Article(id=1198196210768118359, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1198196207379120715, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.0338.2024.0731, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1710518400000, receivedDateStr=2024-03-16, revisedDate=null, revisedDateStr=null, acceptedDate=1714233600000, acceptedDateStr=2024-04-28, onlineDate=1763601838056, onlineDateStr=2025-11-20, pubDate=1735315200000, pubDateStr=2024-12-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1763601838056, onlineIssueDateStr=2025-11-20, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1763601838056, creator=13701087609, updateTime=1763601838056, updator=13701087609, issue=Issue{id=1198196207379120715, tenantId=1146029695717560320, journalId=1189873630562394117, year='2024', volume='49', issue='12', pageStart='1343', pageEnd='1459', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1763601837248, creator=13701087609, updateTime=1763603898104, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1198204851306988030, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1198196207379120715, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1198204851306988031, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1198196207379120715, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=1379, endPage=1385, ext={EN=ArticleExt(id=1198196211166577249, articleId=1198196210768118359, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Analysis of drug resistance in disseminated pulmonary tuberculosis: 71 cases report, columnId=1190310109000602400, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Clinical Research, runingTitle=null, highlight=null, articleAbstract=
Objective To analyze the characteristics of drug resistance in patients with disseminated pulmonary tuberculosis, and provide references for the clinical development of individualized treatment plans. Methods A retrospective analysis was conducted on 71 hospitalized patients with disseminated pulmonary tuberculosis treated at the Beijing Chest Hospital, Capital Medical University from January 2015 to January 2024. The susceptibility of Mycobacterium tuberculosis from these patients to 16 anti-tuberculosis drugs was detected using the microplate method for mycobacterial drug susceptibility testing. The study analyzed the culture results of Mycobacterium tuberculosis, drug susceptibility test results, initial treatment or re-treatment status, drug resistance, and differences in drug resistance types between initial and re-treated patients. Results Among the 71 patients with disseminated pulmonary tuberculosis, there were 51 males (71.8%), and 58 cases (81.7%) of acute disseminated pulmonary tuberculosis, with an overall drug resistance rate to 16 anti-tuberculosis drugs of 38.0%. There was no statistically significant difference in the total drug resistance rate between re-treated patients and those undergoing initial treatment [52.2%(12/23) vs. 31.3%(15/48), P=0.089]. The top 7 drugs to which patients were resistant were streptomycin (Sm) and isoniazid (INH) with 13 cases each (18.3%), rifapentine (Rft) and isoniazid aminosalicylate (Pa) with 10 cases each (14.1%), rifampicin (RFP), rifabutin (Rfb), and capreomycin (Cm) with 9 cases each (12.7%). The top 6 drugs to which initially treated patients were resistant were Cm with 6 cases (12.5%), Sm with 5 cases (10.4%), Pa with 4 cases (8.3%), INH, clarithromycin (Clr), and p-aminosalicylic acid (PAS) with 3 cases each (6.3%). The top 7 drugs to which re-treated patients were resistant were INH with 10 cases (43.5%), Sm, RFP, and Rft with 8 cases each (34.8%), Rfb with 7 cases (30.4%), Pa and levofloxacin (Lfx) with 6 cases each (26.1%). The overall mono-resistance rate, poly-drug resistance rate, and multidrug-resistant rate to 16 anti-tuberculosis drugs were 9.9%, 7.0%, and 11.3%, respectively; all mono-resistance patients were initially treated; there was no statistically significant difference in the poly-drug resistance rate between re-treated and initially treated patients (13.0% vs. 4.2%, P=0.591), but the multidrug-resistant rate was significantly higher in re-treated patients (30.4% vs. 2.1%, P=0.002). Conclusion Drug resistance in disseminated pulmonary tuberculosis is severe. Clinical physicians can develop personalized anti-tuberculosis treatment plans based on drug susceptibility test results.
