In order to further explore the changes in relationships between seasonal succession of zooplankton and temperature-salinity in coastal East China sea, zooplankton survey data of three voyages in May (spring), August (summer) and December (winter) of 2013 were analyzed. Redundancy analysis model (RDA) was used to analyze the relationship between the changes of the dominant species and temperature-salinity, then the general algebraic modeling system (GAMs) was applied to analyze the relationship between temperature-salinity and parameters of the biological diversity. Results show that the dominant species’ succession changes seasonally from spring (2 kinds) to summer (10 kinds), then becomes 5 kinds in winter. Dominant species and the ecological groups are relatively single in spring and winter, but rich in summer. The temporal and spatial distribution of dominant species are the results of a comprehensive multi-level of environmental factors. For example, Calanus sinicus positively relates to surface salinity and bottom salinity in spring, negatively relates to surface temperature and bottom temperature in summer, positively relates to surface salinity in winter. Muggiaea atlantica presents better positive correlations with bottom temperature and bottom salinity in spring. What’s more, salinity is the key factor to determine the distribution of dominant species like warm water species and high temperature-salinity groups in summer, it also presents strong positive correlations. Labidocera euchaeta and Aidanosagitta crassa have strong negative correlations with surface temperature in winter. Shannon-Wiener diversity index negatively correlates with latitude in spring and winter. Biodiversity parameters are significantly affected by the temperature and salinity, but the influence presents differences seasonally.