Article(id=1199334723689480715, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199334721185477563, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2209.2023.0529, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1666627200000, receivedDateStr=2022-10-25, revisedDate=null, revisedDateStr=null, acceptedDate=1670342400000, acceptedDateStr=2022-12-07, onlineDate=1763873280688, onlineDateStr=2025-11-23, pubDate=1714233600000, pubDateStr=2024-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763873280688, onlineIssueDateStr=2025-11-23, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763873280688, creator=13701087609, updateTime=1763873280688, updator=13701087609, issue=Issue{id=1199334721185477563, tenantId=1146029695717560320, journalId=1189873630562394117, year='2024', volume='49', issue='4', pageStart='367', pageEnd='488', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1763873280092, creator=13701087609, updateTime=1763874025072, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1199337845925183534, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199334721185477563, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1199337845925183535, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1199334721185477563, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=416, endPage=425, ext={EN=ArticleExt(id=1199334724851302945, articleId=1199334723689480715, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Risk factors for comprehensive complication index after radical resection of colon cancer and establishment of its dynamic nomogram prediction model, columnId=1190310109000602400, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Clinical Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the independent risk factors of comprehensive complication index (CCI) ≥26.2 after radical resection of colon cancer, and use these factors to establish and verify a dynamic web-based nomogram model. Methods The clinical data of colon cancer patients who underwent radical resection in the Affiliated Hospital of Jiangnan University from November 2020 to April 2022 were retrospectively collected, and divided into main cohort (November 2020 to October 2021, n=438) and validation cohort (November 2021 to April 2022, n=196). CCI scores of all patients were obtained based on CCI calculator (http://www.assessurgery.com). Univariate and multivariate logistic regression analysis were performed to identify the risk factors for CCI ≥26.2, and a nomogram model was constructed. Receiver operator characteristic curve (ROC), C index and calibration curve were used to evaluate the differentiation and consistency of predictive nomogram model, and the decision curve analysis was conducted to assess the clinical benefits of the model. Internal validation of the model is performed in the validation cohort. Results A total of 438 patients were identified in present study, of which 63 cases (14.4%) had CCI ≥26.2. Multivariate logistic regression analysis revealed that age ≥60 years (OR=2.662, 95%CI 1.341-5.285, P=0.005), low third lumbar spine skeletal muscle mass index (L₃MI; OR=4.572, 95%CI 2.435-8.583, P<0.001), NRS2002 ≥3 (OR=4.281, 95%CI 2.304-7.952, P<0.001), and preoperative bowel obstruction (OR=3.785, 95%CI 1.971-7.268, P<0.001) were significant independent risk factors for postoperative CCI ≥26.2. Based on these results, a static and web-based dynamic nomogram was established (https://jndxfsyywcwksyf.shinyapps.io/DynNomCCI/). The C-index and area under the curve (AUC) of the nomogram were 0.742 and 0.787, respectively. The calibration curve indicated a good consistency between the predicted probability and the actual probability. In the validation cohort, the nomogram also presented good discrimination (C-index=0.722, AUC=0.795) and predictive consistency. The decision curve analysis indicated the clinical benefit and application value of the nomogram prediction model. Conclusion This easy-to-use dynamic nomogram based on 4 independent risk factors can conveniently and reliably predict the probability of CCI ≥26.2 after radical resection of colon cancer, which helps optimize the preoperative evaluation system, formulate precise individualized treatment strategies, and enhance recovery after surgery.

