Article(id=1190310109248061832, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.1475.2024.0731, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1699459200000, receivedDateStr=2023-11-09, revisedDate=null, revisedDateStr=null, acceptedDate=1705852800000, acceptedDateStr=2024-01-22, onlineDate=1761721644936, onlineDateStr=2025-10-29, pubDate=1748361600000, pubDateStr=2025-05-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1761721644936, onlineIssueDateStr=2025-10-29, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1761721644936, creator=13701087609, updateTime=1761721644936, updator=13701087609, issue=Issue{id=1190243275249390089, tenantId=1146029695717560320, journalId=1189873630562394117, year='2025', volume='50', issue='5', pageStart='505', pageEnd='640', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1761705710470, creator=13701087609, updateTime=1765784077922, updator=13701087609, preIssue=null, nextIssue=null, ext={EN=IssueExt(id=1207349188233372409, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, language=EN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=), CN=IssueExt(id=1207349188233372410, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1190243275249390089, language=CN, specialIssueTitle=, coverIllustrator=null, specialIssueEditor=, specialIssueAbout=)}, issueFiles=null}, startPage=607, endPage=611, ext={EN=ArticleExt(id=1190310109961093521, articleId=1190310109248061832, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress of transcriptomics sequencing technology in evaluating human endometrial receptivity, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=
Good endometrial receptivity is an essential factor for embryo implantation, and gene expression in endometrial tissue during the window of implantation (WOI) is closely related to receptivity. Transcriptome sequencing technology enables the identification of gene expression profiles of endometrium during different menstrual phases, as well as microRNAs and long-chain non-coding RNA sequences involved in regulating gene expression. Combining this technology with bioinformatics analysis provides a better understanding of specific gene expression during the receptive period and offers technical support for studying its regulatory mechanism. Moreover, gene expression profiles of the endometrium during different menstrual phases hold significant clinical application value for accurately assessing endometrium receptivity in infertility patients and those with repeated implantation failure, thereby guiding individualized embryo transfer strategies. This review summarizes the progress of transcriptome sequencing in evaluating human endometrial receptivity and discusses future research directions. This review aims to understand the complex molecular mechanisms of endometrial receptivity formation and regulation from the transcriptional level, in order to improve the implantation rate of embryos in assisted reproductive technology and reduce the abortion rate.
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良好的子宫内膜容受性是胚胎植入的关键,容受期子宫内膜组织的基因表达与容受性密切相关。通过转录组测序技术可获得不同月经时期子宫内膜的基因表达谱,以及调控基因表达的微小RNA和长链非编码RNA序列;结合生物信息学分析可更好地了解容受期子宫内膜特异基因的表达,并为其调控机制研究提供技术支持。同时,不同月经时期子宫内膜的基因表达谱对于准确判断不孕症及反复植入失败患者的子宫内膜容受性,进一步指导个体化胚胎移植具有重要的临床应用价值。本文对近年来转录组测序技术在评价人子宫内膜容受性中的应用进展进行综述,并探讨未来的研究方向,旨在从转录层面深入了解子宫内膜容受性形成和调控的复杂分子机制,以期提高辅助生殖技术的胚胎着床率,降低流产率。
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马丽娜,医学博士,主要从事妇产科生殖内分泌等方面的研究
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1Department of Obsterics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250014, China
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1山东中医药大学附属医院产科,山东济南 250014
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3Department of Gynecology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1190330396928737648, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, authorId=1190330396773548397, language=CN, stringName=刘洋, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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3黑龙江中医药大学附属第一医院妇科,黑龙江哈尔滨 150040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1190330394974191958, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, xref=3, ext=[AuthorCompanyExt(id=1190330394982580567, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, companyId=1190330394974191958, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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4Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1190330397167812981, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, authorId=1190330396995846514, language=CN, stringName=葛航, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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4黑龙江中医药大学研究生院,黑龙江哈尔滨 150040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1190330395058078041, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, xref=4, ext=[AuthorCompanyExt(id=1190330395066466650, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, companyId=1190330395058078041, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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4Graduate School of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null), CN=AuthorExt(id=1190330397369139578, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, authorId=1190330397226533239, language=CN, stringName=卢凤娟, firstName=null, middleName=null, lastName=null, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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4黑龙江中医药大学研究生院,黑龙江哈尔滨 150040, bio=null, bioImg=null, bioContent=null, aboutCorrespAuthor=null)}, companyList=[AuthorCompany(id=1190330395058078041, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, xref=4, ext=[AuthorCompanyExt(id=1190330395066466650, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, companyId=1190330395058078041, language=EN, country=null, province=null, city=null, postcode=null, companyName=null, departmentName=null, remark=
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4黑龙江中医药大学研究生院,黑龙江哈尔滨 150040)])]), Author(id=1190330397465608572, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, orderNo=6, firstName=null, middleName=null, lastName=null, nameCn=null, orcid=null, stid=null, country=null, authorPic=null, dead=0, email=null, emailSecond=null, emailThird=null, correspondingAuthor=0, authorType=1, ext={EN=AuthorExt(id=1190330397557883262, tenantId=1146029695717560320, journalId=1189873630562394117, articleId=1190310109248061832, authorId=1190330397465608572, language=EN, stringName=Xiao-Ke Wu, firstName=Xiao-Ke, middleName=null, lastName=Wu, prefix=null, suffix=null, authorComment=null, nameInitials=null, affiliation=null, department=null, xref=
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