Article(id=1199335107107586824, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199335100786766058, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.1986.2023.0524, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1663689600000, receivedDateStr=2022-09-21, revisedDate=null, revisedDateStr=null, acceptedDate=1667491200000, acceptedDateStr=2022-11-04, onlineDate=1763873372103, onlineDateStr=2025-11-23, pubDate=1709049600000, pubDateStr=2024-02-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763873372103, onlineIssueDateStr=2025-11-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763873372103, creator=13701087609, updateTime=1763873372103, updator=13701087609, issue=Issue{id=1199335100786766058, tenantId=1146029695717560320, journalId=1189873630562394117, year='2024', volume='49', issue='2', pageStart='123', pageEnd='244', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1763873370596, creator=13701087609, updateTime=1763874072387, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1199338044361896535, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199335100786766058, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1199338044361896536, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199335100786766058, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=220, endPage=228, ext={EN=ArticleExt(id=1199335107388605208, articleId=1199335107107586824, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Advances in the study of neoantigen pulsed dendritic cell vaccines in tumor immunotherapy, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Neoantigen pulsed dendritic cell vaccine (Neo-DCVac) is a new type of tumor immunotherapy. Neoantigen is strong immunologic and tumor-specific mutated peptides expressed in a tumor. Neo-DCVac is a therapeutic modality based on the uptake and processing of neoantigens by dendritic cells and their delivery and activation of T cells to trigger the body's immune response for anti-tumor effects. The development of individualized Neo-DCVac based on high-throughput sequencing is expected to be a new direction for precision immunotherapy of tumors. In this review, we discuss construction of individualized Neo-DCVac, clinical application of combination therapy in solid tumors, suitable population for vaccination and the current limitations of Neo-DCVac, aiming to provide a theoretical reference for research on tumor immunotherapy.

, correspAuthors=Yu-Min Li, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Tong-Xin Wang, Fan Zhang, Xin Yan, Ya-Ting Zhang, Yu-Min Li), CN=ArticleExt(id=1199335108097442613, articleId=1199335107107586824, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=新抗原脉冲树突状细胞疫苗在肿瘤免疫治疗中的作用, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

新抗原脉冲树突状细胞疫苗(Neo-DCVac)是一种新型肿瘤免疫治疗手段。新抗原是指肿瘤细胞突变产生的具有较强免疫原性和肿瘤特异性的肽段。Neo-DCVac是基于新抗原被树突状细胞摄取、加工后递呈并激活T细胞引发机体免疫反应，从而发挥抗肿瘤作用。在高通量测序基础上发展而来的个体化Neo-DCVac有望成为肿瘤精准免疫治疗的新方向。本文从个体化Neo-DCVac构建、在实体瘤中联合治疗的临床应用、适宜接种人群和目前存在的局限性等方面进行综述，旨在为肿瘤免疫治疗的相关研究提供参考。

, correspAuthors=李玉民, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=0lgeZfSe5Q9WAwjVfeRLpg==, magXml=AELYAwoPDkg/b2PAqq+98A==, pdfUrl=null, pdf=ZqtvG4VojQZ1KaVcPhlP3A==, pdfFileSize=1217409, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=uJpLV3ebmUeNf7JCgypURg==, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=Rq+qM/KWe+i4GaUfluFtfQ==, mapNumber=null, authorCompany=null, fund=null, authors=, authorsList=王彤昕, 张凡, 闫鑫, 张雅婷, 李玉民)}, authors=[Author(id=1199335108667867990, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, orderNo=0, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199335109729026908, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335108667867990, language=EN, stringName=Tong-Xin Wang, firstName=Tong-Xin, middleName=null, lastName=Wang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199335109833884512, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335108667867990, language=CN, stringName=王彤昕, firstName=彤昕, middleName=null, lastName=王, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030
²兰州大学第二医院肿瘤外科，甘肃兰州 730030, bio={"content":"

