Article(id=1203057886839664862, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2023.02.0132, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1655395200000, receivedDateStr=2022-06-17, revisedDate=null, revisedDateStr=null, acceptedDate=1663344000000, acceptedDateStr=2022-09-17, onlineDate=1764760951956, onlineDateStr=2025-12-03, pubDate=1677513600000, pubDateStr=2023-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1764760951956, onlineIssueDateStr=2025-12-03, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1764760951956, creator=13701087609, updateTime=1764760951956, updator=13701087609, issue=Issue{id=1203057879566737430, tenantId=1146029695717560320, journalId=1189873630562394117, year='2023', volume='48', issue='2', pageStart='123', pageEnd='244', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1764760950222, creator=13701087609, updateTime=1764762101198, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1203062707223241334, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1203062707223241335, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=132, endPage=137, ext={EN=ArticleExt(id=1203057887204569320, articleId=1203057886839664862, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Analysis of clinical hot issues of chronic hepatitis B, columnId=1190669170040783872, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Expert Review, runingTitle=null, highlight=null, articleAbstract=

Chronic hepatitis B virus infection is prevalent worldwide, and can progress to liver cirrhosis and even hepatocellular carcinoma if left untreated. Over the past 20 years, due to the approval and upgrading of nucleoside/nucleotide analogues, a qualitative leap has been made in inhibiting HBV replication. Most chronic hepatitis B (CHB) patients can achieve relief of hepatocellular inflammation, regression of hepatic fibrosis, improvement of life quality and survival time. With the extension of treatment time and the enrichment of treatment experience, new hot clinical issues gradually emerge, including the clinical application of new serum markers, the expansion of indicators for CHB antiviral treatment, the formation of CHB treatment plan and the improvement of long-term prognosis, which derserve further clinical attention.

, correspAuthors=Yong-Ping Yang, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Dong Ji, Yong-Ping Yang), CN=ArticleExt(id=1203057887514947829, articleId=1203057886839664862, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=慢性乙型肝炎临床热点问题解析, columnId=1190669170267275266, journalTitle=解放军医学杂志, columnName=专家述评, runingTitle=null, highlight=null, articleAbstract=

乙型肝炎病毒慢性感染呈世界性流行态势，如不及时治疗，可持续进展至肝硬化甚至肝细胞癌。近20年来，由于核苷（酸）类似物的上市及更新换代，在抑制乙肝病毒复制方面取得了质的飞跃，大多数慢性乙型肝炎（CHB）患者均可实现减轻肝细胞炎症及纤维化、改善生活质量、延长生存时间等目标。随着治疗时间的延长及治疗经验的积累，新的热点问题逐渐浮现，包括新型血清学标志物在临床的应用，CHB抗病毒治疗适应证的扩大、CHB治疗方案的制定以及长期预后的改善等，值得临床进一步关注。

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纪冬，主任医师，副教授，主要从事病毒性肝炎、肝硬化等方面的临床与基础研究

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纪冬，主任医师，副教授，主要从事病毒性肝炎、肝硬化等方面的临床与基础研究

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杨永平，主任医师，教授，博士研究生导师，解放军总医院第五医学中心肝病医学部主任。中国研究型医院学会肝病专业委员会主任委员，中国肝炎基金会专家委员会理事，中华医学会北京分会肝病专业委员会副主任委员。牵头国家“十三五”及“十二五”重大专项课题，军队“十二五”重点课题和北京市科委军民融合重点课题多项；享受国务院政府特殊津贴；获国家科技进步奖1项，北京市科学技术进步一等奖1项，军队科技进步二等奖6项

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