, correspAuthors=Gui-Rong Wang, authorNote=null, correspAuthorsNote=
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(附
71例报告
), columnId=1190310109164180259, journalTitle=解放军医学杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=
目的 分析血行播散性肺结核患者的耐药特点，为临床制定个体化治疗方案提供参考。方法 回顾性分析2015年1月－2024年1月首都医科大学附属北京胸科医院收治的71例血行播散性肺结核住院患者的临床资料。采用分枝杆菌微孔板药敏检测技术检测来自71例患者的结核分枝杆菌对16种抗结核药的敏感性，分析血行播散性肺结核患者的结核分枝杆菌培养结果、药敏试验结果、初治或复治情况、耐药情况，以及初治与复治患者耐药类型的差异。结果 71例血行播散性肺结核患者中，男51例(71.8%)，急性血行播散性肺结核58例(81.7%)，对16种抗结核药的总耐药率为38.0%。复治患者总耐药率与初治患者比较差异无统计学意义[52.2%(12/23) vs. 31.3%(15/48)，P=0.089]。患者对16种抗结核药任一耐药的前7位为链霉素(Sm)、异烟肼(INH)各13例(18.3%)，利福喷丁(Rft)、对氨基水杨酸异烟肼(Pa)各10例(14.1%)，利福平(RFP)、利福布汀(Rfb)、卷曲霉素(Cm)各9例(12.7%)；初治患者任一耐药的前6位为Cm 6例(12.5%)，Sm 5例(10.4%)，Pa 4例(8.3%)，INH、克拉霉素(Clr)、对氨基水杨酸(PAS)各3例(6.3%)；复治患者任一耐药的前7位为INH 10例(43.5%)，Sm、RFP、Rft各8例(34.8%)，Rfb 7例(30.4%)，Pa、左氧左旋氧氟沙星(Lfx)各6例(26.1%)。患者对16种抗结核药的总单耐药率、总多耐药率、总耐多药率分别为9.9%、7.0%、11.3%；所有单耐药患者均为初治患者；复治患者多耐药率与初治患者比较差异无统计学意义[13.0% vs. 4.2%，P=0.591]，但耐多药率明显高于初治患者[30.4% vs. 2.1%，P=0.002]。结论 血行播散性肺结核耐药情况严峻，临床医师可根据药敏试验结果制定个性化的抗结核治疗方案。
, correspAuthors=王桂荣, authorNote=null, correspAuthorsNote=
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施亦衡，硕士研究生，主要从事结核病诊断新技术及相关机制的研究
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Bilateral cross-resistance distribution of isolated strains from 71 cases of disseminated tuberculosis patients to RFP, Rfb, and Rft, figureFileSmall=OxGNlMW9q5+hfRRk4eKCGA==, figureFileBig=3oh9eCrMdvzduHmbtbaDKQ==, tableContent=null), ArticleFig(id=1198318893509997556, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=图1, caption=
71例血行播散性肺结核患者分离菌株对利福平、利福布汀和利福喷丁的双向交叉耐药性分布 RFP. 利福平；Rfb. 利福布汀；Rft. 利福喷丁
, figureFileSmall=OxGNlMW9q5+hfRRk4eKCGA==, figureFileBig=3oh9eCrMdvzduHmbtbaDKQ==, tableContent=null), ArticleFig(id=1198318893635826683, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=EN, label=Tab.1, caption=
Basic information and clinical characteristics of 71 patients with disseminated tuberculosis [n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 项目 | 合计(n=71) | 初治患者(n=48) | 复治患者(n=23) |
| 性别 | | | |
| 男 | 51(71.8) | 33(68.8) | 18(78.3) |
| 女 | 20(28.2) | 15(31.2) | 5(21.7) |
| 年龄(岁) | | | |
| 10~19 | 5(7.0) | 5(10.4) | 0 |
| 20~29 | 10(14.1) | 6(12.5) | 4(17.4) |
| 30~39 | 10(14.1) | 8(16.7) | 2(8.7) |
| 40~49 | 9(12.7) | 3(6.3) | 6(26.1) |
| 50~59 | 7(10.0) | 3(6.3) | 4(17.4) |
| 60~69 | 13(18.3) | 10(20.8) | 3(13.0) |
| 70~79 | 9(12.7) | 6(12.5) | 3(13.0) |
| 80~89 | 8(11.2) | 7(14.6) | 1(4.3) |
| 居住地 | | | |
| 城镇 | 36(50.7) | 27(56.3) | 9(39.1) |
| 农村 | 35(49.3) | 21(43.8) | 14(60.9) |
| 基础疾病 | | | |
| 低蛋白血症 | 44(62.0) | 28(58.3) | 16(69.6) |
| 贫血 | 34(47.9) | 21(43.8) | 13(56.5) |
| 高尿酸血症 | 28(39.4) | 17(35.4) | 11(47.8) |
| 高血压 | 18(25.4) | 13(27.1) | 5(21.7) |
| 糖尿病 | 11(15.5) | 5(10.4) | 6(26.1) |
| 营养不良 | 9(12.7) | 5(10.4) | 4(17.4) |
