Article(id=1200024247100866773, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1200024241572770746, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.1365.2023.0101, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1655568000000, receivedDateStr=2022-06-19, revisedDate=null, revisedDateStr=null, acceptedDate=1663603200000, acceptedDateStr=2022-09-20, onlineDate=1764037675881, onlineDateStr=2025-11-25, pubDate=1695830400000, pubDateStr=2023-09-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1764037675881, onlineIssueDateStr=2025-11-25, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1764037675881, creator=13701087609, updateTime=1764037675881, updator=13701087609, issue=Issue{id=1200024241572770746, tenantId=1146029695717560320, journalId=1189873630562394117, year='2023', volume='48', issue='9', pageStart='993', pageEnd='1112', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1764037674563, creator=13701087609, updateTime=1764038723302, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1200028640353288193, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1200024241572770746, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1200028640353288194, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1200024241572770746, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1011, endPage=1016, ext={EN=ArticleExt(id=1200024247881007322, articleId=1200024247100866773, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effect of lycopene on inflammatory factors and intestinal mucosal barrier function in mice with traumatic brain injury, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the effect of lycopene (Lyc) on inflammatory factors and intestinal mucosal barrier function in mice with traumatic brain injury (TBI). Methods Forty-five SPF level of adult male BALB/c mice were randomly divided into sham group, TBI group and TBI+Lyc group, with 15 mice in each group. The TBI model was prepared by modified compression injury model, and the mice in sham group underwent an identical process without mechanical trauma. Each group was further divided into 5 subgroups at 1 d, 2 d, 3 d, 7 d and 14 d after modelling (n=3/subgroup). Mice in sham group and TBI group were treated with 10 mg/kg sunflower oil, and in TBI+Lyc group were treated with 10 mg/kg sunflower oil-dissolved Lyc (concentration 1 mg/ml), daily gavage at a fixed time for 14 d. The inferior vena cava blood and ileum tissue of mice in each subgroup were collected. The serum levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), intestinal fatty acid binding protein (I-FABP) and diamine oxidase (DAO) were detected by ELISA, and the serum levels of D-lactic acid (D-LA) and endotoxin were detected by colorimetric method and endpoint chromogenic assay, respectively. Pearson correlation test was used to analyze the correlation between inflammatory factors and intestinal mucosal barrier function indicators. The pathological changes of ileum tissues were observed by HE staining, and the villus height and crypt depth of ileum were measured. Results The serum levels of TNF-α, IL-1β, I-FABP, D-LA, DAO and endotoxin of mice in TBI group and TBI+Lyc group gradually decreased with time, but were obviously higher than those in sham group at different time points (P<0.01 or P<0.001); the serum levels of TNF-α, IL-1β, I-FABP, D-LA, DAO and endotoxin of mice in TBI+Lyc group were significantly lower than those in TBI group at different time points (P<0.01 or P<0.001). Serum TNF-α and IL-1β were significantly positively correlated with I-FABP, D-LA, DAO and endotoxin, respectively (P<0.01). The sham group showed basically normal ileal villi, the structure of ileal villi in TBI group was obviously damaged, and the structure of ileal villi in TBI+Lyc group was basically neat. The ileal villus height and crypt depth of mice in TBI group were lower than those in sham group at each time points (P<0.05), and the ileal villus height and crypt depth of mice in TBI+Lyc group were significantly higher than those in TBI group at different time points (P<0.05). Conclusion Lyc can reduce the levels of inflammatory factors in various stages of TBI mice and may improve the intestinal mucosal barrier function by inhibiting inflammatory response.

, correspAuthors=Tian-Lai Lin, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Hong-Ling Zhang, Cai-Hui Li, Ming-Lian Huang, Yan-Jun Liao, Tian-Lai Lin), CN=ArticleExt(id=1200024249558728969, articleId=1200024247100866773, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=番茄红素对创伤性脑损伤小鼠炎性因子及肠黏膜屏障功能的影响, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨番茄红素(Lyc)对创伤性脑损伤(TBI)小鼠炎性因子及肠黏膜屏障功能的影响。方法 SPF级成年雄性BALB/c小鼠45只，采用随机数字表法分为假手术组、TBI组与TBI+Lyc组，每组15只。采用改良压缩损伤模型的方法制备TBI小鼠模型，假手术组不给予打击。各组按建模后1 d、2 d、3 d、7 d及14 d分为5个亚组，每亚组3只。假手术组及TBI组给予葵花油，TBI+Lyc组给予葵花油溶解的Lyc(浓度为1 mg/ml)，剂量均为10 mg/(kg·d)，每日固定时间灌胃，持续14 d。取各亚组小鼠下腔静脉血及回肠组织，采用ELISA法检测血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、肠型脂肪酸结合蛋白(I-FABP)、二胺氧化酶(DAO)水平，比色法检测血清D-乳酸(D-LA)水平，终点显色法检测血清内毒素水平。Pearson相关检验分析炎性因子与肠黏膜屏障功能指标的相关性。HE染色观察回肠组织病理学变化，并测量回肠绒毛高度及隐窝深度。结果 TBI组、TBI+Lyc组小鼠血清TNF-α、IL-1β、I-FABP、D-LA、DAO、内毒素水平随时间延长逐渐降低，但在各时间点均明显高于假手术组(P<0.01或P<0.001)；TBI+Lyc组小鼠血清TNF-α、IL-1β、I-FABP、D-LA、DAO、内毒素水平在各时间点均明显低于TBI组(P<0.01或P<0.001)。血清TNF-α、IL-1β分别与I-FABP、D-LA、DAO、内毒素水平呈明显正相关关系(P<0.01)。假手术组回肠绒毛基本正常，TBI组回肠绒毛结构明显破坏，TBI+Lyc组回肠绒毛结构基本整齐。TBI组小鼠回肠绒毛高度和隐窝深度在各时间点均低于假手术组(P<0.05)，TBI+Lyc组小鼠回肠绒毛高度和隐窝深度在各时间点均明显高于TBI组(P<0.05)。结论 Lyc可降低TBI小鼠各个时期炎性因子水平，并可能通过抑制炎症反应来改善肠黏膜屏障功能。

