207700266837708869, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=1, pageStart=62, pageEnd=65, url=null, language=null, rfNumber=[22], rfOrder=25, authorNames=Zhou J, Wang WX, Tan XF, journalName=Chin J Gerontol, refType=null, unstructuredReference=Zhou J, Wang WX, Tan XF. The value of APACHE II and LIPS in the evaluation and prognosis of acute respiratory distress syndrome[J]. Chin J Gerontol, 2021, 41(1): 62-65., articleTitle=The value of APACHE II and LIPS in the evaluation and prognosis of acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700268335075399, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=1, pageStart=62, pageEnd=65, url=null, language=null, rfNumber=[22], rfOrder=26, authorNames=周笳, 王维秀, 谭效锋, journalName=中国老年学杂志, refType=null, unstructuredReference=[周笳, 王维秀, 谭效锋. APACHE Ⅱ和LIPS在急性呼吸窘迫综合征病情评估及预后判断中的价值[J]. 中国老年学杂志, 2021, 41(1):62-65.], articleTitle=APACHE Ⅱ和LIPS在急性呼吸窘迫综合征病情评估及预后判断中的价值, refAbstract=null), Reference(id=1207700268548984906, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=17, issue=1, pageStart=159, pageEnd=164, url=null, language=null, rfNumber=[23], rfOrder=27, authorNames=Xu B, Ge Y, Lu Y, journalName=Exp Ther Med, refType=null, unstructuredReference=Xu B, Ge Y, Lu Y, et al. Risk factors and prognosis of acute respiratory distress syndrome following abdominal surgery[J]. Exp Ther Med, 2019, 17(1): 159-164., articleTitle=Risk factors and prognosis of acute respiratory distress syndrome following abdominal surgery, refAbstract=null), Reference(id=1207700268670619724, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2019, volume=11, issue=3, pageStart=673, pageEnd=685, url=null, language=null, rfNumber=[24], rfOrder=28, authorNames=Dai Q, Wang S, Liu R, journalName=J Thorac Dis, refType=null, unstructuredReference=Dai Q, Wang S, Liu R, et al. Risk factors for outcomes of acute respiratory distress syndrome patients: A retrospective study[J]. J Thorac Dis, 2019, 11(3): 673-685., articleTitle=Risk factors for outcomes of acute respiratory distress syndrome patients: A retrospective study, refAbstract=null), Reference(id=1207700268813226062, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2015, volume=147, issue=6, pageStart=1539, pageEnd=1548, url=null, language=null, rfNumber=[25], rfOrder=29, authorNames=Calfee CS, Janz DR, Bernard GR, journalName=Chest, refType=null, unstructuredReference=Calfee CS, Janz DR, Bernard GR, et al. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies[J]. Chest, 2015, 147(6): 1539-1548., articleTitle=Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies, refAbstract=null), Reference(id=1207700269111021648, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2004, volume=351, issue=4, pageStart=327, pageEnd=336, url=null, language=null, rfNumber=[26], rfOrder=30, authorNames=Brower RG, Lanken PN, MacIntyre N, journalName=N Engl J Med, refType=null, unstructuredReference=Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome[J]. N Engl J Med, 2004, 351(4):327-336., articleTitle=Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700269236850770, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2002, volume=30, issue=1, pageStart=1, pageEnd=6, url=null, language=null, rfNumber=[27], rfOrder=31, authorNames=The ARDS Chinical Trials Network, National Heart, Lung, and Blood Institute, National Institutes of Health, journalName=Crit Care Med, refType=null, unstructuredReference=The ARDS Chinical Trials Network; National Heart, Lung, and Blood Institute; National Institutes of Health. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome[J]. Crit Care Med, 2002, 30(1): 1-6., articleTitle=Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome, refAbstract=null), Reference(id=1207700269895356500, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=44, issue=5, pageStart=427, pageEnd=434, url=null, language=null, rfNumber=[28], rfOrder=32, authorNames=Huang X, Wu DW, Lu HN, journalName=Chin J Tuberc Respir Dis, refType=null, unstructuredReference=Huang X, Wu DW, Lu HN, et al. Prognosis and related risk factors of acute respiratory distress syndrome in elder patients[J]. Chin J Tuberc Respir Dis, 2021, 44(5): 427-434., articleTitle=Prognosis and related risk factors of acute respiratory distress syndrome in elder patients, refAbstract=null), Reference(id=1207700270474170454, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=5, pageStart=427, pageEnd=434, url=null, language=null, rfNumber=[28], rfOrder=33, authorNames=黄絮, 吴大玮, 卢海宁, journalName=中华结核和呼吸杂志, refType=null, unstructuredReference=[黄絮, 吴大玮, 卢海宁, 等. 老年急性呼吸窘迫综合征患者的预后及影响因素分析[J]. 中华结核和呼吸杂志, 2021, 44(5):427-434.], articleTitle=老年急性呼吸窘迫综合征患者的预后及影响因素分析, refAbstract=null), Reference(id=1207700270633554008, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2015, volume=13, issue=null, pageStart=172, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=34, authorNames=Xue M, Sun Z, Shao M, journalName=J Transl Med, refType=null, unstructuredReference=Xue M, Sun Z, Shao M, et al. Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury[J]. J Transl Med, 2015, 13: 172., articleTitle=Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury, refAbstract=null), Reference(id=1207700270939738202, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=60, issue=7, pageStart=650, pageEnd=655, url=null, language=null, rfNumber=[30], rfOrder=35, authorNames=Yu SH, Ma YT, Li X, journalName=Chin J Intern Med, refType=null, unstructuredReference=Yu SH, Ma YT, Li X. The correlation between coagulation function and prognosis in patients with acute respiratory distress syndrome caused by extrapulmonary sepsis or pulmonary infection[J]. Chin J Intern Med, 2021, 60(7): 650-655., articleTitle=The correlation between coagulation function and prognosis in patients with acute respiratory distress syndrome caused by extrapulmonary sepsis or pulmonary infection, refAbstract=null), Reference(id=1207700271271088220, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, doi=null, pmid=null, pmcid=null, year=2021, volume=null, issue=7, pageStart=650, pageEnd=655, url=null, language=null, rfNumber=[30], rfOrder=36, authorNames=喻思涵, 马宇腾, 李旭, journalName=中华内科杂志, refType=null, unstructuredReference=[喻思涵, 马宇腾, 李旭. 非肺源性脓毒症和肺部感染致急性呼吸窘迫综合征患者凝血指标差异及与预后的相关性[J]. 中华内科杂志, 2021, 60(7): 650-655.], articleTitle=非肺源性脓毒症和肺部感染致急性呼吸窘迫综合征患者凝血指标差异及与预后的相关性, refAbstract=null)], funds=[Fund(id=1207700257182421013, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, awardId=2019YFC0121700, language=EN, fundingSource=National Key Research and Development Program(2019YFC0121700), fundOrder=null, country=null), Fund(id=1207700257610240023, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, awardId=2019YFC0121700, language=CN, fundingSource=国家重点研发项目(2019YFC0121700), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1207700246012990412, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, xref=null, ext=[AuthorCompanyExt(id=1207700246017184718, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China), AuthorCompanyExt(id=1207700246025573326, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, companyId=1207700246012990412, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043)])], figs=[ArticleFig(id=1207700251767575550, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Fig. 1, caption=Multivariate Cox survival analysis of 30-day mortality in patients with non-severe pulmonary ARDS, figureFileSmall=BrwwrnooHwusICeZCxlU2g==, figureFileBig=s05EUhv3O5Sb80qBnim3uA==, tableContent=null), ArticleFig(id=1207700251838878720, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=图1, caption=非重型肺源性ARDS患者30 d死亡的多因素Cox生存分析

