Article(id=1203002060628254882, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203002056400396334, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2023.06.0670, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1634659200000, receivedDateStr=2021-10-20, revisedDate=null, revisedDateStr=null, acceptedDate=1656950400000, acceptedDateStr=2022-07-05, onlineDate=1764747641951, onlineDateStr=2025-12-03, pubDate=1687881600000, pubDateStr=2023-06-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1764747641951, onlineIssueDateStr=2025-12-03, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1764747641951, creator=13701087609, updateTime=1764747641951, updator=13701087609, issue=Issue{id=1203002056400396334, tenantId=1146029695717560320, journalId=1189873630562394117, year='2023', volume='48', issue='6', pageStart='627', pageEnd='748', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1764747640943, creator=13701087609, updateTime=1764747714497, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1203002364979540735, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203002056400396334, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1203002364979540736, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1203002056400396334, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=670, endPage=675, ext={EN=ArticleExt(id=1203002060938633401, articleId=1203002060628254882, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effect of high mobility group protein B1 in exosomes from monocytes stimulated by heat stress, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To profile the high mobility group protein B1 (HMGB1) in exosomes derived from heat-stressed monocytes and its effect on endothelial cell inflammation. Methods The heatstroke model was established. The rats were divided into control group (n=6) and heatstroke group (n=6). Monocytes from blood were isolated and exosomes were extracted. Isobaric tags for relative and absolute quantification technology were used to identify the exosomal protein components, such as HMGB1, before functional description with annotation databases. Then, Western blotting and enzyme-linked immunosorbent assay (ELISA) were used to verify the changes of monocyte-derived exosomes HMGB1 in rats and patients. Umbilical vein endothelial cells (HUVECs) were treated with exosomes from rats in control group, heatstroke group and heatstorke+ethyl pyruvate group. The expression levels of NOD-like receptor thermal protein domain associated protein 3 (NLRP3) and interleukin-1β (IL-1β) were detected with RT-qPCR and Western blotting. HMGB1, NLRP3 and IL-1β expresion levels in exosomes of patient and healthy donors, were detected with ELISA. Results In heatstroke group, the number of exosomes (×10⁴/monocyte) derived from monocytes significantly increased than that in control group (11.24±2.66 vs. 1.52±0.21, P<0.001). Proteomic analysis showed that the expression of exosome HMGB1 in heatstroke group was up regulated than control group (18.63 times, P<0.001), and these proteins were enriched in NOD-like receptors and other signaling pathways. Western blotting showed that the relative expression of HMGB1 in exosomes of rats in heatstroke group was significantly higher than that in control group (4.13±0.22 vs. 1.00±0.15, P<0.001). ELISA also demonstrated that the level of HMGB1 in exosomes of patients in heatstroke group increased than that in control group [(0.29±0.11) ng/ml vs. (0.12±0.04) ng/ml, P=0.006]. qPCR and Western blotting showed that compared with control group, the mRNA and protein levels of NLRP3 and IL-1β in endothelial cells of heatstroke group were increased, which could be alleviated by the inhibitor of HMGB1, and the difference was statistically significant (P<0.05). Conclusion Heat stress increased the HMGB1 level in the monocyte-derived exosomes and might mediate endothelial cell inflammation via HMGB1.

, correspAuthors=Hua-Sheng Tong, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Ming Zhang, Jing-Wen Yang, Yue Li, Xue-Zhi Shi, Hua-Chu Li, Hua-Sheng Tong), CN=ArticleExt(id=1203002061865574663, articleId=1203002060628254882, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=热打击单核细胞外泌体高迁移率族蛋白B1对内皮细胞炎症的作用, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 观察热打击单核细胞外泌体高迁移率族蛋白B1（HMGB1）对内皮细胞炎症的作用。方法 制备中暑大鼠模型，将大鼠分为对照组（n=6）与中暑组（n=6），分离单核细胞提取外泌体并进行鉴定；对外泌体蛋白进行质谱分析并采用注释数据库进行功能描述；采用Western blotting及酶联免疫吸附法（ELISA）分别验证中暑大鼠及患者单核细胞来源外泌体HMGB1的表达变化；将脐静脉内皮细胞（HUVECs）分为对照组、中暑组以及中暑+丙酮酸乙酯（ethyl pyruvate，EP）组，分别添加来自对照组、中暑组大鼠外周血单核细胞上清中提取的外泌体及EP，采用RT-qPCR及Western blotting检测内皮细胞NOD样受体热蛋白结构域相关蛋白3（NLRP3）及白细胞介素-1β（IL-1β）的表达水平；采用ELISA检测健康志愿者及中暑患者外泌体NLRP3及IL-1β的表达水平。结果 与对照组比较，中暑组大鼠单核细胞来源外泌体数量（×10⁴/单核细胞）明显增多（11.24±2.66 vs. 1.52±0.21，P<0.001）。蛋白质组学分析表明中暑组外泌体HMGB1表达较对照组上调18.63倍（P<0.001），且在NOD样受体等信号通路富集。Western blotting检测结果显示，中暑组大鼠外泌体内含HMGB1表达量较对照组明显升高（4.13±0.22 vs. 1.00±0.15，P<0.001）。ELISA检测结果显示，中暑组患者外泌体内含HMGB1水平（ng/ml）较对照组明显升高（0.29±0.11 vs. 0.12±0.04，P=0.006）。RT-qPCR及Western blotting检测结果显示，与对照组比较，中暑组内皮细胞中NLRP3及IL-1β的mRNA和蛋白表达水平均明显升高，与中暑组比较，中暑+EP组NLRP3及IL-1β的mRNA和蛋白表达水平则明显降低，差异有统计学意义（P<0.05）。结论 热打击可提高单核细胞来源外泌体HMGB1水平，并可能通过HMGB1介导内皮细胞的炎症反应。