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张洪玲，硕士研究生，主治医师，主要从事消化系统重症方面的研究

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张洪玲，硕士研究生，主治医师，主要从事消化系统重症方面的研究

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TNF-α. 肿瘤坏死因子-α；IL-1β. 白细胞介素-1β；TBI. 创伤性脑损伤；Lyc. 番茄红素；与假手术组比较，(1)P<0.01，(2)P<0.001；与TBI组比较，(3)P<0.01，(4)P<0.001

, figureFileSmall=PzVA/8y9ax3tAj5h619tLg==, figureFileBig=RWGh0PFm8mZ8xVGzbExTBA==, tableContent=null), ArticleFig(id=1200024257330774512, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=EN, label=Fig.2, caption=Comparison of serum intestinal mucosal barrier function indexes of mice in each group at different time points ($\bar{x}±s$, n=3), figureFileSmall=w/UR6KZGGRCKUxpjF3/rHg==, figureFileBig=C4Dxp+w0ydkw5jzvkC6zBg==, tableContent=null), ArticleFig(id=1200024257431437813, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=CN, label=图2, caption=各组小鼠不同时间点血清肠黏膜屏障功能指标比较($\bar{x}±s$，n=3)

I-FABP. 肠型脂肪酸结合蛋白；D-LA. D-乳酸；DAO. 二胺氧化酶；TBI. 创伤性脑损伤；Lyc. 番茄红素；与假手术组比较，(1)P<0.01，(2)P<0.001；与TBI组比较，(3)P<0.01，(4)P<0.001

, figureFileSmall=w/UR6KZGGRCKUxpjF3/rHg==, figureFileBig=C4Dxp+w0ydkw5jzvkC6zBg==, tableContent=null), ArticleFig(id=1200024257553072636, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=EN, label=Fig.3, caption=Pathological changes in the ileum tissue of mice in each group (HE ×200), figureFileSmall=ibQptz9RH5aszSlQTEzlTQ==, figureFileBig=ZqZKnhcHlCFWlweeDAyXXg==, tableContent=null), ArticleFig(id=1200024257670513153, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=CN, label=图3, caption=各组小鼠回肠组织病理学变化(HE ×200)

TBI. 创伤性脑损伤；Lyc. 番茄红素

, figureFileSmall=ibQptz9RH5aszSlQTEzlTQ==, figureFileBig=ZqZKnhcHlCFWlweeDAyXXg==, tableContent=null), ArticleFig(id=1200024257850868231, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=EN, label=Fig.4, caption=Comparison of ileal villus height and crypt depth of mice in each group at different time points ($\bar{x}±s$, n=3), figureFileSmall=5SaHEKx0AzTF89H+bnDSng==, figureFileBig=g4kC00GRaB0BkdwS4JcExw==, tableContent=null), ArticleFig(id=1200024257997668879, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=CN, label=图4, caption=各组小鼠不同时间点回肠绒毛高度及隐窝深度比较($\bar{x}±s$, n=3)

TBI. 创伤性脑损伤；Lyc. 番茄红素；与假手术组比较，(1)P<0.05，(2)P<0.01，(3)P<0.001；与TBI组比较，(4)P<0.05，(5)P<0.01

, figureFileSmall=5SaHEKx0AzTF89H+bnDSng==, figureFileBig=g4kC00GRaB0BkdwS4JcExw==, tableContent=null), ArticleFig(id=1200024258123498004, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=EN, label=Tab.1, caption=

Correlation between inflammatory factors and intestinal mucosal barrier function indexes

, figureFileSmall=null, figureFileBig=null, tableContent=

指标	TNF-α		IL-1β
	r	P	r	P
I-FABP	0.970	<0.01	0.981	<0.01
D-LA	0.960	<0.01	0.980	<0.01
DAO	0.965	<0.01	0.982	<0.01
内毒素	0.961	<0.01	0.979	<0.01

), ArticleFig(id=1200024258291270172, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1200024247100866773, language=CN, label=表1, caption=

炎性因子与各肠黏膜屏障功能指标的相关性

, figureFileSmall=null, figureFileBig=null, tableContent=

指标	TNF-α		IL-1β
	r	P	r	P
I-FABP	0.970	<0.01	0.981	<0.01
D-LA	0.960	<0.01	0.980	<0.01
DAO	0.965	<0.01	0.982	<0.01
内毒素	0.961	<0.01	0.979	<0.01

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