| 职业 | | | |
| 农民 | 22(31.0) | 12(25.0) | 10(43.5) |
| 退(离)休人员 | 20(28.2) | 17(35.4) | 3(13.0) |
| 职员 | 8(11.3) | 6(12.5) | 2(8.7) |
| 工人 | 6(8.5) | 4(8.3) | 2(8.7) |
| 学生 | 6(8.5) | 5(10.4) | 1(4.3) |
| 其他 | 9(12.7) | 4(8.3) | 5(21.7) |
), ArticleFig(id=1198318893761655809, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=表1, caption=
71例血行播散性肺结核患者的基本信息与临床特征[例(%)]
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| 项目 | 合计(n=71) | 初治患者(n=48) | 复治患者(n=23) |
| 性别 | | | |
| 男 | 51(71.8) | 33(68.8) | 18(78.3) |
| 女 | 20(28.2) | 15(31.2) | 5(21.7) |
| 年龄(岁) | | | |
| 10~19 | 5(7.0) | 5(10.4) | 0 |
| 20~29 | 10(14.1) | 6(12.5) | 4(17.4) |
| 30~39 | 10(14.1) | 8(16.7) | 2(8.7) |
| 40~49 | 9(12.7) | 3(6.3) | 6(26.1) |
| 50~59 | 7(10.0) | 3(6.3) | 4(17.4) |
| 60~69 | 13(18.3) | 10(20.8) | 3(13.0) |
| 70~79 | 9(12.7) | 6(12.5) | 3(13.0) |
| 80~89 | 8(11.2) | 7(14.6) | 1(4.3) |
| 居住地 | | | |
| 城镇 | 36(50.7) | 27(56.3) | 9(39.1) |
| 农村 | 35(49.3) | 21(43.8) | 14(60.9) |
| 基础疾病 | | | |
| 低蛋白血症 | 44(62.0) | 28(58.3) | 16(69.6) |
| 贫血 | 34(47.9) | 21(43.8) | 13(56.5) |
| 高尿酸血症 | 28(39.4) | 17(35.4) | 11(47.8) |
| 高血压 | 18(25.4) | 13(27.1) | 5(21.7) |
| 糖尿病 | 11(15.5) | 5(10.4) | 6(26.1) |
| 营养不良 | 9(12.7) | 5(10.4) | 4(17.4) |
| 职业 | | | |
| 农民 | 22(31.0) | 12(25.0) | 10(43.5) |
| 退(离)休人员 | 20(28.2) | 17(35.4) | 3(13.0) |
| 职员 | 8(11.3) | 6(12.5) | 2(8.7) |
| 工人 | 6(8.5) | 4(8.3) | 2(8.7) |
| 学生 | 6(8.5) | 5(10.4) | 1(4.3) |
| 其他 | 9(12.7) | 4(8.3) | 5(21.7) |
), ArticleFig(id=1198318893841346563, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=EN, label=Tab.2, caption=
Distribution of 71 patients with disseminated tuberculosis by disease analysis [n(%)]
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| 病情 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) |
| 类型 | | | |
| 急性血行播散性肺结核 | 58(81.7) | 40(83.3) | 18(78.3) |
| 亚急性血行播散性肺结核 | 12(16.9) | 7(14.6) | 5(21.7) |
| 慢性血行播散性肺结核 | 1(1.4) | 1(2.1) | 0 |
| 合并肺外结核情况 | | | |
| 结核性脑膜炎 | 51(71.8) | 30(62.5) | 21(91.3) |
| 脊椎结核 | 11(15.5) | 8(16.7) | 3(13.0) |
| 淋巴结核 | 9(12.7) | 4(8.3) | 5(21.7) |
| 关节结核 | 7(9.9) | 3(6.3) | 4(17.4) |
| 肾结核 | 4(5.6) | 3(6.3) | 1(4.3) |
| 肠结核 | 2(2.8) | 1(2.1) | 1(4.3) |
| 盆腔结核 | 2(2.8) | 1(2.1) | 1(4.3) |
| 脊髓结核 | 2(2.8) | 2(4.2) | 0 |
| 肝结核 | 1(1.4) | 1(2.1) | 0 |
| 膀胱结核 | 1(1.4) | 1(6.3) | 0 |
| 睾丸结核 | 1(1.4) | 1(6.3) | 0 |
| 心包炎 | 1(1.4) | 0 | 1(4.3) |
| 涉及2个及以上肺外部位 | 30(42.3) | 18(37.5) | 12(52.2) |
| 涉及3个及以上肺外部位 | 12(16.9) | 7(14.6) | 5(21.7) |
), ArticleFig(id=1198318893954592783, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=表2, caption=
71例血行播散性肺结核患者病情分布[例(%)]
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| 病情 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) |
| 类型 | | | |
| 急性血行播散性肺结核 | 58(81.7) | 40(83.3) | 18(78.3) |
| 亚急性血行播散性肺结核 | 12(16.9) | 7(14.6) | 5(21.7) |