, correspAuthors=Chuan-Qing Bao, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yi-Fan Shi, Xiao-Ming Shen, Zeng-Hui Yang, Li Xia, Bing-Hua Xu, Chuan-Qing Bao), CN=ArticleExt(id=1199334727778927250, articleId=1199334723689480715, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=结肠癌根治术后严重并发症危险因素分析及动态列线图预测模型构建, columnId=1190310109164180259, journalTitle=解放军医学杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨结肠癌根治术后综合并发症指数(CCI)≥26.2分的独立危险因素，以此建立动态网页列线图预测模型并进行验证。方法 回顾性收集2020年11月-2022年4月于江南大学附属医院接受根治性手术的结肠癌患者的临床资料，基于入院时间分为主要队列(2020年11月-2021年10月，n=438)与验证队列(2021年11月-2022年4月，n=196)。根据CCI计算器(http://www.assessurgery.com)得出所有患者的CCI评分，采用单因素和多因素logistic回归分析结肠癌患者术后CCI≥26.2的危险因素，并构建列线图模型。采用受试者工作特征(ROC)曲线、C指数及校准曲线评估列线图模型的区分度和一致性，决策曲线分析评估模型的临床获益，并对模型进行内部验证。结果 主要队列438例患者中，63例(14.4%)术后CCI≥26.2分。多因素logistic回归分析显示，年龄≥60岁(OR=2.662，95%CI 1.341~5.285，P=0.005)、低第3腰椎旁骨骼肌指数(L₃MI)(OR=4.572，95%CI 2.435~8.583，P<0.001)、NRS2002评分≥3分(OR=4.281，95%CI 2.304~7.952，P<0.001)和术前伴有肠梗阻(OR=3.785，95%CI 1.971~7.268，P<0.001)是结肠癌患者术后CCI≥26.2分的独立危险因素。据此建立静态及网页版动态列线图预测模型(https://jndxfsyywcwksyf.shinyapps.io/DynNomCCI/)。列线图模型的C指数和曲线下面积(AUC)分别为0.742和0.787；校准曲线显示模型的预测概率与实际概率具有较好的一致性；内部验证显示模型具有良好的区分度(C指数=0.722，AUC=0.795)和预测一致性；决策曲线分析显示该预测模型具有临床获益和应用价值。结论 基于4个独立危险因素构建的动态列线图模型能够便捷、可靠地预测结肠癌术后CCI≥26.2分的概率，有助于优化术前评估体系，制定精准的个体化诊疗方案，促进患者快速康复。

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史益凡，博士研究生，主要从事消化道恶性肿瘤的基础及临床方面的研究

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史益凡，博士研究生，主要从事消化道恶性肿瘤的基础及临床方面的研究

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NRS2002. 营养风险筛查2002

, figureFileSmall=KayLpSu0Yt4NJLCEkiCKUA==, figureFileBig=UsZaOqODWYDRKWyAoTZkIw==, tableContent=null), ArticleFig(id=1199334731708990276, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Fig.2, caption=Distribution of CCI in patients with colon cancer after surgery, figureFileSmall=mQrffAy8KZ8FLVL+hEfjdw==, figureFileBig=go6L4XwOMeBXX5v9r7Nodw==, tableContent=null), ArticleFig(id=1199334731805459270, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=图2, caption=结肠癌患者术后CCI分布情况

CCI. 综合并发症指数

, figureFileSmall=mQrffAy8KZ8FLVL+hEfjdw==, figureFileBig=go6L4XwOMeBXX5v9r7Nodw==, tableContent=null), ArticleFig(id=1199334731981620041, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Fig.3, caption=The nomogram for predicting CCI≥26.2 after radical resection of colon cancer, figureFileSmall=ggo++wEJELx9T1xA5/IVXg==, figureFileBig=1nWOXOjoF1+dGiJWZkaQJQ==, tableContent=null), ArticleFig(id=1199334732061311820, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=图3, caption=结肠癌根治术后CCI≥26.2分的列线图预测模型

L₃MI. 第3腰椎旁骨骼肌面积指数；NRS2002. 营养风险筛查2002；CCI. 综合并发症指数

, figureFileSmall=ggo++wEJELx9T1xA5/IVXg==, figureFileBig=1nWOXOjoF1+dGiJWZkaQJQ==, tableContent=null), ArticleFig(id=1199334732166169425, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Fig.4, caption=ROC curves for predicting CCI≥26.2 after radical resection of colon cancer, figureFileSmall=5JQJVPlJZYrsm9ln2b59Ww==, figureFileBig=47+aoIA34pv/p7uH25s2kw==, tableContent=null), ArticleFig(id=1199334732266832724, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=图4, caption=各项预测因素预测结肠癌根治术后CCI≥26.2分风险的ROC曲线

