Article(id=1190310109587800463, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.0804.2025.0218, pmid=null, cstr=null, oa=null, hot=1, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1717689600000, receivedDateStr=2024-06-07, revisedDate=null, revisedDateStr=null, acceptedDate=1722355200000, acceptedDateStr=2024-07-31, onlineDate=1761721645017, onlineDateStr=2025-10-29, pubDate=1748361600000, pubDateStr=2025-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1761721645017, onlineIssueDateStr=2025-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1761721645017, creator=13701087609, updateTime=1769158569818, updator=13701087609, issue=Issue{id=1190243275249390089, tenantId=1146029695717560320, journalId=1189873630562394117, year='2025', volume='50', issue='5', pageStart='505', pageEnd='640', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1761705710470, creator=13701087609, updateTime=1765784077922, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1207349188233372409, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1207349188233372410, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=575, endPage=580, ext={EN=ArticleExt(id=1190310110296637844, articleId=1190310109587800463, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Effects of advanced maternal age on hippocampal synaptic pruning in offspring rats, columnId=1190310110212751762, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Basic Research, runingTitle=null, highlight=null, articleAbstract=

Objective To investigate the effects of advanced maternal age (AMA) on synaptic pruning of the hippocampus of offspring rats. Methods Offspring of 3-month-old SD female rats and 3-month-old SD male rats were designated as the appropriate age group (Ctl group), while offspring of 12-month-old SD female rats and 3-month-old SD male rats were assigned to AMA group. Hippocampal tissues from both groups (n=3 per group at each time point) were subjected to Golgi staining on postnatal days (P) 7, 28, and 60. Dendritic complexity, spine density (DS), and morphology of immature brain neurons at different age stages were compared between the two groups. Results Compared with Ctl group, the dendritic length of AMA group on P7, P28, and P60 was significantly shortened, and the average number of intersections between dendrites and concentric circles on P28 and P60 was also significantly decreased (P<0.05). Compared with Ctl group, the dendritic spine density of AMA group was significantly decreased on P7, P28, and P60. Notably, the density of thin-shaped dendritic spines in AMA group was increased on P7, whereas the densities of stubby-shaped and mushroom-shaped dendritic spines were decreased (P<0.05). On P28 in AMA group, the densities of thin-shaped and mushroom-shaped dendritic spines were significantly increased compared with Ctl group, while the density of stubby-shaped dendritic spines was significantly decreased (P<0.05). The densities of stubby-shaped and mushroom-shaped dendritic spine were markedly lower in AMA group on P60 than those in Ctl group (P<0.05). Conclusions During postnatal brain development periods, there were abnormalities in synaptic pruning in the hippocampal region of the offspring of the AMA, which manifested as reduced dendritic complexity, decreased dendritic spine density, and disorganized dendritic spine morphology. It could be one of the key mechanisms underlying brain dysfunction in the offspring of AMA.

, correspAuthors=Li Jiang, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Chun-Xue Jiang, Zi-Yao Han, Xin-Ru Yan, Wei Han, Li Jiang), CN=ArticleExt(id=1190310253007831058, articleId=1190310109587800463, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=高龄妊娠对子代大鼠海马突触修剪的影响, columnId=1190310110472798614, journalTitle=解放军医学杂志, columnName=基础研究, runingTitle=null, highlight=null, articleAbstract=

目的 探讨高龄妊娠对子代大鼠海马突触修剪的影响。方法 将3月龄SD雌鼠与3月龄SD雄鼠合笼所生子代记为适龄组(Ctl组)，12月龄SD雌鼠与3月龄SD雄鼠合笼所生子代记为高龄组(AMA组)，取两组生后第7、28、60天(每时间点每组3只)的海马组织进行高尔基染色，比较两组各年龄段未成熟脑神经元的树突复杂性、树突棘密度及形态变化。结果 与Ctl组比较，AMA组生后第7、28、60天的树突长度明显缩短，第28、60天的树突与同心圆平均交点数亦明显减少(P<0.05)。与Ctl组比较，AMA组生后第7、28、60天树突棘密度均明显降低，其中生后第7天细长型树突棘密度明显增高，而短粗型、蘑菇型树突棘密度明显降低(P<0.05)，生后第28天细长型、蘑菇型树突棘密度明显增高，而短粗型树突棘密度明显降低(P<0.05)，生后第60天短粗型、蘑菇型树突棘密度均明显降低(P<0.05)。结论 在高龄妊娠子代出生后脑发育过程中，海马区存在突触修剪异常，表现为树突复杂性降低，树突棘密度降低、形态紊乱，这可能是高龄妊娠子代脑功能障碍的机制之一。

