Article(id=1194643390219395233, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1194643387904136153, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.0054.2024.0913, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=null, receivedDate=1705075200000, receivedDateStr=2024-01-13, revisedDate=null, revisedDateStr=null, acceptedDate=1714233600000, acceptedDateStr=2024-04-28, onlineDate=1762754779629, onlineDateStr=2025-11-10, pubDate=1737993600000, pubDateStr=2025-01-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1762754779629, onlineIssueDateStr=2025-11-10, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1762754779629, creator=13701087609, updateTime=1762754779629, updator=13701087609, issue=Issue{id=1194643387904136153, tenantId=1146029695717560320, journalId=1189873630562394117, year='2025', volume='50', issue='1', pageStart='1', pageEnd='120', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=0, createTime=1762754779076, creator=13701087609, updateTime=1762756450259, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1194650397408203370, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1194643387904136153, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1194650397408203371, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1194643387904136153, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=35, endPage=43, ext={EN=ArticleExt(id=1194643390420721828, articleId=1194643390219395233, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Expression and diagnostic value of CYBB and CSF1R in chronic rhinosinusitis with nasal polyps, columnId=1190310109000602400, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Clinical Research, runingTitle=null, highlight=null, articleAbstract=

Objective To analyze the gene expression characteristics of chronic rhinosinusitis with nasal polyps (CRSwNP) using bioinformatics methods, aim to investigate the potential biomarkers and their diagnostic value of CRSwNP. Methods (1) The CRSwNP Gene expression data set was downloaded from the American Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) between CRSwNP patients and healthy controls were screened through data analysis. Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the identified DEGs. Protein-protein interaction (PPI) networks were constructed utilizing the STRING database, and the key genes were identified by using the cytoHubba plugin. The "Cibersort" package was used to analyze the influence of key genes on common immune cells. (2) Thirty-two patients diagnosed with CRSwNP in the First Affiliated Hospital of Hebei North University from June 2022 to June 2023 were selected as the CRSwNP group, and 21 patients with simple deviation of nasal septum without a history of sinusitis during the same period were selected as control group. The pathological characteristics of specimens in the two groups were examined using hematoxylin-eosin (HE) staining. Immunohistochemistry and Western blotting were used to detect the expression levels of key genes in CRSwNP. The levels of key proteins in plasma were detected using ELISA, and ROC curve was used to analyze its efficacy in diagnosing CRSwNP. Results (1) Analysis of three gene expression database sets (GSE36830, GSE23552, and GSE194282) showed that there were 156 DEGs in CRSwNP. GO functional enrichment and KEGG pathway analysis indicated that the functions of the above DEGs were mostly related to immune functions. Key genes such as cytochrome b-245 β chain (CYBB) and colony-stimulating factor 1 receptor (CSF1R) were identified. (2) The results of HE staining revealed that the epithelial of CRSwNP tissue was metaplastic into stratified squamous epithelium with interstitial edema. Both immunohistochemistry and Western blotting analyses indicated that the expression levels of CYBB and CSF1R in the CRSwNP group were significantly increased compared to control group (P<0.05). ELISA results demonstrated that CYBB [(21.20±3.00) μg/ml vs. (17.66±1.66) μg/ml, P<0.05] and CSF1 [(477.37±86.63) pg/ml vs. (370.71±66.24) pg/ml, P<0.05] in CRSwNP group were significantly increased compare to control group. ROC curve analysis showed that plasma concentrations of CYBB and CSF1 had AUCs of 0.888 (95%CI 0.802-0.974) and 0.821 (95%CI 0.711-0.931) for diagnosing of CRSwNP, respectively; their combined AUC was 0.927 (95%CI 0.851-1.000). Conclusions CYBB and CSF1R may be involved in the occurrence and development of CRSwNP. Plasma CYBB and CSF1 have high diagnostic value for CRSwNP.

, correspAuthors=Gang Xue, Xu Lin, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Yu-Long Ma, Geng Li, Jing-Fang Wu, Gang Xue, Xu Lin), CN=ArticleExt(id=1194643617378705813, articleId=1194643390219395233, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=CYBB和CSF1R在慢性鼻窦炎伴鼻息肉中的表达及诊断价值, columnId=1190310109164180259, journalTitle=解放军医学杂志, columnName=临床研究, runingTitle=null, highlight=null, articleAbstract=