CCI. 综合并发症指数；L₃MI. 第3腰椎旁骨骼肌面积指数；A. 主要队列；B. 验证队列

, figureFileSmall=5JQJVPlJZYrsm9ln2b59Ww==, figureFileBig=47+aoIA34pv/p7uH25s2kw==, tableContent=null), ArticleFig(id=1199334732346524504, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Fig.5, caption=Calibration curve of nomogram for predicting CCI≥26.2 after radical resection of colon cancer, figureFileSmall=rsAhd96XYm4BhsnphdLhJw==, figureFileBig=jTQPQOtmohjFOxlEguJL7A==, tableContent=null), ArticleFig(id=1199334732455576410, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=图5, caption=列线图预测结肠癌患者术后CCI≥26.2分风险的校准曲线

CCI. 综合并发症指数；A. 主要队列；B. 验证队列

, figureFileSmall=rsAhd96XYm4BhsnphdLhJw==, figureFileBig=jTQPQOtmohjFOxlEguJL7A==, tableContent=null), ArticleFig(id=1199334732560434014, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Fig.6, caption=Clinical decision curve of nomogram model, figureFileSmall=0NlSpCXy09pq1FZgkWdObA==, figureFileBig=ZdcTRKrqCWNdF7qhK4S2jA==, tableContent=null), ArticleFig(id=1199334732690457442, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=图6, caption=列线图模型的临床决策曲线

水平实心黑线(None)表示所有患者均不接受针对性干预措施，蓝色线(All)表示所有患者均接受针对性干预措施；A. 主要队列；B. 验证队列

, figureFileSmall=0NlSpCXy09pq1FZgkWdObA==, figureFileBig=ZdcTRKrqCWNdF7qhK4S2jA==, tableContent=null), ArticleFig(id=1199334732786926436, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.1, caption=

Clavien-Dindo surgical complications grading system

, figureFileSmall=null, figureFileBig=null, tableContent=

分级	定义
Ⅰ	任何偏离术后正常护理常规，但不需要药物、手术、内镜或介入治疗的情况。允许使用止吐药、退热药、止痛剂、利尿剂、电解质和理疗等治疗，还包括床旁处理的伤口感染
Ⅱ	需要除Ⅰ级干预药物以外的药物治疗，包括输血和全肠外营养
Ⅲ	需要手术、内镜或介入治疗的并发症
Ⅲa	不需要全身麻醉
Ⅲb	需要全身麻醉
Ⅳ	需要重症监护处理的并发症
Ⅳa	单器官衰竭(包括透析)
Ⅳb	多器官衰竭
V	术后死亡

), ArticleFig(id=1199334732870812519, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表1, caption=

Claven-Dindo手术并发症分级系统

, figureFileSmall=null, figureFileBig=null, tableContent=

分级	定义
Ⅰ	任何偏离术后正常护理常规，但不需要药物、手术、内镜或介入治疗的情况。允许使用止吐药、退热药、止痛剂、利尿剂、电解质和理疗等治疗，还包括床旁处理的伤口感染
Ⅱ	需要除Ⅰ级干预药物以外的药物治疗，包括输血和全肠外营养
Ⅲ	需要手术、内镜或介入治疗的并发症
Ⅲa	不需要全身麻醉
Ⅲb	需要全身麻醉
Ⅳ	需要重症监护处理的并发症
Ⅳa	单器官衰竭(包括透析)
Ⅳb	多器官衰竭
V	术后死亡

), ArticleFig(id=1199334732967281514, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.2, caption=

Comparison of baseline characteristics of patients with colon cancer in main cohort and validation cohort [n(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