王彤昕，硕士研究生，主要从事消化系统肿瘤治疗方面的研究

"}, bioImg=null, bioContent=

王彤昕，硕士研究生，主要从事消化系统肿瘤治疗方面的研究

, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])]), Author(id=1199335109989073770, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, orderNo=1, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199335110144263031, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335109989073770, language=EN, stringName=Fan Zhang, firstName=Fan, middleName=null, lastName=Zhang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199335110236537727, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335109989073770, language=CN, stringName=张凡, firstName=凡, middleName=null, lastName=张, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030
²兰州大学第二医院肿瘤外科，甘肃兰州 730030, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])]), Author(id=1199335110362366854, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, orderNo=2, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199335110504973199, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335110362366854, language=EN, stringName=Xin Yan, firstName=Xin, middleName=null, lastName=Yan, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199335110597247897, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335110362366854, language=CN, stringName=闫鑫, firstName=鑫, middleName=null, lastName=闫, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030
²兰州大学第二医院肿瘤外科，甘肃兰州 730030, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])]), Author(id=1199335110697911200, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, orderNo=3, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1199335110840517546, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335110697911200, language=EN, stringName=Ya-Ting Zhang, firstName=Ya-Ting, middleName=null, lastName=Zhang, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199335111062815670, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335110697911200, language=CN, stringName=张雅婷, firstName=雅婷, middleName=null, lastName=张, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2}, address=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030
²兰州大学第二医院肿瘤外科，甘肃兰州 730030, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])]), Author(id=1199335111197033403, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, orderNo=4, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=liym@ lzu.edu.cn, emailSecond=null, emailThird=null, correspondingAuthor=1, authorType=1, ext={EN=AuthorExt(id=1199335111310279619, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335111197033403, language=EN, stringName=Yu-Min Li, firstName=Yu-Min, middleName=null, lastName=Li, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China
²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1199335111410942922, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, authorId=1199335111197033403, language=CN, stringName=李玉民, firstName=玉民, middleName=null, lastName=李, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=^{1, 2, *}, address=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030
²兰州大学第二医院肿瘤外科，甘肃兰州 730030, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])])], keywords=[Keyword(id=1199335111524189136, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, orderNo=1, keyword=neoantigen), Keyword(id=1199335111629046740, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, orderNo=2, keyword=dendritic cell vaccine), Keyword(id=1199335111733904346, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, orderNo=3, keyword=tumor), Keyword(id=1199335111847150557, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, orderNo=4, keyword=immunotherapy), Keyword(id=1199335112023311329, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, orderNo=1, keyword=新抗原), Keyword(id=1199335112165917668, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, orderNo=2, keyword=树突状细胞疫苗), Keyword(id=1199335112287552492, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, orderNo=3, keyword=肿瘤), Keyword(id=1199335112430158834, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, orderNo=4, keyword=免疫治疗)], refs=[Reference(id=1199335114976100411, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=71, issue=3, pageStart=209, pageEnd=249, url=null, language=null, rfNumber=[1], rfOrder=0, authorNames=Sung H, Ferlay J, Siegel RL, journalName=CA Cancer J Clin, refType=null, unstructuredReference=Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2021, 71(3): 209-249., articleTitle=Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, refAbstract=null), Reference(id=1199335115122901054, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2022, volume=135, issue=5, pageStart=584, pageEnd=590, url=null, language=null, rfNumber=[2], rfOrder=1, authorNames=Xia C, Dong X, Li H, journalName=Chin Med J (Engl), refType=null, unstructuredReference=Xia C, Dong X, Li H, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants[J]. Chin Med J (Engl), 2022, 135(5): 584-590., articleTitle=Cancer statistics in China and United States, 2022: profiles, trends, and determinants, refAbstract=null), Reference(id=1199335115223564353, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2020, volume=6, issue=1, pageStart=1, pageEnd=7, url=null, language=null, rfNumber=[3], rfOrder=2, authorNames=Zhang H, Zhou X, Liu D, journalName=Med Drug Discov, refType=null, unstructuredReference=Zhang H, Zhou X, Liu D, et al. Progress and challenges of personalized neoantigens in the clinical treatment of tumors[J]. Med Drug Discov, 2020, 6(1): 1-7., articleTitle=Progress and challenges of personalized neoantigens in the clinical treatment of tumors, refAbstract=null), Reference(id=1199335115357782085, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2022, volume=47, issue=10, pageStart=1057, pageEnd=1062, url=null, language=null, rfNumber=[4], rfOrder=3, authorNames=叶立果, 綦仰之, 陈谦学, journalName=解放军医学杂志, refType=null, unstructuredReference=叶立果, 綦仰之, 陈谦学, 等. 新抗原mRNA肿瘤疫苗在脑胶质瘤治疗中的研究进展[J].解放军医学杂志, 2022, 47(10): 1057-1062., articleTitle=新抗原mRNA肿瘤疫苗在脑胶质瘤治疗中的研究进展, refAbstract=null), Reference(id=1199335115487805516, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2017, volume=17, issue=4, pageStart=209, pageEnd=222, url=null, language=null, rfNumber=[5], rfOrder=4, authorNames=Yarchoan M, Johnson BA, Lutz ER, journalName=Nat Rev Cancer, refType=null, unstructuredReference=Yarchoan M, Johnson BA, Lutz ER, et al. Targeting neoantigens to augment antitumour immunity[J]. Nat Rev Cancer, 2017, 17(4): 209-222., articleTitle=Targeting neoantigens to augment antitumour immunity, refAbstract=null), Reference(id=1199335115571691599, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2017, volume=18, issue=3, pageStart=255, pageEnd=262, url=null, language=null, rfNumber=[6], rfOrder=5, authorNames=Tran E, Robbins PF, Rosenberg SA, journalName=Nat Immunol, refType=null, unstructuredReference=Tran E, Robbins PF, Rosenberg SA. 'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations[J]. Nat Immunol, 2017, 18(3): 255-262., articleTitle='Final common pathway' of human cancer immunotherapy: targeting random somatic mutations, refAbstract=null), Reference(id=1199335115638800466, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=350, issue=6266, pageStart=1387, pageEnd=1390, url=null, language=null, rfNumber=[7], rfOrder=6, authorNames=Tran E, Ahmadzadeh M, Lu YC, journalName=Science, refType=null, unstructuredReference=Tran E, Ahmadzadeh M, Lu YC, et al. Immunogenicity of somatic mutations in human gastrointestinal cancers[J]. Science, 2015, 350(6266): 1387-1390., articleTitle=Immunogenicity of somatic mutations in human gastrointestinal cancers, refAbstract=null), Reference(id=1199335115697520728, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2013, volume=31, issue=32, pageStart=E439, pageEnd=E442, url=null, language=null, rfNumber=[8], rfOrder=7, authorNames=Rooij NV, Buuren MV, Philips D, journalName=J Clin Oncol, refType=null, unstructuredReference=Rooij NV, Buuren MV, Philips D, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma[J]. J Clin Oncol, 2013, 31(32): E439-E442., articleTitle=Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma, refAbstract=null), Reference(id=1199335115798184027, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2018, volume=39, issue=1, pageStart=38, pageEnd=48, url=null, language=null, rfNumber=[9], rfOrder=8, authorNames=Karolina P, Jacques B, journalName=Immunity, refType=null, unstructuredReference=Karolina P, Jacques B. Dendritic-cell-based therapeutic cancer vaccines[J]. Immunity, 2018, 39(1): 38-48., articleTitle=Dendritic-cell-based therapeutic cancer vaccines, refAbstract=null), Reference(id=1199335115919818847, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2020, volume=20, issue=1, pageStart=7, pageEnd=24, url=null, language=null, rfNumber=[10], rfOrder=9, authorNames=Wculek SK, Cueto FJ, Mujal AM, journalName=Nat Rev Immunol, refType=null, unstructuredReference=Wculek SK, Cueto FJ, Mujal AM, et al. Dendritic cells in cancer immunology and immunotherapy[J]. Nat Rev Immunol, 2020, 20(1): 7-24., articleTitle=Dendritic cells in cancer immunology and immunotherapy, refAbstract=null), Reference(id=1199335116024676452, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2022, volume=24, issue=2, pageStart=213, pageEnd=222, url=null, language=null, rfNumber=[11], rfOrder=10, authorNames=Ingels J, de Cock L, Mayer RL, journalName=Cytotherapy, refType=null, unstructuredReference=Ingels J, de Cock L, Mayer RL, et al. Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials[J]. Cytotherapy, 2022, 24(2): 213-222., articleTitle=Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials, refAbstract=null), Reference(id=1199335116125339755, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2013, volume=500, issue=7463, pageStart=415, pageEnd=421, url=null, language=null, rfNumber=[12], rfOrder=11, authorNames=Aparicio S, Alexandrov LB, Nik-Zainal S, journalName=Nature, refType=null, unstructuredReference=Aparicio S, Alexandrov LB, Nik-Zainal S, et al. Signatures of mutational processes in human cancer[J]. Nature, 2013, 500(7463): 415-421., articleTitle=Signatures of mutational processes in human cancer, refAbstract=null), Reference(id=1199335116263751789, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2016, volume=22, issue=2, pageStart=122, pageEnd=124, url=null, language=null, rfNumber=[13], rfOrder=12, authorNames=Katsnelson A, journalName=Nat Med, refType=null, unstructuredReference=Katsnelson A. Mutations as munitions: neoantigen vaccines get a closer look as cancer treatment[J]. Nat Med, 2016, 22(2): 122-124., articleTitle=Mutations as munitions: neoantigen vaccines get a closer look as cancer treatment, refAbstract=null), Reference(id=1199335116356026482, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2019, volume=565, issue=7738, pageStart=234, pageEnd=239, url=null, language=null, rfNumber=[14], rfOrder=13, authorNames=Keskin DB, Anandappa AJ, Sun J, journalName=Nature, refType=null, unstructuredReference=Keskin DB, Anandappa AJ, Sun J, et al. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial[J]. Nature, 2019, 565(7738): 234-239., articleTitle=Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial, refAbstract=null), Reference(id=1199335116490244215, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2000, volume=191, issue=7, pageStart=1221, pageEnd=1232, url=null, language=null, rfNumber=[15], rfOrder=14, authorNames=Colella TA, Bullock T, Russell LB, journalName=J Exp Med, refType=null, unstructuredReference=Colella TA, Bullock T, Russell LB, et al. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy[J]. J Exp Med, 2000, 191(7): 1221-1232., articleTitle=Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen: implications for tumor immunotherapy, refAbstract=null), Reference(id=1199335116611879036, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2018, volume=33, issue=5, pageStart=853, pageEnd=861, url=null, language=null, rfNumber=[16], rfOrder=15, authorNames=Hellmann MD, Callahan MK, Awad MM, journalName=Cancer Cell, refType=null, unstructuredReference=Hellmann MD, Callahan MK, Awad MM, et al. Tumor mutational burden and efficacy of nivolumab monotherapy and in combination with ipilimumab in small-cell lung cancer[J]. Cancer Cell, 2018, 33(5): 853-861., articleTitle=Tumor mutational burden and efficacy of nivolumab monotherapy and in combination with ipilimumab in small-cell lung cancer, refAbstract=null), Reference(id=1199335116699959425, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=348, issue=6230, pageStart=69, pageEnd=74, url=null, language=null, rfNumber=[17], rfOrder=16, authorNames=Schumacher TN, Schreiber RD, journalName=Science, refType=null, unstructuredReference=Schumacher TN, Schreiber RD. Neoantigens in cancer immuno-therapy[J]. Science, 2015, 348(6230): 69-74., articleTitle=Neoantigens in cancer immuno-therapy, refAbstract=null), Reference(id=1199335116800622722, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=348, issue=6230, pageStart=69, pageEnd=74, url=null, language=null, rfNumber=[18], rfOrder=17, authorNames=Schumacher TN, Schreiber RD, journalName=Science, refType=null, unstructuredReference=Schumacher TN, Schreiber RD. Neoantigens in cancer immuno-therapy[J]. Science, 2015, 348(6230): 69-74., articleTitle=Neoantigens in cancer immuno-therapy, refAbstract=null), Reference(id=1199335116888703110, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2012, volume=366, issue=10, pageStart=883, pageEnd=892, url=null, language=null, rfNumber=[19], rfOrder=18, authorNames=Gerlinger M, Rowan AJ, Horswell S, journalName=N Engl J Med, refType=null, unstructuredReference=Gerlinger M, Rowan AJ, Horswell S, et al. Intratumor heterogeneity and branched evolution revealed by multiregion sequencing[J]. N Engl J Med, 2012, 366(10): 883-892., articleTitle=Intratumor heterogeneity and branched evolution revealed by multiregion sequencing, refAbstract=null), Reference(id=1199335116951617673, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2018, volume=6, issue=3, pageStart=276, pageEnd=287, url=null, language=null, rfNumber=[20], rfOrder=19, authorNames=Rech AJ, Balli D, Mantero A, journalName=Cancer Immunol Res, refType=null, unstructuredReference=Rech AJ, Balli D, Mantero A, et al. Tumor immunity and survival as a function of alternative neopeptides in human cancer[J]. Cancer Immunol Res, 2018, 6(3): 276-287., articleTitle=Tumor immunity and survival as a function of alternative neopeptides in human cancer, refAbstract=null), Reference(id=1199335117039698060, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2019, volume=37, issue=1, pageStart=173, pageEnd=200, url=null, language=null, rfNumber=[21], rfOrder=20, authorNames=Schumacher TN, Scheper W, Kvistborg P, journalName=Annu Rev Immunol, refType=null, unstructuredReference=Schumacher TN, Scheper W, Kvistborg P. Cancer Neoantigens[J]. Annu Rev Immunol, 2019, 37(1): 173-200., articleTitle=Cancer Neoantigens, refAbstract=null), Reference(id=1199335117119389840, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=21, issue=6, pageStart=360, pageEnd=378, url=null, language=null, rfNumber=[22], rfOrder=21, authorNames=Saxena M, van der Burg SH, Melief CJM, journalName=Nat Rev Cancer, refType=null, unstructuredReference=Saxena M, van der Burg SH, Melief CJM, et al. Therapeutic cancer vaccines[J]. Nat Rev Cancer, 2021, 21(6): 360-378., articleTitle=Therapeutic cancer vaccines, refAbstract=null), Reference(id=1199335117211664532, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2020, volume=12, issue=537, pageStart=3577, pageEnd=3583, url=null, language=null, rfNumber=[23], rfOrder=22, authorNames=Subudhi SK, Vence L, Zhao H, journalName=Sci Transl Med, refType=null, unstructuredReference=Subudhi SK, Vence L, Zhao H, et al. Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer[J]. Sci Transl Med, 2020, 12(537): 3577-3583., articleTitle=Neoantigen responses, immune correlates, and favorable outcomes after ipilimumab treatment of patients with prostate cancer, refAbstract=null), Reference(id=1199335117341687959, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2019, volume=565, issue=7738, pageStart=240, pageEnd=245, url=null, language=null, rfNumber=[24], rfOrder=23, authorNames=Hilf N, Kuttruff-Coqui S, Frenzel K, journalName=Nature, refType=null, unstructuredReference=Hilf N, Kuttruff-Coqui S, Frenzel K, et al. Actively personalized vaccination trial for newly diagnosed glioblastoma[J]. Nature, 2019, 565(7738): 240-245., articleTitle=Actively personalized vaccination trial for newly diagnosed glioblastoma, refAbstract=null), Reference(id=1199335117425574041, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=160, issue=2, pageStart=48, pageEnd=61, url=null, language=null, rfNumber=[25], rfOrder=24, authorNames=Rooney MS, Shukla SA, Wu CJ, journalName=Cell, refType=null, unstructuredReference=Rooney MS, Shukla SA, Wu CJ, et al. Molecular and genetic properties of tumors associated with local immune cytolytic activity[J]. Cell, 2015, 160(2): 48-61., articleTitle=Molecular and genetic properties of tumors associated with local immune cytolytic activity, refAbstract=null), Reference(id=1199335117538820252, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2016, volume=351, issue=6280, pageStart=1463, pageEnd=1469, url=null, language=null, rfNumber=[26], rfOrder=25, authorNames=Mcgranahan N, Furness A, Rosenthal R, journalName=Science, refType=null, unstructuredReference=Mcgranahan N, Furness A, Rosenthal R, et al. Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade[J]. Science, 2016, 351(6280): 1463-1469., articleTitle=Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade, refAbstract=null), Reference(id=1199335117631094944, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=348, issue=6230, pageStart=124, pageEnd=128, url=null, language=null, rfNumber=[27], rfOrder=26, authorNames=Rizvi NA, Hellmann MD, Snyder A, journalName=Science, refType=null, unstructuredReference=Rizvi NA, Hellmann MD, Snyder A, et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer[J]. Science, 2015, 348(6230): 124-128., articleTitle=Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer, refAbstract=null), Reference(id=1199335118763557027, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2014, volume=24, issue=5, pageStart=743, pageEnd=750, url=null, language=null, rfNumber=[28], rfOrder=27, authorNames=Brown SD, Warren RL, Gibb EA, journalName=Genome Res, refType=null, unstructuredReference=Brown SD, Warren RL, Gibb EA, et al. Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival[J]. Genome Res, 2014, 24(5): 743-750., articleTitle=Neo-antigens predicted by tumor genome meta-analysis correlate with increased patient survival, refAbstract=null), Reference(id=1199335118864220330, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2014, volume=371, issue=23, pageStart=2189, pageEnd=2199, url=null, language=null, rfNumber=[29], rfOrder=28, authorNames=Snyder A, Makarov V, Merghoub T, journalName=N Engl J Med, refType=null, unstructuredReference=Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma[J]. N Engl J Med, 2014, 371(23): 2189-2199., articleTitle=Genetic basis for clinical response to CTLA-4 blockade in melanoma, refAbstract=null), Reference(id=1199335118973272237, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=1973, volume=137, issue=5, pageStart=1142, pageEnd=1162, url=null, language=null, rfNumber=[30], rfOrder=29, authorNames=Steinman RM, Cohn ZA, journalName=J Exp Med, refType=null, unstructuredReference=Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution[J]. J Exp Med 1973, 137(5): 1142-1162., articleTitle=Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution, refAbstract=null), Reference(id=1199335119052964015, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2018, volume=11, issue=1, pageStart=1, pageEnd=22, url=null, language=null, rfNumber=[31], rfOrder=30, authorNames=Fang P, Li X, Dai J, journalName=J Hematol Oncol, refType=null, unstructuredReference=Fang P, Li X, Dai J, et al. Immune cell subset differentiation and tissue inflammation[J]. J Hematol Oncol, 2018, 11(1): 1-22., articleTitle=Immune cell subset differentiation and tissue inflammation, refAbstract=null), Reference(id=1199335119149433008, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2016, volume=22, issue=8, pageStart=1897, pageEnd=1906, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=Bol KF, Schreibelt G, Gerritsen WR, journalName=Clin Cancer Res, refType=null, unstructuredReference=Bol KF, Schreibelt G, Gerritsen WR, et al. Dendritic cell-based immunotherapy: state of the art and beyond[J]. Clin Cancer Res, 2016, 22(8): 1897-1906., articleTitle=Dendritic cell-based immunotherapy: state of the art and beyond, refAbstract=null), Reference(id=1199335119266873522, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2016, volume=168, issue=1, pageStart=74, pageEnd=95, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=Constantino J, Gomes C, Falcão A, journalName=Transl Res, refType=null, unstructuredReference=Constantino J, Gomes C, Falcão A, et al. Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives[J]. Transl Res, 2016, 168(1): 74-95., articleTitle=Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical trials and future perspectives, refAbstract=null), Reference(id=1199335119346565301, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2018, volume=18, issue=3, pageStart=168, pageEnd=182, url=null, language=null, rfNumber=[34], rfOrder=33, authorNames=Hu Z, Ott P A, Wu CJ, journalName=Nat Rev Immunol, refType=null, unstructuredReference=Hu Z, Ott P A, Wu CJ. Towards personalized, tumour-specific, therapeutic vaccines for cancer[J]. Nat Rev Immunol, 2018, 18(3): 168-182., articleTitle=Towards personalized, tumour-specific, therapeutic vaccines for cancer, refAbstract=null), Reference(id=1199335119443034293, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2012, volume=12, issue=4, pageStart=265, pageEnd=277, url=null, language=null, rfNumber=[35], rfOrder=34, authorNames=Palucka K, Banchereau J, journalName=Nat Rev Cancer, refType=null, unstructuredReference=Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells[J]. Nat Rev Cancer, 2012, 12(4): 265-277., articleTitle=Cancer immunotherapy via dendritic cells, refAbstract=null), Reference(id=1199335119526920375, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=125, issue=9, pageStart=3401, pageEnd=3412, url=null, language=null, rfNumber=[36], rfOrder=35, authorNames=Melief C, Hall TV, Arens R, journalName=J Clin Invest, refType=null, unstructuredReference=Melief C, Hall TV, Arens R, et al. Therapeutic cancer vaccines[J]. J Clin Invest, 2015, 125(9): 3401-3412., articleTitle=Therapeutic cancer vaccines, refAbstract=null), Reference(id=1199335119619195065, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2020, volume=69, issue=1, pageStart=135, pageEnd=145, url=null, language=null, rfNumber=[37], rfOrder=36, authorNames=Zhang R, Yuan F, Shu Y, journalName=Cancer Immunol Immunother, refType=null, unstructuredReference=Zhang R, Yuan F, Shu Y, et al. Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models[J]. Cancer Immunol Immunother, 2020, 69(1): 135-145., articleTitle=Personalized neoantigen-pulsed dendritic cell vaccines show superior immunogenicity to neoantigen-adjuvant vaccines in mouse tumor models, refAbstract=null), Reference(id=1199335119690498235, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2011, volume=6, issue=4, pageStart=1, pageEnd=11, url=null, language=null, rfNumber=[38], rfOrder=37, authorNames=Draube A, Klein-González N, Mattheus S, journalName=PLoS ONE, refType=null, unstructuredReference=Draube A, Klein-González N, Mattheus S, et al. Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis [J]. PLoS ONE, 2011, 6(4): 1-11., articleTitle=Dendritic cell based tumor vaccination in prostate and renal cell cancer: a systematic review and meta-analysis, refAbstract=null), Reference(id=1199335119786967230, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2009, volume=49, issue=1, pageStart=124, pageEnd=132, url=null, language=null, rfNumber=[39], rfOrder=38, authorNames=Palmer DH, Midgley RS, Mirza N, journalName=Hepatology, refType=null, unstructuredReference=Palmer DH, Midgley RS, Mirza N, et al. A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma[J]. Hepatology, 2009, 49(1): 124-132., articleTitle=A phase II study of adoptive immunotherapy using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma, refAbstract=null), Reference(id=1199335119845687489, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2017, volume=168, issue=4, pageStart=600, pageEnd=612, url=null, language=null, rfNumber=[40], rfOrder=39, authorNames=Liu XS, Mardis ER, journalName=Cell, refType=null, unstructuredReference=Liu XS, Mardis ER. Applications of immunogenomics to cancer[J]. Cell, 2017, 168(4): 600-612., articleTitle=Applications of immunogenomics to cancer, refAbstract=null), Reference(id=1199335119916990660, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=6, issue=1, pageStart=1, pageEnd=12, url=null, language=null, rfNumber=[41], rfOrder=40, authorNames=Ding Z, Li Q, Zhang R, journalName=Signal Transduct Target Ther, refType=null, unstructuredReference=Ding Z, Li Q, Zhang R, et al. Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer[J]. Signal Transduct Target Ther, 2021, 6(1): 1-12., articleTitle=Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer, refAbstract=null), Reference(id=1199335120013459655, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2009, volume=32, issue=1, pageStart=66, pageEnd=78, url=null, language=null, rfNumber=[42], rfOrder=41, authorNames=West E, Morgan R, Scott K, journalName=J Immunother, refType=null, unstructuredReference=West E, Morgan R, Scott K, et al. Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery[J]. J Immunother, 2009, 32(1): 66-78., articleTitle=Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery, refAbstract=null), Reference(id=1199335120101540042, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2009, volume=9, issue=8, pageStart=755, pageEnd=770, url=null, language=null, rfNumber=[43], rfOrder=42, authorNames=Dohnal AM, Witt V, Hügel H, journalName=Cytotherapy, refType=null, unstructuredReference=Dohnal AM, Witt V, Hügel H, et al. Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer[J]. Cytotherapy, 2009, 9(8): 755-770., articleTitle=Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer, refAbstract=null), Reference(id=1199335120206397645, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2001, volume=166, issue=6, pageStart=4254, pageEnd=4259, url=null, language=null, rfNumber=[44], rfOrder=43, authorNames=Fong L, Brockstedt D, Benike C, journalName=J Immunol, refType=null, unstructuredReference=Fong L, Brockstedt D, Benike C, et al. Dendritic cells injected via different routes induce immunity in cancer patients[J]. J Immunol, 2001, 166(6): 4254-4259., articleTitle=Dendritic cells injected via different routes induce immunity in cancer patients, refAbstract=null), Reference(id=1199335120294478032, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=1998, volume=4, issue=3, pageStart=328, pageEnd=332, url=null, language=null, rfNumber=[45], rfOrder=44, authorNames=Nestle FO, Alijagic S, Gilliet M, journalName=Nat Med, refType=null, unstructuredReference=Nestle FO, Alijagic S, Gilliet M, et al. Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells[J]. Nat Med, 1998, 4(3): 328-332., articleTitle=Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells, refAbstract=null), Reference(id=1199335120390947027, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2007, volume=104, issue=9, pageStart=3360, pageEnd=3365, url=null, language=null, rfNumber=[46], rfOrder=45, authorNames=Hamanishi J, Mandai M, Iwasaki M, journalName=PNAS, refType=null, unstructuredReference=Hamanishi J, Mandai M, Iwasaki M, et al. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer[J]. PNAS, 2007, 104(9): 3360-3365., articleTitle=Programmed cell death 1 ligand 1 and tumor-infiltrating CD8⁺ T lymphocytes are prognostic factors of human ovarian cancer, refAbstract=null), Reference(id=1199335120491610325, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2009, volume=115, issue=2, pageStart=185, pageEnd=192, url=null, language=null, rfNumber=[47], rfOrder=46, authorNames=Inaba T, Ino K, Kajiyama H, journalName=Gynecol Oncol, refType=null, unstructuredReference=Inaba T, Ino K, Kajiyama H, et al. Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma[J]. Gynecol Oncol, 2009, 115(2): 185-192., articleTitle=Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma, refAbstract=null), Reference(id=1199335120562913496, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2004, volume=10, issue=9, pageStart=942, pageEnd=949, url=null, language=null, rfNumber=[48], rfOrder=47, authorNames=Curiel TJ, Coukos G, Zou L, journalName=Nat Med, refType=null, unstructuredReference=Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival[J]. Nat Med, 2004, 10(9): 942-949., articleTitle=Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, refAbstract=null), Reference(id=1199335120625828058, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2005, volume=11, issue=23, pageStart=8326, pageEnd=8331, url=null, language=null, rfNumber=[49], rfOrder=48, authorNames=Wolf D, Wolf AM, Rumpold H, journalName=Clin Cancer Res, refType=null, unstructuredReference=Wolf D, Wolf AM, Rumpold H, et al. The Expression of the regulatory T cell–specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer[J]. Clin Cancer Res, 2005, 11(23): 8326-8331., articleTitle=The Expression of the regulatory T cell–specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer, refAbstract=null), Reference(id=1199335120713908444, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=13, issue=21, pageStart=5508, pageEnd=5525, url=null, language=null, rfNumber=[50], rfOrder=49, authorNames=Sun C, Nagaoka K, Kobayashi Y, journalName=Cancers, refType=null, unstructuredReference=Sun C, Nagaoka K, Kobayashi Y, et al. Neoantigen dendritic cell vaccination combined with anti-CD38 and CpG elicits anti-tumor immunity against the immune checkpoint therapy-resistant murine lung cancer cell line LLC1[J]. Cancers, 2021, 13(21): 5508-5525., articleTitle=Neoantigen dendritic cell vaccination combined with anti-CD38 and CpG elicits anti-tumor immunity against the immune checkpoint therapy-resistant murine lung cancer cell line LLC1, refAbstract=null), Reference(id=1199335120793600222, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2022, volume=9, issue=11, pageStart=2105631, pageEnd=2105645, url=null, language=null, rfNumber=[51], rfOrder=50, authorNames=Wang Y, Zhao Q, Zhao B, journalName=Adv Sci, refType=null, unstructuredReference=Wang Y, Zhao Q, Zhao B, et al. Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency[J]. Adv Sci, 2022, 9(11): 2105631-2105645., articleTitle=Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine Efficiency, refAbstract=null), Reference(id=1199335120890069216, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2020, volume=8, issue=null, pageStart=A383, pageEnd=null, url=null, language=null, rfNumber=[52], rfOrder=51, authorNames=Carroll H, Aleem U, Varghese P, journalName=J Immunother Cancer, refType=null, unstructuredReference=Carroll H, Aleem U, Varghese P, et al. 358 Trial in progress: a pilot study of combined immune checkpoint inhibition in combination with ablative therapies in subjects with hepatocellular carcinoma (HCC)[J]. J Immunother Cancer, 2020, 8(Suppl 3): A383., articleTitle=358 Trial in progress: a pilot study of combined immune checkpoint inhibition in combination with ablative therapies in subjects with hepatocellular carcinoma (HCC), refAbstract=null), Reference(id=1199335120978149602, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2015, volume=348, issue=6236, pageStart=803, pageEnd=808, url=null, language=null, rfNumber=[53], rfOrder=52, authorNames=Carreno BM, Magrini V, Becker-Hapak M, journalName=Science, refType=null, unstructuredReference=Carreno BM, Magrini V, Becker-Hapak M, et al. Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells[J]. Science, 2015, 348(6236): 803-808., articleTitle=Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells, refAbstract=null), Reference(id=1199335121083007204, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2017, volume=547, issue=7662, pageStart=217, pageEnd=221, url=null, language=null, rfNumber=[54], rfOrder=53, authorNames=Ott PA, Hu Z, Keskin DB, journalName=Nature, refType=null, unstructuredReference=Ott PA, Hu Z, Keskin DB, et al. An immunogenic personal neoantigen vaccine for patients with melanoma[J]. Nature, 2017, 547(7662): 217-221., articleTitle=An immunogenic personal neoantigen vaccine for patients with melanoma, refAbstract=null), Reference(id=1199335121175281894, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2022, volume=6, issue=1, pageStart=34, pageEnd=41, url=null, language=null, rfNumber=[55], rfOrder=54, authorNames=Guo Z, Yuan Y, Chen C, journalName=NPJ Precis Oncol, refType=null, unstructuredReference=Guo Z, Yuan Y, Chen C, et al. Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer[J]. NPJ Precis Oncol, 2022, 6(1): 34-41., articleTitle=Durable complete response to neoantigen-loaded dendritic-cell vaccine following anti-PD-1 therapy in metastatic gastric cancer, refAbstract=null), Reference(id=1199335121242390760, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=13, issue=22, pageStart=5801, pageEnd=5816, url=null, language=null, rfNumber=[56], rfOrder=55, authorNames=Harari A, Sarivalasis A, de Jonge K, journalName=Cancers (Basel), refType=null, unstructuredReference=Harari A, Sarivalasis A, de Jonge K, et al. A Personalized neoantigen vaccine in combination with platinum-based chemotherapy induces a T-cell response coinciding with a complete response in endometrial carcinoma[J]. Cancers (Basel), 2021, 13(22): 5801-5816., articleTitle=A Personalized neoantigen vaccine in combination with platinum-based chemotherapy induces a T-cell response coinciding with a complete response in endometrial carcinoma, refAbstract=null), Reference(id=1199335121338859754, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2012, volume=482, issue=7385, pageStart=405, pageEnd=409, url=null, language=null, rfNumber=[57], rfOrder=56, authorNames=Dupage M, Mazumdar C, Schmidt LM, journalName=Nature, refType=null, unstructuredReference=Dupage M, Mazumdar C, Schmidt LM, et al. Expression of tumour-specific antigens underlies cancer immunoediting[J]. Nature, 2012, 482(7385): 405-409., articleTitle=Expression of tumour-specific antigens underlies cancer immunoediting, refAbstract=null), Reference(id=1199335121435328748, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2016, volume=8, issue=7, pageStart=763, pageEnd=766, url=null, language=null, rfNumber=[58], rfOrder=57, authorNames=Furness AJ, Quezada SA, Peggs KS, journalName=Immunotherapy, refType=null, unstructuredReference=Furness AJ, Quezada SA, Peggs KS. Neoantigen heterogeneity: a key driver of immune response and sensitivity to immune checkpoint blockade?[J]. Immunotherapy, 2016, 8(7): 763-766., articleTitle=Neoantigen heterogeneity: a key driver of immune response and sensitivity to immune checkpoint blockade?, refAbstract=null), Reference(id=1199335121527603438, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=8, issue=6, pageStart=2003504, pageEnd=2003516, url=null, language=null, rfNumber=[59], rfOrder=58, authorNames=Zhang D, Lin ZG, Wu M, journalName=Adv Sci, refType=null, unstructuredReference=Zhang D, Lin ZG, Wu M, et al. Cytosolic delivery of thiolated neoantigen nano-vaccine combined with immune checkpoint blockade to boost anti-cancer T cell immunity[J]. Adv Sci, 2021, 8(6): 2003504-2003516., articleTitle=Cytosolic delivery of thiolated neoantigen nano-vaccine combined with immune checkpoint blockade to boost anti-cancer T cell immunity, refAbstract=null), Reference(id=1199335121628266736, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, doi=null, pmid=null, pmcid=null, year=2021, volume=9, issue=4, pageStart=290, pageEnd=302, url=null, language=null, rfNumber=[60], rfOrder=59, authorNames=Pan S, Li K, Huang B, journalName=Ann Transl Med, refType=null, unstructuredReference=Pan S, Li K, Huang B, et al. Efficacy and safety of immune checkpoint inhibitors in gastric cancer: a network meta-analysis of well-designed randomized controlled trials[J]. Ann Transl Med, 2021, 9(4): 290-302., articleTitle=Efficacy and safety of immune checkpoint inhibitors in gastric cancer: a network meta-analysis of well-designed randomized controlled trials, refAbstract=null)], funds=[Fund(id=1199335114577641513, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, awardId=31770537, language=EN, fundingSource=National Natural Science Foundation of China(31770537), fundOrder=null, country=null), Fund(id=1199335114665721902, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, awardId=31770537, language=CN, fundingSource=国家自然科学基金(31770537), fundOrder=null, country=null), Fund(id=1199335114757996593, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, awardId=20ZD7FA003, language=EN, fundingSource=Grand Scientific and Technological Project of Gansu Province(20ZD7FA003), fundOrder=null, country=null), Fund(id=1199335114846076980, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, awardId=20ZD7FA003, language=CN, fundingSource=甘肃省重大科技项目(20ZD7FA003), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1199335108416209731, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=1, ext=[AuthorCompanyExt(id=1199335108424598340, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹Gansu Provincial Key Laboratory of Gastrointestinal Tumors, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108437181253, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108416209731, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=¹甘肃省消化系肿瘤重点实验室，甘肃兰州 730030)]), AuthorCompany(id=1199335108563010379, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, xref=2, ext=[AuthorCompanyExt(id=1199335108571398988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²Department of Tumor Surgery, the Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China), AuthorCompanyExt(id=1199335108575593294, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, companyId=1199335108563010379, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=²兰州大学第二医院肿瘤外科，甘肃兰州 730030)])], figs=[ArticleFig(id=1199335112589542396, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, label=Fig.1, caption=Development and application process of the neoantigen pulsed dendritic cell vaccine, figureFileSmall=P4TCJEGruG+v6PTyaFk/pw==, figureFileBig=uJpLV3ebmUeNf7JCgypURg==, tableContent=null), ArticleFig(id=1199335112757314560, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, label=图1, caption=新抗原脉冲树突状细胞疫苗的研发与应用流程