APACHE Ⅱ. 急性生理与慢性健康评分Ⅱ；NLR. 中性粒细胞/淋巴细胞比值；PaCO2. 动脉血二氧化碳分压

, figureFileSmall=BrwwrnooHwusICeZCxlU2g==, figureFileBig=s05EUhv3O5Sb80qBnim3uA==, tableContent=null), ArticleFig(id=1207700252031815681, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Fig. 2, caption=ROC curve analysis of APACHE Ⅱ score and NLR in predicting prognosis of non-severe pulmonary ARDS patients, figureFileSmall=CrKk3Foe3ZmBd89uhtty6w==, figureFileBig=aI9/RwQaT+RxusuOSWloAg==, tableContent=null), ArticleFig(id=1207700252329611267, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=图2, caption=APCHE Ⅱ评分、NLR预测非重型肺源性ARDS患者预后的ROC曲线分析

APACHE Ⅱ. 急性生理与慢性健康评分Ⅱ；NLR. 中性粒细胞/淋巴细胞比值

, figureFileSmall=CrKk3Foe3ZmBd89uhtty6w==, figureFileBig=aI9/RwQaT+RxusuOSWloAg==, tableContent=null), ArticleFig(id=1207700252442857476, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Tab. 1, caption=

Comparison of baseline characteristics and clinical indicators of patients with non-severe pulmonary ARDS

, figureFileSmall=null, figureFileBig=null, tableContent=
项目存活组(n=78)死亡组(n=45)P
性别[例(%)]  0.051
 男47(60.3)35(77.8)
 女31(39.7)10(22.2)
年龄[岁，M(Q1, Q3)]66.0(59.0, 75.0)65.0(58.0, 77.0)0.912
吸烟[例(%)]31(39.7)16(35.6)0.703
入院前长期使用糖皮质激素[例(%)]15(19.2)14(31.1)0.185
合并症[例(%)]
 高血压35(44.9)23(51.1)0.575
 2型糖尿病28(35.9)9(20.0)0.070
 呼吸系统疾病25(32.1)19(42.2)0.329
 心脏基础疾病20(25.6)16(35.6)0.304
 恶性肿瘤7(9.0)9(20.0)0.098
 肾功能不全25(32.1)24(53.3)0.023
 深静脉血栓9(11.5)12(26.7)0.046
 休克4(5.1)15(33.3)<0.001
 肝功能异常18(23.1)9(20.0)0.822
心率[次/min, M(Q1, Q3)]88(78, 102)100(81, 109)0.052
平均血压[mmHg, M(Q1, Q3)]93(87, 103)88(83, 102)0.088
体温[℃, M(Q1, Q3)]37.1(36.3, 37.4)37.4(37.2, 37.8)0.045
呼吸频率[次/min, M(Q1, Q3)]22(20, 24)24(20, 30)0.004
APACHE Ⅱ评分(分，$\bar{x}±s$)15.7±4.720.4±3.8<0.001
pH($\bar{x}±s$)7.436±0.0547.442±0.0640.551
PaCO2[mmHg, M(Q1, Q3)]35.5(33.0, 41.4)33.6(29.5, 35.4)0.004
HCO3–[mmol/L, M(Q1, Q3)]25.2(23.5, 27.6)24.6(22.3, 26.1)0.348
PaO2/FiO2(mmHg, $\bar{x}±s$)214±58199±660.177
白细胞计数[×109/L, M(Q1, Q3)]8.05(6.1, 10.9)9.7(7.3, 12.0)0.051
NLR[M(Q1, Q3)]6.5(3.04, 8.80)9.93(8.56, 11.79)<0.001
血小板计数[×109/L, M(Q1, Q3)]213(162, 260)165(119，228)0.006
纤维蛋白原[g/L, M(Q1, Q3)]3.56(2.92, 4.48)4.31(3.79, 4.88)0.039
降钙素原[ng/ml, M(Q1, Q3)]0.1(0.05, 0.68)0.21(0.05, 2.68)0.367
CRP[mg/L, M(Q1, Q3)]42(11, 95)99(33, 120)0.007
白蛋白(g/L, $\bar{x}±s$)31.3±6.128.7±6.00.022
BNP[pg/ml, M(Q1, Q3)]539(40, 2397)658(202, 3263)0.085
), ArticleFig(id=1207700253285912582, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=表1, caption=