因素	主要队列 (n=438)	验证队列 (n=196)	χ2	P
人口学资料
性别			2.600	0.107(1)
男	247(56.4)	97(49.5)
女	191(43.6)	99(50.5)
年龄(岁)			0.861	0.354(1)
<60	175(40.0)	86(43.9)
≥60	263(60.0)	110(56.1)
BMI(kg/m2)			0.464	0.793(1)
<18.5	24(5.5)	13(6.6)
18.5~24	341(77.9)	153(78.1)
>24	73(16.7)	30(15.3)
临床特征
aCCI评分(分)			1.958	0.376(1)
0~1	75(17.1)	42(21.4)
2~3	172(39.3)	77(39.3)
≥4	191(43.6)	77(39.3)
NRS2002评分(分)			0.714	0.398(1)
<3	246(43.8)	103(52.6)
≥3	192(56.2)	93(47.4)
低L3MI(cm2/m2)			0.029	0.865(1)
否	274(62.6)	124(63.3)
是	164(37.4)	72(36.7)
癌胚抗原(μg/L)			0.282	0.596(1)
<5	313(71.5)	136(69.4)
≥5	125(28.5)	60(30.6)
白蛋白(g/L)			0.670	0.413(1)
<30	278(63.5)	131(66.8)
≥30	160(36.5)	65(33.2)
贫血			0.851	0.356(1)
无	402(91.8)	184(93.9)
有	36(8.2)	12(6.1)
新辅助化疗			-	0.837(2)
否	428(97.7)	191(97.4)
是	10(2.3)	5(2.6)
肠梗阻			0.713	0.399(1)
无	319(72.8)	149(76.0)
有	119(27.2)	47(24.0)
手术及病理信息
急诊手术			0.026	0.872(1)
否	412(94.1)	185(94.4)
是	26(5.9)	11(5.6)
手术方式			1.606	0.205(1)
开腹	83(18.9)	29(14.8)
腹腔镜	355(81.1)	167(85.2)
肿瘤位置			0.354	0.950(1)
升结肠	173(39.5)	73(29.7)
横结肠	31(7.1)	15(32.6)
降结肠	61(13.9)	27(30.7)
乙状结肠	173(39.5)	81(31.9)
造瘘			0.206	0.650(1)
无	413(94.3)	183(93.4)
有	25(5.7)	13(16.6)
肿瘤长径(cm)			0.043	0.836(1)
<5	205(46.8)	90(45.9)
≥5	233(53.2)	106(54.1)
肿瘤分化程度			0.335	0.846(1)
高分化	16(3.7)	9(4.6)
中分化	266(51.6)	99(50.5)
低分化	196(44.7)	88(44.9)
肿瘤组织学类型			0.951	0.622(1)
腺癌	372(84.9)	172(87.8)
黏液腺癌	42(9.6)	16(8.2)
其他	24(5.5)	8(4.1)
血管侵犯			0.002	0.961(1)
无	307(70.1)	137(69.9)
有	131(29.9)	59(30.1)
神经侵犯			0.248	0.618(1)
无	343(78.3)	150(75.6)
有	95(21.7)	46(23.4)
病理学T分期			0.197	0.906(1)
T2	15(3.4)	8(4.1)
T3	47(10.7)	20(10.2)
T4	376(85.8)	168(85.7)
病理学N分期			0.239	0.888(1)
N0	192(43.8)	82(41.8)
N1	29(6.6)	14(7.1)
N2	217(49.5)	100(51.0)

), ArticleFig(id=1199334733072139118, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表2, caption=