| 慢性血行播散性肺结核 | 1(1.4) | 1(2.1) | 0 |
| 合并肺外结核情况 | | | |
| 结核性脑膜炎 | 51(71.8) | 30(62.5) | 21(91.3) |
| 脊椎结核 | 11(15.5) | 8(16.7) | 3(13.0) |
| 淋巴结核 | 9(12.7) | 4(8.3) | 5(21.7) |
| 关节结核 | 7(9.9) | 3(6.3) | 4(17.4) |
| 肾结核 | 4(5.6) | 3(6.3) | 1(4.3) |
| 肠结核 | 2(2.8) | 1(2.1) | 1(4.3) |
| 盆腔结核 | 2(2.8) | 1(2.1) | 1(4.3) |
| 脊髓结核 | 2(2.8) | 2(4.2) | 0 |
| 肝结核 | 1(1.4) | 1(2.1) | 0 |
| 膀胱结核 | 1(1.4) | 1(6.3) | 0 |
| 睾丸结核 | 1(1.4) | 1(6.3) | 0 |
| 心包炎 | 1(1.4) | 0 | 1(4.3) |
| 涉及2个及以上肺外部位 | 30(42.3) | 18(37.5) | 12(52.2) |
| 涉及3个及以上肺外部位 | 12(16.9) | 7(14.6) | 5(21.7) |
), ArticleFig(id=1198318894072033306, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=EN, label=Tab.3, caption=
Distribution of drug resistance types among 71 newly treated and retreated patients with disseminated tuberculosis [n(%)]
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| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | χ2 | P |
| 单耐药 | 27(38.0) | 15(31.3) | 12(52.2) | 2.889 | 0.089 |
| 链霉素 | 13(18.3) | 5(10.4) | 8(34.8) | 4.650 | 0.031 |
| 异烟肼 | 13(18.3) | 3(6.3) | 10(43.5) | 12.03 | <0.001 |
| 利福喷丁 | 10(14.1) | 2(4.2) | 8(34.8) | 9.647 | 0.002 |
| 对氨基水杨酸异烟肼 | 10(14.1) | 4(8.3) | 6(26.1) | 2.716 | 0.099 |
| 利福平 | 9(12.7) | 1(2.1) | 8(34.8) | 12.21 | <0.001 |
| 利福布汀 | 9(12.7) | 2(4.2) | 7(30.4) | 7.465 | 0.006 |
| 卷曲霉素 | 9(12.7) | 6(12.5) | 3(13.0) | 0.100 | 0.752 |
| 左氧左旋氧氟沙星 | 8(11.3) | 2(4.2) | 6(26.1) | 5.441 | 0.020 |
| 对氨基水杨酸 | 7(9.9) | 3(6.3) | 4(17.4) | - | 0.119 |
| 克拉霉素 | 5(7.0) | 3(6.3) | 2(8.7) | - | 0.656 |
| 氯法齐明 | 5(7.0) | 2(4.2) | 3(13.0) | - | 0.320 |
| 乙胺丁醇 | 3(4.2) | 1(2.1) | 2(8.7) | - | 0.244 |
| 乙硫异烟胺 | 3(4.2) | 0 | 3(13.0) | - | 0.031 |
| 卡那霉素 | 2(2.8) | 1(2.1) | 1(4.3) | - | 0.546 |
| 阿米卡星 | 1(1.4) | 0 | 1(4.3) | - | 0.324 |
| 莫西沙星 | 1(1.4) | 0 | 1(4.3) | - | 0.324 |
), ArticleFig(id=1198318894160113696, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=表3, caption=
71例初治和复治血行播散性肺结核患者任一耐药的分布情况[例(%)]
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| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | χ2 | P |
| 单耐药 | 27(38.0) | 15(31.3) | 12(52.2) | 2.889 | 0.089 |
| 链霉素 | 13(18.3) | 5(10.4) | 8(34.8) | 4.650 | 0.031 |
| 异烟肼 | 13(18.3) | 3(6.3) | 10(43.5) | 12.03 | <0.001 |
| 利福喷丁 | 10(14.1) | 2(4.2) | 8(34.8) | 9.647 | 0.002 |
| 对氨基水杨酸异烟肼 | 10(14.1) | 4(8.3) | 6(26.1) | 2.716 | 0.099 |
| 利福平 | 9(12.7) | 1(2.1) | 8(34.8) | 12.21 | <0.001 |
| 利福布汀 | 9(12.7) | 2(4.2) | 7(30.4) | 7.465 | 0.006 |
| 卷曲霉素 | 9(12.7) | 6(12.5) | 3(13.0) | 0.100 | 0.752 |
| 左氧左旋氧氟沙星 | 8(11.3) | 2(4.2) | 6(26.1) | 5.441 | 0.020 |
| 对氨基水杨酸 | 7(9.9) | 3(6.3) | 4(17.4) | - | 0.119 |
| 克拉霉素 | 5(7.0) | 3(6.3) | 2(8.7) | - | 0.656 |
| 氯法齐明 | 5(7.0) | 2(4.2) | 3(13.0) | - | 0.320 |
| 乙胺丁醇 | 3(4.2) | 1(2.1) | 2(8.7) | - | 0.244 |
| 乙硫异烟胺 | 3(4.2) | 0 | 3(13.0) | - | 0.031 |