非重型肺源性ARDS患者基线资料及临床指标比较

, figureFileSmall=null, figureFileBig=null, tableContent=
项目存活组(n=78)死亡组(n=45)P
性别[例(%)]  0.051
 男47(60.3)35(77.8)
 女31(39.7)10(22.2)
年龄[岁，M(Q1, Q3)]66.0(59.0, 75.0)65.0(58.0, 77.0)0.912
吸烟[例(%)]31(39.7)16(35.6)0.703
入院前长期使用糖皮质激素[例(%)]15(19.2)14(31.1)0.185
合并症[例(%)]
 高血压35(44.9)23(51.1)0.575
 2型糖尿病28(35.9)9(20.0)0.070
 呼吸系统疾病25(32.1)19(42.2)0.329
 心脏基础疾病20(25.6)16(35.6)0.304
 恶性肿瘤7(9.0)9(20.0)0.098
 肾功能不全25(32.1)24(53.3)0.023
 深静脉血栓9(11.5)12(26.7)0.046
 休克4(5.1)15(33.3)<0.001
 肝功能异常18(23.1)9(20.0)0.822
心率[次/min, M(Q1, Q3)]88(78, 102)100(81, 109)0.052
平均血压[mmHg, M(Q1, Q3)]93(87, 103)88(83, 102)0.088
体温[℃, M(Q1, Q3)]37.1(36.3, 37.4)37.4(37.2, 37.8)0.045
呼吸频率[次/min, M(Q1, Q3)]22(20, 24)24(20, 30)0.004
APACHE Ⅱ评分(分，$\bar{x}±s$)15.7±4.720.4±3.8<0.001
pH($\bar{x}±s$)7.436±0.0547.442±0.0640.551
PaCO2[mmHg, M(Q1, Q3)]35.5(33.0, 41.4)33.6(29.5, 35.4)0.004
HCO3–[mmol/L, M(Q1, Q3)]25.2(23.5, 27.6)24.6(22.3, 26.1)0.348
PaO2/FiO2(mmHg, $\bar{x}±s$)214±58199±660.177
白细胞计数[×109/L, M(Q1, Q3)]8.05(6.1, 10.9)9.7(7.3, 12.0)0.051
NLR[M(Q1, Q3)]6.5(3.04, 8.80)9.93(8.56, 11.79)<0.001
血小板计数[×109/L, M(Q1, Q3)]213(162, 260)165(119，228)0.006
纤维蛋白原[g/L, M(Q1, Q3)]3.56(2.92, 4.48)4.31(3.79, 4.88)0.039
降钙素原[ng/ml, M(Q1, Q3)]0.1(0.05, 0.68)0.21(0.05, 2.68)0.367
CRP[mg/L, M(Q1, Q3)]42(11, 95)99(33, 120)0.007
白蛋白(g/L, $\bar{x}±s$)31.3±6.128.7±6.00.022
BNP[pg/ml, M(Q1, Q3)]539(40, 2397)658(202, 3263)0.085
), ArticleFig(id=1207700254825222152, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Tab. 2, caption=

Kaplan-Meier survival analysis of 30-day mortality in patients with non-severe pulmonary ARDS

, figureFileSmall=null, figureFileBig=null, tableContent=
因素Log-rank χ2P
性别3.8220.051
吸烟0.0500.823
长期使用激素2.5390.111
高血压5.4730.065
2型糖尿病4.0320.053
呼吸系统疾病1.1590.282
心脏基础疾病0.8000.371
肿瘤2.9710.085
肾功能不全4.7340.030
深静脉血栓4.6390.031
休克23.714<0.001
肝功能异常0.0630.802
), ArticleFig(id=1207700255605362698, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=表2, caption=

非重型肺源性ARDS患者30 d死亡的Kaplan-Meier生存分析

, figureFileSmall=null, figureFileBig=null, tableContent=
因素Log-rank χ2P
性别3.8220.051
吸烟0.0500.823
长期使用激素2.5390.111
高血压5.4730.065
2型糖尿病4.0320.053
呼吸系统疾病1.1590.282
心脏基础疾病0.8000.371
肿瘤2.9710.085
肾功能不全4.7340.030
深静脉血栓4.6390.031
休克23.714<0.001
肝功能异常0.0630.802
), ArticleFig(id=1207700255710220300, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Tab. 3, caption=

Univariate Cox survival analysis of 30-day mortality in patients with non-severe pulmonary ARDS

, figureFileSmall=null, figureFileBig=null, tableContent=
因素HR95%CIP
年龄0.9440.973~1.0150.576
心率1.0171.002~1.0330.029
平均血压0.9860.965~1.0080.223
体温1.4201.043~1.9320.026
呼吸频率1.0601.022~1.1000.002
pH10.3460.046~23270.398
PaCO20.9270.878~0.9800.007
HCO3~0.9920.927~1.0610.818
PaO2/FiO20.9980.993~1.0020.337
NLR1.0921.049~1.137<0.001
白细胞计数1.0531.008~1.1000.020
血小板计数0.9950.991~0.9990.007
纤维蛋白原1.2211.007~1.4810.043
降钙素原0.9860.963~1.0100.250
CRP1.0081.002~1.0140.006
白蛋白0.9350.888~0.9850.011
BNP1.0001.000~1.0000.097
APACHE Ⅱ评分1.1351.081~1.192<0.001
), ArticleFig(id=1207700255949295630, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=表3, caption=

非重型肺源性ARDS患者30 d死亡的单因素Cox生存分析

, figureFileSmall=null, figureFileBig=null, tableContent=
因素HR95%CIP
年龄0.9440.973~1.0150.576
心率1.0171.002~1.0330.029
平均血压0.9860.965~1.0080.223
体温1.4201.043~1.9320.026
呼吸频率1.0601.022~1.1000.002
pH10.3460.046~23270.398
PaCO20.9270.878~0.9800.007
HCO3~0.9920.927~1.0610.818
PaO2/FiO20.9980.993~1.0020.337
NLR1.0921.049~1.137<0.001
白细胞计数1.0531.008~1.1000.020
血小板计数0.9950.991~0.9990.007
纤维蛋白原1.2211.007~1.4810.043
降钙素原0.9860.963~1.0100.250
CRP1.0081.002~1.0140.006
白蛋白0.9350.888~0.9850.011
BNP1.0001.000~1.0000.097
APACHE Ⅱ评分1.1351.081~1.192<0.001
), ArticleFig(id=1207700256335171600, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=EN, label=Tab. 4, caption=

Predictive efficacy of APACHE Ⅱ score and NLR on non-severe pulmonary ARDS patients

, figureFileSmall=null, figureFileBig=null, tableContent=
因素临界值敏感度特异度阳性预测值阴性预测值准确度约登指数AUC95%CI
APCHE Ⅱ评分16.50.8890.6280.5790.9070.7240.5170.8030.727~0.879
NLR8.130.8440.7050.6230.8870.7560.5490.7720.688~0.856
), ArticleFig(id=1207700256498749458, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1207433496528789759, language=CN, label=表4, caption=