主要队列与验证队列结肠癌患者的基线特征比较[例(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

因素	主要队列 (n=438)	验证队列 (n=196)	χ2	P
人口学资料
性别			2.600	0.107(1)
男	247(56.4)	97(49.5)
女	191(43.6)	99(50.5)
年龄(岁)			0.861	0.354(1)
<60	175(40.0)	86(43.9)
≥60	263(60.0)	110(56.1)
BMI(kg/m2)			0.464	0.793(1)
<18.5	24(5.5)	13(6.6)
18.5~24	341(77.9)	153(78.1)
>24	73(16.7)	30(15.3)
临床特征
aCCI评分(分)			1.958	0.376(1)
0~1	75(17.1)	42(21.4)
2~3	172(39.3)	77(39.3)
≥4	191(43.6)	77(39.3)
NRS2002评分(分)			0.714	0.398(1)
<3	246(43.8)	103(52.6)
≥3	192(56.2)	93(47.4)
低L3MI(cm2/m2)			0.029	0.865(1)
否	274(62.6)	124(63.3)
是	164(37.4)	72(36.7)
癌胚抗原(μg/L)			0.282	0.596(1)
<5	313(71.5)	136(69.4)
≥5	125(28.5)	60(30.6)
白蛋白(g/L)			0.670	0.413(1)
<30	278(63.5)	131(66.8)
≥30	160(36.5)	65(33.2)
贫血			0.851	0.356(1)
无	402(91.8)	184(93.9)
有	36(8.2)	12(6.1)
新辅助化疗			-	0.837(2)
否	428(97.7)	191(97.4)
是	10(2.3)	5(2.6)
肠梗阻			0.713	0.399(1)
无	319(72.8)	149(76.0)
有	119(27.2)	47(24.0)
手术及病理信息
急诊手术			0.026	0.872(1)
否	412(94.1)	185(94.4)
是	26(5.9)	11(5.6)
手术方式			1.606	0.205(1)
开腹	83(18.9)	29(14.8)
腹腔镜	355(81.1)	167(85.2)
肿瘤位置			0.354	0.950(1)
升结肠	173(39.5)	73(29.7)
横结肠	31(7.1)	15(32.6)
降结肠	61(13.9)	27(30.7)
乙状结肠	173(39.5)	81(31.9)
造瘘			0.206	0.650(1)
无	413(94.3)	183(93.4)
有	25(5.7)	13(16.6)
肿瘤长径(cm)			0.043	0.836(1)
<5	205(46.8)	90(45.9)
≥5	233(53.2)	106(54.1)
肿瘤分化程度			0.335	0.846(1)
高分化	16(3.7)	9(4.6)
中分化	266(51.6)	99(50.5)
低分化	196(44.7)	88(44.9)
肿瘤组织学类型			0.951	0.622(1)
腺癌	372(84.9)	172(87.8)
黏液腺癌	42(9.6)	16(8.2)
其他	24(5.5)	8(4.1)
血管侵犯			0.002	0.961(1)
无	307(70.1)	137(69.9)
有	131(29.9)	59(30.1)
神经侵犯			0.248	0.618(1)
无	343(78.3)	150(75.6)
有	95(21.7)	46(23.4)
病理学T分期			0.197	0.906(1)
T2	15(3.4)	8(4.1)
T3	47(10.7)	20(10.2)
T4	376(85.8)	168(85.7)
病理学N分期			0.239	0.888(1)
N0	192(43.8)	82(41.8)
N1	29(6.6)	14(7.1)
N2	217(49.5)	100(51.0)

), ArticleFig(id=1199334733156025203, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.3, caption=

Classification and quantity distribution of complications in colon cancer patients with postoperative CCI≥26.2 [n(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

术后并发症	主要队列(n=438)	验证队列(n=196)
Ⅰ级
切口感染	11(2.5)	4(2.0)
发热≥38.5 ℃	5(1.1)	1(0.5)
Ⅱ级
肺部感染	11(2.5)	6(3.1)
乳糜漏	9(2.1)	5(2.6)
吻合口瘘	7(1.6)	6(3.1)
胃排空障碍	7(1.6)	3(1.5)
尿路感染	6(1.4)	3(1.5)
房颤	6(1.4)	2(1.0)
感染性腹泻	5(1.1)	0
肠梗阻	4(0.9)	0
Ⅲa级
吻合口出血	8(1.8)	4(2.0)
切口裂开	6(1.4)	3(1.5)
腹腔脓肿	4(0.9)	4(2.0)
下肢深静脉血栓	3(0.7)	0
急性脑梗死	1(0.2)	0
Ⅲb级
吻合口瘘	9(2.1)	3(1.5)
腹腔出血	7(1.6)	5(2.6)
尿瘘	2(0.5)	0
小肠破裂	1(0.2)	0
Ⅳa级
呼吸衰竭	4(0.9)	3(1.5)
心力衰竭	2(0.5)	0
Ⅳb级
多器官衰竭	2(0.5)	0

), ArticleFig(id=1199334733260882806, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表3, caption=

术后CCI≥26.2分结肠癌患者的并发症分级和数量分布[例(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