DC. 树突状细胞；IL. 白细胞介素；GM-CSF. 粒细胞-巨噬细胞集落刺激因子；TNF-ɑ. 肿瘤坏死因子-ɑ；PGE2. 地诺前列酮；Neo-DCVac. 新抗原脉冲树突状细胞疫苗

, figureFileSmall=P4TCJEGruG+v6PTyaFk/pw==, figureFileBig=uJpLV3ebmUeNf7JCgypURg==, tableContent=null), ArticleFig(id=1199335113021554703, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, label=Tab.1, caption=

Summary of clinical trials conducted for the new antigen pulse DC vaccine (ClinicalTrials.gov)

, figureFileSmall=null, figureFileBig=null, tableContent=

登记号	时间	肿瘤类型	用药方案	研究阶段	发起单位	招募例数(n)
NCT03674073	2018.10.15-2020.12.15	肝细胞癌	肝细胞癌(3 cm≤肿瘤直径≤5 cm，少于3个肿瘤)患者接受微波消融和7个疗程的Neo-DCVac治疗。在微波消融完成后30 d进行第1剂Neo-DCVac注射。疫苗接种的时间表是 1、8、15、22、50、78、106 d	Ⅰ期	解放军总医院	24
NCT04912765	2021.4.15-2025.5	肝癌、结直肠癌	每2周皮内注射10剂Neo-DCVac，剂量为300~500万个细胞，共10剂，从第2剂疫苗开始静脉输注30 min 240 mg纳武鲁单抗联合治疗；完成10剂Neo-DCVac后，每4周静脉输注480 mg纳武单抗，最多9剂，总持续时间为1年	Ⅱ期	新加坡国家癌症中心	60
NCT03300843	2018.4.11-2019.9.16	黑色素瘤、胃肠道癌、乳腺癌、卵巢癌、胰腺癌	在0 d、14 d(+/- 5 d)、 28 d(+/- 5 d)和 42 d(+/- 5 d)静脉输注或皮下注射肽负载DC疫苗	Ⅱ期	美国国家癌症研究所/美国国立卫生研究院临床中心	1
NCT03871205	2019.4.1-2020.12.30	难治性肺癌	每周在患者相邻淋巴结皮下注射1次Neo-DCVac，总共6剂	Ⅰ期	深圳市人民医院	30
NCT04078269	2019.8.26-2021.12.31	非小细胞肺癌	每 2 周静脉输注 MIDRIXNEO-LUNG DC疫苗，使用患者内剂量递增方案：10×106 DC(最小剂量)、20×106 DC、40×106 DC、80×106 DC、100×106 DC(最大剂量)，直到最大剂量或发生 ≥3 级毒性事件	Ⅰ期	根特大学医院	6
NCT05270720	2022.9.1-2024.4.1	复发性卵巢癌	标准化疗+负载肿瘤相关抗原和患者特异性新抗原的DC疫苗，总DC剂量为5×106，若出现不可接受的不良反应，则剂量降为2.5×106；若未出现不可接受的不良反应，则总剂量增为1×107	Ⅰ期	四川大学华西第二医院	9
NCT05317325	2022.4.1-2024.4.1	食管鳞状细胞癌	首阶段注射HOCl-氧化自体肿瘤裂解物(OCDC)脉冲的自体DC疫苗，增强阶段注射Neo-DCVac	Ⅰ期	四川大学	20
NCT04105582	2019.8.1-2022.3.1	三阴性乳腺癌	完成常规治疗(化疗或手术)的患者接种Neo-DCVac	Ⅰ期	哥伦比亚国立大学	5
NCT01885702	2010.10-2022.10	结直肠癌	——	Ⅰ/Ⅱ期	拉德堡大学医学中心	25
NCT04968366	2021.7.30-2024.8	脑多形性胶质母细胞瘤	在接受替莫唑胺辅助化疗期间，于化疗后2、3、4、7、11周在患者腹股沟和腋窝淋巴结区域静脉注射5~8剂负载多种肿瘤新抗原肽的自体DC疫苗，每剂疫苗含2~1000万个DC细胞及5~20个肿瘤新抗原肽	Ⅰ期	北京天坛医院	10
NCT00923910	2008.2.22-2016.11.15	血液系统恶性肿瘤	每 2 周于上臂或大腿注射 2次Wilm's Tumor 1(WT1) 疫苗，在疫苗注射后约1 h，静脉输注15~30 min供体淋巴细胞，持续 6 周(第 0、2、4、6、8、10 周)	Ⅰ/Ⅱ期	美国国家癌症研究所/美国国立卫生研究院临床中心	10
NCT03735589	2022.5.15-2024.5.1	原发性卵巢癌	试验前2周、0 d和28 d皮内注射α-1型极化DC疫苗联合自然杀伤细胞样细胞毒性T淋巴细胞(nCTLs)	Ⅰ/Ⅱa期	罗斯威尔公园癌症研究所	18
NCT02956551	2016.11.30-2020.6.1	非小细胞肺癌	每2周皮下注射 1次Neo-DCVac，共5剂	Ⅰ期	四川大学	20
NCT04147078	2019.6.1-2023.6.1	胃癌、肝癌、非小细胞肺癌、结直肠癌	间隔2~3周皮下注射1次Neo-DCVac，共3~5次	Ⅰ期	四川大学	80
NCT03870113	2019.4.1-2022.12.30	宫颈上皮内瘤变	每周在相邻淋巴结注射1次负载HPV 16/18 E6/E7的自体成熟DC疫苗，共6剂	Ⅰ期	深圳市人民医院	80
NCT04749641	2021.3.8-2024.4.1	弥漫性内源性脑桥胶质瘤	分别在1、3、15、29、57、85 d皮下注射含有H3.3-K27M靶向新抗原肽和聚ICLC的疫苗，此后每8周注射1次。采用"6+3"剂量递增设计。该疫苗有3个剂量。剂量1：0.5 mg肽+聚 ICLC；剂量2：1.0 mg肽+聚ICLC；剂量3：2.0 mg肽+聚ICLC	Ⅰ期	北京天坛医院	30
NCT04879888	2016.8-2017.7.30	乳腺癌	术后每周用患者血清中的200 μl肽脉冲自体DC疫苗进行皮内接种，共6剂	Ⅰ期	哥伦比亚国立大学医学院	9
NCT04072900	2020.4.21-2022.9.1	黑色素瘤	注射前6 h在注射部位局部涂抹5%咪喹莫特外用药膏，在第84、87、91、98、105、133、161 d给予4×3 mg总肽+3 mg/kg托里帕利单抗，在第81、82、83、95、96、97、102、103、104、130、131、132、158、159、160 d给予3 μg/kg rhGM-CSF	Ⅰ期	中南大学湘雅医院	30
NCT03914768	2019.3.31-2022.12.31	弥漫性内源性脑桥胶质瘤/胶质母细胞瘤	接种前静脉注射环磷酰胺(200 mg/m2)或口服环磷酰胺，次日在肿瘤附近的淋巴组织周围注射Neo-DCVac并静脉注射贝伐珠单抗(15 mg/kg)，连续6个月，每月重复输注，每次注射的DC疫苗细胞量基于先前报告的(5~10)×106，实施初始剂量递增方案	Ⅰ期	深圳市基因免疫医学研究所	10
NCT05020119	2021.4.9-2023.6.30	晚期实体瘤	低、中、高3种不同剂量的新抗原细胞疗法(n=3+3)：(1±20%)×109个，(3±20%)×109个，(9±20%)×109个个体化新抗原扩增T(CIK)细胞/ 200 ml，每14 d给药，共10剂	Ⅰ期	长庚纪念医院	9
NCT00683670	2008.8-2016.6	黑色素瘤	接种前3 d静脉注射环磷酰胺300mg/m2，每3周静脉注射1次Neo-DCVac，共6剂，疫苗含有2种gp100黑色素瘤肽(G209-2M和G280-9V)及10种黑色素瘤特异性肽	Ⅰ期	华盛顿大学医学院	17

), ArticleFig(id=1199335113118023700, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, label=表1, caption=

新抗原脉冲DC疫苗的临床试验开展情况(ClinicalTrials.gov)