APCHE Ⅱ评分、NLR对非重型肺源性ARDS患者预后的预测效能

, figureFileSmall=null, figureFileBig=null, tableContent=
因素临界值敏感度特异度阳性预测值阴性预测值准确度约登指数AUC95%CI
APCHE Ⅱ评分16.50.8890.6280.5790.9070.7240.5170.8030.727~0.879
NLR8.130.8440.7050.6230.8870.7560.5490.7720.688~0.856
)], attaches=null, journal=Journal(id=1146441329971666965, delFlag=0, nameCn=解放军医学杂志, nameEn=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, issn=0577-7402, eissn=null, cn=11-1056/R, coden=null, periodic=0, language=CN, oaType=是, ccby=CC BY-NC-ND, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=6srot5PcoYX30Oa4xeTmeg==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1751262512917, updatedTime=1761735725513, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=6srot5PcoYX30Oa4xeTmeg==, picEn=ELwBh5xqrSTlIs7HmSNt2Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369167564968109, language=CN, name=解放军医学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725537, updatedTime=1761735725537, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369167615299758, language=EN, name=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725549, updatedTime=1761735725549, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189873630562394117, websiteList=[Website(id=1189873845923287108, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN, language=CN, createTime=1761617631655, createBy=18614031015, updateTime=1761622010471, updateBy=18614031015, name=解放军医学杂志-中文, tplId=1146099689490845704, title=解放军医学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924939378520839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=articleTextType, value=kx, createTime=1761629813284, updateTime=1761629813284, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939353355012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=banner, value=null, createTime=1761629813278, updateTime=1761629813278, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939399492362, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=grayFlag, value=0, createTime=1761629813289, updateTime=1761629813289, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939344966403, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629813276, updateTime=1761629813276, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939412075276, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=minRunFlag, value=0, createTime=1761629813292, updateTime=1761629813292, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939374326534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic, createTime=1761629813283, updateTime=1761629813283, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939407880971, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=silenceFlag, value=0, createTime=1761629813291, updateTime=1761629813291, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939361743621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761629813280, updateTime=1761629813280, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939386909448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeColor, value=null, createTime=1761629813286, updateTime=1761629813286, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939395298057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeStyle, value=null, createTime=1761629813288, updateTime=1761629813288, creator=18614031015, updator=18614031015)]), Website(id=1189873846057504839, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN, language=EN, createTime=1761617631687, createBy=18614031015, updateTime=1761622030030, updateBy=18614031015, name=解放军医学杂志-英文, tplId=1146101810881728533, title=Medical Journal of Chinese People’s Liberation Army, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924968168223505, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=articleTextType, value=kx, createTime=1761629820148, updateTime=1761629820148, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968147251982, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=banner, value=null, createTime=1761629820143, updateTime=1761629820143, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968185000724, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=grayFlag, value=0, createTime=1761629820152, updateTime=1761629820152, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968138863373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629820141, updateTime=1761629820141, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968197583638, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=minRunFlag, value=0, createTime=1761629820155, updateTime=1761629820155, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968159834896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic, createTime=1761629820146, updateTime=1761629820146, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968193389333, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=silenceFlag, value=0, createTime=1761629820154, updateTime=1761629820154, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968155640591, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761629820145, updateTime=1761629820145, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968172417810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeColor, value=null, createTime=1761629820149, updateTime=1761629820149, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968180806419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeStyle, value=null, createTime=1761629820151, updateTime=1761629820151, creator=18614031015, updator=18614031015)])], journalTitle=解放军医学杂志, weixinUrl=null, journalUrl=http://zh.jfjyxzz.org.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Medical Journal of Chinese People’s Liberation Army, journalPhotoCn=6srot5PcoYX30Oa4xeTmeg==, journalPhotoEn=ELwBh5xqrSTlIs7HmSNt2Q==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.2022.08.0795, detailUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.2022.08.0795, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/PDF/10.11855/j.issn.0577-7402.2022.08.0795, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/PDF/10.11855/j.issn.0577-7402.2022.08.0795, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
非重型肺源性急性呼吸窘迫综合征患者的预后影响因素分析
收藏切换
PDF下载
孙伟 , 王晶 *
解放军医学杂志 | 临床研究 2022,47(8): 795-801
收起
收藏切换
解放军医学杂志 | 临床研究 2022, 47(8): 795-801
非重型肺源性急性呼吸窘迫综合征患者的预后影响因素分析
全屏
孙伟, 王晶*
作者信息
  • 首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043

    • 孙伟，医学硕士，主治医师，主要从事急性呼吸窘迫综合征及慢性阻塞性肺疾病的临床研究

通讯作者:

王晶，E-mail：
Analysis of the influencing factors for prognosis of patients with non-severe pulmonary acute respiratory distress syndrome
Wei Sun, Jing Wang*
Affiliations
  • Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital (West Campus), Capital Medical University, Beijing 100043, China
出版时间: 2022-08-28 doi: 10.11855/j.issn.0577-7402.2022.08.0795
文章导航
收藏切换
摘要
收起

目的 分析非重型(轻、中型)肺源性急性呼吸窘迫综合征(ARDS)患者的预后影响因素及其对预后的预测效能。方法 收集2017年1月－2021年6月北京朝阳医院京西院区收治的非重型肺源性ARDS患者123例，根据30 d生存情况分为死亡组(n=45)与存活组(n=78)。比较两组基线资料、合并症、基础疾病、动脉血气、血常规、纤维蛋白原、C反应蛋白(CRP)、降钙素原、白蛋白及脑钠肽(BNP)水平。采用Kaplan-Meier和Cox生存分析探讨非重型肺源性ARDS患者生存状态的影响因素，采用受试者工作特征曲线(ROC)分析影响因素对预后的预测效能。结果 与存活组比较，死亡组患者出现肾功能不全、深静脉血栓及休克的比例增高，APACHE Ⅱ评分、体温、呼吸频率、中性粒细胞/淋巴细胞比值(NLR)以及纤维蛋白原、CRP水平增高，动脉血二氧化碳分压(PaCO2)、血小板计数和白蛋白水平降低(P<0.05)。Kaplan-Meier生存分析显示，肾功能不全、深静脉血栓及休克是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05)。单因素Cox生存分析显示，心率、体温、呼吸频率、PaCO2、NLR、白细胞计数、血小板计数、纤维蛋白原、CRP、白蛋白及APACHEⅡ评分是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05)。多因素Cox生存分析显示，高APACHE Ⅱ评分(HR=1.094，95%CI 1.009~1.120，P=0.031)、高NLR(HR=1.087，95%CI 1.012~1.167，P=0.021)及病程中出现休克(HR=3.135，95%CI 1.315~6.964，P=0.010)是非重型肺源性ARDS患者30 d死亡的独立危险因素。APACHE Ⅱ评分及NLR预测非重型肺源性ARDS患者30 d死亡的临界值分别为16.5分、8.13，曲线下面积(AUC)分别为0.803(95%CI 0.727~0.879)、0.772(95%CI 0.688~0.856)。结论 APACHEⅡ评分>16.5分、NLR>8.13及出现休克是非重型肺源性ARDS患者死亡的独立危险因素，这些因素对于该类患者的预后有较高的预测效能。

