首页 期刊 论文 学科刊群 资讯 加盟 关于
EN
image
Article(id=1199688707377824285, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199688705905623579, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.1106.2023.0227, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1652716800000, receivedDateStr=2022-05-17, revisedDate=null, revisedDateStr=null, acceptedDate=1657296000000, acceptedDateStr=2022-07-09, onlineDate=1763957676977, onlineDateStr=2025-11-24, pubDate=1703692800000, pubDateStr=2023-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763957676977, onlineIssueDateStr=2025-11-24, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763957676977, creator=13701087609, updateTime=1763957676977, updator=13701087609, issue=Issue{id=1199688705905623579, tenantId=1146029695717560320, journalId=1189873630562394117, year='2023', volume='48', issue='12', pageStart='1359', pageEnd='1491', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1763957676626, creator=13701087609, updateTime=1763958367038, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1199691601774739748, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199688705905623579, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1199691601774739749, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199688705905623579, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1467, endPage=1472, ext={EN=ArticleExt(id=1199688707629482529, articleId=1199688707377824285, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Premature ovarian insufficient (POI) is one of the important causes of infertility in woman of reproductive age. At present, the clinical treatment of POI is limited and the therapeutic effect is not ideal. Extracellular vesicles derived from stem cells have attracted the attention of many researchers at home and abroad as a new cell-free therapy. Many animal experiment study shows that a variety of extracellular vesicles from stem cells carry microRNAs, lncRNAs, lipids, proteins, and other bioactive substances, improve ovarian function, affect granulosa cell proliferation and apoptosis, promote ovarian angiogenesis, and reduce oxidative stress response, thus playing a therapeutic role on POI. This article will review the mechanisms of extracellular vesicles in treatment of POI, and provide evidence for the application of extracellular vesicles in clinical treatment of POI.

, correspAuthors=Xiao-Feng Sun, authorNote=null, correspAuthorsNote=
E-mail:
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun), CN=ArticleExt(id=1199688708141187621, articleId=1199688707377824285, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

早发性卵巢功能不全(POI)是育龄期女性不孕的重要原因之一，目前临床治疗方法有限，治疗效果不理想。近年来，干细胞来源的细胞外囊泡作为一种新型的无细胞治疗方式备受关注。多项动物实验研究显示，各种干细胞来源的细胞外囊泡携带微小RNA、长链非编码RNA、脂质、蛋白质等多种生物活性物质，可改善卵巢功能、影响颗粒细胞增殖和凋亡、促进卵巢血管生成及减轻氧化应激反应，从而对POI发挥治疗作用。本文对干细胞来源的细胞外囊泡治疗POI的相关机制研究进行综述，旨在为其早日应用于POI的临床治疗提供依据。

, correspAuthors=孙晓峰, authorNote=null, correspAuthorsNote=
孙晓峰，E-mail：
, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=gdPOYU7f9w7wmlrcQvuNZg==, magXml=a6a8/+f/pLjHcTXI4lGLpA==, pdfUrl=null, pdf=jw9+fifDK/W1Sf31LYWXuA==, pdfFileSize=862778, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=TJ8+gs44wetTJOmE5YsU3A==, mapNumber=null, authorCompany=null, fund=null, authors=

曾文卓，硕士研究生，主要从事组织损伤修复等方面的研究

, authorsList=曾文卓, 黄欣怡, 徐数理, 孙晓峰)}, authors=[Author(id=1199700880313384992, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199700880409853986, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880313384992, language=EN, stringName=Wen-Zhuo Zeng, firstName=Wen-Zhuo, middleName=null, lastName=Zeng, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199700880518905894, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880313384992, language=CN, stringName=曾文卓, firstName=文卓, middleName=null, lastName=曾, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学医学院，湖南长沙 410208, bio={"content":"