, figureFileSmall=null, figureFileBig=null, tableContent=

登记号	时间	肿瘤类型	用药方案	研究阶段	发起单位	招募例数(n)
NCT03674073	2018.10.15-2020.12.15	肝细胞癌	肝细胞癌(3 cm≤肿瘤直径≤5 cm，少于3个肿瘤)患者接受微波消融和7个疗程的Neo-DCVac治疗。在微波消融完成后30 d进行第1剂Neo-DCVac注射。疫苗接种的时间表是 1、8、15、22、50、78、106 d	Ⅰ期	解放军总医院	24
NCT04912765	2021.4.15-2025.5	肝癌、结直肠癌	每2周皮内注射10剂Neo-DCVac，剂量为300~500万个细胞，共10剂，从第2剂疫苗开始静脉输注30 min 240 mg纳武鲁单抗联合治疗；完成10剂Neo-DCVac后，每4周静脉输注480 mg纳武单抗，最多9剂，总持续时间为1年	Ⅱ期	新加坡国家癌症中心	60
NCT03300843	2018.4.11-2019.9.16	黑色素瘤、胃肠道癌、乳腺癌、卵巢癌、胰腺癌	在0 d、14 d(+/- 5 d)、 28 d(+/- 5 d)和 42 d(+/- 5 d)静脉输注或皮下注射肽负载DC疫苗	Ⅱ期	美国国家癌症研究所/美国国立卫生研究院临床中心	1
NCT03871205	2019.4.1-2020.12.30	难治性肺癌	每周在患者相邻淋巴结皮下注射1次Neo-DCVac，总共6剂	Ⅰ期	深圳市人民医院	30
NCT04078269	2019.8.26-2021.12.31	非小细胞肺癌	每 2 周静脉输注 MIDRIXNEO-LUNG DC疫苗，使用患者内剂量递增方案：10×106 DC(最小剂量)、20×106 DC、40×106 DC、80×106 DC、100×106 DC(最大剂量)，直到最大剂量或发生 ≥3 级毒性事件	Ⅰ期	根特大学医院	6
NCT05270720	2022.9.1-2024.4.1	复发性卵巢癌	标准化疗+负载肿瘤相关抗原和患者特异性新抗原的DC疫苗，总DC剂量为5×106，若出现不可接受的不良反应，则剂量降为2.5×106；若未出现不可接受的不良反应，则总剂量增为1×107	Ⅰ期	四川大学华西第二医院	9
NCT05317325	2022.4.1-2024.4.1	食管鳞状细胞癌	首阶段注射HOCl-氧化自体肿瘤裂解物(OCDC)脉冲的自体DC疫苗，增强阶段注射Neo-DCVac	Ⅰ期	四川大学	20
NCT04105582	2019.8.1-2022.3.1	三阴性乳腺癌	完成常规治疗(化疗或手术)的患者接种Neo-DCVac	Ⅰ期	哥伦比亚国立大学	5
NCT01885702	2010.10-2022.10	结直肠癌	——	Ⅰ/Ⅱ期	拉德堡大学医学中心	25
NCT04968366	2021.7.30-2024.8	脑多形性胶质母细胞瘤	在接受替莫唑胺辅助化疗期间，于化疗后2、3、4、7、11周在患者腹股沟和腋窝淋巴结区域静脉注射5~8剂负载多种肿瘤新抗原肽的自体DC疫苗，每剂疫苗含2~1000万个DC细胞及5~20个肿瘤新抗原肽	Ⅰ期	北京天坛医院	10
NCT00923910	2008.2.22-2016.11.15	血液系统恶性肿瘤	每 2 周于上臂或大腿注射 2次Wilm's Tumor 1(WT1) 疫苗，在疫苗注射后约1 h，静脉输注15~30 min供体淋巴细胞，持续 6 周(第 0、2、4、6、8、10 周)	Ⅰ/Ⅱ期	美国国家癌症研究所/美国国立卫生研究院临床中心	10
NCT03735589	2022.5.15-2024.5.1	原发性卵巢癌	试验前2周、0 d和28 d皮内注射α-1型极化DC疫苗联合自然杀伤细胞样细胞毒性T淋巴细胞(nCTLs)	Ⅰ/Ⅱa期	罗斯威尔公园癌症研究所	18
NCT02956551	2016.11.30-2020.6.1	非小细胞肺癌	每2周皮下注射 1次Neo-DCVac，共5剂	Ⅰ期	四川大学	20
NCT04147078	2019.6.1-2023.6.1	胃癌、肝癌、非小细胞肺癌、结直肠癌	间隔2~3周皮下注射1次Neo-DCVac，共3~5次	Ⅰ期	四川大学	80
NCT03870113	2019.4.1-2022.12.30	宫颈上皮内瘤变	每周在相邻淋巴结注射1次负载HPV 16/18 E6/E7的自体成熟DC疫苗，共6剂	Ⅰ期	深圳市人民医院	80
NCT04749641	2021.3.8-2024.4.1	弥漫性内源性脑桥胶质瘤	分别在1、3、15、29、57、85 d皮下注射含有H3.3-K27M靶向新抗原肽和聚ICLC的疫苗，此后每8周注射1次。采用"6+3"剂量递增设计。该疫苗有3个剂量。剂量1：0.5 mg肽+聚 ICLC；剂量2：1.0 mg肽+聚ICLC；剂量3：2.0 mg肽+聚ICLC	Ⅰ期	北京天坛医院	30
NCT04879888	2016.8-2017.7.30	乳腺癌	术后每周用患者血清中的200 μl肽脉冲自体DC疫苗进行皮内接种，共6剂	Ⅰ期	哥伦比亚国立大学医学院	9
NCT04072900	2020.4.21-2022.9.1	黑色素瘤	注射前6 h在注射部位局部涂抹5%咪喹莫特外用药膏，在第84、87、91、98、105、133、161 d给予4×3 mg总肽+3 mg/kg托里帕利单抗，在第81、82、83、95、96、97、102、103、104、130、131、132、158、159、160 d给予3 μg/kg rhGM-CSF	Ⅰ期	中南大学湘雅医院	30
NCT03914768	2019.3.31-2022.12.31	弥漫性内源性脑桥胶质瘤/胶质母细胞瘤	接种前静脉注射环磷酰胺(200 mg/m2)或口服环磷酰胺，次日在肿瘤附近的淋巴组织周围注射Neo-DCVac并静脉注射贝伐珠单抗(15 mg/kg)，连续6个月，每月重复输注，每次注射的DC疫苗细胞量基于先前报告的(5~10)×106，实施初始剂量递增方案	Ⅰ期	深圳市基因免疫医学研究所	10
NCT05020119	2021.4.9-2023.6.30	晚期实体瘤	低、中、高3种不同剂量的新抗原细胞疗法(n=3+3)：(1±20%)×109个，(3±20%)×109个，(9±20%)×109个个体化新抗原扩增T(CIK)细胞/ 200 ml，每14 d给药，共10剂	Ⅰ期	长庚纪念医院	9
NCT00683670	2008.8-2016.6	黑色素瘤	接种前3 d静脉注射环磷酰胺300mg/m2，每3周静脉注射1次Neo-DCVac，共6剂，疫苗含有2种gp100黑色素瘤肽(G209-2M和G280-9V)及10种黑色素瘤特异性肽	Ⅰ期	华盛顿大学医学院	17

), ArticleFig(id=1199335114300817434, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=EN, label=Tab.2, caption=

Summary of clinical trials conducted for the new antigen pulse DC vaccine (Chinese Clinical Trial Registry)

, figureFileSmall=null, figureFileBig=null, tableContent=

注册号	注册题目	注册时间	干预措施	研究所处阶段	研究单位
ChiCTR2100054020	肿瘤新抗原致敏的自体DC细胞制剂治疗晚期恶性实体肿瘤的安全性及有效性的I/II期临床研究	2021/12/6	肿瘤新抗原致敏的自体DC细胞制剂治疗	Ⅰ期+Ⅱ期	北京大学肿瘤医院
ChiCTR2100051604	靶向恶性实体肿瘤新抗原的个体化免疫细胞治疗转化研究	2021/9/28	输注靶向突变新抗原的 DC-T 细胞	Ⅰ期临床试验	四川大学华西医院
ChiCTR2100042735	肿瘤新抗原负载的个体化DC疫苗治疗肝癌脊柱转移的前瞻性临床试验研究	2021/1/27	DC疫苗免疫治疗	探索性研究/预试验	海军军医大学长征医院
ChiCTR2000040901	肿瘤新抗原负载的个体化DC疫苗治疗肾癌脊柱转移的前瞻性临床试验研究	2020/12/14	DC疫苗免疫治疗	探索性研究/预试验	上海长征医院
ChiCTR2000040715	肿瘤新抗原负载的个体化DC疫苗治疗肺癌脊柱转移的前瞻性临床试验研究	2020/12/8	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR2000040482	肿瘤新抗原负载的个体化DC疫苗治疗乳腺癌脊柱转移的前瞻性、单中心临床试验研究	2020/11/30	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR2000040158	肿瘤新抗原负载的个体化DC疫苗治疗脊柱转移瘤的前瞻性、单中心临床试验研究	2020/11/23	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR1900022835	嵌合型新抗原反应性T细胞(cnTs)联合负载个体化新抗原的DC肿瘤细胞(neoDC-Vx)治疗进展期难治性恶性肿瘤前瞻性单臂临床研究方案	2019/4/27	免疫治疗	探索性研究/预试验	西南医科大学附属医院
ChiCTR1900021842	靶向肿瘤新抗原的高反应性疫苗治疗复发难治性肺癌	2019/3/12	负载新抗原的DC疫苗皮下注射	Ⅰ期临床试验	深圳市人民医院
ChiCTR1900020883	个体化新抗原复合多肽肿瘤免疫治疗临床试验研究	2019/1/21	肿瘤新抗原多肽负载 DCCs.	Ⅰ期临床试验	甘肃省人民医院
ChiCTR1800016805	个体化多靶点肿瘤新抗原免疫细胞治疗实体瘤的安全性、耐受性和有效性的I/II期临床试验	2018/6/26	新抗原反应性DC细胞疫苗	Ⅰ期+Ⅱ期	郑州大学第一附属医院

), ArticleFig(id=1199335114422452254, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199335107107586824, language=CN, label=表2, caption=

新抗原脉冲DC疫苗的临床试验开展情况(中国临床试验注册中心)