急性呼吸窘迫综合征  /  预后  /  病死率  /  中性粒细胞/淋巴细胞比值  /  休克

Objective To investigate the influencing factors for prognosis in non-severe (mild to moderate) pulmonary acute respiratory distress syndrome (ARDS) patients, and evaluate the efficacy of the risk factors to predict the prognosis. Methods The data of 123 patients with non-severe pulmonary ARDS, hospitalized in the Department of Respiratory and Critical Care Medicine of Beijing Chaoyang Hospital (West Campus) from January 2017 to June 2021, were retrospectively enrolled, and divided into two groups according to 30-day survival condition, i.e., non-survivor group (n=45) and survivor group (n=78). Baseline characteristics, complications, arterial blood gas, blood routine, and levels of fibrinogen, C-reactive protein (CRP), procalcitonin,albumin and brain natriuretic peptide (BNP) were compared between the two groups. Kaplan-Meier and Cox survival analysis were adopted to analyze the risk factors which could affect the survival situation of patients with non-severe pulmonary ARDS.ROC curves were used to assess the efficacy of the risk factors to predict prognosis. Results Compared with survivor group, the proportion of patients with renal insufficiency, deep venous thrombosis and shock, APACHE Ⅱ score, body temperature, respiratory rate, neutrophil to lymphocyte ratio (NLR), fibrinogen and CRP levels in non-survivor group increased, and arterial partial pressure of carbon dioxide (PaCO2), platelet count and albumin levels decreased (P<0.05). Kaplan-Meier survival analysis showed that kidney failure, deep venous thrombosis and shock were the risk factors of 30-day death in patients with non-severe pulmonary ARDS (P<0.05). Univariate Cox analysis demonstrated that heart rate, temperature, respiratory rate, PaCO2, NLR, WBC, platelet count, fibrinogen, CRP, albumin and APACHE Ⅱ score were the risk factors of 30-day death in patients with non-severe pulmonary ARDS (P<0.05). Multivariate Cox analysis showed that higher APACHE Ⅱ score (HR=1.094, 95%CI 1.009-1.120, P=0.031), higher NLR (HR=1.087, 95%CI 1.012-1.167, P=0.021) and the presence of shock presented during course (HR=3.135, 95%CI 1.315-6.964, P=0.010) were independent risk factors for 30-day death of patients with non-severe pulmonary ARDS. The cut-off value of APACHE Ⅱ score and NLR in predicting mortality were 16.5 and 8.13, and the area under the curve (AUC) were 0.803 (95%CI 0.727-0.879) and 0.772 (95%CI 0.688-0.856), respectively. Conclusions APACHE Ⅱ score >16.5, NLR >8.13 and presence of shock were the independent risk factors of mortality for patients with non-severe pulmonary ARDS, and these factors could effectively predict prognosis.