曾文卓，硕士研究生，主要从事组织损伤修复等方面的研究

"}, bioImg=null, bioContent=

曾文卓，硕士研究生，主要从事组织损伤修复等方面的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199700880208527388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, xref=null, ext=[AuthorCompanyExt(id=1199700880216915997, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China), AuthorCompanyExt(id=1199700880225304606, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学医学院，湖南长沙 410208)])]), Author(id=1199700880636346408, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199700880745398318, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880636346408, language=EN, stringName=Xin-Yi Huang, firstName=Xin-Yi, middleName=null, lastName=Huang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199700880875421748, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880636346408, language=CN, stringName=黄欣怡, firstName=欣怡, middleName=null, lastName=黄, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学医学院，湖南长沙 410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199700880208527388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, xref=null, ext=[AuthorCompanyExt(id=1199700880216915997, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China), AuthorCompanyExt(id=1199700880225304606, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学医学院，湖南长沙 410208)])]), Author(id=1199700880971890744, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199700881135468607, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880971890744, language=EN, stringName=Shu-Li Xu, firstName=Shu-Li, middleName=null, lastName=Xu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199700881219354695, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700880971890744, language=CN, stringName=徐数理, firstName=数理, middleName=null, lastName=徐, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=null, address=湖南中医药大学医学院，湖南长沙 410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199700880208527388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, xref=null, ext=[AuthorCompanyExt(id=1199700880216915997, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China), AuthorCompanyExt(id=1199700880225304606, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学医学院，湖南长沙 410208)])]), Author(id=1199700881345183820, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=sunxf23@163.com, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1199700881542316114, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700881345183820, language=EN, stringName=Xiao-Feng Sun, firstName=Xiao-Feng, middleName=null, lastName=Sun, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199700881626202200, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, authorId=1199700881345183820, language=CN, stringName=孙晓峰, firstName=晓峰, middleName=null, lastName=孙, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=*, address=湖南中医药大学医学院，湖南长沙 410208, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199700880208527388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, xref=null, ext=[AuthorCompanyExt(id=1199700880216915997, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China), AuthorCompanyExt(id=1199700880225304606, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学医学院，湖南长沙 410208)])])], keywords=[Keyword(id=1199700881806557282, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=EN, orderNo=1, keyword=premature ovarian insufficient), Keyword(id=1199700881932386410, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=EN, orderNo=2, keyword=extracellular vesicles), Keyword(id=1199700882041438318, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=EN, orderNo=3, keyword=exosomes), Keyword(id=1199700882133713009, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=EN, orderNo=4, keyword=stem cell-derived), Keyword(id=1199700882221793400, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=CN, orderNo=1, keyword=早发性卵巢功能不全), Keyword(id=1199700882330845304, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=CN, orderNo=2, keyword=细胞外囊泡), Keyword(id=1199700882427314302, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=CN, orderNo=3, keyword=外泌体), Keyword(id=1199700882502811777, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=CN, orderNo=4, keyword=干细胞源性)], refs=[Reference(id=1199700885048754357, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=52, issue=9, pageStart=577, pageEnd=581, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Chen ZJ, Tian QJ, Qiao J, journalName=Chin J Obstetr Gynecol, refType=null, unstructuredReference=Chen ZJ, Tian QJ, Qiao J, et al. Chinese expert consensus on the clinical diagnosis and treatment of premature ovarian insufficient [J]. Chin J Obstetr Gynecol, 2017, 52(9): 577-581., articleTitle=Chinese expert consensus on the clinical diagnosis and treatment of premature ovarian insufficient, refAbstract=null), Reference(id=1199700885153611960, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=52, issue=9, pageStart=577, pageEnd=581, url=null, language=null, rfNumber=[1], rfOrder=1, authorNames=陈子江, 田秦杰, 乔杰, journalName=中华妇产科杂志, refType=null, unstructuredReference=陈子江, 田秦杰, 乔杰, 等. 早发性卵巢功能不全的临床诊疗中国专家共识[J]. 中华妇产科杂志, 2017, 52(9): 577-581., articleTitle=早发性卵巢功能不全的临床诊疗中国专家共识, refAbstract=null), Reference(id=1199700885283635388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=3, pageStart=252, pageEnd=257, url=null, language=null, rfNumber=[2], rfOrder=2, authorNames=Ma WQ, Li XR, Xie JX, journalName=Med J Chin PLA, refType=null, unstructuredReference=Ma WQ, Li XR, Xie JX, et al. Expression and clinical value of serum miR-21 and PBMC Peli1 in autoimmune POI patients[J]. Med J Chin PLA, 2021, 46(3): 252-257., articleTitle=Expression and clinical value of serum miR-21 and PBMC Peli1 in autoimmune POI patients, refAbstract=null), Reference(id=1199700885388492992, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=3, pageStart=252, pageEnd=257, url=null, language=null, rfNumber=[2], rfOrder=3, authorNames=马闻擎, 李欣然, 谢嘉欣, journalName=解放军医学杂志, refType=null, unstructuredReference=马闻擎, 李欣然, 谢嘉欣, 等. 免疫性早发性卵巢功能不全患者血清miR-21及外周血单核细胞Peli1的表达及意义[J]. 解放军医学杂志, 2021, 46(3): 252-257., articleTitle=免疫性早发性卵巢功能不全患者血清miR-21及外周血单核细胞Peli1的表达及意义, refAbstract=null), Reference(id=1199700885505933508, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2010, volume=376, issue=9744, pageStart=911, pageEnd=921, url=null, language=null, rfNumber=[3], rfOrder=4, authorNames=de Vos M, Devroey P, Fauser BCJM, journalName=Lancet, refType=null, unstructuredReference=de Vos M, Devroey P, Fauser BCJM. Primary ovarian insufficiency[J]. Lancet, 2010, 376(9744): 911-921., articleTitle=Primary ovarian insufficiency, refAbstract=null), Reference(id=1199700885757591755, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=2020, issue=null, pageStart=8825771, pageEnd=null, url=null, language=null, rfNumber=[4], rfOrder=5, authorNames=Zhao AG, Shah K, Cromer B, journalName=Stem Cells Int, refType=null, unstructuredReference=Zhao AG, Shah K, Cromer B, et al. Mesenchymal stem cell-derived extracellular vesicles and their therapeutic potential[J]. Stem Cells Int, 2020, 2020: 8825771., articleTitle=Mesenchymal stem cell-derived extracellular vesicles and their therapeutic potential, refAbstract=null), Reference(id=1199700885866643660, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=318, issue=22, pageStart=2224, pageEnd=2233, url=null, language=null, rfNumber=[5], rfOrder=6, authorNames=US Preventive Services Task Force, Grossman DC, Curry SJ, journalName=JAMA, refType=null, unstructuredReference=US Preventive Services Task Force, Grossman DC, Curry SJ, et al. Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: us preventive services task force recommendation statement[J]. JAMA, 2017, 318(22): 2224-2233., articleTitle=Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: us preventive services task force recommendation statement, refAbstract=null), Reference(id=1199700885971501262, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=12, issue=4, pageStart=277, pageEnd=287, url=null, language=null, rfNumber=[6], rfOrder=7, authorNames=Shen J, Cao D, Sun JL, journalName=World J Stem Cells, refType=null, unstructuredReference=Shen J, Cao D, Sun JL. Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure[J]. World J Stem Cells, 2020, 12(4): 277-287., articleTitle=Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure, refAbstract=null), Reference(id=1199700886067970257, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=11, issue=1, pageStart=255, pageEnd=null, url=null, language=null, rfNumber=[7], rfOrder=8, authorNames=Yoon SY, Yoon JA, Park M, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Yoon SY, Yoon JA, Park M, et al. Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice[J]. Stem Cell Res Ther, 2020, 11(1): 255., articleTitle=Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice, refAbstract=null), Reference(id=1199700886164439253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=3, pageStart=115, pageEnd=119, url=null, language=null, rfNumber=[8], rfOrder=9, authorNames=Zhang QY, Ye XJ, Guo JJ, journalName=J ShaoXing Univ(Nat Sci), refType=null, unstructuredReference=Zhang QY, Ye XJ, Guo JJ, et al. Current situation of steam cell therapy environment and clinical application in China[J]. J ShaoXing Univ(Nat Sci), 2021, 41(3): 115-119., articleTitle=Current situation of steam cell therapy environment and clinical application in China, refAbstract=null), Reference(id=1199700886290268376, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=41, issue=3, pageStart=115, pageEnd=119, url=null, language=null, rfNumber=[8], rfOrder=10, authorNames=张沁瑶, 叶鑫健, 过金晶, journalName=绍兴文理学院学报(自然科学), refType=null, unstructuredReference=张沁瑶, 叶鑫健, 过金晶, 等. 国内干细胞治疗环境及临床应用现状[J]. 绍兴文理学院学报(自然科学), 2021, 41(3): 115-119., articleTitle=国内干细胞治疗环境及临床应用现状, refAbstract=null), Reference(id=1199700886420291804, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=11, issue=null, pageStart=617704, pageEnd=null, url=null, language=null, rfNumber=[9], rfOrder=11, authorNames=Fàbregues F, Ferreri J, Méndez M, journalName=Front Endocrinol (Lausanne), refType=null, unstructuredReference=Fàbregues F, Ferreri J, Méndez M, et al. In vitro follicular activation and stem cell therapy as a novel treatment strategies in diminished ovarian reserve and primary ovarian insufficiency[J]. Front Endocrinol (Lausanne), 2020, 11: 617704., articleTitle=In vitro follicular activation and stem cell therapy as a novel treatment strategies in diminished ovarian reserve and primary ovarian insufficiency, refAbstract=null), Reference(id=1199700886529343711, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2022, volume=20, issue=1, pageStart=28, pageEnd=null, url=null, language=null, rfNumber=[10], rfOrder=12, authorNames=Huang QY, Chen SR, Chen JM, journalName=Reprod Biol Endocrinol, refType=null, unstructuredReference=Huang QY, Chen SR, Chen JM, et al. Therapeutic options for premature ovarian insufficiency: an updated review[J]. Reprod Biol Endocrinol, 2022, 20(1): 28., articleTitle=Therapeutic options for premature ovarian insufficiency: an updated review, refAbstract=null), Reference(id=1199700886659367139, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2018, volume=102, issue=null, pageStart=254, pageEnd=262, url=null, language=null, rfNumber=[11], rfOrder=13, authorNames=Sheikhansari G, Aghebati-Maleki L, Nouri M, journalName=Biomedecine Pharmacother, refType=null, unstructuredReference=Sheikhansari G, Aghebati-Maleki L, Nouri M, et al. Current approaches for the treatment of premature ovarian failure with stem cell therapy[J]. Biomedecine Pharmacother, 2018, 102: 254-262., articleTitle=Current approaches for the treatment of premature ovarian failure with stem cell therapy, refAbstract=null), Reference(id=1199700886764224742, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=16, issue=null, pageStart=407, pageEnd=418, url=null, language=null, rfNumber=[12], rfOrder=14, authorNames=Zhang Q, Sun J, Huang Y, journalName=Mol Ther Nucleic Acids, refType=null, unstructuredReference=Zhang Q, Sun J, Huang Y, et al. Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis[J]. Mol Ther Nucleic Acids, 2019, 16: 407-418., articleTitle=Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis, refAbstract=null), Reference(id=1199700886852305130, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2018, volume=122, issue=2, pageStart=296, pageEnd=309, url=null, language=null, rfNumber=[13], rfOrder=15, authorNames=Adamiak M, Cheng G, Bobis-Wozowicz S, journalName=Circ Res, refType=null, unstructuredReference=Adamiak M, Cheng G, Bobis-Wozowicz S, et al. Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs[J]. Circ Res, 2018, 122(2): 296-309., articleTitle=Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs, refAbstract=null), Reference(id=1199700886969745648, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=9, issue=16, pageStart=4764, pageEnd=4778, url=null, language=null, rfNumber=[14], rfOrder=16, authorNames=Liu J, Huang Z, Yang L, journalName=Theranostics, refType=null, unstructuredReference=Liu J, Huang Z, Yang L, et al. Embryonic stem cells modulate the cancer-permissive microenvironment of human uveal melanoma[J]. Theranostics, 2019, 9(16): 4764-4778., articleTitle=Embryonic stem cells modulate the cancer-permissive microenvironment of human uveal melanoma, refAbstract=null), Reference(id=1199700887078797556, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=6, issue=6, pageStart=1801899, pageEnd=null, url=null, language=null, rfNumber=[15], rfOrder=17, authorNames=Zhu Q, Ling X, Yang Y, journalName=Adv Sci (Weinh), refType=null, unstructuredReference=Zhu Q, Ling X, Yang Y, et al. Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy[J]. Adv Sci (Weinh), 2019, 6(6): 1801899., articleTitle=Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy, refAbstract=null), Reference(id=1199700887158489333, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2018, volume=8, issue=1, pageStart=1171, pageEnd=null, url=null, language=null, rfNumber=[16], rfOrder=18, authorNames=Cha J, Shin E, Sung J, journalName=Sci Rep, refType=null, unstructuredReference=Cha J, Shin E, Sung J, et al. Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells[J]. Sci Rep, 2018, 8(1): 1171., articleTitle=Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells, refAbstract=null), Reference(id=1199700888290951417, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=318, issue=1, pageStart=C29, pageEnd=C39, url=null, language=null, rfNumber=[17], rfOrder=19, authorNames=Urabe F, Kosaka N, Ito K, journalName=Am J Physiol Cell Physiol, refType=null, unstructuredReference=Urabe F, Kosaka N, Ito K, et al. Extracellular vesicles as biomarkers and therapeutic targets for cancer[J]. Am J Physiol Cell Physiol, 2020, 318(1): C29-C39., articleTitle=Extracellular vesicles as biomarkers and therapeutic targets for cancer, refAbstract=null), Reference(id=1199700888437752062, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=21, issue=4, pageStart=621, pageEnd=626, url=null, language=null, rfNumber=[18], rfOrder=20, authorNames=Wang J, Chen JY, journalName=Chin J Tissue Eng Res, refType=null, unstructuredReference=Wang J, Chen JY. Rencent advances in extracellular vesicles[J]. Chin J Tissue Eng Res, 2017, 21(4): 621-626., articleTitle=Rencent advances in extracellular vesicles, refAbstract=null), Reference(id=1199700888530026753, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=21, issue=4, pageStart=621, pageEnd=626, url=null, language=null, rfNumber=[18], rfOrder=21, authorNames=王琎, 陈建英, journalName=中国组织工程研究, refType=null, unstructuredReference=王琎, 陈建英. 细胞外囊泡研究新进展[J]. 中国组织工程研究, 2017, 21(4): 621-626., articleTitle=细胞外囊泡研究新进展, refAbstract=null), Reference(id=1199700888634884356, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=177, issue=2, pageStart=428, pageEnd=445.e18, url=null, language=null, rfNumber=[19], rfOrder=22, authorNames=Jeppesen DK, Fenix AM, Franklin JL, journalName=Cell, refType=null, unstructuredReference=Jeppesen DK, Fenix AM, Franklin JL, et al. Reassessment of exosome composition[J]. Cell, 2019, 177(2): 428-445.e18., articleTitle=Reassessment of exosome composition, refAbstract=null), Reference(id=1199700888760713477, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2018, volume=19, issue=4, pageStart=213, pageEnd=228, url=null, language=null, rfNumber=[20], rfOrder=23, authorNames=van Niel G, D'Angelo G, Raposo G, journalName=Nat Rev Mol Cell Biol, refType=null, unstructuredReference=van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles [J]. Nat Rev Mol Cell Biol, 2018, 19(4): 213-228., articleTitle=Shedding light on the cell biology of extracellular vesicles, refAbstract=null), Reference(id=1199700888844599560, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=59, issue=4, pageStart=527, pageEnd=533, url=null, language=null, rfNumber=[21], rfOrder=24, authorNames=Zhang J, Yin H, Jiang H, journalName=Taiwan J Obstet Gynecol, refType=null, unstructuredReference=Zhang J, Yin H, Jiang H, et al. The protective effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on cisplatin-damaged granulosa cells[J]. Taiwan J Obstet Gynecol, 2020, 59(4): 527-533., articleTitle=The protective effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on cisplatin-damaged granulosa cells, refAbstract=null), Reference(id=1199700889029148939, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=27, issue=3, pageStart=172, pageEnd=188, url=null, language=null, rfNumber=[22], rfOrder=25, authorNames=Maas SLN, Breakefield XO, Weaver AM, journalName=Trends Cell Biol, refType=null, unstructuredReference=Maas SLN, Breakefield XO, Weaver AM. Extracellular vesicles: unique intercellular delivery vehicles[J]. Trends Cell Biol, 2017, 27(3): 172-188., articleTitle=Extracellular vesicles: unique intercellular delivery vehicles, refAbstract=null), Reference(id=1199700889180143887, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2018, volume=9, issue=1, pageStart=216, pageEnd=null, url=null, language=null, rfNumber=[23], rfOrder=26, authorNames=Huang B, Lu J, Ding C, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Huang B, Lu J, Ding C, et al. Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD[J]. Stem Cell Res Ther, 2018, 9(1): 216., articleTitle=Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD, refAbstract=null), Reference(id=1199700889276612879, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=100, issue=3, pageStart=342, pageEnd=352, url=null, language=null, rfNumber=[24], rfOrder=27, authorNames=Yang M, Lin L, Sha C, journalName=Lab Invest, refType=null, unstructuredReference=Yang M, Lin L, Sha C, et al. Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN[J]. Lab Invest, 2020, 100(3): 342-352., articleTitle=Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN, refAbstract=null), Reference(id=1199700889435996434, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=10, issue=1, pageStart=360, pageEnd=null, url=null, language=null, rfNumber=[25], rfOrder=28, authorNames=Sun B, Ma YJ, Wang F, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Sun B, Ma YJ, Wang F, et al. MiR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis[J]. Stem Cell Res Ther, 2019, 10(1): 360., articleTitle=MiR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis, refAbstract=null), Reference(id=1199700889599574293, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=5, issue=2, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[26], rfOrder=29, authorNames=Park HS, Ashour D, Elsharoud A, journalName=HSOA J Stem Cells Res Dev Ther, refType=null, unstructuredReference=Park HS, Ashour D, Elsharoud A, et al. Towards cell free therapy of premature ovarian insufficiency: human bone marrow mesenchymal stem cells secretome enhances angiogenesis in human ovarian microvascular endothelial cells[J]. HSOA J Stem Cells Res Dev Ther, 2019, 5(2): 019., articleTitle=Towards cell free therapy of premature ovarian insufficiency: human bone marrow mesenchymal stem cells secretome enhances angiogenesis in human ovarian microvascular endothelial cells, refAbstract=null), Reference(id=1199700889687654681, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=29, issue=null, pageStart=963689720923575, pageEnd=null, url=null, language=null, rfNumber=[27], rfOrder=30, authorNames=Liu C, Yin H, Jiang H, journalName=Cell Transplant, refType=null, unstructuredReference=Liu C, Yin H, Jiang H, et al. Extracellular vesicles derived from mesenchymal stem cells recover fertility of premature ovarian insufficiency mice and the effects on their offspring[J]. Cell Transplant, 2020, 29: 963689720923575., articleTitle=Extracellular vesicles derived from mesenchymal stem cells recover fertility of premature ovarian insufficiency mice and the effects on their offspring, refAbstract=null), Reference(id=1199700889905758492, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=7, issue=1, pageStart=2552, pageEnd=null, url=null, language=null, rfNumber=[28], rfOrder=31, authorNames=Sun L, Li D, Song K, journalName=Sci Rep, refType=null, unstructuredReference=Sun L, Li D, Song K, et al. Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro[J]. Sci Rep, 2017, 7(1): 2552., articleTitle=Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro, refAbstract=null), Reference(id=1199700890060947744, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=null, pageStart=711902, pageEnd=null, url=null, language=null, rfNumber=[29], rfOrder=32, authorNames=Li Z, Zhang M, Zheng J, journalName=Front Endocrinol (Lausanne), refType=null, unstructuredReference=Li Z, Zhang M, Zheng J, et al. Human umbilical cord mesenchymal stem cell-derived exosomes improve ovarian function and proliferation of premature ovarian insufficiency by regulating the hippo signaling pathway[J]. Front Endocrinol (Lausanne), 2021, 12: 711902., articleTitle=Human umbilical cord mesenchymal stem cell-derived exosomes improve ovarian function and proliferation of premature ovarian insufficiency by regulating the hippo signaling pathway, refAbstract=null), Reference(id=1199700890190971171, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=38, issue=9, pageStart=1137, pageEnd=1148, url=null, language=null, rfNumber=[30], rfOrder=33, authorNames=Ding C, Zhu L, Shen H, journalName=Stem Cells, refType=null, unstructuredReference=Ding C, Zhu L, Shen H, et al. Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7[J]. Stem Cells, 2020, 38(9): 1137-1148., articleTitle=Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7, refAbstract=null), Reference(id=1199700890337771816, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=10, issue=1, pageStart=250, pageEnd=null, url=null, language=null, rfNumber=[31], rfOrder=34, authorNames=Yang Z, Du X, Wang C, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Yang Z, Du X, Wang C, et al. Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice[J]. Stem Cell Res Ther, 2019, 10(1): 250., articleTitle=Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice, refAbstract=null), Reference(id=1199700890413269291, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=21, issue=null, pageStart=37, pageEnd=50, url=null, language=null, rfNumber=[32], rfOrder=35, authorNames=Ding C, Qian C, Hou S, journalName=Mol Ther Nucleic Acids, refType=null, unstructuredReference=Ding C, Qian C, Hou S, et al. Exosomal miRNA-320a is released from hAMSCs and regulates SIRT4 to prevent reactive oxygen species generation in POI[J]. Mol Ther Nucleic Acids, 2020, 21: 37-50., articleTitle=Exosomal miRNA-320a is released from hAMSCs and regulates SIRT4 to prevent reactive oxygen species generation in POI, refAbstract=null), Reference(id=1199700890501349677, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=26, issue=12, pageStart=906, pageEnd=919, url=null, language=null, rfNumber=[33], rfOrder=36, authorNames=Thabet E, Yusuf A, Abdelmonsif DA, journalName=Mol Hum Reprod, refType=null, unstructuredReference=Thabet E, Yusuf A, Abdelmonsif DA, et al. Extracellular vesicles miRNA-21: a potential therapeutic tool in premature ovarian dysfunction[J]. Mol Hum Reprod, 2020, 26(12): 906-919., articleTitle=Extracellular vesicles miRNA-21: a potential therapeutic tool in premature ovarian dysfunction, refAbstract=null), Reference(id=1199700890660733232, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2020, volume=11, issue=1, pageStart=3, pageEnd=null, url=null, language=null, rfNumber=[34], rfOrder=37, authorNames=Liu M, Qiu Y, Xue Z, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Liu M, Qiu Y, Xue Z, et al. Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway[J]. Stem Cell Res Ther, 2020, 11(1): 3., articleTitle=Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway, refAbstract=null), Reference(id=1199700890748813619, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2019, volume=9, issue=8, pageStart=2346, pageEnd=2360, url=null, language=null, rfNumber=[35], rfOrder=38, authorNames=Song Y, Zhang C, Zhang J, journalName=Theranostics, refType=null, unstructuredReference=Song Y, Zhang C, Zhang J, et al. Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction[J]. Theranostics, 2019, 9(8): 2346-2360., articleTitle=Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction, refAbstract=null), Reference(id=1199700890845282615, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=15, issue=1, pageStart=1519, pageEnd=1538, url=null, language=null, rfNumber=[36], rfOrder=39, authorNames=Zhao M, Liu S, Wang C, journalName=ACS Nano, refType=null, unstructuredReference=Zhao M, Liu S, Wang C, et al. Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA[J]. ACS Nano, 2021, 15(1): 1519-1538., articleTitle=Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA, refAbstract=null), Reference(id=1199700890924974394, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=10, issue=12, pageStart=null, pageEnd=null, url=null, language=null, rfNumber=[37], rfOrder=40, authorNames=Lee KS, Lee J, Kim HK, journalName=J Extracell Vesicles, refType=null, unstructuredReference=Lee KS, Lee J, Kim HK, et al. Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p[J]. J Extracell Vesicles, 2021, 10(12): e12152., articleTitle=Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p, refAbstract=null), Reference(id=1199700891004666173, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2015, volume=19, issue=9, pageStart=2108, pageEnd=2117, url=null, language=null, rfNumber=[38], rfOrder=41, authorNames=Zhu SF, Hu HB, Xu HY, journalName=J Cell Mol Med, refType=null, unstructuredReference=Zhu SF, Hu HB, Xu HY, et al. Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries[J]. J Cell Mol Med, 2015, 19(9): 2108-2117., articleTitle=Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries, refAbstract=null), Reference(id=1199700891134689600, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2012, volume=58, issue=1, pageStart=44, pageEnd=50, url=null, language=null, rfNumber=[39], rfOrder=42, authorNames=Matsuda F, Inoue N, Manabe N, journalName=J Reprod Dev, refType=null, unstructuredReference=Matsuda F, Inoue N, Manabe N, et al. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells[J]. J Reprod Dev, 2012, 58(1): 44-50., articleTitle=Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells, refAbstract=null), Reference(id=1199700891222769987, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=12, issue=1, pageStart=178, pageEnd=null, url=null, language=null, rfNumber=[40], rfOrder=43, authorNames=Zhang S, Huang B, Su P, journalName=Stem Cell Res Ther, refType=null, unstructuredReference=Zhang S, Huang B, Su P, et al. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency[J]. Stem Cell Res Ther, 2021, 12(1): 178., articleTitle=Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency, refAbstract=null), Reference(id=1199700891310850375, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2009, volume=138, issue=6, pageStart=869, pageEnd=881, url=null, language=null, rfNumber=[41], rfOrder=44, authorNames=Robinson RS, Woad KJ, Hammond AJ, journalName=Reproduction, refType=null, unstructuredReference=Robinson RS, Woad KJ, Hammond AJ, et al. Angiogenesis and vascular function in the ovary[J]. Reproduction, 2009, 138(6): 869-881., articleTitle=Angiogenesis and vascular function in the ovary, refAbstract=null), Reference(id=1199700891419902280, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2015, volume=24, issue=10, pageStart=1999, pageEnd=2010, url=null, language=null, rfNumber=[42], rfOrder=45, authorNames=Xia X, Yin T, Yan J, journalName=Cell Transplant, refType=null, unstructuredReference=Xia X, Yin T, Yan J, et al. Mesenchymal stem cells enhance angiogenesis and follicle survival in human cryopreserved ovarian cortex transplantation[J]. Cell Transplant, 2015, 24(10): 1999-2010., articleTitle=Mesenchymal stem cells enhance angiogenesis and follicle survival in human cryopreserved ovarian cortex transplantation, refAbstract=null), Reference(id=1199700891533148493, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2022, volume=47, issue=3, pageStart=243, pageEnd=250, url=null, language=null, rfNumber=[43], rfOrder=46, authorNames=Zhou L, Liao MY, Li X, journalName=Med J Chin PLA, refType=null, unstructuredReference=Zhou L, Liao MY, Li X, et al. Changes of peroxiredoxin 6 level in patients with polycystic ovary syndrome and the relativity with glucose and lipid metabolism and sex hormone levels[J]. Med J Chin PLA, 2022, 47(3): 243-250., articleTitle=Changes of peroxiredoxin 6 level in patients with polycystic ovary syndrome and the relativity with glucose and lipid metabolism and sex hormone levels, refAbstract=null), Reference(id=1199700891642200400, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2022, volume=47, issue=3, pageStart=243, pageEnd=250, url=null, language=null, rfNumber=[43], rfOrder=47, authorNames=周玲, 廖明钰, 李行, journalName=解放军医学杂志, refType=null, unstructuredReference=周玲, 廖明钰, 李行, 等. PRDX6在多囊卵巢综合征患者中的表达变化及其与糖脂代谢、性激素水平的相关性分析[J]. 解放军医学杂志, 2022, 47(3): 243-250., articleTitle=PRDX6在多囊卵巢综合征患者中的表达变化及其与糖脂代谢、性激素水平的相关性分析, refAbstract=null), Reference(id=1199700892774662484, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2021, volume=236, issue=12, pageStart=7966, pageEnd=7983, url=null, language=null, rfNumber=[44], rfOrder=48, authorNames=Wang L, Tang J, Wang L, journalName=J Cell Physiol, refType=null, unstructuredReference=Wang L, Tang J, Wang L, et al. Oxidative stress in oocyte aging and female reproduction[J]. J Cell Physiol, 2021, 236(12): 7966-7983., articleTitle=Oxidative stress in oocyte aging and female reproduction, refAbstract=null), Reference(id=1199700892871131480, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, doi=null, pmid=null, pmcid=null, year=2017, volume=2017, issue=null, pageStart=2398696, pageEnd=null, url=null, language=null, rfNumber=[45], rfOrder=49, authorNames=Bu H, Wedel S, Cavinato M, journalName=Oxid Med Cell Longev, refType=null, unstructuredReference=Bu H, Wedel S, Cavinato M, et al. MicroRNA regulation of oxidative stress-induced cellular senescence[J]. Oxid Med Cell Longev, 2017, 2017: 2398696., articleTitle=MicroRNA regulation of oxidative stress-induced cellular senescence, refAbstract=null)], funds=[Fund(id=1199700884151173268, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=81774362, language=EN, fundingSource=National Natural Science Foundation of China(81774362), fundOrder=null, country=null), Fund(id=1199700884264419481, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=81774362, language=CN, fundingSource=国家自然科学基金(81774362), fundOrder=null, country=null), Fund(id=1199700884369277085, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=81303004, language=EN, fundingSource=National Natural Science Foundation of China(81303004), fundOrder=null, country=null), Fund(id=1199700884469940383, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=81303004, language=CN, fundingSource=国家自然科学基金(81303004), fundOrder=null, country=null), Fund(id=1199700884595769508, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=2018JJ2290, language=EN, fundingSource=Natural Science Foundation of Hunan Province(2018JJ2290), fundOrder=null, country=null), Fund(id=1199700884713210023, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=2018JJ2290, language=CN, fundingSource=湖南省自然科学基金(2018JJ2290), fundOrder=null, country=null), Fund(id=1199700884784513197, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=kq2208187, language=EN, fundingSource=Natural Science Foundation of Changsha City(kq2208187), fundOrder=null, country=null), Fund(id=1199700884860010671, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, awardId=kq2208187, language=CN, fundingSource=长沙市自然科学基金(kq2208187), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1199700880208527388, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, xref=null, ext=[AuthorCompanyExt(id=1199700880216915997, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China), AuthorCompanyExt(id=1199700880225304606, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, companyId=1199700880208527388, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=湖南中医药大学医学院，湖南长沙 410208)])], figs=[ArticleFig(id=1199700882796413064, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=EN, label=Tab.1, caption=