术后并发症	主要队列(n=438)	验证队列(n=196)
Ⅰ级
切口感染	11(2.5)	4(2.0)
发热≥38.5 ℃	5(1.1)	1(0.5)
Ⅱ级
肺部感染	11(2.5)	6(3.1)
乳糜漏	9(2.1)	5(2.6)
吻合口瘘	7(1.6)	6(3.1)
胃排空障碍	7(1.6)	3(1.5)
尿路感染	6(1.4)	3(1.5)
房颤	6(1.4)	2(1.0)
感染性腹泻	5(1.1)	0
肠梗阻	4(0.9)	0
Ⅲa级
吻合口出血	8(1.8)	4(2.0)
切口裂开	6(1.4)	3(1.5)
腹腔脓肿	4(0.9)	4(2.0)
下肢深静脉血栓	3(0.7)	0
急性脑梗死	1(0.2)	0
Ⅲb级
吻合口瘘	9(2.1)	3(1.5)
腹腔出血	7(1.6)	5(2.6)
尿瘘	2(0.5)	0
小肠破裂	1(0.2)	0
Ⅳa级
呼吸衰竭	4(0.9)	3(1.5)
心力衰竭	2(0.5)	0
Ⅳb级
多器官衰竭	2(0.5)	0

), ArticleFig(id=1199334733386711929, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.4, caption=

Univariate analysis of 438 patients with CCI≥26.2 after radical resection of colon cancer [n(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

临床因素	对照组 (n=375)	观察组 (n=63)	χ2	P
性别			0.163	0.686(1)
男	210(56.0)	37(58.7)
女	165(44.0)	26(41.3)
年龄(岁)			7.995	0.005(1)
<60	160(42.7)	15(23.8)
≥60	215(57.3)	48(76.2)
BMI(kg/m2)			-	0.369(2)
<18.5	16(4.3)	4(6.3)
18.5~24.0	288(76.8)	51(81.0)
>24.0	71(18.9)	8(12.7)
aCCI评分(分)			5.242	0.073(1)
0~1	64(17.1)	11(17.5)
2~3	155(41.3)	17(27.0)
≥4	156(41.6)	35(55.6)
NRS2002评分(分)			17.87	<0.001(1)
<3	282(75.2)	31(49.2)
≥3	93(24.8)	32(50.8)
低L3MI(cm2/m2)			23.994	<0.001(1)
否	252(67.2)	22(34.9)
是	123(32.8)	41(65.1)
癌胚抗原(μg/L)			4.105	0.043(1)
<5	218(58.1)	28(44.4)
≥5	157(41.9)	35(55.6)
白蛋白(g/L)			1.988	0.159(1)
<30	243(64.8)	35(55.6)
≥30	132(35.2)	28(44.4)
贫血			0.166	0.684(1)
无	345(92.0)	57(90.5)
有	30(8.0)	6(9.5)
新辅助化疗			-	0.162(2)
否	368(98.1)	60(95.2)
是	7(1.9)	3(4.8)
肠梗阻			7.394	0.007(1)
无	282(75.2)	37(58.7)
有	93(24.8)	26(41.3)
急诊手术			-	0.242(2)
否	355(94.7)	57(90.5)
是	20(5.3)	6(9.5)
手术方式			3.093	0.079(1)
开腹	66(17.6)	17(27.0)
腹腔镜	309(82.4)	46(73.0)
肿瘤位置			-	0.558(2)
升结肠	149(37.7)	24(38.1)
横结肠	26(6.9)	5(7.9)
降结肠	49(13.1)	12(19.0)
乙状结肠	151(42.3)	22(34.9)
造瘘			-	0.383(2)
无	355(94.7)	58(92.1)
有	20(5.3)	5(7.9)
肿瘤长径(cm)			0.018	0.894(1)
<5	176(46.9)	29(46.1)
≥5	199(53.1)	34(54.0)
肿瘤分化程度			-	0.277(2)
高分化	12(3.2)	4(6.3)
中分化	191(50.9)	35(55.6)
低分化	172(45.9)	24(38.1)
肿瘤组织学类型			-	0.840(2)
腺癌	318(84.8)	54(85.7)
黏液腺癌	37(9.9)	5(7.9)
其他	20(5.3)	4(6.3)
血管侵犯			0.002	0.963(1)
无	263(70.1)	44(69.8)
有	112(29.9)	19(30.2)
神经侵犯			1.214	0.270(1)
无	297(79.2)	46(73.0)
有	78(20.8)	17(27.0)
病理学T分期			-	0.166(2)
T2	13(3.5)	2(3.2)
T3	40(10.7)	12(19.0)
T4	322(85.9)	49(77.8)
病理学N分期			-	0.009(2)
N0	174(46.4)	18(28.6)
N1	21(5.6)	8(12.7)
N2	180(48.0)	37(58.7)