acute respiratory distress syndrome  /  prognosis  /  mortality  /  neutrophil to lymphocyte ratio  /  shock
孙伟, 王晶. 非重型肺源性急性呼吸窘迫综合征患者的预后影响因素分析. 解放军医学杂志, 2022 , 47 (8) : 795 -801 . DOI: 10.11855/j.issn.0577-7402.2022.08.0795
Wei Sun, Jing Wang. Analysis of the influencing factors for prognosis of patients with non-severe pulmonary acute respiratory distress syndrome[J]. Medical Journal of Chinese People’s Liberation Army, 2022 , 47 (8) : 795 -801 . DOI: 10.11855/j.issn.0577-7402.2022.08.0795
正文
收起
急性呼吸窘迫综合征(acute respiratory distress syndrome，ARDS)本质上为炎症反应引起的肺损伤，主要表现为肺血管通透性增加、通气肺组织减少及肺实质重量增加[1-3]。尽管ARDS的病理生理机制及治疗研究取得了一些进展，如肺保护性通气策略、俯卧位通气等[4]，但其病死率仍居高不下[5]。大型流行病学调查显示，轻、中、重型ARDS的病死率均较高，分别为34.9%、40.3%、46.1%[6]。因此，对影响ARDS患者预后的因素进行研究显的尤为重要，如何快速准确地利用临床上较为容易获取的数据评估预后成为新的研究方向。有研究发现，血清Clara细胞分泌蛋白16(Clara cells 16，CC16)和可溶性晚期糖基化终产物受体(soluble receptor for advanced glycation end products，sRAGE)对ARDS的诊断及预后评估具有一定价值[7]，但其在临床上不易获得且检测价格昂贵。既往研究发现，影响ARDS病死率的因素包括氧合指数、有创机械通气时的平台压[8]、影像学改变[9]、高血糖[10]等。影响预后的因素不尽相同，也许与引起ARDS的潜在因素不同有关，有研究发现，肺源性与肺外源性ARDS的病理生理机制有明显区别，二者在体内炎症反应[11]、肺组织病理学及呼吸力学特点等方面都存在异质性[12]。此外，不同严重程度的ARDS患者对同一治疗手段的反应亦不同[13]。本研究分析非重型肺源性ARDS患者预后的影响因素，以期为临床医师提供一种准确、简单、易行的预后判断方法。
1 资料与方法
收起
1.1 研究对象
本研究为回顾性研究。收集2017年1月－2021年6月北京朝阳医院京西院区收治的非重型肺源性ARDS患者123例，其中男82例，女41例；轻型ARDS 68例，中型ARDS 55例；ARDS的原因均为肺部感染。根据30 d生存情况分为死亡组(n=45)与存活组(n=78)。纳入标准：(1)年龄≥18岁；(2)出院诊断包括肺炎、Ⅰ型呼吸衰竭(氧合指数100~300 mmHg)；(3)入院24 h内检查胸部CT；(4)符合ARDS诊断标准(发病时间≤1周；胸部影像学表现为双肺渗出影；肺渗出影不能用液体负荷过重或左心衰竭解释)；(5)病历资料完整。排除标准：(1)ARDS并非由肺部原发病引起；(2)合并严重的间质性肺疾病、慢性阻塞性肺疾病、支气管扩张等基础肺疾病；(3)合并严重心脑血管疾病、肝肾疾病或器官衰竭、恶性肿瘤。本研究通过北京朝阳医院医学伦理学委员会批准(2021-科-460)。
1.2 治疗方法
患者入院后均接受胸部CT检查，根据病情给予抗感染、适当的氧疗措施(包括氧疗、高流量吸氧、无创呼吸机，根据患者情况选用)以及其他对症治疗(如复苏抗休克、纠正脏器功能不全、营养支持、维持内环境稳定等综合治疗)。入院24 h检测血常规、C反应蛋白(CRP)、降钙素原、纤维蛋白原、白蛋白、脑钠肽(brain natriuretic peptide，BNP)及动脉血气等，并计算外周血中性粒细胞/淋巴细胞比值(NLR)和氧合指数(PaO2/FiO2)。
1.3 临床观察指标
收集患者的基线资料(包括年龄、性别、入院时APACHE Ⅱ评分等)，合并症(包括深静脉血栓、肾衰竭、休克、肝功能异常等)，基础疾病(包括入院前是否使用糖皮质激素、高血压、2型糖尿病、呼吸系统疾病、心脏基础疾病、恶性肿瘤等)，以及入院时生命体征(包括心率、血压、体温及脉搏等)。记录病程中是否出现深静脉血栓、肾功能不全及休克等情况。
1.4 观察时间
观察时间为30 d，主要终点事件为死亡。若患者在第30天时仍未出院，则在医院观察生存状态；若患者在第30天已经出院，则电话联系患者或家属确定其生存状态。
1.5 ARDS患者生存状态的影响因素分析
使用Kaplan-Meier法绘制生存曲线，采用log-rank检验评估生存曲线的差异。采用Cox比例风险回归模型分析影响患者生存状态的危险因素。将单因素分析中有统计学差异的指标及有临床意义的指标纳入多因素Cox生存分析。
1.6 影响因素对ARDS患者预后的预测效能分析
采用ROC曲线评估上述影响因素对ARDS患者预后的预测效能，计算ROC曲线下面积(area under the curve，AUC)及临界值，以AUC>0.5为具有诊断价值。
1.7 统计学处理
采用SPSS 21.0软件进行统计分析，GraphPad Prism 7软件绘图。符合正态分布的连续变量以$\bar{x}±s$表示，两组间比较采用t检验；不符合正态分布的连续变量以M(Q1，Q3)表示，两组间比较采用Mann–Whitney U检验。分类变量以例(%)表示，两组间比较采用χ2检验。P<0.05为差异有统计学意义。
2 结果
收起
2.1 两组基线资料及临床指标比较
观察30 d，死亡45例，存活78例，病死率为36.6%。两组性别、年龄，吸烟、入院前长期使用糖皮质激素比例，心率、平均血压、pH、HCO3–、PaO2/FiO2、白细胞计数、降钙素原、BNP水平比较，差异均无统计学意义(P>0.05)。在合并症方面，死亡组患者出现肾功能不全、深静脉血栓及休克的比例高于存活组(P<0.05)。与存活组比较，死亡组患者入院时体温较高(P=0.045)、呼吸频率较快(P=0.004)。在临床指标方面，死亡组患者APACHE Ⅱ评分、NLR及纤维蛋白原、CRP水平均高于存活组(P<0.05)，动脉血二氧化碳分压(PaCO2)、血小板计数及白蛋白水平均低于存活组(P<0.05)(表1)。
2.2 非重型肺源性ARDS患者生存状态的影响因素分析
Kaplan-Meier生存分析显示，肾功能不全、深静脉血栓及休克是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05，表2)。
单因素Cox生存分析显示，心率、体温、呼吸频率、PaCO2、NLR、白细胞计数、血小板计数、纤维蛋白原、CRP、白蛋白及APACHE Ⅱ评分是非重型肺源性ARDS患者30 d死亡的危险因素(P<0.05，表3)。多因素Cox生存分析显示，高APACHE Ⅱ评分(HR=1.094，95%CI 1.009~1.120，P=0.031)、高NLR (HR=1.087，95%CI 1.012~1.167，P=0.021)及病程中出现休克(HR=3.135，95%CI 1.315~6.964，P=0.010)是非重型肺源性ARDS患者30 d死亡的独立危险因素(图1)。
2.3 APACHE Ⅱ评分、NLR对非重型肺源性ARDS预后的预测效能
ROC曲线分析结果显示，APACHE Ⅱ评分、NLR预测非重型肺源性ARDS患者30 d死亡的截断值分别为16.5分、8.13，曲线下面积(AUC)分别为0.803(95%CI 0.727~0.879，P<0.001)和0.772(95%CI 0.688~0.856，P<0.001) (图2、表4)。
3 讨论
收起
ARDS病死率高、治疗手段有限，且轻、中型ARDS可进展为重型，致使病死率进一步增高。因此，准确简便地评估病情、找到与预后相关的因素，并给予相应的治疗措施是降低ARDS病死率、改善预后的关键。本研究以非重型肺源性ARDS患者为研究对象，发现休克、NLR>8.13、APACHE Ⅱ评分>16.5分是其30 d死亡的独立危险因素。因此，对于初始NLR高、APACHE Ⅱ评分高，且病程中出现休克的患者，应给予充分的重视及积极的救治以降低病死率。
作为一个炎症指标，NLR已被证实与多种疾病的预后相关[14-16]。Wang等[17]发现，NLR>14是ARDS患者死亡的独立影响因素，较本研究中NLR临界值高，分析原因可能是其研究纳入的ARDS患者不单是肺源性的，还包括肺外因素引起的ARDS。另外，该研究纳入患者的氧合指数为126 mmHg，明显低于本研究的数值(存活组氧合指数为214 mmHg、死亡组为199 mmHg)，提示NLR越高，ARDS患者体内炎症反应越重，氧合指数可能越低。Li等[18]发现，高NLR是ARDS患者死亡的独立危险因素。中性粒细胞与感染密切相关，任何部位的感染都可诱发骨髓释放大量中性粒细胞[19]，中性粒细胞计数越高提示感染程度越重、病死率可能越高。此外，中性粒细胞是ARDS病程中首先被募集到炎症部位的白细胞[20]，被募集后通过释放氧自由基、多种蛋白酶及形成细胞外网的方式执行抗菌功能，但不可控的中性粒细胞过度活化会对局部组织造成严重损伤[21]，如肺毛细血管的通透性增加等，从而加重缺氧。本研究死亡组缺氧程度较存活组严重[氧合指数(199±66) mmHg vs.(214±58) mmHg]，虽然无统计学差异，但也提示死亡患者的组织损伤较存活者严重。