| 卡那霉素 | 2(2.8) | 1(2.1) | 1(4.3) | - | 0.546 |
| 阿米卡星 | 1(1.4) | 0 | 1(4.3) | - | 0.324 |
| 莫西沙星 | 1(1.4) | 0 | 1(4.3) | - | 0.324 |
), ArticleFig(id=1198318894264971299, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=EN, label=Tab.4, caption=
Distribution of different types of poly-drug resistance types in 71 newly treated and retreated patients with disseminated tuberculosis [n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | P |
| 合计 | 5(7.0) | 2(4.2) | 3(13.0) | 0.320 |
| INH+Sm | 2(2.8) | 1(2.1) | 1(4.3) | 0.546 |
| INH+Sm+EMB | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+Rfb+Rft | 1(1.4) | 1(2.1) | 0 | 1.000 |
| Sm+RFP+Rfb+Rft | 1(1.4) | 0 | 1(4.3) | 0.324 |
), ArticleFig(id=1198318894369828907, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=表4, caption=
不同多耐药类型在71例血行播散性肺结核初治及复治患者中的分布情况[例(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | P |
| 合计 | 5(7.0) | 2(4.2) | 3(13.0) | 0.320 |
| INH+Sm | 2(2.8) | 1(2.1) | 1(4.3) | 0.546 |
| INH+Sm+EMB | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+Rfb+Rft | 1(1.4) | 1(2.1) | 0 | 1.000 |
| Sm+RFP+Rfb+Rft | 1(1.4) | 0 | 1(4.3) | 0.324 |
), ArticleFig(id=1198318894466297905, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=EN, label=Tab.5, caption=
Distribution of different types of multidrug resistance in 71 newly treated and retreated patients with disseminated tuberculosis [n(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | P |
| INH+RFP | 8(11.3) | 1(2.1) | 7(30.4) | 0.002 |
| INH+RFP+Rft | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Rfb+Lfx+Rft+Mfx | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+Rfb+Lfx+Rft+Pa | 2(2.8) | 0 | 2(8.7) | 0.102 |
| INH+RFP+Sm+Rfb+PAS+Lfx+Rft+Pa | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+EMB+Rfb+Lfx+Rft+Pa | 1(1.4) | 1(2.1) | 0 | 1.000 |
| INH+RFP+Sm+Rfb+PAS+Lfx+Rft+Pto+Pa | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+EMB+Rfb+Am+Cm+Lfx+Rft+Km+Pto+Clr+Pa+Cfz | 1(1.4) | 0 | 1(4.3) | 0.324 |
), ArticleFig(id=1198318894550183988, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1198196210768118359, language=CN, label=表5, caption=
不同耐多药类型在71例血行播散性肺结核初治复治患者中的分布情况[例(%)]
, figureFileSmall=null, figureFileBig=null, tableContent=
| 耐药类型 | 合计 (n=71) | 初治患者 (n=48) | 复治患者 (n=23) | P |
| INH+RFP | 8(11.3) | 1(2.1) | 7(30.4) | 0.002 |
| INH+RFP+Rft | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Rfb+Lfx+Rft+Mfx | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+Rfb+Lfx+Rft+Pa | 2(2.8) | 0 | 2(8.7) | 0.102 |
| INH+RFP+Sm+Rfb+PAS+Lfx+Rft+Pa | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+EMB+Rfb+Lfx+Rft+Pa | 1(1.4) | 1(2.1) | 0 | 1.000 |
| INH+RFP+Sm+Rfb+PAS+Lfx+Rft+Pto+Pa | 1(1.4) | 0 | 1(4.3) | 0.324 |
| INH+RFP+Sm+EMB+Rfb+Am+Cm+Lfx+Rft+Km+Pto+Clr+Pa+Cfz | 1(1.4) | 0 | 1(4.3) | 0.324 |
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