), ArticleFig(id=1199334733491569532, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表4, caption=

438例结肠癌患者根治术后CCI≥26.2的单因素分析[例(%)]

, figureFileSmall=null, figureFileBig=null, tableContent=

临床因素	对照组 (n=375)	观察组 (n=63)	χ2	P
性别			0.163	0.686(1)
男	210(56.0)	37(58.7)
女	165(44.0)	26(41.3)
年龄(岁)			7.995	0.005(1)
<60	160(42.7)	15(23.8)
≥60	215(57.3)	48(76.2)
BMI(kg/m2)			-	0.369(2)
<18.5	16(4.3)	4(6.3)
18.5~24.0	288(76.8)	51(81.0)
>24.0	71(18.9)	8(12.7)
aCCI评分(分)			5.242	0.073(1)
0~1	64(17.1)	11(17.5)
2~3	155(41.3)	17(27.0)
≥4	156(41.6)	35(55.6)
NRS2002评分(分)			17.87	<0.001(1)
<3	282(75.2)	31(49.2)
≥3	93(24.8)	32(50.8)
低L3MI(cm2/m2)			23.994	<0.001(1)
否	252(67.2)	22(34.9)
是	123(32.8)	41(65.1)
癌胚抗原(μg/L)			4.105	0.043(1)
<5	218(58.1)	28(44.4)
≥5	157(41.9)	35(55.6)
白蛋白(g/L)			1.988	0.159(1)
<30	243(64.8)	35(55.6)
≥30	132(35.2)	28(44.4)
贫血			0.166	0.684(1)
无	345(92.0)	57(90.5)
有	30(8.0)	6(9.5)
新辅助化疗			-	0.162(2)
否	368(98.1)	60(95.2)
是	7(1.9)	3(4.8)
肠梗阻			7.394	0.007(1)
无	282(75.2)	37(58.7)
有	93(24.8)	26(41.3)
急诊手术			-	0.242(2)
否	355(94.7)	57(90.5)
是	20(5.3)	6(9.5)
手术方式			3.093	0.079(1)
开腹	66(17.6)	17(27.0)
腹腔镜	309(82.4)	46(73.0)
肿瘤位置			-	0.558(2)
升结肠	149(37.7)	24(38.1)
横结肠	26(6.9)	5(7.9)
降结肠	49(13.1)	12(19.0)
乙状结肠	151(42.3)	22(34.9)
造瘘			-	0.383(2)
无	355(94.7)	58(92.1)
有	20(5.3)	5(7.9)
肿瘤长径(cm)			0.018	0.894(1)
<5	176(46.9)	29(46.1)
≥5	199(53.1)	34(54.0)
肿瘤分化程度			-	0.277(2)
高分化	12(3.2)	4(6.3)
中分化	191(50.9)	35(55.6)
低分化	172(45.9)	24(38.1)
肿瘤组织学类型			-	0.840(2)
腺癌	318(84.8)	54(85.7)
黏液腺癌	37(9.9)	5(7.9)
其他	20(5.3)	4(6.3)
血管侵犯			0.002	0.963(1)
无	263(70.1)	44(69.8)
有	112(29.9)	19(30.2)
神经侵犯			1.214	0.270(1)
无	297(79.2)	46(73.0)
有	78(20.8)	17(27.0)
病理学T分期			-	0.166(2)
T2	13(3.5)	2(3.2)
T3	40(10.7)	12(19.0)
T4	322(85.9)	49(77.8)
病理学N分期			-	0.009(2)
N0	174(46.4)	18(28.6)
N1	21(5.6)	8(12.7)
N2	180(48.0)	37(58.7)

), ArticleFig(id=1199334733596427137, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.5, caption=