APACHE Ⅱ评分被广泛用于重症患者的评估。国内的ARDS相关研究发现，APACHE Ⅱ评分在存活组与死亡组ARDS患者间差异明显[22]。既往研究发现，腹腔手术后继发ARDS与未发生ARDS的患者APACHE Ⅱ评分差异明显，且是预测ARDS患者死亡的独立危险因素[23]。此外，一项纳入207例ARDS(包括肺源性和肺外源性ARDS)患者的研究发现，APACHE Ⅱ评分也是影响ARDS患者生存状态的独立危险因素[24]。本研究发现，APACHE Ⅱ评分是影响非重型肺源性ARDS患者生存状态的独立危险因素。肺源性和肺外源性ARDS均以肺上皮细胞及肺血管内皮细胞受损为主要特征，这些上皮细胞及内皮细胞受损可导致肺毛细血管通透性增加，使肺局部产生的炎性因子更多地进入到循环血中，从而引起全身不良反应[25]，进而引起APACHE Ⅱ评分升高。
国外大型研究发现，ARDS可大致分为高炎症反应和低炎症反应，高炎症反应患者出现低血压或使用血管活性药物的比例较高，且病死率明显高于低炎症反应患者[26-27]。本研究结果显示，死亡组患者的NLR及CRP水平均高于存活组，提示死亡组患者体内炎症反应较存活组严重；死亡组患者出现休克的比例及病死率高于存活组，与国外大型研究结果[26]一致。另有研究发现，休克是高龄ARDS患者死亡的独立危险因素[28]，该研究纳入患者的年龄为65岁以上，而本研究纳入的两组患者的中位年龄分别为66岁和65岁，与上述研究相仿。
除以上三个独立影响生存状态的因素外，还有一些指标值得注意。本研究结果显示，发生深静脉血栓是死亡的危险因素，且死亡组患者的血小板计数明显低于存活组，纤维蛋白原水平明显高于存活组，提示非重型ARDS患者体内的凝血功能被异常激活。既往有研究发现，ARDS患者外周血组织因子水平高于非ARDS患者，而组织因子是最强的外源性凝血激活因子[29]。本研究虽未测定组织因子水平，但死亡组发生深静脉血栓的比例较高且凝血系统异常激活，与既往研究结果[29]一致。另有研究发现，非肺源性ARDS患者的凝血功能紊乱较肺源性ARDS患者明显[30]。
综上所述，对于非重型肺源性ARDS患者，高APACHE Ⅱ评分(>16.5分)、高NLR(>8.13)以及病程中出现休克是其死亡的独立危险因素。由于缺乏特异的治疗手段，ARDS患者的病死率仍居高不下，准确快捷地识别死亡危险因素有助于改善ARDS的预后。因此，早期评估、密切观察病情变化有利于预后评估，而根据病情及时调整治疗方案可改善患者的临床结局。本研究的不足之处为单中心回顾性研究，样本量较小，未来仍需通过大样本、多中心前瞻性研究进一步探讨影响非重型肺源性ARDS患者生存状态的因素。
基金
收起
  • 国家重点研发项目(2019YFC0121700)
文献
收起
参考文献 引证文献
排序方式：
[1]
Pham T, Rubenfeld GD. Fifty years of research in ARDS. The epidemiology of acute respiratory distress syndrome. A 50th birthday review[J]. Am J Respir Crit Care Med, 2017, 195(7):860-870.
[2]
Zhang RH, Xia JG, Zhan QY. Research progress on risk factors and predictive scores of sepsis patients developing into acute respiratory distress syndrome[J]. Med J Chin PLA, 2020, 45(12): 1309-1314.
[张芮豪, 夏金根, 詹庆元. 脓毒症并发急性呼吸窘迫综合征的危险因素及预测评分研究进展[J]. 解放军医学杂志, 2020, 45(12): 1309-1314.]
[3]
Zheng GL, Ding JC, Li XF, et al. Application of mobile extracorporeal membrane oxygenation in inter-hospital transport of pediatric acute respiratory distress syndrome: retrospective studies for 7 case[J]. Med J Chin PLA, 2020, 45(4): 435-440.
[郑贵浪, 丁家畅, 李旭锋, 等. 移动体外膜肺氧合在小儿急性呼吸窘迫综合征院际转运中的应用：7例回顾性病例研究[J]. 解放军医学杂志, 2020, 45(4): 435-440.]
[4]
Fan E, Brodie D, Slutsky AS. Acute respiratory distress syndrome: Advances in diagnosis and treatment[J]. JAMA, 2018, 319(7): 698-710.
[5]
Yadav H, Thompson BT, Gajic O. Fifty years of research in ARDS. Is acute respiratory distress syndrome a preventable disease?[J]. Am J Respir Crit Care Med, 2017, 195(6): 725-736.
[6]
Bellani G, Laffey JG, Pham T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries[J]. JAMA, 2016, 315(8): 788-800.
[7]
Gao Y, Li J. Significance of combined application of biomarkers in the diagnosis and prognosis assessment of patients with acute respiratory distress syndrome[J]. Chin Crit Care Med, 2021, 33(1): 69-73.
[高杨, 李军. 生物标志物联合应用在急性呼吸窘迫综合征患者诊断及预后评估中的意义[J]. 中华危重病急救医学, 2021, 33(1): 69-73.]
[8]
Villar J, Pérez-Méndez L, Basaldúa S, et al. A risk tertiles model for predicting mortality in patients with acute respiratory distress syndrome: age, plateau pressure, and PaO2/FiO2 at ARDS onset can predict mortality[J]. Respir Care, 2011, 56(4): 420-428.
[9]
Kotok D, Yang L, Evankovich JW, et al. The evolution of radiographic edema in ARDS and its association with clinical outcomes: A prospective cohort study in adult patients[J]. J Crit Care, 2020, 56: 222-228.
[10]
Li X, Yu J, Huang W, et al. Risk factors analysis of acute respiratory distress syndrome in intensive care unit traumatic patients[J]. Chin Crit Care Med, 2018, 30(10): 978-982.
[11]
Yang Q, Yan CS, Wang YF, et al. Serial changes in biomarkers in pulmonary and extrapulmonary acute respiratory distress syndrome[J]. Chin Med J, 2019, 99(36): 2816-2819.
[12]
Gattinoni L, Pelosi P, Suter PM, et al. Acute respiratory distress syndrome caused by pulmonary and extrapulmonary disease. Different syndromes?[J]. Am J Respir Crit Care Med, 1998, 158(1): 3-11.