目的 采用生物信息学方法分析慢性鼻窦炎鼻息肉(CRSwNP)基因表达的特点，探寻CRSwNP潜在的生物标志物及其诊断价值。方法 (1)从美国GEO基因表达数据库下载CRSwNP基因表达数据集，通过数据分析筛选CRSwNP与健康对照的差异表达基因(DEGs)；对获取的DEGs进行基因本体论(GO)功能和京都基因与基因组百科全书(KEGG)通路分析，利用STRING数据库构建蛋白-蛋白互作(PPI)网络，利用cytoHubba插件筛选关键基因。利用Cibersort包分析关键基因对常见免疫细胞的影响。(2)选取2022年6月－2023年6月在河北北方学院附属第一医院确诊的32例CRSwNP患者为CRSwNP组，另选取同期无鼻窦炎病史的单纯鼻中隔偏曲患者21例作为对照组。HE染色观察两组标本的病理学特点，免疫组化和Western blotting检测CRSwNP关键基因的表达水平，ELISA法检测血浆关键蛋白的水平，并绘制ROC曲线分析关键蛋白诊断CRSwNP的效能。结果 (1)对获取的3个基因表达数据库集(GSE36830、GSE23552和GSE194282)进行分析显示，CRSwNP有156个DEGs；GO功能和KEGG通路分析显示，上述DEGs的作用多与免疫功能有关；筛选出细胞色素b-245 β链(CYBB)和集落刺激因子1受体(CSF1R)等关键基因。(2)HE染色结果显示，CRSwNP组织上皮化生为复层鳞状上皮，间质水肿；免疫组化和Western blotting检测结果显示，与对照组比较，CRSwNP组CYBB、CSF1R表达水平均明显升高(P<0.05)。ELISA检测结果显示，与对照组比较，CRSwNP组血浆CYBB[(21.20±3.00) μg/ml vs. (17.66±1.66) μg/ml，P<0.001]和CSF1[(477.37±86.63) pg/ml vs. (370.71±66.24) pg/ml，P<0.001]水平均明显升高。ROC曲线分析显示，血浆CYBB和CSF1水平诊断CRSwNP的曲线下面积(AUC)分别为0.888(95%CI 0.802~0.974)、0.821(95%CI 0.711~0.931)，二者联合诊断CRSwNP的AUC为0.927(95%CI 0.851~1.000)。结论 CYBB、CSF1R可能参与了CRSwNP的发生发展，血浆CYBB、CSF1水平可能成为CRSwNP的诊断标志物。

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马宇龙，主要从事耳鼻咽喉疾病生物信息学方面的研究

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马宇龙，主要从事耳鼻咽喉疾病生物信息学方面的研究

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CRSwNP. 慢性鼻窦炎鼻息肉；DEGs. 差异表达基因；A. 主坐标分析(PCoA)图；B. DEGs的火山图；C. DEGs的热图(Top20)

, figureFileSmall=X0CWjwhiWPn0eDkn0KsvnA==, figureFileBig=rVg03YC0YRdYp+jr3eUPAg==, tableContent=null), ArticleFig(id=1194662028930421719, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=EN, label=Fig.2, caption=Enrichment analysis of related functions in CRSwNP, figureFileSmall=iMyhyTyu88+MDRNd8GFPmw==, figureFileBig=ilhA2yC22pdxqg+05yas5Q==, tableContent=null), ArticleFig(id=1194662028989141977, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=CN, label=图2, caption=CRSwNP中相关基因的功能富集分析

CRSwNP. 慢性鼻窦炎鼻息肉；NES. 归一化后的富集分数；FDR. 伪发现率；GO. 基因本体论；KEGG. 京都基因与基因组百科全书；GSEA. 基因集富集分析；A. CRSwNP中差异表达基因的GO功能富集分析和KEGG通路分析结果；B. CRSwNP中相关基因的GSEA分析结果

, figureFileSmall=iMyhyTyu88+MDRNd8GFPmw==, figureFileBig=ilhA2yC22pdxqg+05yas5Q==, tableContent=null), ArticleFig(id=1194662029052056539, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=EN, label=Fig.3, caption=PPI network diagram of DEGs in CRSwNP, figureFileSmall=cakShpJvWcCfIwbVxr7ULA==, figureFileBig=vA8fGC61RiEJNp3+1wkpDg==, tableContent=null), ArticleFig(id=1194662030113215453, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=CN, label=图3, caption=CRSwNP中DEGs的PPI网络图

CRSwNP. 慢性鼻窦炎鼻息肉；DEGs. 差异表达基因；PPI. 蛋白质-蛋白质相互作用；CYBB. 细胞色素b-245 β链；CSF1R. 集落刺激因子1受体；A. PPI网络；B. 采用cytoHubba筛选的核心基因

, figureFileSmall=cakShpJvWcCfIwbVxr7ULA==, figureFileBig=vA8fGC61RiEJNp3+1wkpDg==, tableContent=null), ArticleFig(id=1194662030171935711, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=EN, label=Fig.4, caption=Immune infiltration results of CYBB and CSF1R in CRSwNP in GEO database, figureFileSmall=Jkxp80uFR41UXNvsm8fffQ==, figureFileBig=E/Lt7gYU+dBPbuIQNP/0Nw==, tableContent=null), ArticleFig(id=1194662030260016097, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1194643390219395233, language=CN, label=图4, caption=基于GEO数据库的CRSwNP中CYBB、CSF1R免疫浸润分析结果

CRSwNP. 慢性鼻窦炎鼻息肉；CYBB. 细胞色素b-245 β链；CSF1R. 集落刺激因子1受体；A. CYBB的免疫浸润结果；B. CSF1R的免疫浸润结果；*P<0.05，**P<0.01，***P<0.001

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CRSwNP. 慢性鼻窦炎鼻息肉；A. 对照组；B. Eos-CRSwNP组；C. nonEos-CRSwNP组

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CRSwNP. 慢性鼻窦炎鼻息肉；CYBB. 细胞色素b-245 β链；CSF1R. 集落刺激因子1受体

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CRSwNP. 慢性鼻窦炎鼻息肉；CYBB. 细胞色素b-245 β链；CSF1R. 集落刺激因子1受体；***P<0.001

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CRSwNP. 慢性鼻窦炎鼻息肉；CYBB. 细胞色素b-245 β链；CSF1R. 集落刺激因子1受体；AUC. 曲线下面积；A. 两组血浆CYBB、CSF1水平比较；B. 血浆CYBB、CSF1水平及两者联合诊断CRSwNP的ROC曲线；***P<0.001

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