Article(id=1203057885212274888, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2023.02.0190, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1636905600000, receivedDateStr=2021-11-15, revisedDate=null, revisedDateStr=null, acceptedDate=1641657600000, acceptedDateStr=2022-01-09, onlineDate=1764760951568, onlineDateStr=2025-12-03, pubDate=1677513600000, pubDateStr=2023-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1764760951568, onlineIssueDateStr=2025-12-03, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1764760951568, creator=13701087609, updateTime=1764760951568, updator=13701087609, issue=Issue{id=1203057879566737430, tenantId=1146029695717560320, journalId=1189873630562394117, year='2023', volume='48', issue='2', pageStart='123', pageEnd='244', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1764760950222, creator=13701087609, updateTime=1764762101198, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1203062707223241334, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1203062707223241335, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203057879566737430, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=190, endPage=197, ext={EN=ArticleExt(id=1203057886206324944, articleId=1203057885212274888, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effect and mechanism of ZCCHC12 on epithelial-mesenchymal transition and invasion in differentiated thyroid cancer cells, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the effect and mechanism of ZCCHC12 on epithelial-mesenchymal transition and invasion of differentiated thyroid cancer cells. Methods A total of 50 patients with differentiated thyroid adenocarcinoma admitted to Hebei General Hospital from May 2017 to December 2018 were selected, and set as differentiated thyroid cancer group. In addition, 50 subjects for healthy examination in the hospital during the same period were selected as the healthy control group.The contents of PKA/cAMP response element binding protein (CREB) and p21 in serum was detected by ELISA. Western blotting was used to detect the relative expressions of CREB and p21 in HUM-CELL-0097, TPC-1 and FTC-133 cell lines. TPC-1 cells and FTC-133 cells were taken and set up blank control group (normally cultured), NC si group (transfected with non-specific siRNA),and ZCCHC12 si group (transfected with ZCCHC12 siRNA), ZCCHC12 si+NC pc group (transfected with ZCCHC12 siRNA followed by the transfection with pcDNA.3.1), ZCCHC12 si+CREB pc group (transfected with ZCCHC12 siRNA followed by the transfection with pcDNA.3.1-CREB), ZCCHC12 si+NC si group (transfected with ZCCHC12 siRNA followed by the transfection with non-specific siRNA), ZCCHC12 si+p21 si group (transfected with ZCCHC12 siRNA followed by the transfection with p21 siRNA). Western blotting was performed to detect the relative expressions of ZCCHC12, CREB, P21, E-cadherin and N-cadherin proteins. Transwell method was used to detect the cell invasion ability. Results Compared with healthy control group, the serum content of CREB increased (P<0.05), and of p21 decreased (P<0.01) in differentiated thyroid cancer group. Compared with HUM-CELL-0097 cells, the content of CREB increased (P<0.01), and of p21 decreased (P<0.01) in TPC-1 and FTC-133 cells. Compared with NC si group, the relative expressions of E-cadherin and p21 protein increased, while the relative protein expressions of CREB and N-cadherin and the number of cell migration decreased (P<0.01) in ZCCHC12 si group. The expression of p21 protein in ZCCHC12 si+CREB pc group was lower than that in ZCCHC12 si+NC pc group (P<0.01), which reversed the promoting effect of interfering ZCCHC12 on p21 protein expression. Compared with ZCCHC12 si+NC si group, the relative expression of E-cadherin protein significantly decreased, while the relative expression of N-cadherin protein and the number of cell migration were significantly increased (P<0.01) in the ZCCHC12 si+p21 si group, which reversed the inhibitory effect of ZCCHC12 interference on the epithelial-mesenchymal transition and invasive capacity in differentiated thyroid cancer cells. Conclusions Interfering with ZCCHC12 can effectively inhibit the epithelial-mesenchymal transition and invasion of differentiated thyroid cancer cells by regulating CREB and p21, providing a certain theoretical basis for the treatment of differentiated thyroid cancer.

, correspAuthors=Lian-Chun Zhao, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Guang-Xia Liu, Fang Chen, Ya-Min Lu, Li-Xia Niu, Zhan Hou, Lian-Chun Zhao), CN=ArticleExt(id=1203057887640776957, articleId=1203057885212274888, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=ZCCHC12对分化型甲状腺癌细胞上皮-间质转化和侵袭的作用及其机制, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨ZCCHC12对分化型甲状腺癌细胞上皮-间质转化和侵袭的作用及其机制。方法 选取2017年5月-2018年12月河北省人民医院收治的50例分化型甲状腺腺癌患者作为分化型甲状腺癌组，另选取该院同期50名健康体检者作为健康对照组。采用ELISA法检测血清中PKA/cAMP反应元素结合蛋白（CREB）和p21的含量。采用Western blotting检测HUM-CELL-0097、TPC-1和FTC-133细胞系中CREB和p21蛋白的相对表达量。取TPC-1细胞和FTC-133细胞，分别设置空白对照组（正常培养TPC-1或FTC-133细胞）、NC si组（转染non-specific siRNA）、ZCCHC12 si组（转染ZCCHC12 siRNA）、ZCCHC12 si+NC pc组（转染ZCCHC12 siRNA后，转染pcDNA.3.1）、ZCCHC12 si+CREB pc组（转染ZCCHC12 siRNA后，转染pcDNA.3.1-CREB）、ZCCHC12 si+NC si组（转染ZCCHC12 siRNA后，转染non-specific siRNA）、ZCCHC12 si+p21 si组（转染ZCCHC12 siRNA后，转染p21 siRNA），采用Western blotting检测ZCCHC12、CREB、P21、E-cadherin和N-cadherin蛋白的相对表达量，Transwell实验检测细胞侵袭能力。结果 与健康对照组比较，分化型甲状腺癌组血清中CREB含量升高（P<0.05），p21含量降低（P<0.01）。与HUM-CELL-0097细胞比较，TPC-1和FTC-133细胞中CREB含量升高（P<0.01），p21含量降低（P<0.01）。与NC si组比较，ZCCHC12 si组E-cadherin、p21蛋白相对表达量升高，CREB、N-cadherin蛋白相对表达量及细胞迁移数降低（P<0.01）。ZCCHC12 si+CREB pc组p21蛋白相对表达量较ZCCHC12 si+NC pc组降低（P<0.01），逆转了干扰ZCCHC12对p21蛋白表达的促进作用。与ZCCHC12 si+NC si组比较，ZCCHC12 si+p21 si组E-cadherin蛋白相对表达量明显下降，N-cadherin蛋白相对表达量及细胞迁移数明显升高（P<0.01），逆转了干扰ZCCHC12对分化型甲状腺癌细胞上皮-间质转化和侵袭能力的抑制作用。结论 干扰ZCCHC12可通过CREB/p21信号通路有效抑制分化型甲状腺癌细胞的上皮-间质转化和侵袭，为分化型甲状腺癌的治疗提供了一定的理论基础。