, figureFileSmall=null, figureFileBig=null, tableContent=

注册号	注册题目	注册时间	干预措施	研究所处阶段	研究单位
ChiCTR2100054020	肿瘤新抗原致敏的自体DC细胞制剂治疗晚期恶性实体肿瘤的安全性及有效性的I/II期临床研究	2021/12/6	肿瘤新抗原致敏的自体DC细胞制剂治疗	Ⅰ期+Ⅱ期	北京大学肿瘤医院
ChiCTR2100051604	靶向恶性实体肿瘤新抗原的个体化免疫细胞治疗转化研究	2021/9/28	输注靶向突变新抗原的 DC-T 细胞	Ⅰ期临床试验	四川大学华西医院
ChiCTR2100042735	肿瘤新抗原负载的个体化DC疫苗治疗肝癌脊柱转移的前瞻性临床试验研究	2021/1/27	DC疫苗免疫治疗	探索性研究/预试验	海军军医大学长征医院
ChiCTR2000040901	肿瘤新抗原负载的个体化DC疫苗治疗肾癌脊柱转移的前瞻性临床试验研究	2020/12/14	DC疫苗免疫治疗	探索性研究/预试验	上海长征医院
ChiCTR2000040715	肿瘤新抗原负载的个体化DC疫苗治疗肺癌脊柱转移的前瞻性临床试验研究	2020/12/8	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR2000040482	肿瘤新抗原负载的个体化DC疫苗治疗乳腺癌脊柱转移的前瞻性、单中心临床试验研究	2020/11/30	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR2000040158	肿瘤新抗原负载的个体化DC疫苗治疗脊柱转移瘤的前瞻性、单中心临床试验研究	2020/11/23	DC疫苗免疫治疗	Ⅱ期临床试验	上海长征医院
ChiCTR1900022835	嵌合型新抗原反应性T细胞(cnTs)联合负载个体化新抗原的DC肿瘤细胞(neoDC-Vx)治疗进展期难治性恶性肿瘤前瞻性单臂临床研究方案	2019/4/27	免疫治疗	探索性研究/预试验	西南医科大学附属医院
ChiCTR1900021842	靶向肿瘤新抗原的高反应性疫苗治疗复发难治性肺癌	2019/3/12	负载新抗原的DC疫苗皮下注射	Ⅰ期临床试验	深圳市人民医院
ChiCTR1900020883	个体化新抗原复合多肽肿瘤免疫治疗临床试验研究	2019/1/21	肿瘤新抗原多肽负载 DCCs.	Ⅰ期临床试验	甘肃省人民医院
ChiCTR1800016805	个体化多靶点肿瘤新抗原免疫细胞治疗实体瘤的安全性、耐受性和有效性的I/II期临床试验	2018/6/26	新抗原反应性DC细胞疫苗	Ⅰ期+Ⅱ期	郑州大学第一附属医院

)], attaches=null, journal=Journal(id=1146441329971666965, delFlag=0, nameCn=解放军医学杂志, nameEn=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, issn=0577-7402, eissn=null, cn=11-1056/R, coden=null, periodic=0, language=CN, oaType=是, ccby=CC BY-NC-ND, superviseOffice=null, ownerOffice=null, pubOffice=null, editorOffice=null, officeType=null, aims=null, clcCode=null, officeProv=null, officeCity=null, officeAddr=null, officeZip=null, officeEmail=null, officePhone=null, editDirector=null, officeDirector=null, officeDirectorPhone=null, officeStaffNum=null, officeEmpNum=null, coverPicUrl=6srot5PcoYX30Oa4xeTmeg==, journalPrice=null, startedYear=null, abbrevIsoEn=null, journalRemark=null, publicationField=null, createdTime=1751262512917, updatedTime=1761735725513, createdBy=18614031015, updatedBy=13701087609, firstLetterCn=M, firstLetterEn=M, subjectCode=Life Sciences, subjectName=Life Sciences, subjectCodeEn=Life Sciences, subjectNameEn=null, picCn=6srot5PcoYX30Oa4xeTmeg==, picEn=ELwBh5xqrSTlIs7HmSNt2Q==, jcr=null, cjcr=null, exts=[JournalExt(id=1190369167564968109, language=CN, name=解放军医学杂志, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725537, updatedTime=1761735725537, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""}), JournalExt(id=1190369167615299758, language=EN, name=Medical Journal of Chinese People’s Liberation Army, nameHistory1=null, nameHistory2=null, managedBy=, sponsoredBy=, publishedBy=, editorOffice=, officeProv=null, officeCity=null, officeAddr=, officeZip=, editDirector=, officeDirector=null, officePhone=null, coverPicUrl=null, journalRemark=, submitArticleUrl=null, websiteUrl=, createdTime=1761735725549, updatedTime=1761735725549, createdBy=13701087609, updatedBy=13701087609, submissionGuidelinesUrl=, submissionAuthorUrl=#, submissionEditorUrl=#, submissionReviewUrl=#, submissionCeEditorUrl=, submissionAeEditorUrl=, option={"copyright":""})], databaseList=null, tenantJournalId=1189873630562394117, websiteList=[Website(id=1189873845923287108, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN, language=CN, createTime=1761617631655, createBy=18614031015, updateTime=1761622010471, updateBy=18614031015, name=解放军医学杂志-中文, tplId=1146099689490845704, title=解放军医学杂志, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924939378520839, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=articleTextType, value=kx, createTime=1761629813284, updateTime=1761629813284, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939353355012, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=banner, value=null, createTime=1761629813278, updateTime=1761629813278, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939399492362, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=grayFlag, value=0, createTime=1761629813289, updateTime=1761629813289, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939344966403, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629813276, updateTime=1761629813276, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939412075276, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=minRunFlag, value=0, createTime=1761629813292, updateTime=1761629813292, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939374326534, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/file/pic, createTime=1761629813283, updateTime=1761629813283, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939407880971, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=silenceFlag, value=0, createTime=1761629813291, updateTime=1761629813291, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939361743621, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_cn_619/, createTime=1761629813280, updateTime=1761629813280, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939386909448, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeColor, value=null, createTime=1761629813286, updateTime=1761629813286, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924939395298057, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873845923287108, code=themeStyle, value=null, createTime=1761629813288, updateTime=1761629813288, creator=18614031015, updator=18614031015)]), Website(id=1189873846057504839, webName=null, webTitle=null, webDomain=null, webCopyrigh=null, webIpcNo=null, seoTitle=null, seoKeywords=null, seoDescription=null, tenantJournalId=null, journalId=1189873630562394117, journalNameCn=null, journalNameEn=null, grayFlag=null, tenantId=1146029695717560320, platformId=null, journalGroupId=null, journalGroupNameCn=null, journalGroupNameEn=null, type=1, domain=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN, language=EN, createTime=1761617631687, createBy=18614031015, updateTime=1761622030030, updateBy=18614031015, name=解放军医学杂志-英文, tplId=1146101810881728533, title=Medical Journal of Chinese People’s Liberation Army, delFlag=0, indexPage=/home, props=[WebsiteProps(id=1189924968168223505, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=articleTextType, value=kx, createTime=1761629820148, updateTime=1761629820148, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968147251982, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=banner, value=null, createTime=1761629820143, updateTime=1761629820143, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968185000724, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=grayFlag, value=0, createTime=1761629820152, updateTime=1761629820152, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968138863373, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=logo, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic?fileId=+zXjYVhun8ZOAA6+aKx2hw==, createTime=1761629820141, updateTime=1761629820141, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968197583638, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=minRunFlag, value=0, createTime=1761629820155, updateTime=1761629820155, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968159834896, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=picServerUrl, value=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/file/pic, createTime=1761629820146, updateTime=1761629820146, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968193389333, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=silenceFlag, value=0, createTime=1761629820154, updateTime=1761629820154, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968155640591, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=staticResourcePath, value=https://castjournals.cast.org.cn/joweb/cast_kjdb_en_623/, createTime=1761629820145, updateTime=1761629820145, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968172417810, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeColor, value=null, createTime=1761629820149, updateTime=1761629820149, creator=18614031015, updator=18614031015), WebsiteProps(id=1189924968180806419, tenantId=1146029695717560320, journalId=null, journalGroupId=null, siteId=1189873846057504839, code=themeStyle, value=null, createTime=1761629820151, updateTime=1761629820151, creator=18614031015, updator=18614031015)])], journalTitle=解放军医学杂志, weixinUrl=null, journalUrl=http://zh.jfjyxzz.org.cn/, iacademicId=null, status=1, seqNo=null, journalTitleEn=Medical Journal of Chinese People’s Liberation Army, journalPhotoCn=6srot5PcoYX30Oa4xeTmeg==, journalPhotoEn=ELwBh5xqrSTlIs7HmSNt2Q==, journalFirstLetter=M, journalRecommend=null, journalNew=null, journalCollection=null, jcrJf=null, cjcrJf=null, jcrJfStr=null, cjcrJfStr=null, submissionFirstDecision=null, sciSubjectClassification=null, casSubjectClassification=null, citeScore=null, totalCitationFrequency=null, icpCode=null, psCode=null, advertisingLicenseCode=null, copyrightInformation=null, country=null, option=, provinceCode=null, provinceName=null, collectFlag=false), detailUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/10.11855/j.issn.0577-7402.1986.2023.0524, detailUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/10.11855/j.issn.0577-7402.1986.2023.0524, pdfUrlCn=https://castjournals.cast.org.cn/joweb/jfjyxzz/CN/PDF/10.11855/j.issn.0577-7402.1986.2023.0524, pdfUrlEn=https://castjournals.cast.org.cn/joweb/jfjyxzz/EN/PDF/10.11855/j.issn.0577-7402.1986.2023.0524, aliStartDate=null, aliEndDate=null, collectionFlag=false, citedCount=null, citedUrl=null, reference=null)