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张明，博士研究生，副主任医师，主要从事中暑和脓毒症方面的临床与基础研究

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张明，博士研究生，副主任医师，主要从事中暑和脓毒症方面的临床与基础研究

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NTA. 纳米粒子跟踪分析仪；A. NTA测定外泌体直径和浓度；B. 根据外泌体来源单核细胞数量，校正并比较对照组和中暑组外泌体个数；C. Western blotting检测外泌体裂解物的表面抗原；D. 扫描电镜验证外泌体典型的双层膜结构；与对照组比较，（1）P<0.05

, figureFileSmall=ro4j67WyLjAdqUaF0/Mg5g==, figureFileBig=d/wQ9wPyPB1gu4foCZxSBQ==, tableContent=null), ArticleFig(id=1203008553310187708, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203002060628254882, language=EN, label=Fig.2, caption=

Signal pathway of exosomal protein enrichment from monocytes under heat shock of rats

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HMGB1. 高迁移率族蛋白B1；A. Western blotting检测大鼠单核细胞来源外泌体内HMGB1水平（CD63为外泌体特异性蛋白）；B. ELISA检测健康对照者及中暑患者单核细胞来源外泌体内HMGB1水平；与对照组比较，（1）P<0.05

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HMGB1. 高迁移率族蛋白B1；NLRP3. NOD样受体热蛋白结构域相关蛋白3；IL-1β. 白细胞介素-1β；EP. 丙酮酸乙酯；A. RT-qPCR检测内皮细胞NLRP3、IL-1β的mRNA表达；B. Western blotting检测内皮细胞NLRP3、IL-1β蛋白表达；C. ELISA检测内皮细胞上清中活化的IL-1β水平；与对照组比较，（1）P<0.05；与中暑+EP组比较，（2）P<0.05

, figureFileSmall=F3oDkSiwYHBN0e7Kc+GgpA==, figureFileBig=wxfWuPq6wP0Cl6ER54FGRQ==, tableContent=null), ArticleFig(id=1203008553788338386, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203002060628254882, language=EN, label=Tab.1, caption=

Characterization of exosomes derived from monocytes of rats

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基因名称	蛋白质名称	上调/下调	倍数P
Cxcl10	C-X-C基序趋化因子10	22.51	0.0001
Hmgb1	高迁移率族蛋白B1	18.63	0.0001
Csfgm	粒细胞集落刺激因子	15.23	0.0001
Cldn1	Claudin-1	12.78	0.0001
Cxcl6	C-X-C基序趋化因子6	10.56	0.0001
Il18bp	白细胞介素18结合蛋白	9.24	0.0001
Tnfsf2	肿瘤坏死因子	8.25	0.0001
Ptx3	Pentraxin-related protein 3	7.05	0.0001
Cxcl2	C-X-C基序趋化因子2	7.64	0.0001
Psma7	蛋白酶体亚基7	6.57	0.0001
Igll1	免疫球蛋白λ样多肽1	0.21	0.0001
C3	补体3	0.28	0.0160
Plg	血纤维蛋白溶酶原	0.29	0.0280
Saa3	血清淀粉样蛋白A3	0.32	0.0350
IL-4	白细胞介素4	0.43	0.0410

), ArticleFig(id=1203008553884807383, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1203002060628254882, language=CN, label=表1, caption=

大鼠单核细胞源性外泌体内含蛋白鉴定

, figureFileSmall=null, figureFileBig=null, tableContent=

基因名称	蛋白质名称	上调/下调	倍数P
Cxcl10	C-X-C基序趋化因子10	22.51	0.0001
Hmgb1	高迁移率族蛋白B1	18.63	0.0001
Csfgm	粒细胞集落刺激因子	15.23	0.0001
Cldn1	Claudin-1	12.78	0.0001
Cxcl6	C-X-C基序趋化因子6	10.56	0.0001
Il18bp	白细胞介素18结合蛋白	9.24	0.0001
Tnfsf2	肿瘤坏死因子	8.25	0.0001
Ptx3	Pentraxin-related protein 3	7.05	0.0001
Cxcl2	C-X-C基序趋化因子2	7.64	0.0001
Psma7	蛋白酶体亚基7	6.57	0.0001
Igll1	免疫球蛋白λ样多肽1	0.21	0.0001
C3	补体3	0.28	0.0160
Plg	血纤维蛋白溶酶原	0.29	0.0280
Saa3	血清淀粉样蛋白A3	0.32	0.0350
IL-4	白细胞介素4	0.43	0.0410

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