[13]
Cavalcanti AB, Suzumura ÉA, Laranjeira LN, et al. Effect of lung recruitment and titrated positive end-expiratory pressure (PEEP)vs low PEEP on mortality in patients with acute respiratory distress syndrome: A randomized clinical trial[J]. JAMA, 2017, 318(14): 1335-1345.
[14]
Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis[J]. Am J Emerg Med, 2020, 38(3): 641-647.
[15]
Ferro D, Matias M, Neto J, et al. Neutrophil-to-lymphocyte ratio predicts cerebral edema and clinical worsening early after reperfusion therapy in stroke[J]. Stroke, 2021, 52(3): 859-867.
[16]
Mao WJ, Yin C, Li B, et al. Predictive value of preoperative inflammatory immune and nutritional indicators for the prognosis of patients with thymoma[J]. Med J Chin PLA, 2021, 46(11): 1104-1111.
[毛文杰, 尹泚, 李斌, 等. 术前炎症免疫及营养指标对胸腺瘤患者预后的预测价值[J]. 解放军医学杂志, 2021, 46(11): 1104-1111.]
[17]
Wang Y, Ju M, Chen C, et al. Neutrophil-to-lymphocyte ratio as a prognostic marker in acute respiratory distress syndrome patients: a retrospective study[J]. J Thorac Dis, 2018, 10(1):273-282.
[18]
Li W, Ai X, Ni Y, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in patients with acute respiratory distress syndrome: A retrospective cohort study[J]. Shock, 2019, 51(2): 161-167.
[19]
Silvestre-Roig C, Fridlender ZG, Glogauer M, et al. Neutrophil diversity in health and disease[J]. Trends Immunol, 2019, 40(7):565-583.
[20]
Song C, Li H, Mao Z, et al. Delayed neutrophil apoptosis may enhance NET formation in ARDS[J]. Respir Res, 2022, 23(1):155.
[21]
Song C, Li H, Li Y, et al. NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization[J]. Exp Cell Res, 2019, 382(2): 111486.
[22]
Zhou J, Wang WX, Tan XF. The value of APACHE II and LIPS in the evaluation and prognosis of acute respiratory distress syndrome[J]. Chin J Gerontol, 2021, 41(1): 62-65.
[周笳, 王维秀, 谭效锋. APACHE Ⅱ和LIPS在急性呼吸窘迫综合征病情评估及预后判断中的价值[J]. 中国老年学杂志, 2021, 41(1):62-65.]
[23]
Xu B, Ge Y, Lu Y, et al. Risk factors and prognosis of acute respiratory distress syndrome following abdominal surgery[J]. Exp Ther Med, 2019, 17(1): 159-164.
[24]
Dai Q, Wang S, Liu R, et al. Risk factors for outcomes of acute respiratory distress syndrome patients: A retrospective study[J]. J Thorac Dis, 2019, 11(3): 673-685.
[25]
Calfee CS, Janz DR, Bernard GR, et al. Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies[J]. Chest, 2015, 147(6): 1539-1548.
[26]
Brower RG, Lanken PN, MacIntyre N, et al. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome[J]. N Engl J Med, 2004, 351(4):327-336.
[27]
The ARDS Chinical Trials Network; National Heart, Lung, and Blood Institute; National Institutes of Health. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome[J]. Crit Care Med, 2002, 30(1): 1-6.
[28]
Huang X, Wu DW, Lu HN, et al. Prognosis and related risk factors of acute respiratory distress syndrome in elder patients[J]. Chin J Tuberc Respir Dis, 2021, 44(5): 427-434.
[黄絮, 吴大玮, 卢海宁, 等. 老年急性呼吸窘迫综合征患者的预后及影响因素分析[J]. 中华结核和呼吸杂志, 2021, 44(5):427-434.]
[29]
Xue M, Sun Z, Shao M, et al. Diagnostic and prognostic utility of tissue factor for severe sepsis and sepsis-induced acute lung injury[J]. J Transl Med, 2015, 13: 172.
[30]
Yu SH, Ma YT, Li X. The correlation between coagulation function and prognosis in patients with acute respiratory distress syndrome caused by extrapulmonary sepsis or pulmonary infection[J]. Chin J Intern Med, 2021, 60(7): 650-655.
[喻思涵, 马宇腾, 李旭. 非肺源性脓毒症和肺部感染致急性呼吸窘迫综合征患者凝血指标差异及与预后的相关性[J]. 中华内科杂志, 2021, 60(7): 650-655.]
2022年第47卷第8期
PDF下载
87
32
引用本文
BibTeX
文章信息
doi: 10.11855/j.issn.0577-7402.2022.08.0795
  • 接收时间：2021-12-28
  • 首发时间：2025-12-15
  • 出版时间：2022-08-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2021-12-28
  • 录用日期：2022-03-17
基金
National Key Research and Development Program(2019YFC0121700)
国家重点研发项目(2019YFC0121700)
作者信息
    首都医科大学附属北京朝阳医院京西院区呼吸与危重症医学科，北京 100043

通讯作者:

王晶，E-mail：
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.2022.08.0795
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持