Mechanism and effect of extracellular vesicles from different stem cells in treatment of POI

, figureFileSmall=null, figureFileBig=null, tableContent=
干细胞类型EVs类型机制及效果参考文献
脂肪间充质干细胞外泌体

改善卵巢功能
通过SMAD途径影响GCs增殖和凋亡

[23]
骨髓间充质干细胞外泌体

改善卵巢功能
携带miR-144-5p及miR-644-5p影响GCs的增殖和凋亡
促进卵巢血管的生成

[24-26]
脐带间充质干细胞外泌体、EVs、微囊泡

改善卵巢功能
提高生殖能力
通过Hippo途径影响GCs增殖和凋亡以及卵巢功能
通过传递miR-17-5p抑制SRIT7，减轻氧化应激反应
促进卵巢血管生成
提高生育能力，对后代无影响

[21，27-31]
人羊膜间充质干细胞外泌体

恢复卵巢功能
影响GCs的增殖与凋亡
通过miR-320a调节SIRT4，减轻氧化应激反应
提高生育能力

[32]
羊水间充质干细胞EVs

恢复卵巢功能
携带miRNA-21，部分靶向PTEN和PI3K/PTEN，促进卵泡再生，抑制凋亡

[33]
胚胎干细胞EVs

恢复卵巢功能
通过PI3K/Akt通路影响GCs增殖与凋亡

[34]
), ArticleFig(id=1199700883878543499, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199688707377824285, language=CN, label=表1, caption=

不同干细胞来源的EVs治疗早发性卵巢功能不全的机制及效果

, figureFileSmall=null, figureFileBig=null, tableContent=
干细胞类型EVs类型机制及效果参考文献
脂肪间充质干细胞外泌体

改善卵巢功能
通过SMAD途径影响GCs增殖和凋亡

[23]
骨髓间充质干细胞外泌体

改善卵巢功能
携带miR-144-5p及miR-644-5p影响GCs的增殖和凋亡
促进卵巢血管的生成

[24-26]
脐带间充质干细胞外泌体、EVs、微囊泡

改善卵巢功能
提高生殖能力
通过Hippo途径影响GCs增殖和凋亡以及卵巢功能
通过传递miR-17-5p抑制SRIT7，减轻氧化应激反应
促进卵巢血管生成
提高生育能力，对后代无影响

[21，27-31]
人羊膜间充质干细胞外泌体

恢复卵巢功能
影响GCs的增殖与凋亡
通过miR-320a调节SIRT4，减轻氧化应激反应
提高生育能力

[32]
羊水间充质干细胞EVs

恢复卵巢功能
携带miRNA-21，部分靶向PTEN和PI3K/PTEN，促进卵泡再生，抑制凋亡

[33]
胚胎干细胞EVs

恢复卵巢功能
通过PI3K/Akt通路影响GCs增殖与凋亡

[34]
)], attaches=null, journal=Journal(id=1146441329971666965, delFlag=0, nameCn=解放军医学杂志, nameEn=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, issn=0577-7402, eissn=null, cn=11-1056/R, coden=null, periodic=0, language=CN, oaType=是, ccby=CC BY-NC-ND, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=6srot5PcoYX30Oa4xeTmeg==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1751262512917, updatedTime=1761735725513, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=6srot5PcoYX30Oa4xeTmeg==, picEn=ELwBh5xqrSTlIs7HmSNt2Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369167564968109, language=CN, name=解放军医学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725537, updatedTime=1761735725537, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369167615299758, language=EN, name=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725549, updatedTime=1761735725549, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189873630562394117, websiteList=[Website(id=1189873845923287108, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN, language=CN, createTime=1761617631655, createBy=18614031015, updateTime=1761622010471, updateBy=18614031015, name=解放军医学杂志-中文, tplId=1146099689490845704, title=解放军医学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924939378520839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=articleTextType, value=kx, createTime=1761629813284, updateTime=1761629813284, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939353355012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=banner, value=null, createTime=1761629813278, updateTime=1761629813278, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939399492362, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=grayFlag, value=0, createTime=1761629813289, updateTime=1761629813289, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939344966403, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629813276, updateTime=1761629813276, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939412075276, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=minRunFlag, value=0, createTime=1761629813292, updateTime=1761629813292, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939374326534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic, createTime=1761629813283, updateTime=1761629813283, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939407880971, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=silenceFlag, value=0, createTime=1761629813291, updateTime=1761629813291, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939361743621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761629813280, updateTime=1761629813280, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939386909448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeColor, value=null, createTime=1761629813286, updateTime=1761629813286, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939395298057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeStyle, value=null, createTime=1761629813288, updateTime=1761629813288, creator=18614031015, updator=18614031015)]), Website(id=1189873846057504839, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN, language=EN, createTime=1761617631687, createBy=18614031015, updateTime=1761622030030, updateBy=18614031015, name=解放军医学杂志-英文, tplId=1146101810881728533, title=Medical Journal of Chinese People’s Liberation Army, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924968168223505, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=articleTextType, value=kx, createTime=1761629820148, updateTime=1761629820148, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968147251982, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=banner, value=null, createTime=1761629820143, updateTime=1761629820143, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968185000724, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=grayFlag, value=0, createTime=1761629820152, updateTime=1761629820152, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968138863373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629820141, updateTime=1761629820141, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968197583638, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=minRunFlag, value=0, createTime=1761629820155, updateTime=1761629820155, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968159834896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic, createTime=1761629820146, updateTime=1761629820146, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968193389333, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=silenceFlag, value=0, createTime=1761629820154, updateTime=1761629820154, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968155640591, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761629820145, updateTime=1761629820145, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968172417810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeColor, value=null, createTime=1761629820149, updateTime=1761629820149, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968180806419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeStyle, value=null, createTime=1761629820151, updateTime=1761629820151, creator=18614031015, updator=18614031015)])], journalTitle=解放军医学杂志, weixinUrl=null, journalUrl=http://zh.jfjyxzz.org.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Medical Journal of Chinese People’s Liberation Army, journalPhotoCn=6srot5PcoYX30Oa4xeTmeg==, journalPhotoEn=ELwBh5xqrSTlIs7HmSNt2Q==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.1106.2023.0227, detailUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.1106.2023.0227, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/PDF/10.11855/j.issn.0577-7402.1106.2023.0227, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/PDF/10.11855/j.issn.0577-7402.1106.2023.0227, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)
收藏切换
干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展
收藏切换
PDF下载
曾文卓 , 黄欣怡 , 徐数理 , 孙晓峰 *
解放军医学杂志 | 综述 2023,48(12): 1467-1472
收起
收藏切换
解放军医学杂志 | 综述 2023, 48(12): 1467-1472
干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展
全屏
曾文卓, 黄欣怡, 徐数理, 孙晓峰*
作者信息
  • 湖南中医药大学医学院，湖南长沙 410208

    • 曾文卓，硕士研究生，主要从事组织损伤修复等方面的研究

通讯作者:

孙晓峰，E-mail：
Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency
Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun*
Affiliations
  • Medical College, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China
出版时间: 2023-12-28 doi: 10.11855/j.issn.0577-7402.1106.2023.0227
文章导航
收藏切换
摘要
收起

早发性卵巢功能不全(POI)是育龄期女性不孕的重要原因之一，目前临床治疗方法有限，治疗效果不理想。近年来，干细胞来源的细胞外囊泡作为一种新型的无细胞治疗方式备受关注。多项动物实验研究显示，各种干细胞来源的细胞外囊泡携带微小RNA、长链非编码RNA、脂质、蛋白质等多种生物活性物质，可改善卵巢功能、影响颗粒细胞增殖和凋亡、促进卵巢血管生成及减轻氧化应激反应，从而对POI发挥治疗作用。本文对干细胞来源的细胞外囊泡治疗POI的相关机制研究进行综述，旨在为其早日应用于POI的临床治疗提供依据。

早发性卵巢功能不全  /  细胞外囊泡  /  外泌体  /  干细胞源性

Premature ovarian insufficient (POI) is one of the important causes of infertility in woman of reproductive age. At present, the clinical treatment of POI is limited and the therapeutic effect is not ideal. Extracellular vesicles derived from stem cells have attracted the attention of many researchers at home and abroad as a new cell-free therapy. Many animal experiment study shows that a variety of extracellular vesicles from stem cells carry microRNAs, lncRNAs, lipids, proteins, and other bioactive substances, improve ovarian function, affect granulosa cell proliferation and apoptosis, promote ovarian angiogenesis, and reduce oxidative stress response, thus playing a therapeutic role on POI. This article will review the mechanisms of extracellular vesicles in treatment of POI, and provide evidence for the application of extracellular vesicles in clinical treatment of POI.