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刘光霞，硕士研究生，主要从事甲状腺检验诊断方面的研究

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刘光霞，硕士研究生，主要从事甲状腺检验诊断方面的研究

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CREB. 环磷腺苷效应元件结合蛋白；A. ELISA检测患者血清CREB、p21含量；B. Western blotting检测细胞系中CREB、p21蛋白相对表达量；与健康对照组比较，(1)P<0.05，(2)P<0.01；与HUM-CELL-0097细胞比较，(3)P<0.01

, figureFileSmall=PUPfPDx4iRSpknxo1iJuFQ==, figureFileBig=jqQ1y/+KmVKN4zD6ckd50g==, tableContent=null), ArticleFig(id=1203057892564890095, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=EN, label=Fig. 2, caption=Influence of ZCCHC12 interference on epithelial-mesenchymal transition and invasion of differentiated thyroid cancer cells, figureFileSmall=a6T56P5pKyq88pu4GaSfyg==, figureFileBig=daFJ0t1k57F0CgOsJXPJnA==, tableContent=null), ArticleFig(id=1203057892644581877, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=CN, label=图2, caption=干扰ZCCHC12对分化型甲状腺癌细胞上皮-间质转化和侵袭能力的影响

A. Western blotting检测上皮-间质转化相关蛋白的表达(n=3)；B. Transwell实验检测细胞侵袭能力(n=3)；与空白对照组比较，(1)P<0.01；与NC si组比较，(2)P<0.01

, figureFileSmall=a6T56P5pKyq88pu4GaSfyg==, figureFileBig=daFJ0t1k57F0CgOsJXPJnA==, tableContent=null), ArticleFig(id=1203057892757828089, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=EN, label=Fig. 3, caption=Influence of ZCCHC12 interference on the protein expressions of CREB and p21 in differentiated thyroid cancer cells(Western blotting, n=3), figureFileSmall=9vgYyBEfwYXVFzT+QP5RDQ==, figureFileBig=T9F8k2kN/rVWp0VOav7Gag==, tableContent=null), ArticleFig(id=1203057892858491388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=CN, label=图3, caption=干扰ZCCHC12对分化型甲状腺癌细胞中CREB、p21蛋白表达的影响(Western blotting, n=3)

CREB. 环磷腺苷效应元件结合蛋白；与空白对照组比较，(1)P<0.01；与NC si组比较，(2)P<0.01

, figureFileSmall=9vgYyBEfwYXVFzT+QP5RDQ==, figureFileBig=T9F8k2kN/rVWp0VOav7Gag==, tableContent=null), ArticleFig(id=1203057892933988864, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=EN, label=Fig. 4, caption=Influence of ZCCHC12 interference and CREB overexpression on the protein expression of p21 in differentiated thyroid cancer cells (Western blotting, n=3), figureFileSmall=ReBc+u7JgBlTLREsIaBwUQ==, figureFileBig=Iz+1MqITRlNV0H8GmN3jYQ==, tableContent=null), ArticleFig(id=1203057892988514820, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=CN, label=图4, caption=干扰ZCCHC12且过表达CREB对分化型甲状腺癌细胞中p21蛋白表达的影响( Western blotting, n=3)

与ZCCHC12 si组比较，(1)P<0.01；与ZCCHC12 si+NC pc组比较，(2)P<0.01

, figureFileSmall=ReBc+u7JgBlTLREsIaBwUQ==, figureFileBig=Iz+1MqITRlNV0H8GmN3jYQ==, tableContent=null), ArticleFig(id=1203057893064012296, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=EN, label=Fig. 5, caption=Influence of interference of ZCCHC12 and p21 on epithelial-mesenchymal transition and invasion of differentiated thyroid cancer cells, figureFileSmall=IqOUJMppSrvViXXjcfmxjA==, figureFileBig=TB9ncuzx//JRta8KClthTg==, tableContent=null), ArticleFig(id=1203057893156286991, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203057885212274888, language=CN, label=图5, caption=干扰ZCCHC12和p21对分化型甲状腺癌细胞上皮-间质转化和侵袭能力的影响

A. Western blotting检测上皮-间质转化相关蛋白的表达(n=3)；B. Transwell实验检测细胞侵袭能力(n=3)；与ZCCHC12 si组比较，(1)P<0.01；与ZCCHC12 si+NC si组比较，(2)P<0.01

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