Article(id=1208106713203445846, tenantId=1146029695717560320, journalId=1189873630562394117, issueId=1208106710208717234, articleNumber=null, orderNo=null, doi=10.11855/j.issn.0577-7402.2022.04.0407, pmid=null, cstr=null, oa=null, hot=null, price=null, onlineType=0, articleFormat=0, articleType=null, articleTypeStr=research-article, receivedDate=1617120000000, receivedDateStr=2021-03-31, revisedDate=null, revisedDateStr=null, acceptedDate=1623686400000, acceptedDateStr=2021-06-15, onlineDate=1765964685964, onlineDateStr=2025-12-17, pubDate=1651075200000, pubDateStr=2022-04-28, doiRegisterDate=null, doiRegisterDateStr=null, onlineIssueDate=1765964685964, onlineIssueDateStr=2025-12-17, onlineJustAcceptDate=null, onlineJustAcceptDateStr=null, onlineFirstDate=null, onlineFirstDateStr=null, sourceXml=null, magXml=null, createTime=1765964685964, creator=13701087609, updateTime=1765964685964, updator=13701087609, issue=Issue{id=1208106710208717234, tenantId=1146029695717560320, journalId=1189873630562394117, year='2022', volume='47', issue='4', pageStart='321', pageEnd='426', issueExtLink='null', onlineDate='null', pubDate='null', beforeIssueId=null, nextIssueId=null, price=null, status=1, issueComplete=1, articleOrder=1, issueType=-1, specialIssue=null, createTime=1765964685250, creator=13701087609, updateTime=1765964685250, updator=13701087609, preIssue=null, nextIssue=null, ext=null, issueFiles=null}, startPage=407, endPage=411, ext={EN=ArticleExt(id=1208106713450909799, articleId=1208106713203445846, tenantId=1146029695717560320, journalId=1189873630562394117, language=EN, title=Research progress on the role of neutrophil extracellular traps in tumor microenvironment, columnId=1190243275882729994, journalTitle=Medical Journal of Chinese People’s Liberation Army, columnName=Review, runingTitle=null, highlight=null, articleAbstract=

Neutrophil extracellular trap (NETs) is a kind of DNA-based skeleton released by neutrophils to the outside of the cell, in which a variety of granular proteins, proteolytic enzymes, antibacterial peptides, and other network structures are embedded.In recent years, studies have confirmed that NETs are highly expressed in a variety of tumors, and tumor microenvironment (TME)is a special environment for tumor cell survival and development, including cellular and non-cellular components. This article mainly explains that TME can stimulate the formation of NETs, and NETs can also promote tumor proliferation, invasion and metastasis by affecting tumor cells, immune cells, endothelial cells, epithelial cells, fibroblasts and extracellular matrix in TME. Finally, the clinical application prospects of NETs as tumor markers and potential therapeutic targets are discussed.

, correspAuthors=De-Kui Zhang, authorNote=null, correspAuthorsNote=, copyrightStatement=null, copyrightOwner=null, extLink=null, articleAbsUrl=null, sourceXml=null, magXml=null, pdfUrl=null, pdf=null, pdfFileSize=null, pdfExtLink=null, richHtmlUrl=null, mobilePdfUrl=null, reviewReport=null, pdfFirstPage=null, abstractGraph=null, abstractGraphContent=null, abstractVideo=null, citation=null, cebUrl=null, magXmlContent=null, mapNumber=null, authorCompany=null, fund=null, authors=null, authorsList=Xue-Ni Ma, Hui-Mei Xu, De-Kui Zhang), CN=ArticleExt(id=1208106713744511094, articleId=1208106713203445846, tenantId=1146029695717560320, journalId=1189873630562394117, language=CN, title=中性粒细胞外诱捕网在肿瘤微环境中的作用研究进展, columnId=1190243276029530637, journalTitle=解放军医学杂志, columnName=综述, runingTitle=null, highlight=null, articleAbstract=

中性粒细胞外诱捕网(NETs)是中性粒细胞受到各种刺激后产生的以DNA为骨架，其间镶嵌各种颗粒蛋白、蛋白水解酶及抗菌肽等的网状结构。近年来的研究证实，NETs在多种肿瘤中高表达，而肿瘤微环境(TME)是肿瘤细胞生存和发展的特殊环境，包括细胞成分及非细胞成分。TME中的白细胞介素(IL)-8及肿瘤相关成纤维细胞产生的淀粉样蛋白β能刺激NETs的形成，而NETs同时通过影响TME中肿瘤细胞的生物学特性、免疫细胞杀伤肿瘤的能力、内皮细胞的表型、肿瘤相关成纤维细胞的功能及细胞外基质的组分等促进肿瘤增殖、侵袭及转移。本文从以上几个方面对NETs在TME中的作用进行综述，以探讨NETs作为肿瘤标志物及潜在治疗靶点的临床应用前景。

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马雪妮，博士研究生，主要从事中性粒细胞外诱捕网与消化系统疾病的关系研究

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