premature ovarian insufficient  /  extracellular vesicles  /  exosomes  /  stem cell-derived
曾文卓, 黄欣怡, 徐数理, 孙晓峰. 干细胞源性细胞外囊泡治疗早发性卵巢功能不全的机制研究进展. 解放军医学杂志, 2023 , 48 (12) : 1467 -1472 . DOI: 10.11855/j.issn.0577-7402.1106.2023.0227
Wen-Zhuo Zeng, Xin-Yi Huang, Shu-Li Xu, Xiao-Feng Sun. Progress in the mechanism of stem cell derived extracellular vesicles in treatment of early onset ovarian insufficiency[J]. Medical Journal of Chinese People’s Liberation Army, 2023 , 48 (12) : 1467 -1472 . DOI: 10.11855/j.issn.0577-7402.1106.2023.0227
正文
收起
早发性卵巢功能不全(premature ovarian insufficient，POI)指女性在40岁前出现的卵巢功能减退，主要表现为月经异常、促性腺激素(FSH)水平升高(>25 U/L)、雌激素水平波动性下降，其终末阶段称为卵巢早衰(premature ovarian failure，POF)，此阶段表现为闭经、激素严重紊乱(FSH>40 U/L)并伴不同程度的围绝经期症状[1-2]。POI患者雌激素水平的降低可增加代谢性骨病、心血管疾病及神经系统疾病的患病风险[3]，降低患者的生活质量。同时，POI也是不孕症的重要病因之一。当前，我国人口老龄化形势严峻，提高人口出生率势在必行，因此，女性生殖健康问题不仅是患者的自身健康问题，更是事关人口结构优化的社会问题。目前常用的针对POI的治疗及辅助生殖技术均存在不同程度的局限性。因此，亟需找到一种安全可靠的治疗方法以解决POI带来的一系列问题。来源于干细胞的细胞外囊泡(extracellular vesicles，EVs)不仅具有其亲代干细胞的治疗功效，且免疫原性低、可跨越细胞屏障，近年来已成为多种疾病治疗研究的热点[4]。本文从POI的治疗现状及前景入手，基于改善卵巢功能、影响颗粒细胞(granulosa cells，GCs)增殖及凋亡、促进卵巢血管生成、减轻氧化应激反应、影响生育能力及后代等方面对干细胞来源的EVs治疗POI的机制进行综述，旨在为EVs用于POI的临床治疗提供依据。
1 POI的治疗现状及前景
收起
激素替代疗法(hormone replacement therapy，HRT)是临床上应用最广泛的POI治疗方法，可调节激素紊乱，缓解各种更年期症状，但无法从根本上恢复卵巢功能和生育能力，且存在诱发静脉血栓及癌症等风险[5]。对于有生育需求的POI患者，常在HRT治疗的基础上借助辅助生殖技术和生育力保存方法。有效的辅助生殖技术为赠卵体外受精-胚胎移植技术(IVF-ET)，生育力保存方法包括胚胎冷冻、卵细胞冷冻及卵巢组织冷冻等[1]。但此类方法仍存在技术、管理、安全性及伦理上的问题，促排卵药物的使用还可使患者面临卵巢过度刺激综合征的风险。随着干细胞研究的深入，大量研究提示，干细胞移植在动物模型中可修复损伤卵巢组织、改善内分泌，从而恢复卵巢功能[6-7]。在膝骨关节炎、移植物抗宿主病及糖尿病等疾病中干细胞治疗已进入临床试验阶段[8]，在POI中也已有少量不完善的初期临床研究[9-11]。但干细胞移植的局限性如伦理争议、移植细胞存活率低、异体移植排斥、侵入性操作及肿瘤转化等[12]限制了其进一步应用。EVs是干细胞移植治疗的重要旁分泌机制之一。一项关于心脏修复的研究证实，EVs具有其亲代诱导多能干细胞的治疗功效，且无致瘤性[13]。多项研究也证实EVs没有致瘤风险[14-15]。EVs能包裹活性物质、隔绝外界酶的影响，在血液循环和远距离治疗中更安全稳定，是理想的药物载体[16]。此外，EVs具有干细胞的多种治疗功效，又能弥补干细胞移植的劣势，有望成为干细胞移植的优势替代方法。对于肿瘤患者，EVs可作为临床诊断和预后评估的标志物[17]。在POI的治疗中，EVs已被多项动物实验研究证实能通过改善卵巢功能、影响GCs增殖凋亡等不同机制恢复卵巢功能。因此，EVs作为一种新兴的细胞间通信方式，可能成为打破POI治疗瓶颈的关键。
2 干细胞来源的EVs
收起
EVs是一种可由多种细胞分泌的具有脂质双分子膜结构的纳米级囊泡[18]，根据大小、释放方式及表面标记物的不同，可分为微囊泡(microvesicles，MVs)、外泌体(exosomes，EXOs)、凋亡小体(apoptotic bodies，ABs)等多种亚群。MVs是膜蛋白重塑出芽分离出的具有脂质双分子层的囊泡，其直径一般为150~1000 nm；外泌体直径一般为40~150 nm，早期在细胞内形成多泡体(multivesicular bodies，MVBs)，其内包含有多个腔内囊泡(intraluminal vesicles，ILVs)即外泌体的前体，MVBs与细胞膜融合后释放出的ILVs即为外泌体；凋亡小体直径一般为1~5 μm，是通过发芽脱落机制或自噬体形成机制使胞膜皱缩内陷，包裹胞质、DNA及细胞器形成的泡状小体[19-20]。EVs广泛分布在母乳、血液等生物体液中，可由干细胞、上皮细胞等多种细胞分泌[21]，而考虑到低免疫原性及可大量扩增等优势，干细胞是目前相关研究工作中EVs的主要来源。干细胞来源的EVs可包含各种生物活性物质，如蛋白质、脂质、DNA、微小RNA(microRNAs，miRNAs)、长链非编码RNA(long non-coding RNAs，lncRNAs)等，能通过传递内容物参与细胞间通信，进而影响靶细胞的表型及功能[22]。
3 EVs治疗POI的机制
收起
多项动物实验证实，各种干细胞来源的EVs可通过不同机制对POI起到治疗作用。具体机制及治疗效果可见表1[21,23-34]。
3.1 改善卵巢功能
EVs及其携带的活性物质可恢复损伤卵巢的重量及形态、增加卵泡数量、调节激素分泌及改善异常发情周期。Huang等[23]将人脂肪间充质干细胞来源的外泌体注射到环磷酰胺(cyclophosphamide，CTX)诱导的POI模型小鼠卵巢中，4周后卵巢卵泡数量明显增多，雌二醇(E2)和抗缪勒管激素水平升高，FSH水平下降。另一项研究则是通过腹腔注射将骨髓间充质干细胞来源的外泌体移植入CTX诱导的化疗源性POF大鼠模型中，结果发现POF大鼠发情周期及激素水平恢复正常，健康卵泡数量增加，卵巢功能得到改善[24]。也有学者将人脐带造血干细胞来源的EVs分离鉴定后经尾静脉注入POI模型小鼠，结果显示小鼠体重明显增加，卵巢质量提高，卵母细胞及胚胎数增多，E2水平升高，FSH水平降低[27]。羊水间充质干细胞(amniotic fluid mesenchymal stem cells，AFMSCs)是从羊水中获取的干细胞。Thabet等[33]证实，AFMSCs来源的EVs与AFMSCs一样，可恢复激素水平及发情周期，且EVs与AFMSCs均可通过增强miRNA-21的表达，降低miRNA-21下游的PTEN和casepase-3的表达，最终改善化疗诱导的卵巢储备功能损伤。
目前，临床前实验研究中大部分EVs移植是通过原位组织注射或静脉注射两种方式，结果显示EVs均有效[35-37]，但两种移植方式的选择仍需进一步探索。一项人脐带间充质干细胞(human umbilical cord mesenchymal stem cells，HUCMSC)修复化疗性大鼠卵巢损伤模型的研究对比了卵巢注射及尾静脉注射两种移植方式的治疗效果，结果发现静脉注射创伤更小，且有助于修复化疗性的多器官损伤，因而更具优势[38]，但EVs移植是否优先考虑静脉注射仍值得探讨。
3.2 影响卵巢GCs的增殖及凋亡
POI患者卵巢生理功能及生殖能力常因卵泡耗竭、闭锁而减弱[29]。卵泡由核心的卵母细胞及周围的GCs和卵泡膜细胞构成。卵母细胞为生殖细胞，GCs对卵母细胞有重要的营养和支持作用。GCs分泌包括E2、生长因子、细胞因子在内的多种活性因子，对卵泡的发育至关重要，同时GCs的凋亡会诱发卵泡闭锁[39]。因此，GCs对卵泡生长、发育、闭锁极为重要，其增殖与凋亡必然会影响卵巢的生理功能及生育能力。
多项研究表明，干细胞来源的EVs对GCs有促进增殖和抑制凋亡的作用。Sun等[25]发现，骨髓间充质干细胞来源的外泌体通过传递miR-644-5p靶向p53可抑制卵巢GCs凋亡，并改善卵巢功能。另一项研究证实，GCs能有效吸收HUCMSC来源的外泌体，调节凋亡相关的蛋白，从而保护卵巢GCs免受顺铂诱导的损伤；此外，该研究进一步预测分析显示，microRNA-24、microRNA-106a、microRNA-19b、microRNA-25可能与细胞凋亡有关[28]。有研究者用CTX诱导建立小鼠POI模型后，通过腹腔注射移植HUCMSC来源的外泌体，恢复了小鼠激素水平和发情周期，并通过Hippo通路恢复了GCs促卵泡激素受体的表达，从而促进GCs在体内的增殖，最终改善了POI小鼠的卵巢功能[29]。Zhang等[21]将HUCMSC衍生的EVs加入顺铂诱导的GCs化疗损伤模型中进行培养，结果显示EVs成功整合到GCs中，并通过调节Bcl-2/Bax比例和抑制caspase-3介导的凋亡级联反应保护了GCs免受化疗诱导的损伤，提示EVs在GCs合成和分泌类固醇激素过程中发挥了重要作用。一项探讨月经血源性基质细胞(menstrual blood-derived stromal cells，MenSCs)衍生外泌体对POI影响的研究将分离出的外泌体经尾静脉注入经4-乙烯基环己烯二环氧化物(VCD)诱导的SD大鼠POI模型中，结果显示，MenSCs衍生外泌体可促进卵泡发育及GCs增殖，抑制GCs凋亡，且该外泌体具有卵巢皮质倾向性，可调节卵巢生理功能及卵巢微环境[40]。经尾静脉注射来源于胚胎干细胞的EVs可恢复POF模型小鼠的卵巢功能，并通过激活PI3K-Akt通路促进GCs增殖，抑制GCs凋亡[34]。
3.3 促进卵巢血管的形成
卵巢功能依赖复杂的卵巢血管系统和持续性的血管重塑，以为卵泡和黄体提供所必需的营养、氧气及激素支持[41]。优势卵泡的产生也与初级卵泡中丰富的血管网络有关[31]。由此可见，促进卵巢血管形成及重塑对POI的治疗具有重要作用。血管内皮生长因子(vascular endothelial growth factor，VEGF)、胰岛素样生长因子1(insulin-like growth factor-1，IGF-1)、血管生成素是重要的血管生成因子，尤其是血管生成素可明显刺激新生血管生成，从而参与卵泡的发育[42]。Yang等[31]从HUCMSC内提取出MVs作用于POI模型小鼠，结果发现，HUCMSC-MVs移植后血管生成因子(包括VEGF、IGF-1、血管生成素)表达水平明显升高，且可能通过PI3K-Akt通路诱导血管生成来恢复卵巢功能。此外，Park等[26]用骨髓间充质干细胞的条件培养基(MSC CM)处理人卵巢内皮细胞，结果发现，MSC CM可促进卵巢内皮细胞的增殖及血管生成标记物的表达，并通过PI3K-ALK通路促进血管生成，且采用小管形成实验验证了MSC CM对卵巢内皮细胞成血管能力的促进作用。但该研究未对培养基的具体作用成分进行分析。此外，考虑到血管生成可促进肿瘤生长，EVs的促血管作用是否有致癌作用值得进一步探讨。
3.4 减轻氧化应激反应