Multivariate logistic analysis of 438 patients with CCI≥26.2 after radical resection of colon cancer

, figureFileSmall=null, figureFileBig=null, tableContent=

临床因素	赋值	β	SE	Wald	OR(95%CI)	P
年龄(岁)
<60	0	-	-	-	1	-
≥60	1	0.979	0.350	7.827	2.662(1.341~5.285)	0.005
NRS2002评分(分)
<3	0	-	-	-	1	-
≥3	1	1.454	0.316	21.176	4.281(2.304~7.952)	<0.001
低L3MI(cm2/m2)
否	0	-	-	-	1	-
是	1	1.520	0.321	22.364	4.572(2.435~8.583)	<0.001
癌胚抗原(μg/L)
<5	0	-	-	-	1	-
≥5	1	0.526	0.311	2.854	1.692(0.919~3.116)	0.091
肠梗阻
无	0	-	-	-	1	-
有	1	1.331	0.333	15.993	3.785(1.971~7.268)	<0.001
病理学N分期
N0	1	-	-	-	1	-
N1	2	0.794	0.548	2.098	2.212(0.756~6.473)	0.147
N2	3	0.497	0.345	2.079	1.644(0.836~3.233)	0.149

), ArticleFig(id=1199334733705479045, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表5, caption=

438例结肠癌患者根治术后CCI≥26.2分的多因素logistic分析结果

, figureFileSmall=null, figureFileBig=null, tableContent=

临床因素	赋值	β	SE	Wald	OR(95%CI)	P
年龄(岁)
<60	0	-	-	-	1	-
≥60	1	0.979	0.350	7.827	2.662(1.341~5.285)	0.005
NRS2002评分(分)
<3	0	-	-	-	1	-
≥3	1	1.454	0.316	21.176	4.281(2.304~7.952)	<0.001
低L3MI(cm2/m2)
否	0	-	-	-	1	-
是	1	1.520	0.321	22.364	4.572(2.435~8.583)	<0.001
癌胚抗原(μg/L)
<5	0	-	-	-	1	-
≥5	1	0.526	0.311	2.854	1.692(0.919~3.116)	0.091
肠梗阻
无	0	-	-	-	1	-
有	1	1.331	0.333	15.993	3.785(1.971~7.268)	<0.001
病理学N分期
N0	1	-	-	-	1	-
N1	2	0.794	0.548	2.098	2.212(0.756~6.473)	0.147
N2	3	0.497	0.345	2.079	1.644(0.836~3.233)	0.149

), ArticleFig(id=1199334733793559432, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=EN, label=Tab.6, caption=

Area under the curve of each predictor for predicting CCI≥26.2 after radical resection of colon cancer

, figureFileSmall=null, figureFileBig=null, tableContent=

临床因素	主要队列		验证队列
	AUC(95%CI)	P	AUC(95%CI)	P
年龄	0.594(0.547~0.641)	0.002	0.636(0.589~0.681)	<0.001
低L3MI	0.661(0.615~0.706)	<0.001	0.665(0.619~0.709)	<0.001
NRS2002评分	0.582(0.535~0.629)	0.013	0.580(0.532~0.626)	0.107
肠梗阻	0.630(0.583~0.675)	<0.001	0.600(0.552~0.646)	0.047
列线图	0.787(0.745~0.824)	<0.001	0.795(0.754~0.831)	<0.001

), ArticleFig(id=1199334733890028427, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1199334723689480715, language=CN, label=表6, caption=

各预测因素预测结肠癌根治术后CCI≥26.2分的ROC曲线下面积

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临床因素	主要队列		验证队列
	AUC(95%CI)	P	AUC(95%CI)	P
年龄	0.594(0.547~0.641)	0.002	0.636(0.589~0.681)	<0.001
低L3MI	0.661(0.615~0.706)	<0.001	0.665(0.619~0.709)	<0.001
NRS2002评分	0.582(0.535~0.629)	0.013	0.580(0.532~0.626)	0.107
肠梗阻	0.630(0.583~0.675)	<0.001	0.600(0.552~0.646)	0.047
列线图	0.787(0.745~0.824)	<0.001	0.795(0.754~0.831)	<0.001

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