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Front Synaptic Neurosci, 2014, 6: 5., articleTitle=The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity, refAbstract=null), Reference(id=1190330534145393567, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, doi=null, pmid=null, pmcid=null, year=2017, volume=72, issue=11, pageStart=1465, pageEnd=1473, url=null, language=null, rfNumber=[32], rfOrder=31, authorNames=Sampino S, Stankiewicz AM, Zacchini F, journalName=J Gerontol A Biol Sci Med Sci, refType=null, unstructuredReference=Sampino S, Stankiewicz AM, Zacchini F, et al. Pregnancy at advanced maternal age affects behavior and hippocampal gene expression in mouse offspring[J]. J Gerontol A Biol Sci Med Sci, 2017, 72(11): 1465-1473., articleTitle=Pregnancy at advanced maternal age affects behavior and hippocampal gene expression in mouse offspring, refAbstract=null), Reference(id=1190330534216696736, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, doi=null, pmid=null, pmcid=null, year=2021, volume=46, issue=5, pageStart=456, pageEnd=461, url=null, language=null, rfNumber=[33], rfOrder=32, authorNames=潘亚男, 韩慰, 杨静, journalName=解放军医学杂志, refType=null, unstructuredReference=潘亚男, 韩慰, 杨静, 等. 高龄妊娠对子代大鼠海马甲基化水平的影响[J]. 解放军医学杂志, 2021, 46(5): 456-461., articleTitle=高龄妊娠对子代大鼠海马甲基化水平的影响, refAbstract=null)], funds=[Fund(id=1190330530571846526, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, awardId=82301654, language=EN, fundingSource=National Natural Science Foundation of China(82301654), fundOrder=null, country=null), Fund(id=1190330530655732607, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, awardId=KJQN202100423, language=EN, fundingSource=Scientific and Technological Research Program of Chongqing Municipal Education Commission(KJQN202100423), fundOrder=null, country=null)], companyList=[AuthorCompany(id=1190330527619056443, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, xref=null, ext=[AuthorCompanyExt(id=1190330527631639356, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, companyId=1190330527619056443, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=Department of Neurology, Children's Hospital of Chongqing Medical University/National Clinical Research Center for Child Health and Disorders/Ministry of Education Key Laboratory of Child Development and Disorders/Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing 400014, China), AuthorCompanyExt(id=1190330527640027965, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, companyId=1190330527619056443, language=CN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=重庆医科大学附属儿童医院神经内科/国家儿童健康与疾病临床医学研究中心/儿童发育疾病研究教育部重点实验室/ 儿童神经发育与认知障碍重庆市重点实验室，重庆 400014)])], figs=[ArticleFig(id=1190330529896563574, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=EN, label=Fig.1, caption=Processes for analyzing dendritic complexity, figureFileSmall=HYxZhVHeUJAOYVKJdYNrQg==, figureFileBig=fTv4xZOn4kpi8MFvi07t8g==, tableContent=null), ArticleFig(id=1190330530014004087, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=CN, label=图1, caption=树突复杂性的分析流程

A. 高尔基染色后海马区神经元图像；B. 追踪目标神经元树突轨迹以获得树突长度；C. 将轨迹图转换为二进制格式获得目标神经元树突二维分布图；D. 以目标神经元胞体为中心进行Sholl分析

, figureFileSmall=HYxZhVHeUJAOYVKJdYNrQg==, figureFileBig=fTv4xZOn4kpi8MFvi07t8g==, tableContent=null), ArticleFig(id=1190330530123055992, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=EN, label=Fig.2, caption=Diagram of dendritic spine morphology classification in hippocampal neurons, figureFileSmall=HqV/7hT746d6DRMAkXYxsg==, figureFileBig=HueGEYIW3CBRkeFRRnwjmA==, tableContent=null), ArticleFig(id=1190330530181776249, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=CN, label=图2, caption=海马区神经元树突棘形态分类示意图, figureFileSmall=HqV/7hT746d6DRMAkXYxsg==, figureFileBig=HueGEYIW3CBRkeFRRnwjmA==, tableContent=null), ArticleFig(id=1190330530236302202, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=EN, label=Fig.3, caption=Comparison of dendritic complexity of hippocampus neurons in offspring rats between the two groups, figureFileSmall=esNFUfqq09MNzuudnXGu0Q==, figureFileBig=f8wzWOGVSjUwgNWJV/2EQg==, tableContent=null), ArticleFig(id=1190330530315993979, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=CN, label=图3, caption=两组大鼠海马区神经元树突复杂性比较

Ctl组. 适龄组；AMA组. 高龄组；A. 生后第7、28、60天两组大鼠海马神经元树突与同心圆交点分布，相邻两个同心圆间隔10 μm；B. 生后第7、28、60天两组大鼠海马树突长度及树突与同心圆平均交点数的柱状图；纳入统计的神经元个数：第7天，Ctl组56个、AMA组58个；第28天，Ctl组76个、AMA组85个；第60天，Ctl组102个、AMA组104个；与Ctl组比较，*P<0.05，**P<0.01，***P<0.001

, figureFileSmall=esNFUfqq09MNzuudnXGu0Q==, figureFileBig=f8wzWOGVSjUwgNWJV/2EQg==, tableContent=null), ArticleFig(id=1190330530387297148, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=EN, label=Fig.4, caption=Effect of advanced maternal age on dendritic spines of hippocampus in offspring rats, figureFileSmall=JDzXwdVKez8iveuZfOEixQ==, figureFileBig=l9MyfatN69cn+B4iU6exeA==, tableContent=null), ArticleFig(id=1190330530454406013, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109587800463, language=CN, label=图4, caption=高龄妊娠对子代大鼠海马区树突棘的影响

Ctl组. 适龄组；AMA组. 高龄组；A、B、C. 生后第7、28、60天两组海马区不同形态树突棘密度；纳入统计的树突节段的段数：第7天，Ctl组129个、AMA组146个；第28天，Ctl组235个、AMA组225个；第60天，Ctl组188个、AMA组213个；与Ctl组比较，*P<0.05，**P<0.01，***P<0.001

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