生理状态下，活性氧(reactive oxygen species，ROS)与抗氧化剂保持平衡状态，当ROS过量导致平衡被打破时，机体产生氧化应激反应(oxidative stress，OS)，使卵泡发生衰老[43]，因此，氧化应激可能是多种生殖疾病的启动因素，并参与卵泡闭锁、减数分裂异常等病理过程[44]。在各种表观遗传事件中，microRNA是控制氧化应激和细胞衰老的重要参与者[45]。目前已有研究证实，外泌体可通过传递microRNA抑制ROS的积累，进而改善卵巢功能。Ding等[30]证实，来源于人脐带干细胞的外泌体可通过miRNA-17-5p的表达下调SIRT7及下游靶基因(PARP1、γH2AX、XRCC6)的表达，抑制ROS的积累，改善POI患者的卵巢功能，且其作用具有剂量依赖性。而人羊膜间充质干细胞来源外泌体中的miRNA-320a则可通过抑制GCs和卵母细胞中的氧化应激调节因子STRT4来降低ROS的水平[32]。
3.5 对生育能力及后代的影响
生育能力的恢复及后代的健康问题是育龄期POI患者关注的重点。Li等[28]发现，HUCMSC来源的外泌体可提高POI小鼠的妊娠率，增加后代数量并缩短怀孕时间。Liu等[27]首次利用体外受精和交配实验检测POI小鼠的生育能力，并评估其在接受HUCMSC EVs移植后子代的情况，结果发现EVs移植增加了卵母细胞和胚胎的数量，缩短了小鼠的怀孕时间，且子代小鼠的生长及即时工作记忆和识别记忆均未受到明显影响，提示EVs治疗并不会导致后代的认知缺陷。但是相关研究仍需更全面、更系统地验证及更长期的随访，以确保其安全性。
4 总结与展望
收起
EVs通过各种机制对POI发挥治疗作用，以上实验研究共同表明EVs在未来POI的临床治疗中拥有巨大的潜力。EVs是一种理想的药物载体，并有望成为干细胞移植的优势替代方法，通过运输miRNA等活性物质恢复卵巢功能、提高生育能力，为POI患者带来了希望。但就目前的研究现状来看，EVs想要实现临床应用，仍存在许多待解决的难题：(1)EVs携带的活性成分及作用机制研究不全；(2)EVs提取与修饰的技术与标准不规范；(3)给药途径、剂量及标准不确定。此外，EVs的应用还需更加严谨的临床研究以评估其安全性。总之，EVs在POI的治疗中表现出巨大的潜力，相信关于EVs的研究将会给POI的临床治疗注入新的活力。
基金
收起
  • 国家自然科学基金(81774362)
  • 国家自然科学基金(81303004)
  • 湖南省自然科学基金(2018JJ2290)
  • 长沙市自然科学基金(kq2208187)
文献
收起
参考文献 引证文献
排序方式：
[1]
Chen ZJ, Tian QJ, Qiao J, et al. Chinese expert consensus on the clinical diagnosis and treatment of premature ovarian insufficient [J]. Chin J Obstetr Gynecol, 2017, 52(9): 577-581.
陈子江, 田秦杰, 乔杰, 等. 早发性卵巢功能不全的临床诊疗中国专家共识[J]. 中华妇产科杂志, 2017, 52(9): 577-581.
[2]
Ma WQ, Li XR, Xie JX, et al. Expression and clinical value of serum miR-21 and PBMC Peli1 in autoimmune POI patients[J]. Med J Chin PLA, 2021, 46(3): 252-257.
马闻擎, 李欣然, 谢嘉欣, 等. 免疫性早发性卵巢功能不全患者血清miR-21及外周血单核细胞Peli1的表达及意义[J]. 解放军医学杂志, 2021, 46(3): 252-257.
[3]
de Vos M, Devroey P, Fauser BCJM. Primary ovarian insufficiency[J]. Lancet, 2010, 376(9744): 911-921.
[4]
Zhao AG, Shah K, Cromer B, et al. Mesenchymal stem cell-derived extracellular vesicles and their therapeutic potential[J]. Stem Cells Int, 2020, 2020: 8825771.
[5]
US Preventive Services Task Force, Grossman DC, Curry SJ, et al. Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: us preventive services task force recommendation statement[J]. JAMA, 2017, 318(22): 2224-2233.
[6]
Shen J, Cao D, Sun JL. Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure[J]. World J Stem Cells, 2020, 12(4): 277-287.
[7]
Yoon SY, Yoon JA, Park M, et al. Recovery of ovarian function by human embryonic stem cell-derived mesenchymal stem cells in cisplatin-induced premature ovarian failure in mice[J]. Stem Cell Res Ther, 2020, 11(1): 255.
[8]
Zhang QY, Ye XJ, Guo JJ, et al. Current situation of steam cell therapy environment and clinical application in China[J]. J ShaoXing Univ(Nat Sci), 2021, 41(3): 115-119.
张沁瑶, 叶鑫健, 过金晶, 等. 国内干细胞治疗环境及临床应用现状[J]. 绍兴文理学院学报(自然科学), 2021, 41(3): 115-119.
[9]
Fàbregues F, Ferreri J, Méndez M, et al. In vitro follicular activation and stem cell therapy as a novel treatment strategies in diminished ovarian reserve and primary ovarian insufficiency[J]. Front Endocrinol (Lausanne), 2020, 11: 617704.
[10]
Huang QY, Chen SR, Chen JM, et al. Therapeutic options for premature ovarian insufficiency: an updated review[J]. Reprod Biol Endocrinol, 2022, 20(1): 28.
[11]
Sheikhansari G, Aghebati-Maleki L, Nouri M, et al. Current approaches for the treatment of premature ovarian failure with stem cell therapy[J]. Biomedecine Pharmacother, 2018, 102: 254-262.
[12]
Zhang Q, Sun J, Huang Y, et al. Human amniotic epithelial cell-derived exosomes restore ovarian function by transferring microRNAs against apoptosis[J]. Mol Ther Nucleic Acids, 2019, 16: 407-418.
[13]
Adamiak M, Cheng G, Bobis-Wozowicz S, et al. Induced pluripotent stem cell (iPSC)-derived extracellular vesicles are safer and more effective for cardiac repair than iPSCs[J]. Circ Res, 2018, 122(2): 296-309.
[14]
Liu J, Huang Z, Yang L, et al. Embryonic stem cells modulate the cancer-permissive microenvironment of human uveal melanoma[J]. Theranostics, 2019, 9(16): 4764-4778.
[15]
Zhu Q, Ling X, Yang Y, et al. Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy[J]. Adv Sci (Weinh), 2019, 6(6): 1801899.
[16]
Cha J, Shin E, Sung J, et al. Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells[J]. Sci Rep, 2018, 8(1): 1171.
[17]
Urabe F, Kosaka N, Ito K, et al. Extracellular vesicles as biomarkers and therapeutic targets for cancer[J]. Am J Physiol Cell Physiol, 2020, 318(1): C29-C39.
[18]
Wang J, Chen JY. Rencent advances in extracellular vesicles[J]. Chin J Tissue Eng Res, 2017, 21(4): 621-626.
王琎, 陈建英. 细胞外囊泡研究新进展[J]. 中国组织工程研究, 2017, 21(4): 621-626.
[19]
Jeppesen DK, Fenix AM, Franklin JL, et al. Reassessment of exosome composition[J]. Cell, 2019, 177(2): 428-445.e18.
[20]
van Niel G, D'Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles [J]. Nat Rev Mol Cell Biol, 2018, 19(4): 213-228.
[21]
Zhang J, Yin H, Jiang H, et al. The protective effects of human umbilical cord mesenchymal stem cell-derived extracellular vesicles on cisplatin-damaged granulosa cells[J]. Taiwan J Obstet Gynecol, 2020, 59(4): 527-533.
[22]
Maas SLN, Breakefield XO, Weaver AM. Extracellular vesicles: unique intercellular delivery vehicles[J]. Trends Cell Biol, 2017, 27(3): 172-188.
[23]
Huang B, Lu J, Ding C, et al. Exosomes derived from human adipose mesenchymal stem cells improve ovary function of premature ovarian insufficiency by targeting SMAD[J]. Stem Cell Res Ther, 2018, 9(1): 216.
[24]
Yang M, Lin L, Sha C, et al. Bone marrow mesenchymal stem cell-derived exosomal miR-144-5p improves rat ovarian function after chemotherapy-induced ovarian failure by targeting PTEN[J]. Lab Invest, 2020, 100(3): 342-352.
[25]
Sun B, Ma YJ, Wang F, et al. MiR-644-5p carried by bone mesenchymal stem cell-derived exosomes targets regulation of p53 to inhibit ovarian granulosa cell apoptosis[J]. Stem Cell Res Ther, 2019, 10(1): 360.
[26]
Park HS, Ashour D, Elsharoud A, et al. Towards cell free therapy of premature ovarian insufficiency: human bone marrow mesenchymal stem cells secretome enhances angiogenesis in human ovarian microvascular endothelial cells[J]. HSOA J Stem Cells Res Dev Ther, 2019, 5(2): 019.
[27]
Liu C, Yin H, Jiang H, et al. Extracellular vesicles derived from mesenchymal stem cells recover fertility of premature ovarian insufficiency mice and the effects on their offspring[J]. Cell Transplant, 2020, 29: 963689720923575.
[28]
Sun L, Li D, Song K, et al. Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro[J]. Sci Rep, 2017, 7(1): 2552.
[29]
Li Z, Zhang M, Zheng J, et al. Human umbilical cord mesenchymal stem cell-derived exosomes improve ovarian function and proliferation of premature ovarian insufficiency by regulating the hippo signaling pathway[J]. Front Endocrinol (Lausanne), 2021, 12: 711902.
[30]
Ding C, Zhu L, Shen H, et al. Exosomal miRNA-17-5p derived from human umbilical cord mesenchymal stem cells improves ovarian function in premature ovarian insufficiency by regulating SIRT7[J]. Stem Cells, 2020, 38(9): 1137-1148.
[31]
Yang Z, Du X, Wang C, et al. Therapeutic effects of human umbilical cord mesenchymal stem cell-derived microvesicles on premature ovarian insufficiency in mice[J]. Stem Cell Res Ther, 2019, 10(1): 250.
[32]
Ding C, Qian C, Hou S, et al. Exosomal miRNA-320a is released from hAMSCs and regulates SIRT4 to prevent reactive oxygen species generation in POI[J]. Mol Ther Nucleic Acids, 2020, 21: 37-50.
[33]
Thabet E, Yusuf A, Abdelmonsif DA, et al. Extracellular vesicles miRNA-21: a potential therapeutic tool in premature ovarian dysfunction[J]. Mol Hum Reprod, 2020, 26(12): 906-919.
[34]
Liu M, Qiu Y, Xue Z, et al. Small extracellular vesicles derived from embryonic stem cells restore ovarian function of premature ovarian failure through PI3K/AKT signaling pathway[J]. Stem Cell Res Ther, 2020, 11(1): 3.
[35]
Song Y, Zhang C, Zhang J, et al. Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction[J]. Theranostics, 2019, 9(8): 2346-2360.
[36]
Zhao M, Liu S, Wang C, et al. Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA[J]. ACS Nano, 2021, 15(1): 1519-1538.
[37]
Lee KS, Lee J, Kim HK, et al. Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p[J]. J Extracell Vesicles, 2021, 10(12): e12152.
[38]
Zhu SF, Hu HB, Xu HY, et al. Human umbilical cord mesenchymal stem cell transplantation restores damaged ovaries[J]. J Cell Mol Med, 2015, 19(9): 2108-2117.
[39]
Matsuda F, Inoue N, Manabe N, et al. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells[J]. J Reprod Dev, 2012, 58(1): 44-50.
[40]
Zhang S, Huang B, Su P, et al. Concentrated exosomes from menstrual blood-derived stromal cells improves ovarian activity in a rat model of premature ovarian insufficiency[J]. Stem Cell Res Ther, 2021, 12(1): 178.
[41]
Robinson RS, Woad KJ, Hammond AJ, et al. Angiogenesis and vascular function in the ovary[J]. Reproduction, 2009, 138(6): 869-881.
[42]
Xia X, Yin T, Yan J, et al. Mesenchymal stem cells enhance angiogenesis and follicle survival in human cryopreserved ovarian cortex transplantation[J]. Cell Transplant, 2015, 24(10): 1999-2010.
[43]
Zhou L, Liao MY, Li X, et al. Changes of peroxiredoxin 6 level in patients with polycystic ovary syndrome and the relativity with glucose and lipid metabolism and sex hormone levels[J]. Med J Chin PLA, 2022, 47(3): 243-250.
周玲, 廖明钰, 李行, 等. PRDX6在多囊卵巢综合征患者中的表达变化及其与糖脂代谢、性激素水平的相关性分析[J]. 解放军医学杂志, 2022, 47(3): 243-250.
[44]
Wang L, Tang J, Wang L, et al. Oxidative stress in oocyte aging and female reproduction[J]. J Cell Physiol, 2021, 236(12): 7966-7983.
[45]
Bu H, Wedel S, Cavinato M, et al. MicroRNA regulation of oxidative stress-induced cellular senescence[J]. Oxid Med Cell Longev, 2017, 2017: 2398696.
2023年第48卷第12期
PDF下载
178
75
引用本文
BibTeX
文章信息
doi: 10.11855/j.issn.0577-7402.1106.2023.0227
  • 接收时间：2022-05-17
  • 首发时间：2025-11-24
  • 出版时间：2023-12-28
补充材料
相关文章
文章信息
作者
出版历史
  • 收稿日期：2022-05-17
  • 录用日期：2022-07-09
基金
National Natural Science Foundation of China(81774362)
国家自然科学基金(81774362)
National Natural Science Foundation of China(81303004)
国家自然科学基金(81303004)
Natural Science Foundation of Hunan Province(2018JJ2290)
湖南省自然科学基金(2018JJ2290)
Natural Science Foundation of Changsha City(kq2208187)
长沙市自然科学基金(kq2208187)
作者信息
    湖南中医药大学医学院，湖南长沙 410208

通讯作者:

孙晓峰，E-mail：
参考文献
分享链接
https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.1106.2023.0227
分享至
全文二维码

扫描看全文

引用本文
BibTeX
本文的引用情况
2种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
相关链接
论文
最新文章
热读文章
热点专题
内参
蓝皮书
产业发展报告
传播力报告
期刊分级目录
资讯
学术新闻
行业新闻
学术会议
行业会议
关于
关于我们
联系我们
北京市海淀区学院南路86号
100081
010-62199257
qkjq@cast.org.cn

中国科学技术协会版权所有 京ICP 备10216604号-4 海淀分局备案 1101084647
科技导报社主办 中国科协信息中心技术支持